{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:21:42Z","timestamp":1790612502737,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Genome Biol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>The prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male fetuses early in the course of conception\/pregnancy. Previously, we showed that the sexual dimorphism in experimental autoimmune encephalomyelitis (EAE) is associated with copy number variation (CNV) in Y chromosome multicopy genes. Here, we test the hypothesis that CNV in Y chromosome multicopy genes influences the paternal parent-of-origin effect on EAE susceptibility in female mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We show that C57BL\/6\u00a0J consomic strains of mice possessing an identical X chromosome and CNV in Y chromosome multicopy genes exhibit sperm head abnormalities and female-biased sex ratio. This is consistent with X-Y intragenomic conflict arising from an imbalance in CNV between homologous X:Y chromosome multicopy genes. These males also display paternal transmission of EAE to female offspring and differential loading of microRNAs within the sperm nucleus. Furthermore, in humans, families of probands with multiple sclerosis similarly exhibit a female-biased sex ratio, whereas families of probands affected with non-sexually dimorphic autoimmune diseases exhibit unbiased sex ratios.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>These findings provide evidence for a mechanism at the level of the male gamete that contributes to the sexual dimorphism in EAE and paternal parent-of-origin effects in female mice, raising the possibility that a similar mechanism may contribute to the sexual dimorphism in multiple sclerosis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/s13059-015-0591-7","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T14:42:25Z","timestamp":1423492945000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring"],"prefix":"10.1186","volume":"16","author":[{"given":"Laure K","family":"Case","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma H","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"Osmanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Dragon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresha","family":"Saligrama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P","family":"Blankenhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"Teuscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,10]]},"reference":[{"key":"591_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.yfrne.2014.04.004","volume":"35","author":"ST Ngo","year":"2014","unstructured":"Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Front Neuroendocrinol. 2014;35:347\u201369.","journal-title":"Front Neuroendocrinol"},{"key":"591_CR2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1086\/285346","volume":"139","author":"I Folstad","year":"1992","unstructured":"Folstad I, Karter AJ. Parasites, bright males, and the immunocompetence handicap. Am Nat. 1992;139:603\u201322.","journal-title":"Am Nat"},{"key":"591_CR3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/ajhb.20419","volume":"17","author":"MP Muehlenbein","year":"2005","unstructured":"Muehlenbein MP, Bribiescas RG. Testosterone-mediated immune functions and male life histories. Am J Hum Biol. 2005;17:527\u201358.","journal-title":"Am J Hum Biol"},{"key":"591_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/0961203307085111","volume":"17","author":"LN Moorthy","year":"2008","unstructured":"Moorthy LN, Peterson MG, Onel KB, Lehman TJ. Do children with lupus have fewer male siblings? Lupus. 2008;17:128\u201331.","journal-title":"Lupus"},{"key":"591_CR5","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3899\/jrheum.120643","volume":"40","author":"R Aggarwal","year":"2013","unstructured":"Aggarwal R, Sestak AL, Chakravarty EF, Harley JB, Scofield RH. Excess female siblings and male fetal loss in families with systemic lupus erythematosus. J Rheumatol. 2013;40:430\u20134.","journal-title":"J Rheumatol"},{"key":"591_CR6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1749-4877.2012.00284.x","volume":"7","author":"M Hartfield","year":"2012","unstructured":"Hartfield M, Keightley PD. Current hypotheses for the evolution of sex and recombination. Integr Zool. 2012;7:192\u2013209.","journal-title":"Integr Zool"},{"key":"591_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tree.2012.08.015","volume":"28","author":"B Crespi","year":"2013","unstructured":"Crespi B, Nosil P. Conflictual speciation: species formation via genomic conflict. Trends Ecol Evol. 2013;28:48\u201357.","journal-title":"Trends Ecol Evol"},{"key":"591_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00439-012-1257-0","volume":"132","author":"LO Huang","year":"2013","unstructured":"Huang LO, Labbe A, Infante-Rivard C. Transmission ratio distortion: review of concept and implications for genetic association studies. Hum Genet. 2013;132:245\u201363.","journal-title":"Hum Genet"},{"key":"591_CR9","doi-asserted-by":"publisher","first-page":"e1002900","DOI":"10.1371\/journal.pgen.1002900","volume":"8","author":"J Cocquet","year":"2012","unstructured":"Cocquet J, Ellis PJ, Mahadevaiah SK, Affara NA, Vaiman D, Burgoyne PS. A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 2012;8:e1002900.","journal-title":"PLoS Genet"},{"key":"591_CR10","doi-asserted-by":"publisher","first-page":"e1000244","DOI":"10.1371\/journal.pbio.1000244","volume":"7","author":"J Cocquet","year":"2009","unstructured":"Cocquet J, Ellis PJ, Yamauchi Y, Mahadevaiah SK, Affara NA, Ward MA, et al. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244.","journal-title":"PLoS Biol"},{"key":"591_CR11","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1093\/hmg\/ddr204","volume":"20","author":"PJ Ellis","year":"2011","unstructured":"Ellis PJ, Bacon J, Affara NA. Association of Sly with sex-linked gene amplification during mouse evolution: a side effect of genomic conflict in spermatids? Hum Mol Genet. 2011;20:3010\u201321.","journal-title":"Hum Mol Genet"},{"key":"591_CR12","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0092-8674(92)90509-B","volume":"71","author":"PS Burgoyne","year":"1992","unstructured":"Burgoyne PS, Mahadevaiah SK, Sutcliffe MJ, Palmer SJ. Fertility in mice requires X-Y pairing and a Y-chromosomal 'spermiogenesis' gene mapping to the long arm. Cell. 1992;71:391\u20138.","journal-title":"Cell"},{"key":"591_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1017\/S0016672300029268","volume":"57","author":"J Styrna","year":"1991","unstructured":"Styrna J, Imai HT, Moriwaki K. An increased level of sperm abnormalities in mice with a partial deletion of the Y-chromosome. Genet Res. 1991;57:195\u20139.","journal-title":"Genet Res"},{"key":"591_CR14","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1095\/biolreprod47.4.549","volume":"47","author":"M Xian","year":"1992","unstructured":"Xian M, Azuma S, Naito K, Kunieda T, Moriwaki K, Toyoda Y. Effect of a partial deletion of Y chromosome on in vitro fertilizing ability of mouse spermatozoa. Biol Reprod. 1992;47:549\u201353.","journal-title":"Biol Reprod"},{"key":"591_CR15","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1534\/genetics.166.2.901","volume":"166","author":"A Toure","year":"2004","unstructured":"Toure A, Szot M, Mahadevaiah SK, Rattigan A, Ojarikre OA, Burgoyne PS. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics. 2004;166:901\u201312.","journal-title":"Genetics"},{"key":"591_CR16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1242\/jcs.114488","volume":"126","author":"JM Riel","year":"2013","unstructured":"Riel JM, Yamauchi Y, Sugawara A, Li HY, Ruthig V, Stoytcheva Z, et al. Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging. J Cell Sci. 2013;126:803\u201313.","journal-title":"J Cell Sci"},{"key":"591_CR17","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1093\/hmg\/ddi304","volume":"14","author":"PJ Ellis","year":"2005","unstructured":"Ellis PJ, Clemente EJ, Ball P, Toure A, Ferguson L, Turner JM, et al. Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids. Hum Mol Genet. 2005;14:2705\u201315.","journal-title":"Hum Mol Genet"},{"key":"591_CR18","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1242\/jcs.049916","volume":"122","author":"LN Reynard","year":"2009","unstructured":"Reynard LN, Turner JM. Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions. J Cell Sci. 2009;122:4239\u201348.","journal-title":"J Cell Sci"},{"key":"591_CR19","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1095\/biolreprod.108.075382","volume":"81","author":"LN Reynard","year":"2009","unstructured":"Reynard LN, Cocquet J, Burgoyne PS. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol Reprod. 2009;81:250\u20137.","journal-title":"Biol Reprod"},{"key":"591_CR20","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1101\/gr.156703.113","volume":"23","author":"LK Case","year":"2013","unstructured":"Case LK, Wall EH, Dragon JA, Saligrama N, Krementsov DN, Moussawi M, et al. The Y chromosome as a regulatory element shaping Immune cell transcriptomes and susceptibility to autoimmune disease. Genome Res. 2013;23:1474\u201385.","journal-title":"Genome Res"},{"key":"591_CR21","doi-asserted-by":"publisher","first-page":"8024","DOI":"10.1073\/pnas.0600536103","volume":"103","author":"C Teuscher","year":"2006","unstructured":"Teuscher C, Noubade R, Spach K, McElvany B, Bunn JY, Fillmore PD, et al. Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc Natl Acad Sci U S A. 2006;103:8024\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"591_CR22","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/genetics\/158.4.1675","volume":"158","author":"LL Washburn","year":"2001","unstructured":"Washburn LL, Albrecht KH, Eicher EM. C57BL\/6\u00a0J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry allele. Genetics. 2001;158:1675\u201381.","journal-title":"Genetics"},{"key":"591_CR23","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1034\/j.1600-0463.2003.11101221.x","volume":"111","author":"MY Lam","year":"2003","unstructured":"Lam MY, Nadeau JH. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS. 2003;111:184\u201390. discussion 191.","journal-title":"APMIS"},{"key":"591_CR24","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1101\/gr.7160508","volume":"18","author":"S Gregorova","year":"2008","unstructured":"Gregorova S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, et al. Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res. 2008;18:509\u201315.","journal-title":"Genome Res"},{"key":"591_CR25","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00335-012-9426-y","volume":"23","author":"JH Nadeau","year":"2012","unstructured":"Nadeau JH, Forejt J, Takada T, Shiroishi T. Chromosome substitution strains: gene discovery, functional analysis, and systems studies. Mamm Genome. 2012;23:693\u2013705.","journal-title":"Mamm Genome"},{"key":"591_CR26","first-page":"135","volume":"169","author":"FS Vom Saal","year":"1984","unstructured":"Vom Saal FS. The intrauterine position phenomenon: effects on physiology, aggressive behavior and population dynamics in house mice. Prog Clin Biol Res. 1984;169:135\u201379.","journal-title":"Prog Clin Biol Res"},{"key":"591_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10577-012-9334-8","volume":"21","author":"KH Lee","year":"2013","unstructured":"Lee KH, Kim WC, Shin KS, Roh JK, Cho DH, Cho K. Large interrelated clusters of repetitive elements (REs) and RE arrays predominantly represent reference mouse chromosome Y. Chromosome Res. 2013;21:15\u201326.","journal-title":"Chromosome Res"},{"key":"591_CR28","unstructured":"Ensembl Genome Browser. http:\/\/www.ensembl.org\/Mus_musculus\/Info\/Index%5D."},{"key":"591_CR29","doi-asserted-by":"crossref","unstructured":"Soh YQ, Alfoldi J, Pyntikova T, Brown LG, Graves T, Minx PJ, et al. Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes. Cell 2014;159:800-13. http:\/\/dx.doi.org\/10.1016\/j.cell.2014.09.052.","DOI":"10.1016\/j.cell.2014.09.052"},{"key":"591_CR30","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1111\/febs.12724","volume":"281","author":"A Comptour","year":"2014","unstructured":"Comptour A, Moretti C, Serrentino ME, Auer J, Ialy-Radio C, Ward MA, et al. SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. FEBS J. 2014;281:1571\u201384.","journal-title":"FEBS J"},{"key":"591_CR31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature04674","volume":"441","author":"M Rassoulzadegan","year":"2006","unstructured":"Rassoulzadegan M, Grandjean V, Gounon P, Vincent S, Gillot I, Cuzin F. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature. 2006;441:469\u201374.","journal-title":"Nature"},{"key":"591_CR32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrurol.2012.183","volume":"9","author":"U Schagdarsurengin","year":"2012","unstructured":"Schagdarsurengin U, Paradowska A, Steger K. Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction. Nat Rev Urol. 2012;9:609\u201319.","journal-title":"Nat Rev Urol"},{"key":"591_CR33","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/ana.22642","volume":"70","author":"EP Blankenhorn","year":"2011","unstructured":"Blankenhorn EP, Butterfield R, Case LK, Wall EH, del Rio R, Diehl SA, et al. Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. Ann Neurol. 2011;70:887\u201396.","journal-title":"Ann Neurol"},{"key":"591_CR34","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","volume":"476","author":"S Sawcer","year":"2011","unstructured":"Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011;476:214\u20139.","journal-title":"Nature"},{"key":"591_CR35","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/ng0896-464","volume":"13","author":"S Sawcer","year":"1996","unstructured":"Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J, et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet. 1996;13:464\u20138.","journal-title":"Nat Genet"},{"key":"591_CR36","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/ng0896-472","volume":"13","author":"GC Ebers","year":"1996","unstructured":"Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, et al. A full genome search in multiple sclerosis. Nat Genet. 1996;13:472\u20136.","journal-title":"Nat Genet"},{"key":"591_CR37","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/art.20066","volume":"50","author":"D Jawaheer","year":"2004","unstructured":"Jawaheer D, Lum RF, Amos CI, Gregersen PK, Criswell LA. Clustering of disease features within 512 multicase rheumatoid arthritis families. Arthritis Rheum. 2004;50:736\u201341.","journal-title":"Arthritis Rheum"},{"key":"591_CR38","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/genetics\/161.4.1551","volume":"161","author":"M Belloni","year":"2002","unstructured":"Belloni M, Tritto P, Bozzetti MP, Palumbo G, Robbins LG. Does Stellate cause meiotic drive in Drosophila melanogaster? Genetics. 2002;161:1551\u20139.","journal-title":"Genetics"},{"key":"591_CR39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/genetics\/142.2.641","volume":"142","author":"LD Hurst","year":"1996","unstructured":"Hurst LD. Further evidence consistent with Stellate\u2019s involvement in meiotic drive. Genetics. 1996;142:641\u20133.","journal-title":"Genetics"},{"key":"591_CR40","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev-genom-090711-163855","volume":"13","author":"JF Hughes","year":"2012","unstructured":"Hughes JF, Rozen S. Genomics and genetics of human and primate y chromosomes. Annu Rev Genomics Hum Genet. 2012;13:83\u2013108.","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"591_CR41","unstructured":"The Jackson Laboratory website. http:\/\/www.jax.org\/."},{"key":"591_CR42","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.4049\/jimmunol.161.4.1860","volume":"161","author":"RJ Butterfield","year":"1998","unstructured":"Butterfield RJ, Sudweeks JD, Blankenhorn EP, Korngold R, Marini JC, Todd JA, et al. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol. 1998;161:1860\u20137.","journal-title":"J Immunol"},{"key":"591_CR43","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0002-9440(10)63176-8","volume":"164","author":"C Teuscher","year":"2004","unstructured":"Teuscher C, Poynter ME, Offner H, Zamora A, Watanabe T, Fillmore PD, et al. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Am J Pathol. 2004;164:883\u201392.","journal-title":"Am J Pathol"},{"key":"591_CR44","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1172\/JCI32792","volume":"117","author":"R Noubade","year":"2007","unstructured":"Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, Rincon M, et al. Histamine receptor H-1 is-required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Investig. 2007;117:3507\u201318.","journal-title":"J Clin Investig"},{"key":"591_CR45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Series B. 1995;57:289\u2013300.","journal-title":"J R Stat Soc Series B"},{"key":"591_CR46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30:207\u201310.","journal-title":"Nucleic Acids Res"},{"key":"591_CR47","unstructured":"GEO SuperSeries. http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE65048."}],"container-title":["Genome Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13059-015-0591-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13059-015-0591-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13059-015-0591-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13059-015-0591-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:13:02Z","timestamp":1728922382000},"score":1,"resource":{"primary":{"URL":"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-015-0591-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,10]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["591"],"URL":"https:\/\/doi.org\/10.1186\/s13059-015-0591-7","relation":{},"ISSN":["1465-6906"],"issn-type":[{"value":"1465-6906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,10]]},"assertion":[{"value":"9 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"28"}}