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All participants were aged 18 or above and provided informed consent prior to their involvement. The study protocol was approved by the Ethical Committee of the Medical School, University of Zagreb, and by the Multi-Centre Research Ethics Committee for Scotland. All experimental methods were performed in accordance with the principles of the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"FV and AFH are employees of Genos Ltd. FP received advisory and lecture fees from Sanofi Aventis. All other authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"261"}}