{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:55:03Z","timestamp":1793998503673,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hainan Cerebrovascular Disease Clinical Medical Research Center","award":["LCYX202206"],"award-info":[{"award-number":["LCYX202206"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Direct"],"DOI":"10.1186\/s13062-024-00536-4","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T03:41:40Z","timestamp":1729050100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia\/reperfusion injury through YTHDC1"],"prefix":"10.1186","volume":"19","author":[{"given":"Zhengtao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"536_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fnmol.2020.00103","volume":"13","author":"W Si","year":"2020","unstructured":"Si W, et al. Methyltransferase 3 mediated miRNA m6A methylation promotes stress granule formation in the early stage of Acute ischemic stroke. Front Mol Neurosci. 2020;13:103.","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"536_CR2","first-page":"2043","volume":"18","author":"WT Lee","year":"2018","unstructured":"Lee WT, et al. YC\u20131 reduces inflammatory responses by inhibiting nuclear factor\u2013\u03baB translocation in mice subjected to transient focal cerebral ischemia. Mol Med Rep. 2018;18(2):2043\u201351.","journal-title":"Mol Med Rep"},{"issue":"1","key":"536_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between Deficit and Infarct. N Engl J Med. 2018;378(1):11\u201321.","journal-title":"N Engl J Med"},{"issue":"2","key":"536_CR4","first-page":"1470","volume":"16","author":"ZR Li","year":"2018","unstructured":"Li ZR, et al. Nobiletin protects PC12 cells from ERS-induced apoptosis in OGD\/R injury via activation of the PI3K\/AKT pathway. Exp Ther Med. 2018;16(2):1470\u20136.","journal-title":"Exp Ther Med"},{"issue":"1","key":"536_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","volume":"11","author":"Y Niu","year":"2013","unstructured":"Niu Y, et al. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteom Bioinf. 2013;11(1):8\u201317.","journal-title":"Genomics Proteom Bioinf"},{"key":"536_CR6","doi-asserted-by":"publisher","first-page":"869081","DOI":"10.3389\/fnins.2022.869081","volume":"16","author":"Y Li","year":"2022","unstructured":"Li Y, et al. The alteration profiles of m(6)A-Tagged circRNAs in the Peri-infarct Cortex after cerebral ischemia in mice. Front Neurosci. 2022;16:869081.","journal-title":"Front Neurosci"},{"key":"536_CR7","doi-asserted-by":"publisher","first-page":"204062232091602","DOI":"10.1177\/2040622320916024","volume":"11","author":"K Xu","year":"2020","unstructured":"Xu K, et al. N(6)-methyladenosine demethylases Alkbh5\/Fto regulate cerebral ischemia-reperfusion injury. Ther Adv Chronic Dis. 2020;11:2040622320916024.","journal-title":"Ther Adv Chronic Dis"},{"issue":"26","key":"536_CR8","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1182\/blood.2021011707","volume":"138","author":"Y Sheng","year":"2021","unstructured":"Sheng Y, et al. A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication. Blood. 2021;138(26):2838\u201352.","journal-title":"Blood"},{"issue":"12","key":"536_CR9","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"X Zhao","year":"2014","unstructured":"Zhao X, et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 2014;24(12):1403\u201319.","journal-title":"Cell Res"},{"issue":"11","key":"536_CR10","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/s41419-020-03186-2","volume":"11","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, et al. YTHDC1 mitigates ischemic stroke by promoting akt phosphorylation through destabilizing PTEN mRNA. Cell Death Dis. 2020;11(11):977.","journal-title":"Cell Death Dis"},{"issue":"3","key":"536_CR11","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","volume":"172","author":"F Kopp","year":"2018","unstructured":"Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172(3):393\u2013407.","journal-title":"Cell"},{"issue":"3","key":"536_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.bbrc.2016.11.143","volume":"485","author":"LK Wang","year":"2017","unstructured":"Wang LK, et al. Dissection of functional lncRNAs in Alzheimer\u2019s disease by construction and analysis of lncRNA-mRNA networks based on competitive endogenous RNAs. Biochem Biophys Res Commun. 2017;485(3):569\u201376.","journal-title":"Biochem Biophys Res Commun"},{"key":"536_CR13","doi-asserted-by":"crossref","unstructured":"Choe HK, Cho J. Comprehensive genome-wide approaches to activity-dependent translational control in neurons. Int J Mol Sci, 2020. 21(5).","DOI":"10.3390\/ijms21051592"},{"issue":"6","key":"536_CR14","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41419-020-2686-7","volume":"11","author":"W Yao","year":"2020","unstructured":"Yao W, et al. N(6)-methyladenosine (m(6)A) methylation in ischemia-reperfusion injury. Cell Death Dis. 2020;11(6):478.","journal-title":"Cell Death Dis"},{"issue":"9","key":"536_CR15","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41419-020-03021-8","volume":"11","author":"S Xu","year":"2020","unstructured":"Xu S, et al. Oxygen glucose deprivation\/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation. Cell Death Dis. 2020;11(9):816.","journal-title":"Cell Death Dis"},{"issue":"23","key":"536_CR16","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1080\/15384101.2017.1380125","volume":"16","author":"J Chen","year":"2017","unstructured":"Chen J, et al. YTH domain family 2 orchestrates epithelial-mesenchymal transition\/proliferation dichotomy in pancreatic cancer cells. Cell Cycle. 2017;16(23):2259\u201371.","journal-title":"Cell Cycle"},{"issue":"3","key":"536_CR17","doi-asserted-by":"publisher","first-page":"e1872","DOI":"10.1002\/mgg3.1872","volume":"10","author":"P Tandel","year":"2022","unstructured":"Tandel P, et al. Decreased expression of autophagy-related genes in the complete remission phase of acute myeloid leukemia. Mol Genet Genomic Med. 2022;10(3):e1872.","journal-title":"Mol Genet Genomic Med"},{"key":"536_CR18","doi-asserted-by":"crossref","unstructured":"Chun Y, Kim J. Autophagy: an Essential Degradation Program for Cellular Homeostasis and Life. Cells, 2018. 7(12).","DOI":"10.3390\/cells7120278"},{"issue":"7","key":"536_CR19","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1080\/15548627.2020.1783822","volume":"17","author":"Q Huang","year":"2021","unstructured":"Huang Q, et al. Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice. Autophagy. 2021;17(7):1753\u201367.","journal-title":"Autophagy"},{"key":"536_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1146\/annurev-biophys-060414-034248","volume":"44","author":"NN Noda","year":"2015","unstructured":"Noda NN, Inagaki F. Mech Autophagy Annu Rev Biophys. 2015;44:101\u201322.","journal-title":"Mech Autophagy Annu Rev Biophys"},{"issue":"24","key":"536_CR21","doi-asserted-by":"publisher","first-page":"4672","DOI":"10.1111\/febs.13540","volume":"282","author":"Y Katsuragi","year":"2015","unstructured":"Katsuragi Y, Ichimura Y, Komatsu M. p62\/SQSTM1 functions as a signaling hub and an autophagy adaptor. Febs j. 2015;282(24):4672\u20138.","journal-title":"Febs j"},{"key":"536_CR22","doi-asserted-by":"publisher","first-page":"112836","DOI":"10.1016\/j.biopha.2022.112836","volume":"149","author":"L Yu","year":"2022","unstructured":"Yu L, et al. Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2\/STAT3 signaling pathway. Biomed Pharmacother. 2022;149:112836.","journal-title":"Biomed Pharmacother"},{"key":"536_CR23","doi-asserted-by":"publisher","first-page":"720468","DOI":"10.3389\/fcell.2021.720468","volume":"9","author":"L Wang","year":"2021","unstructured":"Wang L, et al. ATP2B1-AS1 promotes cerebral Ischemia\/Reperfusion Injury through regulating the miR-330-5p\/TLR4-MyD88-NF-\u03baB signaling pathway. Front Cell Dev Biol. 2021;9:720468.","journal-title":"Front Cell Dev Biol"},{"key":"536_CR24","doi-asserted-by":"publisher","first-page":"153849","DOI":"10.1016\/j.phymed.2021.153849","volume":"94","author":"Y Guo","year":"2022","unstructured":"Guo Y, et al. Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist. Phytomedicine. 2022;94:153849.","journal-title":"Phytomedicine"},{"issue":"2","key":"536_CR25","doi-asserted-by":"publisher","first-page":"2259234","DOI":"10.1080\/0886022X.2023.2259234","volume":"45","author":"J Min","year":"2023","unstructured":"Min J, et al. Butylphthalide improves brain damage induced by renal ischemia-reperfusion injury rats through Nrf2\/HO-1 and NOD2\/MAPK\/NF-\u03baB pathways. Ren Fail. 2023;45(2):2259234.","journal-title":"Ren Fail"},{"issue":"1","key":"536_CR26","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41467-020-20844-3","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, et al. The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia-reperfusion injury. Nat Commun. 2021;12(1):522.","journal-title":"Nat Commun"},{"issue":"1\u20132","key":"536_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-020-03754-2","volume":"472","author":"CH Fu","year":"2020","unstructured":"Fu CH, et al. Silencing of long non-coding RNA CRNDE promotes autophagy and alleviates neonatal hypoxic-ischemic brain damage in rats. Mol Cell Biochem. 2020;472(1\u20132):1\u20138.","journal-title":"Mol Cell Biochem"},{"issue":"10","key":"536_CR28","doi-asserted-by":"publisher","first-page":"e10994","DOI":"10.1016\/j.heliyon.2022.e10994","volume":"8","author":"TT Sun","year":"2022","unstructured":"Sun TT, et al. Regulatory effect of long-stranded non-coding RNA-CRNDE on neurodegeneration during retinal ischemia-reperfusion. Heliyon. 2022;8(10):e10994.","journal-title":"Heliyon"},{"issue":"5","key":"536_CR29","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","volume":"15","author":"KD Meyer","year":"2014","unstructured":"Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014;15(5):313\u201326.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"536_CR30","doi-asserted-by":"publisher","first-page":"109553","DOI":"10.1016\/j.cellsig.2020.109553","volume":"69","author":"X Gu","year":"2020","unstructured":"Gu X, et al. N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation. Cell Signal. 2020;69:109553.","journal-title":"Cell Signal"},{"issue":"4","key":"536_CR31","doi-asserted-by":"publisher","first-page":"e201800113","DOI":"10.26508\/lsa.201800113","volume":"1","author":"M Anders","year":"2018","unstructured":"Anders M, et al. Dynamic m(6)a methylation facilitates mRNA triaging to stress granules. Life Sci Alliance. 2018;1(4):e201800113.","journal-title":"Life Sci Alliance"},{"issue":"3","key":"536_CR32","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","volume":"170","author":"T Yu","year":"2017","unstructured":"Yu T, et al. Fusobacterium nucleatum promotes Chemoresistance to Colorectal Cancer by modulating Autophagy. Cell. 2017;170(3):548\u2013e56316.","journal-title":"Cell"},{"issue":"9","key":"536_CR33","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.7150\/thno.24173","volume":"8","author":"KC Lin","year":"2018","unstructured":"Lin KC, et al. Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis. Theranostics. 2018;8(9):2477\u201387.","journal-title":"Theranostics"},{"issue":"6","key":"536_CR34","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1080\/15548627.2016.1162930","volume":"12","author":"Y Wang","year":"2016","unstructured":"Wang Y, et al. Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy. 2016;12(6):949\u201362.","journal-title":"Autophagy"},{"issue":"6","key":"536_CR35","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.7150\/thno.21717","volume":"8","author":"J Ji","year":"2018","unstructured":"Ji J, et al. XIAP limits autophagic degradation of Sox2 and is a therapeutic target in nasopharyngeal carcinoma stem cells. Theranostics. 2018;8(6):1494\u2013510.","journal-title":"Theranostics"},{"issue":"12","key":"536_CR36","doi-asserted-by":"publisher","first-page":"e52705","DOI":"10.1371\/journal.pone.0052705","volume":"7","author":"YK Jo","year":"2012","unstructured":"Jo YK, et al. Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis. PLoS ONE. 2012;7(12):e52705.","journal-title":"PLoS ONE"},{"issue":"7","key":"536_CR37","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1002\/ijc.30205","volume":"139","author":"K Xie","year":"2016","unstructured":"Xie K, et al. Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival. Int J Cancer. 2016;139(7):1564\u201373.","journal-title":"Int J Cancer"},{"key":"536_CR38","first-page":"1141","volume":"19","author":"J Zhao","year":"2020","unstructured":"Zhao J, Li H, Chang N. LncRNA HOTAIR promotes MPP+-induced neuronal injury in Parkinson\u2019s disease by regulating the miR-874-5p\/ATG10 axis. Excli j. 2020;19:1141\u201353.","journal-title":"Excli j"}],"container-title":["Biology Direct"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13062-024-00536-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13062-024-00536-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13062-024-00536-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T19:09:26Z","timestamp":1729105766000},"score":1,"resource":{"primary":{"URL":"https:\/\/biologydirect.biomedcentral.com\/articles\/10.1186\/s13062-024-00536-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["536"],"URL":"https:\/\/doi.org\/10.1186\/s13062-024-00536-4","relation":{},"ISSN":["1745-6150"],"issn-type":[{"value":"1745-6150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,16]]},"assertion":[{"value":"18 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that there are no conflicts of interest in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures complied with ARRIVE guideline and were assigned with the number 2023-049 by Ethics of Affiliated Haikou Hospital of Xiangya School of Central South. No human sample was used in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"92"}}