{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:37:14Z","timestamp":1792186634654,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Science and Technology Commission of Shanghai Municipality","award":["24ZR1429500"],"award-info":[{"award-number":["24ZR1429500"]}]},{"name":"Shanghai Municipal Health Commission Talent Development Program","award":["2022YQ064"],"award-info":[{"award-number":["2022YQ064"]}]},{"name":"National Nature Science Foundations of China","award":["8130017"],"award-info":[{"award-number":["8130017"]}]},{"name":"National Nature Science Foundations of China","award":["81400354"],"award-info":[{"award-number":["81400354"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biol Direct"],"DOI":"10.1186\/s13062-025-00657-4","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T01:56:12Z","timestamp":1748224572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation"],"prefix":"10.1186","volume":"20","author":[{"given":"Yanjun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"8","key":"657_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"10219","key":"657_CR2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and National sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200\u201311.","journal-title":"Lancet"},{"issue":"20","key":"657_CR3","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1001\/jama.2019.5791","volume":"321","author":"CW Seymour","year":"2019","unstructured":"Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, et al. Derivation, validation, and potential treatment implications of novel clinical phenotypes for Sepsis. JAMA. 2019;321(20):2003\u201317.","journal-title":"JAMA"},{"issue":"1","key":"657_CR4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12929-020-00702-6","volume":"28","author":"A Pant","year":"2021","unstructured":"Pant A, Mackraj I, Govender T. Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology. J Biomed Sci. 2021;28(1):6.","journal-title":"J Biomed Sci"},{"key":"657_CR5","doi-asserted-by":"crossref","unstructured":"Song J, Fang X, Zhou K, Bao H, Li L. Sepsis\u2013induced cardiac dysfunction and pathogenetic mechanisms (Review). Mol Med Rep. 2023;28(6).","DOI":"10.3892\/mmr.2023.13114"},{"issue":"1","key":"657_CR6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12929-024-01029-2","volume":"31","author":"MA Gafar","year":"2024","unstructured":"Gafar MA, Omolo CA, Elhassan E, Ibrahim UH, Govender T. Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis. J Biomed Sci. 2024;31(1):40.","journal-title":"J Biomed Sci"},{"issue":"4","key":"657_CR7","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.bbadis.2018.10.011","volume":"1865","author":"G Stanzani","year":"2019","unstructured":"Stanzani G, Duchen MR, Singer M. The role of mitochondria in sepsis-induced cardiomyopathy. Biochim Biophys Acta Mol Basis Dis. 2019;1865(4):759\u201373.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"6","key":"657_CR8","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","volume":"18","author":"SM Hollenberg","year":"2021","unstructured":"Hollenberg SM, Singer M. Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol. 2021;18(6):424\u201334.","journal-title":"Nat Rev Cardiol"},{"key":"657_CR9","doi-asserted-by":"crossref","unstructured":"Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O et al. Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction. J Clin Invest. 2023;133(4).","DOI":"10.1172\/JCI159498"},{"issue":"1","key":"657_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-023-01027-9","volume":"119","author":"M Sansonetti","year":"2024","unstructured":"Sansonetti M, Al Soodi B, Thum T, Jung M. Macrophage-based therapeutic approaches for cardiovascular diseases. Basic Res Cardiol. 2024;119(1):1\u201333.","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"657_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s10753-018-0890-8","volume":"42","author":"P Qiu","year":"2019","unstructured":"Qiu P, Liu Y, Zhang J. Review: the role and mechanisms of macrophage autophagy in Sepsis. Inflammation. 2019;42(1):6\u201319.","journal-title":"Inflammation"},{"issue":"11","key":"657_CR12","doi-asserted-by":"publisher","first-page":"5858","DOI":"10.1172\/JCI130996","volume":"130","author":"D Patoli","year":"2020","unstructured":"Patoli D, Mignotte F, Deckert V, Dusuel A, Dumont A, Rieu A, et al. Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis. J Clin Invest. 2020;130(11):5858\u201374.","journal-title":"J Clin Invest"},{"issue":"3","key":"657_CR13","first-page":"271","volume":"45","author":"N Arulkumaran","year":"2016","unstructured":"Arulkumaran N, Deutschman CS, Pinsky MR, Zuckerbraun B, Schumacker PT, Gomez H, et al. Mitochondrial Function Sepsis Shock. 2016;45(3):271\u201381.","journal-title":"Mitochondrial Function Sepsis Shock"},{"issue":"1","key":"657_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","volume":"12","author":"RJ Youle","year":"2011","unstructured":"Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12(1):9\u201314.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"657_CR15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nchembio.2287","volume":"13","author":"ND Georgakopoulos","year":"2017","unstructured":"Georgakopoulos ND, Wells G, Campanella M. The Pharmacological regulation of cellular mitophagy. Nat Chem Biol. 2017;13(2):136\u201346.","journal-title":"Nat Chem Biol"},{"issue":"8","key":"657_CR16","doi-asserted-by":"publisher","first-page":"e14199","DOI":"10.1111\/eci.14199","volume":"54","author":"M Forte","year":"2024","unstructured":"Forte M, D\u2019Ambrosio L, Schiattarella GG, Salerno N, Perrone MA, Loffredo FS, et al. Mitophagy modulation for the treatment of cardiovascular diseases. Eur J Clin Invest. 2024;54(8):e14199.","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"657_CR17","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/15548627.2024.2307215","volume":"20","author":"M Degli Esposti","year":"2024","unstructured":"Degli Esposti M. Did mitophagy follow the origin of mitochondria? Autophagy. 2024;20(5):985\u201393.","journal-title":"Autophagy"},{"issue":"12","key":"657_CR18","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/s41419-024-07303-3","volume":"15","author":"S Xu","year":"2024","unstructured":"Xu S, Wang Z, Guo F, Zhang Y, Peng H, Zhang H, et al. Mitophagy in ischemic heart disease: molecular mechanisms and clinical management. Cell Death Dis. 2024;15(12):934.","journal-title":"Cell Death Dis"},{"issue":"2","key":"657_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ncb2012","volume":"12","author":"S Geisler","year":"2010","unstructured":"Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1. Nat Cell Biol. 2010;12(2):119\u201331.","journal-title":"Nat Cell Biol"},{"issue":"3","key":"657_CR20","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","volume":"12","author":"K Nakahira","year":"2011","unstructured":"Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12(3):222\u201330.","journal-title":"Nat Immunol"},{"issue":"5","key":"657_CR21","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/ni.2563","volume":"14","author":"C Lupfer","year":"2013","unstructured":"Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol. 2013;14(5):480\u20138.","journal-title":"Nat Immunol"},{"issue":"7329","key":"657_CR22","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221\u20135.","journal-title":"Nature"},{"issue":"5","key":"657_CR23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/ni.3130","volume":"16","author":"Q Zhang","year":"2015","unstructured":"Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, et al. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol. 2015;16(5):458\u201366.","journal-title":"Nat Immunol"},{"issue":"7","key":"657_CR24","doi-asserted-by":"publisher","first-page":"3517","DOI":"10.4049\/jimmunol.1202628","volume":"190","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, Xu X, Ma J, Wu J, Wang Y, Zhou R, et al. Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. J Immunol. 2013;190(7):3517\u201324.","journal-title":"J Immunol"},{"issue":"8","key":"657_CR25","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1080\/15548627.2016.1183081","volume":"12","author":"MJ Kim","year":"2016","unstructured":"Kim MJ, Bae SH, Ryu JC, Kwon Y, Oh JH, Kwon J, et al. SESN2\/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 2016;12(8):1272\u201391.","journal-title":"Autophagy"},{"issue":"11","key":"657_CR26","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.4161\/auto.26502","volume":"9","author":"J Piquereau","year":"2013","unstructured":"Piquereau J, Godin R, Deschenes S, Bessi VL, Mofarrahi M, Hussain SN, et al. Protective role of PARK2\/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Autophagy. 2013;9(11):1837\u201351.","journal-title":"Autophagy"},{"issue":"7","key":"657_CR27","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1164\/rccm.201604-0730OC","volume":"195","author":"H Amatullah","year":"2017","unstructured":"Amatullah H, Shan Y, Beauchamp BL, Gali PL, Gupta S, Maron-Gutierrez T, et al. DJ-1\/PARK7 impairs bacterial clearance in Sepsis. Am J Respir Crit Care Med. 2017;195(7):889\u2013905.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6727","key":"657_CR28","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/19083","volume":"398","author":"B De Strooper","year":"1999","unstructured":"De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999;398(6727):518\u201322.","journal-title":"Nature"},{"issue":"9","key":"657_CR29","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1002\/eji.200838722","volume":"39","author":"E Monsalve","year":"2009","unstructured":"Monsalve E, Ruiz-Garcia A, Baladron V, Ruiz-Hidalgo MJ, Sanchez-Solana B, Rivero S, et al. Notch1 upregulates LPS-induced macrophage activation by increasing NF-kappaB activity. Eur J Immunol. 2009;39(9):2556\u201370.","journal-title":"Eur J Immunol"},{"issue":"6","key":"657_CR30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S1074-7613(03)00325-X","volume":"19","author":"I Maillard","year":"2003","unstructured":"Maillard I, Adler SH, Pear WS. Notch and the immune system. Immunity. 2003;19(6):781\u201391.","journal-title":"Immunity"},{"issue":"5","key":"657_CR31","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.jcmgh.2023.01.002","volume":"15","author":"Y Yang","year":"2023","unstructured":"Yang Y, Ni M, Zong R, Yu M, Sun Y, Li J, et al. Targeting Notch1-YAP circuit reprograms macrophage polarization and alleviates acute liver injury in mice. Cell Mol Gastroenterol Hepatol. 2023;15(5):1085\u2013104.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"657_CR32","doi-asserted-by":"publisher","first-page":"762","DOI":"10.3389\/fimmu.2018.00762","volume":"9","author":"X Bai","year":"2018","unstructured":"Bai X, He T, Liu Y, Zhang J, Li X, Shi J, et al. Acetylation-Dependent regulation of Notch signaling in macrophages by SIRT1 affects Sepsis development. Front Immunol. 2018;9:762.","journal-title":"Front Immunol"},{"key":"657_CR33","doi-asserted-by":"publisher","first-page":"1134556","DOI":"10.3389\/fimmu.2023.1134556","volume":"14","author":"T Liu","year":"2023","unstructured":"Liu T, Zhang C, Ying J, Wang Y, Yan G, Zhou Y, et al. Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis. Front Immunol. 2023;14:1134556.","journal-title":"Front Immunol"},{"issue":"11","key":"657_CR34","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1161\/CIRCRESAHA.118.312910","volume":"122","author":"L Jia","year":"2018","unstructured":"Jia L, Wang Y, Wang Y, Ma Y, Shen J, Fu Z, et al. Heme Oxygenase-1 in macrophages drives septic cardiac dysfunction via suppressing lysosomal degradation of inducible nitric oxide synthase. Circ Res. 2018;122(11):1532\u201344.","journal-title":"Circ Res"},{"issue":"10","key":"657_CR35","doi-asserted-by":"publisher","first-page":"e3316","DOI":"10.1371\/journal.pone.0003316","volume":"3","author":"ZH Chen","year":"2008","unstructured":"Chen ZH, Kim HP, Sciurba FC, Lee SJ, Feghali-Bostwick C, Stolz DB, et al. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS ONE. 2008;3(10):e3316.","journal-title":"PLoS ONE"},{"issue":"2","key":"657_CR36","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/bmb.20999","volume":"45","author":"E Lacazette","year":"2016","unstructured":"Lacazette E. A laboratory practical illustrating the use of the ChIP-qPCR method in a robust model: Estrogen receptor alpha Immunoprecipitation using Mcf\u20107 culture cells. Biochem Mol Biol Educ. 2016;45(2):152\u201360.","journal-title":"Biochem Mol Biol Educ"},{"key":"657_CR37","doi-asserted-by":"publisher","first-page":"664896","DOI":"10.3389\/fcell.2021.664896","volume":"9","author":"CL Zhu","year":"2021","unstructured":"Zhu CL, Yao RQ, Li LX, Li P, Xie J, Wang JF, et al. Mechanism of mitophagy and its role in Sepsis induced organ dysfunction: A review. Front Cell Dev Biol. 2021;9:664896.","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"657_CR38","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41556-018-0176-2","volume":"20","author":"K Palikaras","year":"2018","unstructured":"Palikaras K, Lionaki E, Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. Nat Cell Biol. 2018;20(9):1013\u201322.","journal-title":"Nat Cell Biol"},{"issue":"6","key":"657_CR39","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41374-019-0191-3","volume":"99","author":"T Li","year":"2019","unstructured":"Li T, Liu Y, Xu W, Dai X, Liu R, Gao Y, et al. Polydatin mediates Parkin-dependent mitophagy and protects against mitochondria-dependent apoptosis in acute respiratory distress syndrome. Lab Invest. 2019;99(6):819\u201329.","journal-title":"Lab Invest"},{"key":"657_CR40","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.redox.2017.07.007","volume":"13","author":"H Zhou","year":"2017","unstructured":"Zhou H, Zhu P, Guo J, Hu N, Wang S, Li D, et al. Ripk3 induces mitochondrial apoptosis via Inhibition of FUNDC1 mitophagy in cardiac IR injury. Redox Biol. 2017;13:498\u2013507.","journal-title":"Redox Biol"},{"issue":"1","key":"657_CR41","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/jcp.30527","volume":"237","author":"R Wang","year":"2022","unstructured":"Wang R, Xu Y, Fang Y, Wang C, Xue Y, Wang F, et al. Pathogenetic mechanisms of septic cardiomyopathy. J Cell Physiol. 2022;237(1):49\u201358.","journal-title":"J Cell Physiol"},{"issue":"Pt B","key":"657_CR42","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.biocel.2016.07.032","volume":"81","author":"S Alvarez","year":"2016","unstructured":"Alvarez S, Vico T, Vanasco V. Cardiac dysfunction, mitochondrial architecture, energy production, and inflammatory pathways: interrelated aspects in endotoxemia and sepsis. Int J Biochem Cell Biol. 2016;81(Pt B):307\u201314.","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"657_CR43","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.chest.2018.08.1037","volume":"155","author":"L Martin","year":"2019","unstructured":"Martin L, Derwall M, Al Zoubi S, Zechendorf E, Reuter DA, Thiemermann C, et al. The septic heart: current Understanding of molecular mechanisms and clinical implications. Chest. 2019;155(2):427\u201337.","journal-title":"Chest"},{"issue":"9","key":"657_CR44","doi-asserted-by":"publisher","first-page":"5362","DOI":"10.4049\/jimmunol.176.9.5362","volume":"176","author":"E Monsalve","year":"2006","unstructured":"Monsalve E, Perez MA, Rubio A, Ruiz-Hidalgo MJ, Baladron V, Garcia-Ramirez JJ, et al. Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity. J Immunol. 2006;176(9):5362\u201373.","journal-title":"J Immunol"},{"issue":"4","key":"657_CR45","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","volume":"73","author":"SL Fink","year":"2005","unstructured":"Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun. 2005;73(4):1907\u201316.","journal-title":"Infect Immun"},{"issue":"6","key":"657_CR46","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"E Latz","year":"2013","unstructured":"Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13(6):397\u2013411.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"657_CR47","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1172\/JCI94495","volume":"127","author":"KT Cheng","year":"2017","unstructured":"Cheng KT, Xiong S, Ye Z, Hong Z, Di A, Tsang KM, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127(11):4124\u201335.","journal-title":"J Clin Invest"},{"issue":"7","key":"657_CR48","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1172\/JCI136908","volume":"130","author":"S Xiong","year":"2020","unstructured":"Xiong S, Hong Z, Huang LS, Tsukasaki Y, Nepal S, Di A, et al. IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury. J Clin Invest. 2020;130(7):3684\u201398.","journal-title":"J Clin Invest"},{"issue":"1","key":"657_CR49","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.immuni.2018.04.032","volume":"49","author":"A Di","year":"2018","unstructured":"Di A, Xiong S, Ye Z, Malireddi RKS, Kometani S, Zhong M, et al. The TWIK2 potassium efflux channel in macrophages mediates NLRP3 Inflammasome-Induced inflammation. Immunity. 2018;49(1):56\u2013e654.","journal-title":"Immunity"},{"key":"657_CR50","doi-asserted-by":"publisher","first-page":"591803","DOI":"10.3389\/fimmu.2020.591803","volume":"11","author":"M Biasizzo","year":"2020","unstructured":"Biasizzo M, Kopitar-Jerala N. Interplay between NLRP3 inflammasome and autophagy. Front Immunol. 2020;11:591803.","journal-title":"Front Immunol"}],"container-title":["Biology Direct"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13062-025-00657-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13062-025-00657-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13062-025-00657-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:18:17Z","timestamp":1748229497000},"score":1,"resource":{"primary":{"URL":"https:\/\/biologydirect.biomedcentral.com\/articles\/10.1186\/s13062-025-00657-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["657"],"URL":"https:\/\/doi.org\/10.1186\/s13062-025-00657-4","relation":{},"ISSN":["1745-6150"],"issn-type":[{"value":"1745-6150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study were conducted following the guidelines of the Basel Declaration and approved by the Ethics Committee of Shanghai University of Health and Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"65"}}