{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:21:34Z","timestamp":1782962494093,"version":"3.54.5"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13063-015-0718-x","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T19:37:02Z","timestamp":1429213022000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of two strategies for initiating renal replacement therapy in the intensive care unit: study protocol for a randomized controlled trial (AKIKI)"],"prefix":"10.1186","volume":"16","author":[{"given":"St\u00e9phane","family":"Gaudry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hajage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9derique","family":"Schortgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Martin-Lefevre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tubach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lerolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Chevrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lautrette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bretagnol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mayaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Thirion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Markowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillemette","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Dellamonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Richecoeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Darmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"de Prost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodane","family":"Yonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Megarbane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Loubi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Blayau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Maizel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Zuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Nseir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efke","family":"Big\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Damien","family":"Ricard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dreyfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"718_CR1","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1097\/CCM.0b013e318168c590","volume":"36","author":"EAJ Hoste","year":"2008","unstructured":"Hoste EAJ, Schurgers M. Epidemiology of acute kidney injury: how big is the problem? Crit Care Med. 2008;36:S146\u201351.","journal-title":"Crit Care Med"},{"key":"718_CR2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1001\/jama.294.7.813","volume":"294","author":"S Uchino","year":"2005","unstructured":"Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294:813\u20138.","journal-title":"JAMA"},{"key":"718_CR3","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s001340051281","volume":"26","author":"A De Mendon\u00e7a","year":"2000","unstructured":"De Mendon\u00e7a A, Vincent JL, Suter PM, Moreno R, Dearden NM, Antonelli M, et al. Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med. 2000;26:915\u201321.","journal-title":"Intensive Care Med"},{"key":"718_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1164\/ajrccm.162.1.9907098","volume":"162","author":"F Schortgen","year":"2000","unstructured":"Schortgen F, Soubrier N, Delclaux C, Thuong M, Girou E, Brun-Buisson C, et al. Hemodynamic tolerance of intermittent hemodialysis in critically ill patients: usefulness of practice guidelines. Am J Respir Crit Care Med. 2000;162:197\u2013202.","journal-title":"Am J Respir Crit Care Med"},{"key":"718_CR5","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.amjmed.2005.01.069","volume":"118","author":"YP Ympa","year":"2005","unstructured":"Ympa YP, Sakr Y, Reinhart K, Vincent J-L. Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med. 2005;118:827\u201332.","journal-title":"Am J Med"},{"key":"718_CR6","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1164\/rccm.200711-1664ST","volume":"181","author":"L Brochard","year":"2010","unstructured":"Brochard L, Abroug F, Brenner M, Broccard AF, Danner RL, Ferrer M, et al. An official ATS\/ERS\/ESICM\/SCCM\/SRLF statement: prevention and management of acute renal failure in the ICU patient: an international consensus conference in intensive care medicine. Am J Respir Crit Care Med. 2010;181:1128\u201355.","journal-title":"Am J Respir Crit Care Med"},{"key":"718_CR7","doi-asserted-by":"crossref","unstructured":"Section 5: dialysis interventions for treatment of AKI. Kidney Int Suppl. (2011). 2012; 2(1):89\u2013115.","DOI":"10.1038\/kisup.2011.35"},{"key":"718_CR8","first-page":"11","volume":"14","author":"Y-X Yang","year":"2003","unstructured":"Yang Y-X, Lewis JD. Prevention and treatment of stress ulcers in critically ill patients. Semin Gastrointest Dis. 2003;14:11\u20139.","journal-title":"Semin Gastrointest Dis"},{"key":"718_CR9","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1007\/s00134-003-1863-3","volume":"29","author":"C Faisy","year":"2003","unstructured":"Faisy C, Guerot E, Diehl J-L, Iftimovici E, Fagon J-Y. Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Intensive Care Med. 2003;29:1306\u201313.","journal-title":"Intensive Care Med"},{"key":"718_CR10","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/cc8037","volume":"13","author":"SM Bagshaw","year":"2009","unstructured":"Bagshaw SM, Cruz DN, Gibney RTN, Ronco C. A proposed algorithm for initiation of renal replacement therapy in adult critically ill patients. Crit Care. 2009;13:317.","journal-title":"Crit Care"},{"key":"718_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/cc10109","volume":"15","author":"M Joannidis","year":"2011","unstructured":"Joannidis M, Forni LG. Clinical review: timing of renal replacement therapy. Crit Care. 2011;15:223.","journal-title":"Crit Care"},{"key":"718_CR12","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/MCC.0b013e32834cd360","volume":"17","author":"Z Ricci","year":"2011","unstructured":"Ricci Z, Ronco C. Timing, dose and mode of dialysis in acute kidney injury. Curr Opin Crit Care. 2011;17:556\u201361.","journal-title":"Curr Opin Crit Care"},{"key":"718_CR13","doi-asserted-by":"publisher","first-page":"R221","DOI":"10.1186\/cc9355","volume":"14","author":"MM Elseviers","year":"2010","unstructured":"Elseviers MM, Lins RL, Van der Niepen P, Hoste E, Malbrain ML, Damas P, et al. Renal replacement therapy is an independent risk factor for mortality in critically ill patients with acute kidney injury. Crit Care. 2010;14:R221.","journal-title":"Crit Care"},{"key":"718_CR14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/cc9405","volume":"15","author":"C Vinsonneau","year":"2011","unstructured":"Vinsonneau C, Monchi M. Too early initiation of renal replacement therapy may be harmful. Crit Care. 2011;15:112.","journal-title":"Crit Care"},{"key":"718_CR15","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/ndt\/gfr501","volume":"27","author":"AG Schneider","year":"2012","unstructured":"Schneider AG, Uchino S, Bellomo R. Severe acute kidney injury not treated with renal replacement therapy: characteristics and outcome. Nephrol Dial Transplant. 2012;27:947\u201352.","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"718_CR16","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jcrc.2014.07.014","volume":"29","author":"S Gaudry","year":"2014","unstructured":"Gaudry S, Ricard J-D, Leclaire C, Rafat C, Messika J, Bedet A, et al. Acute kidney injury in critical care: experience of a conservative strategy. J Crit Care. 2014;29(6):1022\u20137.","journal-title":"J Crit Care"},{"key":"718_CR17","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1093\/ndt\/gfr740","volume":"27","author":"E Clark","year":"2012","unstructured":"Clark E, Wald R, Walsh M, Bagshaw SM, Canadian Acute Kidney Injury (CANAKI) Investigators. Timing of initiation of renal replacement therapy for acute kidney injury: a survey of nephrologists and intensivists in Canada. Nephrol Dial Transplant. 2012;27:2761\u20137.","journal-title":"Nephrol Dial Transplant"},{"key":"718_CR18","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/1745-6215-15-270","volume":"15","author":"SD Barbar","year":"2014","unstructured":"Barbar SD, Binquet C, Monchi M, Bruy\u00e8re R, Quenot J-P. Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial. Trials. 2014;15:270.","journal-title":"Trials"},{"key":"718_CR19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/1745-6215-14-320","volume":"14","author":"OM Smith","year":"2013","unstructured":"Smith OM, Wald R, Adhikari NKJ, Pope K, Weir MA, Bagshaw SM, et al. Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Trials. 2013;14:320.","journal-title":"Trials"},{"key":"718_CR20","doi-asserted-by":"crossref","unstructured":"Section 2: AKI definition. Kidney Int Suppl. (2011). 2012;2(1):19\u201336.","DOI":"10.1038\/kisup.2011.32"},{"key":"718_CR21","doi-asserted-by":"crossref","unstructured":"Vinsonneau C, Allain-Launay E, blayau C, Darmon M, du Cheyron D, Gaillot T, et al. \u00c9puration extrar\u00e9nale en r\u00e9animation adulte et p\u00e9diatrique. Recommandations formalis\u00e9es d\u2019experts sous l\u2019\u00e9gide de la Soci\u00e9t\u00e9 de r\u00e9animation de langue fran\u00e7aise (SRLF), avec la participation de la Soci\u00e9t\u00e9 fran\u00e7aise d\u2019anesth\u00e9sie-r\u00e9animation (Sfar), du Groupe francophone de r\u00e9animation et urgences p\u00e9diatriques (GFRUP)et de la Soci\u00e9t\u00e9 francophone de dialyse (SFD). R\u00e9animation. 2014; 23:714\u201337.","DOI":"10.1007\/s13546-014-0917-6"},{"key":"718_CR22","doi-asserted-by":"publisher","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"AS Levey","year":"1999","unstructured":"Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130:461\u201370.","journal-title":"Ann Intern Med"},{"key":"718_CR23","doi-asserted-by":"publisher","first-page":"429","DOI":"10.7326\/0003-4819-157-6-201209180-00537","volume":"157","author":"J Savovi\u0107","year":"2012","unstructured":"Savovi\u0107 J, Jones HE, Altman DG, Harris RJ, J\u00fcni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med. 2012;157:429\u201338.","journal-title":"Ann Intern Med"},{"key":"718_CR24","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0140-6736(06)69111-3","volume":"368","author":"C Vinsonneau","year":"2006","unstructured":"Vinsonneau C, Camus C, Combes A, de Beauregard MAC, Klouche K, Boulain T, et al. Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet. 2006;368:379\u201385.","journal-title":"Lancet"},{"key":"718_CR25","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1056\/NEJMoa0902413","volume":"361","author":"R Bellomo","year":"2009","unstructured":"RENAL Replacement Therapy Study Investigators, Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627\u201338.","journal-title":"N Engl J Med"},{"key":"718_CR26","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1097\/00003246-200210000-00005","volume":"30","author":"CSC Bouman","year":"2002","unstructured":"Bouman CSC, Oudemans-Van Straaten HM, Tijssen JGP, Zandstra DF, Kesecioglu J. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med. 2002;30:2205\u201311.","journal-title":"Crit Care Med"},{"key":"718_CR27","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S0197-2456(03)00092-8","volume":"24","author":"TG Karrison","year":"2003","unstructured":"Karrison TG, Huo D, Chappell R. A group sequential, response-adaptive design for randomized clinical trials. Control Clin Trials. 2003;24:506\u201322.","journal-title":"Control Clin Trials"},{"key":"718_CR28","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.2215\/CJN.07210714","volume":"9","author":"FP Wilson","year":"2014","unstructured":"Wilson FP. A policy of preemption: the timing of renal replacement therapy in AKI. Clin J Am Soc Nephrol. 2014;9:1510\u20132.","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0718-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-015-0718-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0718-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0718-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:07:27Z","timestamp":1630580847000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-015-0718-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,17]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["718"],"URL":"https:\/\/doi.org\/10.1186\/s13063-015-0718-x","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,17]]},"assertion":[{"value":"23 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"170"}}