{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:32:11Z","timestamp":1778538731509,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T00:00:00Z","timestamp":1433548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13063-015-0768-0","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T19:50:05Z","timestamp":1433533805000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The NAtional randomised controlled Trial of Tonsillectomy IN Adults (NATTINA): a clinical and cost-effectiveness study: study protocol for a randomised control trial"],"prefix":"10.1186","volume":"16","author":[{"given":"Isabel","family":"Rubie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Haighton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"O\u2019Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikki","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Steen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah D.","family":"Stocken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Vale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Wilkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,6]]},"reference":[{"key":"768_CR1","volume-title":"Management of sore throat and indications for tonsillectomy: a national clinical guideline (117)","author":"Scottish Intercollegiate Guidelines Network (SIGN)","year":"2010","unstructured":"Scottish Intercollegiate Guidelines Network (SIGN). Management of sore throat and indications for tonsillectomy: a national clinical guideline (117). Edinburgh, UK: Healthcare Improvement Scotland; 2010."},{"issue":"2","key":"768_CR2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1749-4486.2010.02086.x","volume":"35","author":"M Suleman","year":"2010","unstructured":"Suleman M, Clark MP, Goldacre M, Burton M. Exploring the variation in paediatric tonsillectomy rates between English regions: a 5-year NHS and independent sector data analysis. Clin Otolaryngol. 2010;35(2):111\u20137.","journal-title":"Clin Otolaryngol"},{"key":"768_CR3","first-page":"CD001802","volume":"1","author":"MJ Burton","year":"2009","unstructured":"Burton MJ, Glasziou PP. Tonsillectomy or adeno-tonsillectomy versus non-surgical treatment for chronic\/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2009;1:CD001802.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7600","key":"768_CR4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1136\/bmj.39140.632604.55","volume":"334","author":"O-P Alho","year":"2007","unstructured":"Alho O-P, Koivunen P, Penna T, Teppo H, Koskela M, Luotonen J. Tonsillectomy versus watchful waiting in recurrent streptococcal pharyngitis in adults: randomised controlled trial. BMJ (Clinical research ed). 2007;334(7600):939.","journal-title":"BMJ (Clinical research ed)"},{"key":"768_CR5","unstructured":"Hospital Episode Statistics, Admitted Patient Care - England, 2012\u201313. Leeds, England: Health and Social Care Information Centre; 2012\u201313."},{"key":"768_CR6","unstructured":"Hospital Episode Statistics, Admitted Patient Care - England, 2011\u201312. Leeds, England: Health and Social Care Information Centre; 2011\u201312."},{"issue":"3","key":"768_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1399-6576.2010.02389.x","volume":"55","author":"O Mathiesen","year":"2011","unstructured":"Mathiesen O, Jorgensen DG, Hilsted KL, Trolle W, Stjernholm P, Christiansen H, et al. Pregabalin and dexamethasone improves post-operative pain treatment after tonsillectomy. Acta Anaesthesiol Scand. 2011;55(3):297\u2013305.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"768_CR8","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1080\/00016480500540501","volume":"127","author":"APP Hsu","year":"2007","unstructured":"Hsu APP, Tan KL, Tan YB, Han HJ. Lu PKS Benefits and efficacy of tonsillectomy for recurrent tonsillitis in adults. Acta Otolaryngol. 2007;127(1):62\u20134.","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"768_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1046\/j.1365-2273.2001.00433.x","volume":"26","author":"A Chidambaram","year":"2001","unstructured":"Chidambaram A, Nigam A, Cardozo AA. Anticipated absence from work ('sick leave') following routine ENT surgery: are we giving the correct advice? A postal questionnaire survey. Clin Otolaryngol Allied Sci. 2001;26(2):104\u20138.","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"5","key":"768_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/000348941212100509","volume":"121","author":"R Mathew","year":"2012","unstructured":"Mathew R, Asimacopoulos E, Walker D, Gutierrez T, Valentine P. Pitkin L Analysis of clinical negligence claims following tonsillectomy in England 1995 to 2010. Ann Otol Rhinol Laryngol. 2012;121(5):337\u201340.","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"6","key":"768_CR11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/lary.23270","volume":"122","author":"C Heiser","year":"2012","unstructured":"Heiser C, Landis BN, Giger R, Van Cao H, Guinand N, H\u00f6rmann K, et al. Taste disorders after tonsillectomy: a long-term follow-up. Laryngoscope. 2012;122(6):1265\u20136.","journal-title":"Laryngoscope"},{"issue":"5","key":"768_CR12","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1017\/S0022215108003277","volume":"123","author":"A Smithard","year":"2009","unstructured":"Smithard A, Cullen C, Thirlwall AS, Aldren C. Tonsillectomy may cause altered tongue sensation in adult patients. J Laryngol Otol. 2009;123(5):545\u20139.","journal-title":"J Laryngol Otol"},{"issue":"4","key":"768_CR13","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1524-4733.2007.00286.x","volume":"11","author":"AR Salkind","year":"2008","unstructured":"Salkind AR, Wright JM. Economic burden of adult pharyngitis: the payer's perspective. Value Health. 2008;11(4):621\u20137.","journal-title":"Value Health"},{"issue":"605","key":"768_CR14","doi-asserted-by":"publisher","first-page":"e801","DOI":"10.3399\/bjgp12X659268","volume":"62","author":"AW van der Velden","year":"2012","unstructured":"van der Velden AW, Pijpers EJ, Kuyvenhoven MM, Tonkin-Crine SK, Little P. Verheij T J Effectiveness of physician-targeted interventions to improve antibiotic use for respiratory tract infections. Br J Gen Pract. 2012;62(605):e801\u20137.","journal-title":"Br J Gen Pract"},{"issue":"7104","key":"768_CR15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/bmj.315.7104.350","volume":"215","author":"P Little","year":"1997","unstructured":"Little P, Gould C, Williamson I, Warner G, Gantley M, Kinmonth AL. Reattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics. BMJ (Clinical research ed). 1997;215(7104):350\u20132.","journal-title":"BMJ (Clinical research ed)"},{"issue":"7082","key":"768_CR16","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1136\/bmj.314.7082.722","volume":"314","author":"P Little","year":"1997","unstructured":"Little P. Open randomised trial of prescribing strategies in managing sore throat. BMJ (Clinical research ed). 1997;314(7082):722\u20137.","journal-title":"BMJ (Clinical research ed)."},{"issue":"Suppl 3","key":"768_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1258\/jhsrp.2008.008028","volume":"13","author":"I de Salis","year":"2008","unstructured":"de Salis I, Tomlin Z, Toerien M. Donovan J Using qualitative research methods to improve recruitment to randomized controlled trials: the quartet study. J Health Serv Res Policy. 2008;13 Suppl 3:92\u20136.","journal-title":"J Health Serv Res Policy."},{"issue":"13","key":"768_CR18","first-page":"1","volume":"14","author":"C Lock","year":"2010","unstructured":"Lock C, Wilson J, Steen N, Eccles M, Mason H, Carrie S, et al. North of England and Scotland Study of Tonsillectomy and Adeno-tonsillectomy in Children (NESSTAC): a pragmatic randomised controlled trial with a parallel non-randomised preference study. Health Technol Assess (Winchester, England). 2010;14(13):1\u2013164. iii-iv.","journal-title":"Health Technol Assess (Winchester, England)"},{"issue":"3","key":"768_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1136\/adc.2009.165530","volume":"95","author":"CA Lock","year":"2010","unstructured":"Lock CA, Wilson J, Steen N, Eccles M, Brittain K, Carrie S, et al. Childhood tonsillectomy: who is referred and what treatment choices are made? Baseline findings from the North of England and Scotland Study of Tonsillectomy and Adenotonsillectomy in Children (NESSTAC). Arch Dis Child. 2010;95(3):203\u20138.","journal-title":"Arch Dis Child"},{"issue":"7227","key":"768_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/bmj.320.7227.114","volume":"320","author":"C Pope","year":"2000","unstructured":"Pope C, Ziebland S, Mays N. Analysing qualitative data. BMJ. 2000;320(7227):114\u20136.","journal-title":"BMJ"},{"issue":"7","key":"768_CR21","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1177\/1049732303253331","volume":"13","author":"R Barbour","year":"2003","unstructured":"Barbour R. The newfound credibility of qualitative research? Tales of technical essentialism and co-option. Qual Health Res. 2003;13(7):1019\u201327.","journal-title":"Qual Health Res"},{"issue":"3","key":"768_CR22","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1348\/014466599162782","volume":"38","author":"R Elliott","year":"1999","unstructured":"Elliott R, Fischer C, Rennie D. Evolving guidelines for publication of qualitative research studies in psychology and related fields. Br J Clin Psychol. 1999;38(3):215\u201329.","journal-title":"Br J Clin Psychol"},{"key":"768_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/1472-6963-11-245","volume":"11","author":"CR May","year":"2011","unstructured":"May CR, Finch T, Ballini L, MacFarlane A, Mair F, Murray E, et al. Evaluating complex interventions and health technologies using normalization process theory: development of a simplified approach and web-enabled toolkit. BMC Health Serv Res. 2011;11:245.","journal-title":"BMC Health Serv Res."},{"issue":"10","key":"768_CR24","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1080\/08870440903194015","volume":"25","author":"JJ Francis","year":"2010","unstructured":"Francis JJ, Johnston M, Robertson C, Glidewell L, Entwistle V, Eccles MP, et al. What is an adequate sample size? Operationalising data saturation for theory-based interview studies. Psychol Health. 2010;25(10):1229\u201345.","journal-title":"Psychol Health"},{"issue":"9","key":"768_CR25","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00106-012-2545-7","volume":"60","author":"T Skevas","year":"2012","unstructured":"Skevas T, Klingmann C, Plinkert PK, Blaumann I. Development and validation of the tonsillectomy outcome inventory 14. HNO. 2012;60(9):801\u20136.","journal-title":"HNO"},{"key":"768_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","volume":"34","author":"JE Ware","year":"1996","unstructured":"Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220\u201333.","journal-title":"Med Care."},{"issue":"2","key":"768_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","volume":"21","author":"J Brazier","year":"2002","unstructured":"Brazier J, Roberts J, Deverill M. The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002;21(2):271\u201392.","journal-title":"J Health Econ"},{"key":"768_CR28","volume-title":"Unit costs of health and social care","author":"L Curtis","year":"2012","unstructured":"Curtis L. Unit costs of health and social care. Canterbury: PSSRU, University of Kent; 2012."},{"key":"768_CR29","first-page":"2013","volume-title":"Guide to the methods of technology appraisal","author":"National Institute for Health and Care Excellence (NICE)","year":"2013","unstructured":"National Institute for Health and Care Excellence (NICE). Guide to the methods of technology appraisal. London: National Institute for Health and Care Excellence (NICE); 2013. p. 2013."},{"key":"768_CR30","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/0272989X9601600314","volume":"16","author":"B O'Brien","year":"1996","unstructured":"O'Brien B, Gafni A. When do the dollars make sense? Toward a conceptual framework for contingent valuation studies in health care. Med Decis Making. 1996;16:288\u201399.","journal-title":"Med Decis Making."}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-015-0768-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0768-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-015-0768-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:17:47Z","timestamp":1630592267000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-015-0768-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,6]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["768"],"URL":"https:\/\/doi.org\/10.1186\/s13063-015-0768-0","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,6]]},"assertion":[{"value":"25 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"263"}}