{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:52:27Z","timestamp":1791532347633,"version":"4.3.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"German Cancer Consortium (DKTK) Dresden"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s13063-016-1679-4","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T06:53:54Z","timestamp":1479192834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["PRONTOX \u2013 proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial"],"prefix":"10.1186","volume":"17","author":[{"given":"Sebastian","family":"Zschaeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"L\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther G. C.","family":"Troost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"St\u00fctzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Wohlfahrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Appold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Makocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"B\u00fctof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mechthild","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"issue":"3","key":"1679_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/annonc\/mdj117","volume":"17","author":"A Aup\u00e9rin","year":"2006","unstructured":"Aup\u00e9rin A, Le P\u00e9choux C, Pignon JP, Koning C, Jeremic B, Clamon G, et al. Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (NSCLC): a meta-analysis of individual data from 1764 patients. Ann Oncol. 2006;17(3):473\u201383.","journal-title":"Ann Oncol"},{"issue":"2","key":"1679_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","volume":"16","author":"JD Bradley","year":"2015","unstructured":"Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015;16(2):187\u201399.","journal-title":"Lancet Oncol"},{"issue":"1","key":"1679_CR3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.radonc.2013.08.035","volume":"109","author":"G Nalbantov","year":"2013","unstructured":"Nalbantov G, Kietselaer B, Vandecasteele K, Oberije C, Berbee M, Troost E, Dingemans A-M, et al. Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients. Radiother Oncol. 2013;109(1):100\u20136.","journal-title":"Radiother Oncol"},{"issue":"13","key":"1679_CR4","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1002\/cncr.25848","volume":"117","author":"S Sejpal","year":"2011","unstructured":"Sejpal S, Komaki R, Tsao A, Chang JY, Liao Z, Wei X, et al. Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer. Cancer. 2011;117(13):3004\u201313.","journal-title":"Cancer"},{"issue":"6","key":"1679_CR5","doi-asserted-by":"publisher","first-page":"772","DOI":"10.3109\/0284186X.2011.582519","volume":"50","author":"IR Vogelius","year":"2011","unstructured":"Vogelius IR, Westerly DC, Aznar MC, Cannon GM, Korreman SS, Mackie TR, et al. Estimated radiation pneumonitis risk after photon versus proton therapy alone or combined with chemotherapy for lung cancer. Acta Oncol. 2011;50(6):772\u20136.","journal-title":"Acta Oncol"},{"issue":"4","key":"1679_CR6","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ijrobp.2013.07.029","volume":"87","author":"DA Palma","year":"2013","unstructured":"Palma DA, Senan S, Oberije C, Belderbos J, de Dios NR, Bradley JD, et al. Predicting esophagitis after chemoradiation therapy for non-small cell lung cancer: an individual patient data meta-analysis. Int J Radiat Oncol. 2013;87(4):690\u20136.","journal-title":"Int J Radiat Oncol"},{"issue":"2","key":"1679_CR7","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.ijrobp.2012.04.043","volume":"85","author":"DA Palma","year":"2013","unstructured":"Palma DA, Senan S, Tsujino K, Barriger RB, Rengan R, Moreno M, et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis. Int J Radiat Oncol. 2013;85(2):444\u201350.","journal-title":"Int J Radiat Oncol"},{"issue":"4","key":"1679_CR8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/jjco\/29.4.192","volume":"29","author":"T Makimoto","year":"1999","unstructured":"Makimoto T, Tsuchiya S, Hayakawa K, Saitoh R, Mori M. Risk factors for severe radiation pneumonitis in lung cancer. Jpn J Clin Oncol. 1999;29(4):192\u20137.","journal-title":"Jpn J Clin Oncol"},{"issue":"8","key":"1679_CR9","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ctrv.2010.04.004","volume":"36","author":"LG Marcu","year":"2010","unstructured":"Marcu LG. Altered fractionation in radiotherapy: from radiobiological rationale to therapeutic gain. Cancer Treat Rev. 2010;36(8):606\u201314.","journal-title":"Cancer Treat Rev"},{"issue":"6","key":"1679_CR10","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1053\/j.seminoncol.2014.09.022","volume":"41","author":"L Kollar","year":"2014","unstructured":"Kollar L, Rengan R. Stereotactic body radiotherapy. Semin Oncol. 2014;41(6):776\u201389.","journal-title":"Semin Oncol"},{"issue":"1","key":"1679_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0169-5002(00)00156-2","volume":"31","author":"N Choi","year":"2001","unstructured":"Choi N, Baumann M, Flentjie M, Kellokumpu-Lehtinen P, Senan S, Zamboglou N, et al. Predictive factors in radiotherapy for non-small cell lung cancer: present status. Lung Cancer. 2001;31(1):43\u201356.","journal-title":"Lung Cancer"},{"issue":"8","key":"1679_CR12","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1200\/JCO.2009.24.7221","volume":"28","author":"A Baardwijk van","year":"2010","unstructured":"van Baardwijk A, Wanders S, Boersma L, Borger J, Ollers M, Dingemans A-M, Bootsma G, et al. Mature results of an individualized radiation dose prescription study based on normal tissue constraints in stages I to III non-small-cell lung cancer. J Clin Oncol. 2010;28(8):1380\u20136.","journal-title":"J Clin Oncol"},{"issue":"5","key":"1679_CR13","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.ijrobp.2011.10.032","volume":"83","author":"A Hoffmann","year":"2012","unstructured":"Hoffmann A, Troost E, Huizenga H, Kaanders J, Bussink J. Individualized dose prescription for hypofractionation in advanced non-small-cell lung cancer radiotherapy: an in silico trial. Int J Radiat Oncol. 2012;83(5):1596\u2013602.","journal-title":"Int J Radiat Oncol"},{"issue":"1","key":"1679_CR14","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.radonc.2011.06.031","volume":"100","author":"M Baumann","year":"2011","unstructured":"Baumann M, Herrmann T, Koch R, Matthiessen W, Appold S, Wahlers B, et al. Final results of the randomized phase III CHARTWEL-trial (ARO 97\u20131) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC). Radiother Oncol. 2011;100(1):76\u201385.","journal-title":"Radiother Oncol"},{"issue":"5","key":"1679_CR15","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cllc.2011.11.008","volume":"13","author":"BS Hoppe","year":"2012","unstructured":"Hoppe BS, Flampouri S, Henderson RH, Pham D, Bajwa AA, D\u2019Agostino H, et al. Proton therapy with concurrent chemotherapy for non-small-cell lung cancer: technique and early results. Clin Lung Cancer. 2012;13(5):352\u20138.","journal-title":"Clin Lung Cancer"},{"issue":"2","key":"1679_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0167-8140(99)00087-0","volume":"52","author":"M Saunders","year":"1999","unstructured":"Saunders M, Dische S, Barrett A, Harvey A, Griffiths G, Palmar M. Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. CHART Steering Committee. Radiother Oncol. 1999;52(2):137\u201348.","journal-title":"Radiother Oncol"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-016-1679-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-016-1679-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-016-1679-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T05:20:44Z","timestamp":1487654444000},"score":1,"resource":{"primary":{"URL":"http:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-016-1679-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1679"],"URL":"https:\/\/doi.org\/10.1186\/s13063-016-1679-4","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]},"article-number":"543"}}