{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:38:41Z","timestamp":1793417921954,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13063-017-2126-x","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T11:50:23Z","timestamp":1502711423000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A randomized, multi-center, prospective study comparing best medical treatment versus best medical treatment plus renal artery stenting in patients with hemodynamically relevant atherosclerotic renal artery stenosis (RADAR) \u2013 one-year results of a pre-maturely terminated study"],"prefix":"10.1186","volume":"18","author":[{"name":"for the RADAR Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Zeller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Krankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrejs","family":"Erglis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Blessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Fuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dierk","family":"Scheinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Weser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix B.","family":"Doerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfrid D.","family":"Yollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Radermacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"2126_CR1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.7326\/0003-4819-118-9-199305010-00010","volume":"118","author":"JM Rimmer","year":"1993","unstructured":"Rimmer JM, Gennari FJ. Atherosclerotic renovascular disease and progressive renal failure. Ann Intern Med. 1993;118:712\u20139.","journal-title":"Ann Intern Med"},{"key":"2126_CR2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0741-5214(91)90084-8","volume":"14","author":"DF Tollefson","year":"1991","unstructured":"Tollefson DF, Ernst CB. Natural history of atherosclerotic renal artery stenosis associated with aortic disease. J Vasc Surg. 1991;14:327\u201331.","journal-title":"J Vasc Surg"},{"key":"2126_CR3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJM200102083440607","volume":"344","author":"RD Safian","year":"2001","unstructured":"Safian RD, Textor SC. Renal-artery stenosis. N Engl J Med. 2001;344:431\u201342.","journal-title":"N Engl J Med"},{"key":"2126_CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejvs.2014.12.026","volume":"49","author":"IV Mohan","year":"2015","unstructured":"Mohan IV, Bourke V. The management of renal artery stenosis: an alternative interpretation of ASTRAL and CORAL. Eur J Vasc Endovasc Surg. 2015;49:465\u201373.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2126_CR5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11883-014-0416-2","volume":"16","author":"CG Jennings","year":"2014","unstructured":"Jennings CG, Houston JG, Severn A, Bell S, Mackenzie IS, Macdonald TM. Renal artery stenosis-when to screen, what to stent? Curr Atheroscler Rep. 2014;16:416.","journal-title":"Curr Atheroscler Rep"},{"key":"2126_CR6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1745-6215-10-60","volume":"10","author":"U Schwarzwaelder","year":"2009","unstructured":"Schwarzwaelder U, Hauk M, Zeller T. RADAR - A randomised, multi-centre, prospective study comparing best medical treatment versus best medical treatment plus renal artery stenting in patients with haemodynamically relevant atherosclerotic renal artery stenosis. Trials. 2009;10:60.","journal-title":"Trials"},{"key":"2126_CR7","first-page":"162","volume":"23","author":"A Bolz","year":"1996","unstructured":"Bolz A, Amon M, Ozbek C, Heublein B, Schaldach M. Coating of cardiovascular stents with a semiconductor to improve their hemocompatibility. Tex Heart Inst J. 1996;23:162\u20136.","journal-title":"Tex Heart Inst J"},{"key":"2126_CR8","first-page":"304","volume":"47","author":"SH Monnink","year":"1999","unstructured":"Monnink SH, van Boven AJ, Peels HO, Tigchelaar I, de Kam PJ, Crijns HJ, van Oeveren W. Silicon-carbide coated coronary stents have low platelet and leukocyte adhesion during platelet activation. J Investig Med. 1999;47:304\u201310.","journal-title":"J Investig Med"},{"key":"2126_CR9","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa0905368","volume":"361","author":"K Wheatley","year":"2009","unstructured":"Wheatley K, Ives N, Gray R, Kalra PA, Moss JG, Baigent C, Carr S, Chalmers N, Eadington D, Hamilton G, Lipkin G, Nicholson A, Scoble J. Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med. 2009;361:1953\u201362.","journal-title":"N Engl J Med"},{"key":"2126_CR10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/ccd.21525","volume":"71","author":"T Zeller","year":"2008","unstructured":"Zeller T, Bonvini RF, Sixt S. Color-coded duplex ultrasound for diagnosis of renal artery stenosis and as follow-up examination after revascularization. Catheter Cardiovasc Interv. 2008;71:995\u20139.","journal-title":"Catheter Cardiovasc Interv"},{"key":"2126_CR11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-2001-15287","volume":"22","author":"T Zeller","year":"2001","unstructured":"Zeller T, Frank U, Spath M, Roskamm H. [Color duplex ultrasound imaging of renal arteries and detection of hemodynamically relevant renal artery stenoses]. Ultraschall Med. 2001;22:116\u201321. German.","journal-title":"Ultraschall Med"},{"key":"2126_CR12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/HJH.0b013e328365b29c","volume":"32","author":"F Viazzi","year":"2014","unstructured":"Viazzi F, Leoncini G, Derchi LE, Pontremoli R. Ultrasound Doppler renal resistive index: a useful tool for the management of the hypertensive patient. J Hypertens. 2014;32:149\u201353.","journal-title":"J Hypertens"},{"key":"2126_CR13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/152660280701400211","volume":"14","author":"T Zeller","year":"2007","unstructured":"Zeller T, Rastan A, Schwarzwalder U, Muller C, Frank U, Burgelin K, Sixt S, Schwarz T, Noory E, Neumann FJ. Regression of left ventricular hypertrophy following stenting of renal artery stenosis. J Endovasc Ther. 2007;14:189\u201397.","journal-title":"J Endovasc Ther"},{"key":"2126_CR14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/080370599439661","volume":"8","author":"B Symonides","year":"1999","unstructured":"Symonides B, Chodakowska J, Januszewicz A, Lapinski M, Januszewicz M, Rowinski O, Szmidt J, Kuch-Wocial A, Kurzyna M, Malek G, Berent H, Szmigielski C, Januszewicz W. Effects of the correction of renal artery stenosis on blood pressure, renal function and left ventricular morphology. Blood Press. 1999;8:141\u201350.","journal-title":"Blood Press"},{"key":"2126_CR15","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fendo.2014.00168","volume":"5","author":"C Catena","year":"2014","unstructured":"Catena C, Colussi G, Nait F, Martinis F, Pezzutto F, Sechi LA. Aldosterone and the heart: still an unresolved issue? Front Endocrinol (Lausanne). 2014;5:168.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2126_CR16","doi-asserted-by":"crossref","first-page":"17A","DOI":"10.1016\/0002-9149(93)90240-D","volume":"71","author":"DA Duprez","year":"1993","unstructured":"Duprez DA, Bauwens FR, De Buyzere ML, De Backer TL, Kaufman JM, Van HJ, Vermeulen A, Clement DL. Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension. Am J Cardiol. 1993;71:17A\u201320.","journal-title":"Am J Cardiol"},{"key":"2126_CR17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ccd.26090","volume":"86","author":"JH Segrest","year":"2015","unstructured":"Segrest JH, Hillegass WB. Renal artery stenting: patient selection post-CORAL. Catheter Cardiovasc Interv. 2015;86:310\u20131.","journal-title":"Catheter Cardiovasc Interv"},{"key":"2126_CR18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/ccd.25263","volume":"83","author":"I Weinberg","year":"2014","unstructured":"Weinberg I, Keyes MJ, Giri J, Rogers KR, Olin JW, White CJ, Jaff MR. Blood pressure response to renal artery stenting in 901 patients from five prospective multicenter FDA-approved trials. Catheter Cardiovasc Interv. 2014;83:603\u20139.","journal-title":"Catheter Cardiovasc Interv"},{"key":"2126_CR19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.7326\/0003-4819-150-12-200906160-00119","volume":"150","author":"L Bax","year":"2009","unstructured":"Bax L, Woittiez AJ, Kouwenberg HJ, Mali WP, Buskens E, Beek FJ, Braam B, Huysmans FT, Schultze Kool LJ, Rutten MJ, Doorenbos CJ, Aarts JC, Rabelink TJ, Plouin PF, Raynaud A, van Montfrans GA, Reekers JA, van den Meiracker AH, Pattynama PM, van de Ven PJ, Vroegindeweij D, Kroon AA, de Haan MW, Postma CT, Beutler JJ. Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial. Ann Intern Med. 2009;150:840\u20131.","journal-title":"Ann Intern Med"},{"key":"2126_CR20","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.jvs.2014.09.072","volume":"61","author":"AY Mousa","year":"2015","unstructured":"Mousa AY, AbuRahma AF, Bozzay J, Broce M, Bates M. Update on intervention versus medical therapy for atherosclerotic renal artery stenosis. J Vasc Surg. 2015;61:1613\u201323.","journal-title":"J Vasc Surg"},{"key":"2126_CR21","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/ccd.25559","volume":"84","author":"SA Parikh","year":"2014","unstructured":"Parikh SA, Shishehbor MH, Gray BH, White CJ, Jaff MR. SCAI expert consensus statement for renal artery stenting appropriate use. Catheter Cardiovasc Interv. 2014;84:1163\u201371.","journal-title":"Catheter Cardiovasc Interv"},{"issue":"Suppl 1","key":"2126_CR22","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0140-6736(15)60326-9","volume":"385","author":"D Green","year":"2015","unstructured":"Green D, Ritchie JP, Chrysochou C, Kalra PA. Revascularisation of renal artery stenosis as a therapy for heart failure: an observational cohort study. Lancet. 2015;385 Suppl 1:S11.","journal-title":"Lancet"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-017-2126-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T11:22:11Z","timestamp":1570015331000},"score":1,"resource":{"primary":{"URL":"http:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-017-2126-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2126"],"URL":"https:\/\/doi.org\/10.1186\/s13063-017-2126-x","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]},"article-number":"380"}}