{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:21:06Z","timestamp":1740144066409,"version":"3.37.3"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Townsville Hospital and Health Service Research Trust Fund Grant (SERTA moneys)","award":["62622"],"award-info":[{"award-number":["62622"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13063-017-2304-x","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T08:05:06Z","timestamp":1510819506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inositol in the MAnaGemENt of abdominal aortic aneurysm (IMAGEN): study protocol for a randomised controlled trial"],"prefix":"10.1186","volume":"18","author":[{"given":"Sophie E.","family":"Rowbotham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna L.","family":"Pinchbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernie","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Christian","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Jaeggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason S.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey S.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan K.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Velu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisan","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Moxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-8848","authenticated-orcid":false,"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"issue":"10","key":"2304_CR1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cpcardiol.2010.08.004","volume":"35","author":"JV Moxon","year":"2010","unstructured":"Moxon JV, et al. Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects. Curr Probl Cardiol. 2010;35(10):512\u201348.","journal-title":"Curr Probl Cardiol"},{"issue":"11","key":"2304_CR2","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/bjs.9578","volume":"101","author":"S Khosla","year":"2014","unstructured":"Khosla S, et al. Meta-analysis of peak wall stress in ruptured, symptomatic and intact abdominal aortic aneurysms. Br J Surg. 2014;101(11):1350\u20137.","journal-title":"Br J Surg"},{"issue":"6","key":"2304_CR3","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.jvs.2011.07.048","volume":"54","author":"PE Norman","year":"2011","unstructured":"Norman PE, Muller J, Golledge J. The cardiovascular and prognostic significance of the infrarenal aortic diameter. J Vasc Surg. 2011;54(6):1817\u201320.","journal-title":"J Vasc Surg"},{"issue":"1","key":"2304_CR4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejvs.2010.08.026","volume":"41","author":"P Cao","year":"2011","unstructured":"Cao P, et al. Comparison of surveillance versus aortic endografting for small aneurysm repair (CAESAR): results from a randomised trial. Eur J Vasc Endovasc Surg. 2011;41(1):13\u201325.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"19","key":"2304_CR5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMoa012573","volume":"346","author":"FA Lederle","year":"2002","unstructured":"Lederle FA, et al. Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med. 2002;346(19):1437\u201344.","journal-title":"N Engl J Med"},{"issue":"5","key":"2304_CR6","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jvs.2009.10.113","volume":"51","author":"K Ouriel","year":"2010","unstructured":"Ouriel K, et al. Endovascular repair compared with surveillance for patients with small abdominal aortic aneurysms. J Vasc Surg. 2010;51(5):1081\u20137.","journal-title":"J Vasc Surg"},{"issue":"19","key":"2304_CR7","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMoa013527","volume":"346","author":"United Kingdom Small Aneurysm Trial Participants","year":"2002","unstructured":"United Kingdom Small Aneurysm Trial Participants. Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med. 2002;346(19):1445\u201352.","journal-title":"N Engl J Med."},{"issue":"12","key":"2304_CR8","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.ATV.0000245819.32762.cb","volume":"26","author":"J Golledge","year":"2006","unstructured":"Golledge J, et al. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006;26(12):2605\u201313.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2304_CR9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2011.03.006","volume":"217","author":"J Golledge","year":"2011","unstructured":"Golledge J, Norman PE. Current status of medical management for abdominal aortic aneurysm. Atherosclerosis. 2011;217(1):57\u201363.","journal-title":"Atherosclerosis"},{"issue":"9478","key":"2304_CR10","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/S0140-6736(05)66627-5","volume":"365","author":"EVAR trial participants","year":"2005","unstructured":"EVAR trial participants. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet. 2005;365(9478):2179\u201386.","journal-title":"Lancet"},{"issue":"2","key":"2304_CR11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/01.sla.0000253965.95368.52","volume":"245","author":"J Golledge","year":"2007","unstructured":"Golledge J, et al. The outcome of endovascular repair of small abdominal aortic aneurysms. Ann Surg. 2007;245(2):326\u201333.","journal-title":"Ann Surg"},{"issue":"5","key":"2304_CR12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jvs.2005.07.039","volume":"42","author":"CL Hayter","year":"2005","unstructured":"Hayter CL, et al. Follow-up costs increase the cost disparity between endovascular and open abdominal aortic aneurysm repair. J Vasc Surg. 2005;42(5):912\u20138.","journal-title":"J Vasc Surg"},{"issue":"9141","key":"2304_CR13","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/S0140-6736(98)10284-2","volume":"352","author":"UK Small Aneurysm Trial Participants","year":"1998","unstructured":"UK Small Aneurysm Trial Participants. Health service costs and quality of life for early elective surgery or ultrasonographic surveillance for small abdominal aortic aneurysms. Lancet. 1998;352(9141):1656\u201360.","journal-title":"Lancet"},{"key":"2304_CR14","first-page":"CD010447","volume":"1","author":"L Robertson","year":"2014","unstructured":"Robertson L, Atallah E, Stansby G. Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm. Cochrane Database Syst Rev. 2014;1:CD010447.","journal-title":"Cochrane Database Syst Rev."},{"issue":"1","key":"2304_CR15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jvs.2016.08.003","volume":"65","author":"J Golledge","year":"2017","unstructured":"Golledge J, et al. Challenges and opportunities in limiting abdominal aortic aneurysm growth. J Vasc Surg. 2017;65(1):225\u201333.","journal-title":"J Vasc Surg"},{"key":"2304_CR16","doi-asserted-by":"crossref","first-page":"653561","DOI":"10.1155\/2014\/653561","volume":"2014","author":"R D\u2019Anna","year":"2014","unstructured":"D\u2019Anna R, et al. Effects of a new flavonoid and myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial. Int J Endocrinol. 2014;2014:653561.","journal-title":"Int J Endocrinol."},{"issue":"1","key":"2304_CR17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/gme.0b013e3181e8e1b1","volume":"18","author":"D Giordano","year":"2011","unstructured":"Giordano D, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102\u20134.","journal-title":"Menopause"},{"issue":"3","key":"2304_CR18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3177\/jnsv.54.196","volume":"54","author":"R Maeba","year":"2008","unstructured":"Maeba R, et al. Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome. J Nutr Sci Vitaminol (Tokyo). 2008;54(3):196\u2013202.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"5","key":"2304_CR19","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/13697137.2011.631063","volume":"15","author":"A Santamaria","year":"2012","unstructured":"Santamaria A, et al. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. 2012;15(5):490\u20135.","journal-title":"Climacteric"},{"issue":"9","key":"2304_CR20","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1093\/ajcn\/33.9.1954","volume":"33","author":"RS Clements Jr","year":"1980","unstructured":"Clements Jr RS, Darnell B. Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr. 1980;33(9):1954\u201367.","journal-title":"Am J Clin Nutr"},{"issue":"14","key":"2304_CR21","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","volume":"368","author":"R Estruch","year":"2013","unstructured":"Estruch R, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368(14):1279\u201390.","journal-title":"N Engl J Med"},{"issue":"8","key":"2304_CR22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/CIRCULATIONAHA.112.000728","volume":"128","author":"O Stackelberg","year":"2013","unstructured":"Stackelberg O, et al. Fruit and vegetable consumption with risk of abdominal aortic aneurysm. Circulation. 2013;128(8):795\u2013802.","journal-title":"Circulation"},{"issue":"2","key":"2304_CR23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BJ20140361","volume":"461","author":"PG Billcliff","year":"2014","unstructured":"Billcliff PG, Lowe M. Inositol lipid phosphatases in membrane trafficking and human disease. Biochem J. 2014;461(2):159\u201375.","journal-title":"Biochem J"},{"issue":"10","key":"2304_CR24","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.biochi.2013.05.011","volume":"95","author":"ML Croze","year":"2013","unstructured":"Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013;95(10):1811\u201327.","journal-title":"Biochimie"},{"issue":"10","key":"2304_CR25","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.bbamcr.2014.03.007","volume":"1843","author":"H Ivanova","year":"2014","unstructured":"Ivanova H, et al. Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival. Biochim Biophys Acta. 2014;1843(10):2164\u201383.","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"2304_CR26","doi-asserted-by":"crossref","first-page":"e41005","DOI":"10.1371\/journal.pone.0041005","volume":"7","author":"C Cond\u00e9","year":"2012","unstructured":"Cond\u00e9 C, et al. The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-\u03baB activation by disturbing the interaction of XIAP with RIP2. PLoS One. 2012;7(7):e41005.","journal-title":"PLoS One"},{"issue":"3","key":"2304_CR27","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2015.01.019","volume":"136","author":"MJ Gold","year":"2015","unstructured":"Gold MJ, et al. Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1). J Allergy Clin Immunol. 2015;136(3):725\u201336. e2.","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"2304_CR28","first-page":"1307","volume":"69","author":"M Kapral","year":"2012","unstructured":"Kapral M, et al. Inhibitory effect of inositol hexaphosphate on metalloproteinases transcription in colon cancer cells stimulated with phorbol-12-myristate 13-acetate. Acta Pol Pharm. 2012;69(6):1307\u201312.","journal-title":"Acta Pol Pharm"},{"issue":"11","key":"2304_CR29","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00384-012-1445-3","volume":"27","author":"M Kapral","year":"2012","unstructured":"Kapral M, et al. The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1\u03b2-stimulated colon cancer cells. Int J Colorectal Dis. 2012;27(11):1419\u201328.","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"2304_CR30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15252\/embr.201439466","volume":"16","author":"HR Luo","year":"2015","unstructured":"Luo HR, Mondal S. Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep. 2015;16(2):149\u201363.","journal-title":"EMBO Rep"},{"issue":"3","key":"2304_CR31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bcp.2013.11.012","volume":"87","author":"G Semini","year":"2014","unstructured":"Semini G, et al. Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. Biochem Pharmacol. 2014;87(3):477\u201388.","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"2304_CR32","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.2353\/ajpath.2010.090416","volume":"176","author":"J Golledge","year":"2010","unstructured":"Golledge J, et al. The novel association of the chemokine CCL22 with abdominal aortic aneurysm. Am J Pathol. 2010;176(5):2098\u2013106.","journal-title":"Am J Pathol"},{"issue":"11","key":"2304_CR33","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1161\/CIRCRESAHA.107.148668","volume":"101","author":"T Miyake","year":"2007","unstructured":"Miyake T, et al. Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor \u03baB and Ets in a rabbit model. Circ Res. 2007;101(11):1175\u201384.","journal-title":"Circ Res"},{"issue":"12","key":"2304_CR34","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1161\/ATVBAHA.114.304587","volume":"34","author":"CS Moran","year":"2014","unstructured":"Moran CS, et al. Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse. Arterioscler Thromb Vasc Biol. 2014;34(12):2609\u201316.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"23","key":"2304_CR35","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1161\/CIRCULATIONAHA.104.464727","volume":"111","author":"CS Moran","year":"2005","unstructured":"Moran CS, et al. Association of osteoprotegerin with human abdominal aortic aneurysm progression. Circulation. 2005;111(23):3119\u201325.","journal-title":"Circulation"},{"issue":"1","key":"2304_CR36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvs298","volume":"97","author":"T Saito","year":"2013","unstructured":"Saito T, et al. Importance of endothelial NF-\u03baB signalling in vascular remodelling and aortic aneurysm formation. Cardiovasc Res. 2013;97(1):106\u201314.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"2304_CR37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/cvr\/cvs331","volume":"97","author":"Z Yang","year":"2013","unstructured":"Yang Z. Endothelial NF-\u03baB: the remote controller of the backyard fire in the vascular wall? Cardiovasc Res. 2013;97(1):8\u20139.","journal-title":"Cardiovasc Res"},{"issue":"1","key":"2304_CR38","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/01.CIR.0000105725.61763.A2","volume":"109","author":"H Nakashima","year":"2004","unstructured":"Nakashima H, et al. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor \u03baB and Ets transcription factors. Circulation. 2004;109(1):132\u20138.","journal-title":"Circulation"},{"key":"2304_CR39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1749-6632.2012.06725.x","volume":"1271","author":"JY Lee","year":"2012","unstructured":"Lee JY, et al. Inositol polyphosphate multikinase signaling in the regulation of metabolism. Ann N Y Acad Sci. 2012;1271:68\u201374.","journal-title":"Ann N Y Acad Sci."},{"issue":"4","key":"2304_CR40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1161\/ATVBAHA.112.301006","volume":"33","author":"CS Moran","year":"2013","unstructured":"Moran CS, et al. Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes. Arterioscler Thromb Vasc Biol. 2013;33(4):814\u201321.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"2304_CR41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ejvs.2014.02.006","volume":"47","author":"M Rouer","year":"2014","unstructured":"Rouer M, et al. Rapamycin limits the growth of established experimental abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2014;47(5):493\u2013500.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2304_CR42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nyas.12091","volume":"1280","author":"S Iyer","year":"2013","unstructured":"Iyer S, Margulies BS, Kerr WG. Role of SHIP1 in bone biology. Ann N Y Acad Sci. 2013;1280:11\u20134.","journal-title":"Ann N Y Acad Sci."},{"issue":"9","key":"2304_CR43","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI200318141","volume":"112","author":"D Bruemmer","year":"2003","unstructured":"Bruemmer D, et al. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest. 2003;112(9):1318\u201331.","journal-title":"J Clin Invest"},{"issue":"3","key":"2304_CR44","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1161\/01.ATV.0000255560.49503.4e","volume":"27","author":"J Golledge","year":"2007","unstructured":"Golledge J, et al. Association between osteopontin and human abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2007;27(3):655\u201360.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"2304_CR45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3109\/14767058.2013.766691","volume":"26","author":"B Matarrelli","year":"2013","unstructured":"Matarrelli B, et al. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. J Matern Fetal Neonatal Med. 2013;26(10):967\u201372.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"2304_CR46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/hup.2369","volume":"29","author":"T Mukai","year":"2014","unstructured":"Mukai T, et al. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol. 2014;29(1):55\u201363.","journal-title":"Hum Psychopharmacol"},{"issue":"20","key":"2304_CR47","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1161\/CIRCULATIONAHA.107.717926","volume":"116","author":"J Golledge","year":"2007","unstructured":"Golledge J, et al. Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. Circulation. 2007;116(20):2275\u20139.","journal-title":"Circulation"},{"issue":"23","key":"2304_CR48","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/CIRCULATIONAHA.108.802074","volume":"118","author":"J Golledge","year":"2008","unstructured":"Golledge J, et al. Circulating markers of abdominal aortic aneurysm presence and progression. Circulation. 2008;118(23):2382\u201392.","journal-title":"Circulation"},{"issue":"10","key":"2304_CR49","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.amjcard.2009.12.076","volume":"105","author":"J Golledge","year":"2010","unstructured":"Golledge J, et al. Association between serum lipoproteins and abdominal aortic aneurysm. Am J Cardiol. 2010;105(10):1480\u20134.","journal-title":"Am J Cardiol"},{"issue":"1","key":"2304_CR50","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCGENETICS.113.000343","volume":"7","author":"JV Moxon","year":"2014","unstructured":"Moxon JV, et al. Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. Circ Cardiovasc Genet. 2014;7(1):71\u20139.","journal-title":"Circ Cardiovasc Genet"},{"issue":"6","key":"2304_CR51","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/HCO.0b013e328330c2d3","volume":"24","author":"J Golledge","year":"2009","unstructured":"Golledge J, Norman PE. Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients\u2019 management. Curr Opin Cardiol. 2009;24(6):532\u20138.","journal-title":"Curr Opin Cardiol"},{"issue":"9","key":"2304_CR52","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1517\/17425247.2012.701616","volume":"9","author":"S Grazia De","year":"2012","unstructured":"De Grazia S, et al. Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects. Expert Opin Drug Deliv. 2012;9(9):1033\u20139.","journal-title":"Expert Opin Drug Deliv"},{"issue":"1","key":"2304_CR53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejrad.2009.12.018","volume":"79","author":"A Parr","year":"2011","unstructured":"Parr A, et al. Comparison of volume and diameter measurement in assessing small abdominal aortic aneurysm expansion examined using computed tomographic angiography. Eur J Radiol. 2011;79(1):42\u20137.","journal-title":"Eur J Radiol"},{"key":"2304_CR54","unstructured":"The Australia and New Zealand Society of Vascular Surgery. The Australian Vascular Audit. February 2014."},{"issue":"8","key":"2304_CR55","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.0007-1323.2001.01845.x","volume":"88","author":"S Vammen","year":"2001","unstructured":"Vammen S, et al. Randomized double-blind controlled trial of roxithromycin for prevention of abdominal aortic aneurysm expansion. Br J Surg. 2001;88(8):1066\u201372.","journal-title":"Br J Surg"},{"issue":"22","key":"2304_CR56","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1001\/jama.287.22.2968","volume":"287","author":"FA Lederle","year":"2002","unstructured":"Lederle FA, et al. Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair. JAMA. 2002;287(22):2968\u201372.","journal-title":"JAMA"},{"issue":"2","key":"2304_CR57","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.ATV.0000198390.34524.ba","volume":"26","author":"RW Jayalath","year":"2006","unstructured":"Jayalath RW, Jackson P, Golledge J. Quantification of abdominal aortic calcification on CT. Arterioscler Thromb Vasc Biol. 2006;26(2):429\u201330.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2304_CR58","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jvs.2010.08.013","volume":"53","author":"A Parr","year":"2011","unstructured":"Parr A, et al. Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. J Vasc Surg. 2011;53(1):28\u201335.","journal-title":"J Vasc Surg"},{"issue":"8","key":"2304_CR59","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s00330-014-3185-y","volume":"24","author":"D Rai","year":"2014","unstructured":"Rai D, et al. Abdominal aortic aneurysm calcification and thrombus volume are not associated with outcome following endovascular abdominal aortic aneurysm repair. Eur Radiol. 2014;24(8):1768\u201376.","journal-title":"Eur Radiol"},{"issue":"2","key":"2304_CR60","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ahj.2009.11.016","volume":"159","author":"CD Ferguson","year":"2010","unstructured":"Ferguson CD, et al. Association of statin prescription with small abdominal aortic aneurysm progression. Am Heart J. 2010;159(2):307\u201313.","journal-title":"Am Heart J"},{"issue":"3","key":"2304_CR61","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.jvs.2012.11.070","volume":"58","author":"G Martufi","year":"2013","unstructured":"Martufi G, et al. Multidimensional growth measurements of abdominal aortic aneurysms. J Vasc Surg. 2013;58(3):748\u201355.","journal-title":"J Vasc Surg"},{"issue":"3","key":"2304_CR62","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejvs.2013.12.018","volume":"47","author":"TC Gasser","year":"2014","unstructured":"Gasser TC, et al. A novel strategy to translate the biomechanical rupture risk of abdominal aortic aneurysms to their equivalent diameter risk: method and retrospective validation. Eur J Vasc Endovasc Surg. 2014;47(3):288\u201395.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"3","key":"2304_CR63","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/eurheartj\/ehq171","volume":"32","author":"J Golledge","year":"2011","unstructured":"Golledge J, et al. Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm. Eur Heart J. 2011;32(3):354\u201364.","journal-title":"Eur Heart J"},{"issue":"10","key":"2304_CR64","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/bjs.6345","volume":"95","author":"L Smallwood","year":"2008","unstructured":"Smallwood L, et al. Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm. Br J Surg. 2008;95(10):1239\u201344.","journal-title":"Br J Surg"},{"issue":"11","key":"2304_CR65","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1161\/01.ATV.0000242799.81434.7d","volume":"26","author":"P Clancy","year":"2006","unstructured":"Clancy P, et al. Assessment of a serum assay for quantification of abdominal aortic calcification. Arterioscler Thromb Vasc Biol. 2006;26(11):2574\u20136.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"15","key":"2304_CR66","doi-asserted-by":"crossref","first-page":"12984","DOI":"10.18632\/oncotarget.3848","volume":"6","author":"E Biros","year":"2015","unstructured":"Biros E, et al. Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease. Oncotarget. 2015;6(15):12984\u201396.","journal-title":"Oncotarget"},{"issue":"1","key":"2304_CR67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2013.12.017","volume":"233","author":"E Biros","year":"2014","unstructured":"Biros E, et al. Differential gene expression in the proximal neck of human abdominal aortic aneurysm. Atherosclerosis. 2014;233(1):211\u20138.","journal-title":"Atherosclerosis"},{"issue":"11","key":"2304_CR68","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1042\/CS20130599","volume":"126","author":"E Biros","year":"2014","unstructured":"Biros E, et al. microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155. Clin Sci (Lond). 2014;126(11):795\u2013803.","journal-title":"Clin Sci (Lond)"},{"issue":"4","key":"2304_CR69","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0741-5214(02)00131-3","volume":"36","author":"PF Chong","year":"2002","unstructured":"Chong PF, et al. The intermittent claudication questionnaire: a patient-assessed condition-specific health outcome measure. J Vasc Surg. 2002;36(4):764\u201371. discussion 863\u20134.","journal-title":"J Vasc Surg"},{"issue":"4","key":"2304_CR70","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1079\/BJN19940064","volume":"72","author":"SA Bingham","year":"1994","unstructured":"Bingham SA, et al. Comparison of dietary assessment methods in nutritional epidemiology: weighed records v. 24\u00a0h recalls, food-frequency questionnaires and estimated-diet records. Br J Nutr. 1994;72(4):619\u201343.","journal-title":"Br J Nutr"},{"issue":"2","key":"2304_CR71","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.atherosclerosis.2013.04.030","volume":"229","author":"J Golledge","year":"2013","unstructured":"Golledge J, et al. Body mass index is inversely associated with mortality in patients with peripheral vascular disease. Atherosclerosis. 2013;229(2):549\u201355.","journal-title":"Atherosclerosis"},{"issue":"2","key":"2304_CR72","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.atherosclerosis.2013.11.034","volume":"232","author":"J Golledge","year":"2014","unstructured":"Golledge J, et al. Association of chronic kidney disease categories defined with different formulae with major adverse events in patients with peripheral vascular disease. Atherosclerosis. 2014;232(2):289\u201397.","journal-title":"Atherosclerosis"},{"key":"2304_CR73","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12933-014-0147-2","volume":"13","author":"J Golledge","year":"2014","unstructured":"Golledge J, et al. Association of impaired fasting glucose, diabetes and their management with the presentation and outcome of peripheral artery disease: a cohort study. Cardiovasc Diabetol. 2014;13:147.","journal-title":"Cardiovasc Diabetol."},{"issue":"1","key":"2304_CR74","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1186\/s12889-016-3801-7","volume":"16","author":"NW Burton","year":"2016","unstructured":"Burton NW, et al. Efficacy of brief behavioral counselling by allied health professionals to promote physical activity in people with peripheral arterial disease (BIPP): study protocol for a multi-center randomized controlled trial. BMC Public Health. 2016;16(1):1148.","journal-title":"BMC Public Health"},{"key":"2304_CR75","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s13063-015-0793-z","volume":"16","author":"DR Morris","year":"2015","unstructured":"Morris DR, et al. TElmisartan in the management of abDominal aortic aneurYsm (TEDY): the study protocol for a randomized controlled trial. Trials. 2015;16:274.","journal-title":"Trials."},{"key":"2304_CR76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.18203\/2349-3259.ijct20163960","volume":"3","author":"SE Rowbotham","year":"2016","unstructured":"Rowbotham SE. Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME)-2: the study protocol for a multi-centre, randomised, placebo-controlled trial. Int J Clin Trials. 2016;3:217\u201324.","journal-title":"Int J Clin Trials."},{"issue":"1","key":"2304_CR77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13063-016-1752-z","volume":"18","author":"SE Rowbotham","year":"2017","unstructured":"Rowbotham SE, et al. Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial. Trials. 2017;18(1):1.","journal-title":"Trials"},{"issue":"3","key":"2304_CR78","doi-asserted-by":"crossref","first-page":"e0173346","DOI":"10.1371\/journal.pone.0173346","volume":"12","author":"D Sun","year":"2017","unstructured":"Sun D, et al. Evaluation of the performance of national health systems in 2004-2011: an analysis of 173 countries. PLoS One. 2017;12(3):e0173346.","journal-title":"PLoS One"},{"issue":"12","key":"2304_CR79","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-159-12-201312170-00007","volume":"159","author":"CA Meijer","year":"2013","unstructured":"Meijer CA, et al. Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial. Ann Intern Med. 2013;159(12):815\u201323.","journal-title":"Ann Intern Med"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-017-2304-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T02:40:18Z","timestamp":1570329618000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-017-2304-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["2304"],"URL":"https:\/\/doi.org\/10.1186\/s13063-017-2304-x","relation":{},"ISSN":["1745-6215"],"issn-type":[{"type":"electronic","value":"1745-6215"}],"subject":[],"published":{"date-parts":[[2017,11,16]]},"article-number":"547"}}