{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:51:17Z","timestamp":1772070677836,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific research Projects unit of Chongqing","award":["cstc2016shms-ztzx"],"award-info":[{"award-number":["cstc2016shms-ztzx"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13063-018-2673-9","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T20:42:10Z","timestamp":1528922530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Non-invasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: Study protocol for a multi-center prospective randomized controlled trial"],"prefix":"10.1186","volume":"19","author":[{"name":"for the NHFOV Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Wang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-601X","authenticated-orcid":false,"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"key":"2673_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0377-1237(07)80152-3","volume":"63","author":"SS Mathal","year":"2007","unstructured":"Mathal SS, Raju U, Kannitkar M. Management of respiratory distress in the newborn. Med J Armed Forces India. 2007;63:269\u201372.","journal-title":"Med J Armed Forces India"},{"key":"2673_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000448985","volume":"111","author":"DG Sweet","year":"2017","unstructured":"Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, Saugstad OD, Simeoni U, Speer CP, Vento M, et al. European consensus guidelines on the management of respiratory distress syndrome-2016 update. Neonatology. 2017;111:107\u201325.","journal-title":"Neonatology"},{"key":"2673_CR3","doi-asserted-by":"publisher","unstructured":"Cumming JJ, Polin RA, AAP the COMMITTEE ON FETUS AND NEWBORN. Noninvasive respiratory support. Pediatrics. 2016;137(1). \n                    https:\/\/doi.org\/10.1542\/peds.2015-3758\n                    \n                  . Epub 2015 Dec 29","DOI":"10.1542\/peds.2015-3758"},{"key":"2673_CR4","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1542\/peds.112.5.1031","volume":"112","author":"BM Stefanescu","year":"2003","unstructured":"Stefanescu BM, Murphy WP, Hansell BJ, Fuloria M, Morgan TM, Aschner JL. A randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants. Pediatrics. 2003;112:1031\u20138.","journal-title":"Pediatrics"},{"key":"2673_CR5","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1542\/peds.107.4.638","volume":"107","author":"KJ Barrington","year":"2001","unstructured":"Barrington KJ, Bull D, Finer NN. Randomized trial of nasal synchronized intermittent mandatory ventilation compared with continuous positive airway pressure after extubation of very low birth weight infants. Pediatrics. 2001;107:638\u201341.","journal-title":"Pediatrics"},{"key":"2673_CR6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/jp.2012.1","volume":"32","author":"R Ramanathan","year":"2012","unstructured":"Ramanathan R, Sekar KC, Rasmussen M, Bhatia J, Soll RF. Nasal intermittent positive pressure ventilation after surfactant treatment for respiratory distress syndrome in preterm infants <30 weeks\u2019 gestation: a randomized, controlled trial. J Perinatal. 2012;32:336\u201343.","journal-title":"J Perinatal"},{"key":"2673_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00431-014-2419-y","volume":"174","author":"HS Fischer","year":"2015","unstructured":"Fischer HS, Bohlin K, B\u00fchrer C, Schmalisch G, Cremer M, Reiss L, Czernik C. Nasal high-frequency oscillation ventilation in neonates: a survey in five European countries. Eur J Pediatr. 2015;174:465\u201371.","journal-title":"Eur J Pediatr"},{"key":"2673_CR8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/pr.2016.98","volume":"80","author":"R Cayabyab","year":"2016","unstructured":"Cayabyab R, Arora V, Wertheimer F, Durand M, Ramanathan R. Graded oxygen saturation targets and retinopathy of prematurity in extremely preterm infants. Pediatr Res. 2016;80:401\u20136.","journal-title":"Pediatr Res"},{"key":"2673_CR9","doi-asserted-by":"publisher","first-page":"F85","DOI":"10.1136\/adc.2009.169219","volume":"95","author":"G Lista","year":"2010","unstructured":"Lista G, Casoldi F, Fotana P, Daniele L, Caviqioli F, Rossi S, Mancuso D, Reali R. Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomized control trial. Arch Dis Child Fetal Neonatal Ed. 2010;95:F85\u20139.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2673_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2431-12-43","volume":"12","author":"K O\u2019Brien","year":"2012","unstructured":"O\u2019Brien K, Campell C, Brown L, Wenger L, Shah L. Infant flow biphasic nasal continuous positive airway pressure (BP-NCPAP) vs. infant flow NCPAP for the facilitation of extubation in infants \u2264 1,250 grams: a randomized controlled trial. BMC Pediatr. 2012;12:43\u201351.","journal-title":"BMC Pediatr"},{"key":"2673_CR11","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J RespirCrit Care Med. 2001;163:1723\u20139.","journal-title":"Am J RespirCrit Care Med"},{"key":"2673_CR12","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500gm. J Pediatr. 1978;92:529\u201334.","journal-title":"J Pediatr"},{"key":"2673_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","volume":"187","author":"MJ Bell","year":"1978","unstructured":"Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing ebterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1\u20137.","journal-title":"Ann Surg"},{"key":"2673_CR14","doi-asserted-by":"crossref","unstructured":"Zhu XW, Zhao JN, Tang SF, Yan J, Shi Y. Noninvasive high-frequency oscillatory ventilation versus nasal continuous positive airway pressure in preterm infants with moderate-severe respiratory distress syndrome: A preliminary report. Pediatr Pulmonol. 2017;52:1038\u20131042.","DOI":"10.1002\/ppul.23755"},{"key":"2673_CR15","first-page":"177","volume":"55","author":"CH Wang","year":"2017","unstructured":"Wang CH, Shi LP, Ma XL, Lin HJ, Xu YP, Du LZ. Use of noninvasive high-frequency oscillatory ventilation in very low birth weight infants. ZhonghuaErKeZaZhi. 2017;55:177\u201381.","journal-title":"ZhonghuaErKeZaZhi"},{"issue":"1","key":"2673_CR16","doi-asserted-by":"publisher","first-page":"F61","DOI":"10.1136\/fn.79.1.F61","volume":"79","author":"M Van der Hoeven","year":"1998","unstructured":"Van der Hoeven M, Brouwer E, Blanco CE. Nasal high frequency ventilation in neonates with moderate respiratory insufficiency. Arch Dis Child Fetal Neonatal Ed. 1998;79(1):F61\u20133.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2673_CR17","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1111\/j.1651-2227.2008.00900.x","volume":"97","author":"TT Colaizy","year":"2008","unstructured":"Colaizy TT, Younis UM, Bell EF, Klein JM. Nasal high-frequency ventilation for premature infants. Acta Paediatr. 2008;97:1518\u201322.","journal-title":"Acta Paediatr"},{"key":"2673_CR18","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3109\/14767058.2011.580401","volume":"25","author":"C Czernik","year":"2012","unstructured":"Czernik C, Schmalisch G, B\u00fchrer C, Proquitt\u00e9 H. Weaning of neonates from mechanical ventilation by use of nasopharyngeal high frequency oscillatory ventilation: a preliminary study. J Matern Fetal Neonatal Med. 2012;25:374\u20138.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2673_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/tropej\/fmv088","volume":"62","author":"S Aktas","year":"2016","unstructured":"Aktas S, Unal S, Aksu M, Ozcan E, Ergenekon E, Turkyilmaz C, Hirfanoglu L, Atalay Y. Nasal HFOV with Binasal Cannula appears effective and feasible in ELBW Newborns. J Trop Pediatr. 2016;62:165\u20138.","journal-title":"J Trop Pediatr"},{"key":"2673_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1055\/s-0034-1381317","volume":"30","author":"A Mukerji","year":"2015","unstructured":"Mukerji A, Singh B, Helou SE, Fusch C, Dunn M, Belik J, Shah V. Use of noninvasive high frequency ventilation in the neonatal intensive care unit: a retrospective review. Am J Perinatol. 2015;30:171\u20136.","journal-title":"Am J Perinatol"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-018-2673-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-018-2673-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-018-2673-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:13:44Z","timestamp":1560453224000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-018-2673-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,14]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2673"],"URL":"https:\/\/doi.org\/10.1186\/s13063-018-2673-9","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,14]]},"assertion":[{"value":"10 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"These are the participating centers and investigators of the NHFOV Study Group:","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 information"}},{"value":"The trial has been approved by the ethics committee of Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, and the institutional review boards of each of the participating centers. Informed parental consent will be obtained prior to any study-related procedures. The trial investigators and institutions will permit trial-related monitoring, audits, research ethics committee review, and regulatory inspections, by providing direct access to source data and documents. Trial participants are informed of this during the informed consent discussion. The trial will be run in accordance with good clinical practice and current regulatory guidance.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication is not applicable. Participants will not be identified by name on any documents or in connection with any data that leave the study sites, nor will they be reported by name in any report or publication resulting from data collected in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"319"}}