{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:15:13Z","timestamp":1782396913588,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Florida Department of Health\u2019s Ed and Ethel Moore Alzheimer\u2019s Research Program","award":["Grant Number 7AZ01"],"award-info":[{"award-number":["Grant Number 7AZ01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13063-018-2865-3","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T09:18:32Z","timestamp":1539940712000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Physical exercise and cognitive engagement outcomes for mild neurocognitive disorder: a group-randomized pilot trial"],"prefix":"10.1186","volume":"19","author":[{"given":"Liselotte","family":"De Wit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tripti","family":"Bhaskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Crook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-9484","authenticated-orcid":false,"given":"Glenn","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"issue":"3","key":"2865_CR1","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","volume":"7","author":"Marilyn S. Albert","year":"2011","unstructured":"Albert MS, Dekosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011; https:\/\/doi.org\/10.1016\/j.jalz.2011.03.008","journal-title":"Alzheimer's & Dementia"},{"key":"2865_CR2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental Disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental Disorders. 5th ed. Arlington: American Psychiatric Publishing; 2013.","edition":"5"},{"key":"2865_CR3","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1056\/NEJMsa1204629","volume":"368","author":"MD Hurd","year":"2013","unstructured":"Hurd MD, Martorell P, Delavande A, Mullen KJ, Langa KM. Monetary costs of dementia in the United States. N Engl J Med. 2013;368:1326\u201334. https:\/\/doi.org\/10.1056\/NEJMsa1204629 .","journal-title":"N Engl J Med"},{"key":"2865_CR4","volume-title":"Preventing cognitive decline and dementia","author":"National Academies of Sciences, Engineering, and Medicine","year":"2017","unstructured":"National Academies of Sciences, Engineering, and Medicine. Preventing cognitive decline and dementia. Washington, D.C.: National Academies Press; 2017. https:\/\/doi.org\/10.17226\/24782"},{"key":"2865_CR5","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1159\/000315933","volume":"57","author":"LWA Joosten-Weyn Banningh","year":"2010","unstructured":"Joosten-Weyn Banningh LWA, Prins JB, Vernooij-Dassen MJFJ, Wijnen H, Olde Rikkert MGM, Kessels RPC. Group therapy for patients with mild cognitive impairment and their significant others: results of a waiting-list controlled trial. Gerontology. 2010;57:444\u201354. https:\/\/doi.org\/10.1159\/000315933","journal-title":"Gerontology"},{"key":"2865_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/1533317508320352","volume":"23","author":"MC Greenaway","year":"2008","unstructured":"Greenaway MC, Hanna SM, Lepore SW, Smith GE. A behavioral rehabilitation intervention for amnestic mild cognitive impairment. Am J Alzheimers Dis Other Demen. 2008;23:451\u201361. https:\/\/doi.org\/10.1177\/1533317508320352","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"2865_CR7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/gps.3838","volume":"28","author":"MC Greenaway","year":"2013","unstructured":"Greenaway MC, Duncan NLL, Smith GE. The memory support system for mild cognitive impairment: randomized trial of a cognitive rehabilitation intervention. Int J Geriatr Psychiatry. 2013;28:402\u20139. https:\/\/doi.org\/10.1002\/gps.3838","journal-title":"Int J Geriatr Psychiatry"},{"key":"2865_CR8","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","volume":"385","author":"T Ngandu","year":"2015","unstructured":"Ngandu T, Lehtisalo J, Solomon A, Lev\u00e4lahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255\u201363. https:\/\/doi.org\/10.1016\/S0140-6736(15)60461-5","journal-title":"Lancet"},{"key":"2865_CR9","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.neuroimage.2013.07.069","volume":"85","author":"M Strenziok","year":"2014","unstructured":"Strenziok M, Parasuraman R, Clarke E, Cisler DS, Thompson JC, Greenwood PM. Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity. NeuroImage. 2014;85:1027\u201339. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.07.069","journal-title":"NeuroImage"},{"key":"2865_CR10","doi-asserted-by":"publisher","unstructured":"Lampit A, Hallock H, Suo C, Naismith SL, Valenzuela M. Cognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study. Front Aging Neurosci. 2015;7:14. https:\/\/doi.org\/10.3389\/fnagi.2015.00014 .","DOI":"10.3389\/fnagi.2015.00014"},{"issue":"9","key":"2865_CR11","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1001\/jama.300.9.1027","volume":"300","author":"Nicola T. Lautenschlager","year":"2008","unstructured":"Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease. JAMA. 2008;300:1027. https:\/\/doi.org\/10.1001\/jama.300.9.1027 .","journal-title":"JAMA"},{"key":"2865_CR12","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.neuroimage.2015.09.050","volume":"131","author":"T K\u00f6be","year":"2016","unstructured":"K\u00f6be T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, et al. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. NeuroImage. 2016;131:226\u201338. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.09.050","journal-title":"NeuroImage"},{"key":"2865_CR13","first-page":"23","volume":"2","author":"JH Burdette","year":"2010","unstructured":"Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q, Vechlekar CD, et al. Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2:23. https:\/\/doi.org\/10.3389\/fnagi.2010.00023","journal-title":"Front Aging Neurosci"},{"key":"2865_CR14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fnagi.2013.00075","volume":"5","author":"SB Chapman","year":"2013","unstructured":"Chapman SB, Aslan S, Spence JS, Defina LF, Keebler MW, Didehbani N, et al. Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci. 2013;5:75. https:\/\/doi.org\/10.3389\/fnagi.2013.00075","journal-title":"Front Aging Neurosci"},{"key":"2865_CR15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jneumeth.2010.06.028","volume":"191","author":"JC Smith","year":"2010","unstructured":"Smith JC, Paulson ES, Cook DB, Verber MD, Tian Q. Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: implications for fMRI. J Neurosci Methods. 2010;191:258\u201362. https:\/\/doi.org\/10.1016\/j.jneumeth.2010.06.028","journal-title":"J Neurosci Methods"},{"issue":"3","key":"2865_CR16","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3233\/JAD-161151","volume":"57","author":"Theresa J. Chirles","year":"2017","unstructured":"Chirles TJ, Reiter K, Weiss LR, Alfini AJ, Nielson KA. Exercise training and functional connectivity changes in mild cognitive Empairment and healthy elders. J Alzheimers Dis. 2017;57:845\u201356. http:\/\/epublications.marquette.edu\/cgi\/viewcontent.cgi?article=1270&context=psych_fac .","journal-title":"Journal of Alzheimer's Disease"},{"key":"2865_CR17","first-page":"32","volume":"2","author":"MW Voss","year":"2010","unstructured":"Voss MW, Prakash RS, Erickson KI, Basak C, Chaddock L, Kim JS, et al. Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci. 2010;2:32. https:\/\/doi.org\/10.3389\/fnagi.2010.00032","journal-title":"Front Aging Neurosci."},{"key":"2865_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1532-5415.2011.03761.x","volume":"60","author":"SB Hindin","year":"2012","unstructured":"Hindin SB, Zelinski EM. Extended practice and aerobic exercise interventions benefit untrained cognitive outcomes in older adults: a meta-analysis. J Am Geriatr Soc. 2012;60:136\u201341. https:\/\/doi.org\/10.1111\/j.1532-5415.2011.03761.x","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"2865_CR19","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","volume":"43","author":"J. C. Morris","year":"1993","unstructured":"Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412\u20134.","journal-title":"Neurology"},{"key":"2865_CR20","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1111\/j.1532-5415.2008.02167.x","volume":"57","author":"GE Smith","year":"2009","unstructured":"Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, Mahncke HW, et al. A cognitive training program based on principles of brain plasticity: results from the improvement in memory with plasticity-based adaptive cognitive training (IMPACT) study. J Am Geriatr Soc. 2009;57:594\u2013603. https:\/\/doi.org\/10.1111\/j.1532-5415.2008.02167.x","journal-title":"J Am Geriatr Soc"},{"key":"2865_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1111\/j.1532-5415.2010.03277.x","volume":"59","author":"EM Zelinski","year":"2011","unstructured":"Zelinski EM, Spina LM, Yaffe K, Ruff R, Kennison RF, Mahncke HW, et al. Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up. J Am Geriatr Soc. 2011;59:258\u201365. https:\/\/doi.org\/10.1111\/j.1532-5415.2010.03277.x","journal-title":"J Am Geriatr Soc"},{"key":"2865_CR22","volume-title":"Dementia rating Scale-2: DRS-2: professional manual","author":"P Jurica","year":"2001","unstructured":"Jurica P, Leitten C, Mattis S. Dementia rating Scale-2: DRS-2: professional manual. Chicaco: Psychological Assessment Resources; 2001."},{"key":"2865_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/0891988714522700","volume":"27","author":"BA Springate","year":"2014","unstructured":"Springate BA, Tremont G, Papandonatos G, Ott BR. Screening for mild cognitive impairment using the dementia rating Scale-2. J Geriatr Psychiatry Neurol. 2014;27:139\u201344. https:\/\/doi.org\/10.1177\/0891988714522700","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"2865_CR24","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/arclin\/act021","volume":"28","author":"YY Lim","year":"2013","unstructured":"Lim YY, Jaeger J, Harrington K, Ashwood T, Ellis KA, Stoffler A, et al. Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer\u2019s disease: results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Arch Clin Neuropsychol. 2013;28:320\u201330. https:\/\/doi.org\/10.1093\/arclin\/act021","journal-title":"Arch Clin Neuropsychol"},{"key":"2865_CR25","unstructured":"Lezak MD. Neuropsychological assessment. New York: Oxford University Press; 2004."},{"key":"2865_CR26","unstructured":"Rey A. L\u2019examen clinique en psychologie. 2e e\u0301d. Paris: Presses universitaires de France; 1964."},{"key":"2865_CR27","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/0028-3932(74)90072-4","volume":"12","author":"EK Warrington","year":"1974","unstructured":"Warrington EK, Weiskrantz L. The effect of prior learning on subsequent retention in amnesic patients. Neuropsychologia. 1974;12:419\u201328. https:\/\/doi.org\/10.1016\/0028-3932(74)90072-4","journal-title":"Neuropsychologia"},{"key":"2865_CR28","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1037\/0278-7393.11.2.386","volume":"II","author":"P Graf","year":"1985","unstructured":"Graf P, Shimamura AP, Squire LR. Priming across modalities and priming across category levels: extending the domain of preserved function in amnesia. J Exp Psychol Learn Mem Cogn. 1985;II:386\u201396.","journal-title":"J Exp Psychol Learn Mem Cogn"},{"key":"2865_CR29","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/01688638808408254","volume":"10","author":"DP Salmon","year":"1988","unstructured":"Salmon DP, Shimamura AP, Butters N, Smith S. Lexical and semantic priming deficits in patients with Alzheimer\u2019s disease. J Clin Exp Neuropsychol. 1988;10:477\u201394. https:\/\/doi.org\/10.1080\/01688638808408254","journal-title":"J Clin Exp Neuropsychol"},{"key":"2865_CR30","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1037\/0735-7044.107.6.899","volume":"107","author":"JDE Gabrieli","year":"1993","unstructured":"Gabrieli JDE, Corkin S, Mickel SF, Growdon JH. Intact acquisition and long-term retention of mirror-tracing skill in Alzheimer\u2019s disease and in global amnesia. Behav Neurosci. 1993;107:899\u2013910. https:\/\/doi.org\/10.1037\/0735-7044.107.6.899","journal-title":"Behav Neurosci"},{"key":"2865_CR31","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1017\/S1355617712001270","volume":"19","author":"A Gabriel","year":"2013","unstructured":"Gabriel A, Maillart C, Stefaniak N, Lejeune C, Desmottes L, Meulemans T. Procedural learning in specific language impairment: effects of sequence complexity. J Int Neuropsychol Soc. 2013;19:264\u201371. https:\/\/doi.org\/10.1017\/S1355617712001270","journal-title":"J Int Neuropsychol Soc"},{"key":"2865_CR32","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3758\/s13428-011-0168-7","volume":"44","author":"S Math\u00f4t","year":"2012","unstructured":"Math\u00f4t S, Schreij D, Theeuwes J. OpenSesame: An open-source, graphical experiment builder for the social sciences. Behav Res Methods. 2012;44:314\u201324. https:\/\/doi.org\/10.3758\/s13428-011-0168-7","journal-title":"Behav Res Methods"},{"key":"2865_CR33","volume-title":"WRAT 4: wide range achievement test; professional manual","author":"G Wilkinson","year":"2006","unstructured":"Wilkinson G, Robertson G. WRAT 4: wide range achievement test; professional manual. 4th ed. Lutz: Psychological Assessment Resources; 2006.","edition":"4"},{"key":"2865_CR34","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.neurobiolaging.2009.10.013","volume":"32","author":"AM Brickman","year":"2011","unstructured":"Brickman AM, Siedlecki KL, Muraskin J, Manly JJ, Luchsinger JA, Yeung LK, et al. White matter hyperintensities and cognition: testing the reserve hypothesis. Neurobiol Aging. 2011;32:1588\u201398. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.10.013","journal-title":"Neurobiol Aging"},{"key":"2865_CR35","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1037\/0894-4105.22.4.531","volume":"22","author":"ST Farias","year":"2008","unstructured":"Farias ST, Mungas D, Reed BR, Cahn-Weiner D, Jagust W, Baynes K, et al. The measurement of everyday cognition (ECog): scale development and psychometric properties. Neuropsychology. 2008;22:531\u201344. https:\/\/doi.org\/10.1037\/0894-4105.22.4.531","journal-title":"Neuropsychology"},{"key":"2865_CR36","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/geronj\/37.3.323","volume":"37","author":"RI Pfeffer","year":"1982","unstructured":"Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323\u20139.","journal-title":"J Gerontol"},{"key":"2865_CR37","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","volume":"49","author":"JM Guralnik","year":"1994","unstructured":"Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85\u201394.","journal-title":"J Gerontol"},{"key":"2865_CR38","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","volume":"64","author":"RG Logsdon","year":"2002","unstructured":"Logsdon RG, Gibbons LE, McCurry SM, Teri L. Assessing quality of life in older adults with cognitive impairment. Psychosom Med. 2002;64:510\u20139. https:\/\/doi.org\/10.1097\/00006842-200205000-00016","journal-title":"Psychosom Med"},{"key":"2865_CR39","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/014662167700100306","volume":"1","author":"LS Radloff","year":"1977","unstructured":"Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385\u2013401. https:\/\/doi.org\/10.1177\/014662167700100306","journal-title":"Appl Psychol Meas"},{"key":"2865_CR40","unstructured":"Spielberger CD, Gorsuch RL, Lushene RD, Vagg PR, Jacobs GA. Manual for the state-trait anxiety inventory (STAI). Palo Alto. CA, USA: Consulting Psychologists Press, Inc.; 1983."},{"key":"2865_CR41","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1037\/0882-7974.18.3.375","volume":"18","author":"SR Wisniewski","year":"2003","unstructured":"Wisniewski SR, Belle SH, Coon DW, Marcus SM, Ory MG, Burgio LD, et al. The resources for enhancing Alzheimer\u2019s caregiver health (REACH): project design and baseline characteristics. Psychol Aging. 2003;18:375\u201384. https:\/\/doi.org\/10.1037\/0882-7974.18.3.375","journal-title":"Psychol Aging"},{"key":"2865_CR42","doi-asserted-by":"crossref","unstructured":"Lorig K. Outcome measures for health education and other health care interventions. Thousand Oaks, California: Sage Publications; 1996.","DOI":"10.4135\/9781452232966"},{"key":"2865_CR43","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/geront\/30.5.583","volume":"30","author":"LI Pearlin","year":"1990","unstructured":"Pearlin LI, Mullan JT, Semple SJ, Skaff MM. Caregiving and the stress process: an overview of concepts and their measures. Gerontologist. 1990;30:583\u201394.","journal-title":"Gerontologist"},{"key":"2865_CR44","first-page":"547","volume":"16","author":"JL Kibler","year":"2006","unstructured":"Kibler JL, Brisco K. Evaluation of a brief questionnaire for assessing barriers to research participation. Ethn Dis. 2006;16:547\u201350.","journal-title":"Ethn Dis"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-018-2865-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-018-2865-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-018-2865-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T07:50:54Z","timestamp":1662277854000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-018-2865-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2865"],"URL":"https:\/\/doi.org\/10.1186\/s13063-018-2865-3","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]},"assertion":[{"value":"17 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The University of Florida (#20170004), Mayo Clinic Jacksonville (#17-000290), and Tallahassee Memorial Healthcare (#2017-17) each have obtained approval from their Institution Review Board (IRB). Informed consent is\/will be obtained by any of the authors or other investigators that are approved by the IRB of the concerning study-site. Informed consent will be obtained by going over a consent form that contains all relevant information in a private setting. Participants will be told that they can change their mind about participate and withdraw from the trial at any time without being penalized or losing benefits in any way.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"573"}}