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Additionally approval from Swissmedic was obtained (reference number 2018DR4111). The trial was registered on clinicaltrials.gov (NCT03633643). All patients will be informed about the benefits and risks of this study before participating. Furthermore, they will be informed that participation is voluntary and the withdrawal is possible any time without specific reasons. Written informed consent will be obtained from all participating patients.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All trials results will be published with open access in peer-reviewed journal publications. We intend to publish the study protocol of the CITrUS Trial in a peer reviewed journal. Authorship to publications will be granted according to the rules of the International Committee of Medical Journal Editors (ICMJE).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"142"}}