{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:01:49Z","timestamp":1794265309690,"version":"4.9.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2017\/06835-8"],"award-info":[{"award-number":["2017\/06835-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13063-019-3300-0","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:04:24Z","timestamp":1554991464000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of the masticatory muscle function, physiological sleep variables, and salivary parameters after electromechanical therapeutic approaches in adult patients with Down syndrome: a randomized controlled clinical trial"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6609-2794","authenticated-orcid":false,"given":"Lilian Chrystiane","family":"Giannasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marign\u00eas T. S.","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L. S.","family":"Tenguan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela P.","family":"Mancilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela R. C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Fillietaz-Bacigalupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Politti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio R.","family":"Nacif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel F.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o C.","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina T.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus M.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis V. F.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmar","family":"de Mello Rode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Yumi","family":"Koga-Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose B. O.","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A. C.","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica F.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"issue":"8","key":"3300_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1590\/1806-9282.63.08.693","volume":"63","author":"AMBR Duarte","year":"2017","unstructured":"Duarte AMBR, Bessa J\u00fanior J, Mrad FCC, Tibiri\u00e7\u00e1 SHC, Camargo MLS, Vieira AAP, Araujo FCC, Figueiredo AA, Bastos-Netto JM. Smoking and its association with cryptorchidism in Down syndrome. Rev Assoc Med Bras. 2017;63(8):693\u20136.","journal-title":"Rev Assoc Med Bras"},{"key":"3300_CR2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1590\/1516-3180.2015.00710108","volume":"133","author":"BE Bermudez","year":"2015","unstructured":"Bermudez BE, Medeiros SL, Bermudez MB, Novadzki IM, Magdalena NI. Down syndrome: Prevalence and distribution of congenital heart disease in Brazil. S\u00e3o Paulo Med J. 2015;133:521\u20134.","journal-title":"S\u00e3o Paulo Med J"},{"issue":"2","key":"3300_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00408-016-9856-5","volume":"194","author":"CA Gerdung","year":"2016","unstructured":"Gerdung CA, Tsang A, Yasseen AS 3rd, Armstrong K, McMillan HJ, Kovesi T. Association between chronic aspiration and chronic airway infection with Pseudomonas aeruginosa and other Gram-negative bacteria in children with cerebral palsy. Lung. 2016;194(2):307\u201314.","journal-title":"Lung"},{"key":"3300_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/jir.12236","volume":"60","author":"AJ Esbensen","year":"2016","unstructured":"Esbensen AJ. Sleep problems and associated comorbidities among adults with Down syndrome. J Intellect Disabil Res. 2016;60:68\u201379.","journal-title":"J Intellect Disabil Res"},{"key":"3300_CR5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.5665\/sleep.5554","volume":"1","author":"M Maris","year":"2016","unstructured":"Maris M, Verhulst S, Wojciechowski M, Van de Heyning P, Boudewyns A. Prevalence of obstructive sleep apnea in children with Down syndrome. Sleep. 2016;1:699\u2013704.","journal-title":"Sleep"},{"key":"3300_CR6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5664\/jcsm.27541","volume":"5","author":"MS Trois","year":"2009","unstructured":"Trois MS, Capone GT, Lutz J\u00c1, Melenfres MC, Schwartz AR, Collop NA, Marcus CL. Obstructive sleep apnea in adults with Down syndrome. J Clin Sleep Med. 2009;5:317\u201323.","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"3300_CR7","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/sleep\/32.3.361","volume":"32","author":"AS Jordan","year":"2009","unstructured":"Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep. 2009;32(3):361\u20138.","journal-title":"Sleep"},{"issue":"10","key":"3300_CR8","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.5665\/sleep.4072","volume":"37","author":"Andrew M. Kim","year":"2014","unstructured":"Kim AM, Keenan BT, Jackson N, Chan EL, Staley B, Poptani H, Schwab RJ. Tongue fat and its relationship to obstructive sleep apnea. Sleep. 2014 ;37(10):1639\u201348.","journal-title":"Sleep"},{"issue":"4","key":"3300_CR9","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1067\/mod.2001.112667","volume":"119","author":"HG Song","year":"2001","unstructured":"Song HG, Pae EK. Changes in orofacial muscle activity in response to changes in respiratory resistance. Am J Orthod Dentofac Orthop. 2001;119(4):436\u201342.","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"3","key":"3300_CR10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/j.1469-7793.1999.00897.x","volume":"520","author":"SA Shea","year":"1999","unstructured":"Shea SA, Edwards JK, White DP. Effect of wake sleep transitions and rapid eye movement sleep on pharyngeal muscle response to negative pressure in humans. J Physiol. 1999;520(3):897\u2013908.","journal-title":"J Physiol"},{"issue":"10","key":"3300_CR11","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1164\/rccm.200806-981OC","volume":"179","author":"KC Guimar\u00e3es","year":"2009","unstructured":"Guimar\u00e3es KC, Drage LF, Genta PR, Marcondes BF, Lorenzi-Filho G. Effects of oropharyngeal exercises on patients with moderate obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2009;179(10):962\u20136.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"3300_CR12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1378\/chest.14-2953","volume":"148","author":"V Ieto","year":"2015","unstructured":"Ieto V, Kayamori F, Montes MI, Hirata RP, Greg\u00f3rio MG, Alencar AM, Lorenzi-Filho G. Effects of oropharyngeal exercises on snoring: a randomized trial. Chest J. 2015;148(3):683\u201391.","journal-title":"Chest J"},{"issue":"1","key":"3300_CR13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jbmt.2013.05.009","volume":"18","author":"LC Giannasi","year":"2014","unstructured":"Giannasi LC, Freitas Batista SR, Matsui MY, Hardt CT, Gomes CP, Oliveira Amorim JB, Oliveira CS, de Oliveira LV, Gomes MF. Effect of a hyperbolide mastication apparatus for the treatment of severe sleep bruxism in a child with cerebral palsy: long-term follow-up. J Bodyw Mov Ther. 2014;18(1):62\u20137.","journal-title":"J Bodyw Mov Ther"},{"issue":"13","key":"3300_CR14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1471-2474-13-71","volume":"15","author":"LC Giannasi","year":"2012","unstructured":"Giannasi LC, Matsui MY, Freitas SR, Hardt CT, Amorim JB, de Carvalho A, Collnage L, dos Reis dos Santos I, Dias IS, de Oliveira LVF, de Oliveira CS, Gomes MF. Effects of neuromuscular electrical stimulation, laser therapy and LED therapy on the masticatory system and the impact on sleep variables in cerebral palsy patients: a randomized, five arms clinical trial. BMC Musculoskelet Disord. 2012;15(13):71.","journal-title":"BMC Musculoskelet Disord"},{"issue":"8","key":"3300_CR15","doi-asserted-by":"publisher","first-page":"e0128959","DOI":"10.1371\/journal.pone.0128959","volume":"10","author":"LC Giannasi","year":"2015","unstructured":"Giannasi LC, Matsui MY, Freitas SR, Caldas BF, Grossmann E, Amorim JB, dos Santos IR, Oliveira LV, Oliveira CS, Gomes MF. Effects of neuromuscular electrical stimulation on the masticatory muscles and physiologic sleep variables in adults with cerebral palsy: a novel therapeutic approach. PLoS One. 2015;10(8):e0128959.","journal-title":"PLoS One"},{"issue":"4","key":"3300_CR16","doi-asserted-by":"publisher","first-page":"641","DOI":"10.5585\/conssaude.v14n4.5688","volume":"14","author":"CA Herpich","year":"2015","unstructured":"Herpich CA, Gomes CAFP, Hage YE, Gloria IPS, Amaral AP, Politti F, Biasotto-Gonzalez DA. Effects of hyperboloid masticator apparatus in temporomandibular disorder\u2014case study. ConScientiae Sa\u00fade. 2015;14(4):641\u20135.","journal-title":"ConScientiae Sa\u00fade"},{"key":"3300_CR17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.2165\/00007256-199213050-00003","volume":"13","author":"DA Lake","year":"1992","unstructured":"Lake DA. Neuromuscular electrical stimulation. An overview and its application in the treatment of sports injuries. Sport med. 1992;13:320\u201336.","journal-title":"Sport med"},{"key":"3300_CR18","doi-asserted-by":"publisher","unstructured":"Pinheiro DLDSA, Alves GADS, Fausto FMM, Pessoa LSF, Silvia LDA, Pereira SMF, Almeida LNA. Effects of electrostimulation associated with masticatory training in individuals with down syndrome. Codas. 2018. \n                    https:\/\/doi.org\/10.1590\/2317-1782\/20182017074\n                    \n                  .","DOI":"10.1590\/2317-1782\/20182017074"},{"issue":"1","key":"3300_CR19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1590\/1982-0216201514613","volume":"17","author":"DFB Fraga","year":"2015","unstructured":"Fraga DFB, Pereira KR, Dornelles S, Olchik MR, Levy DS. Swallowing evaluation in infants with congenital heart disease and Down syndrome: clinical study cases. Rev CEFAC. 2015;17(1):277.","journal-title":"Rev CEFAC"},{"issue":"6","key":"3300_CR20","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/0003-9993(94)90194-5","volume":"75","author":"E Abdel-Moty","year":"1994","unstructured":"Abdel-Moty E, Fishbain DA, Goldberg M, Cutler R, Zaki AM, Khalil TM, Peppard T, Rosomoff RS, Rosomoff HL. Functional electrical stimulation treatment of postradiculopathy associated muscle weakness. Arch Phys Med Rehabil. 1994;75(6):680\u20136.","journal-title":"Arch Phys Med Rehabil"},{"key":"3300_CR21","doi-asserted-by":"publisher","unstructured":"Tong RKY, Wang X, Leung KWC, Lee GTY, Lau CCY, Wai HW, Pang PMK, Leung HC. How to prepare a person with complete spinal cord injury to use surface electrodes for FES trike cycling. IEEE Int Cof Rehabil Robot. 2017. \n                    https:\/\/doi.org\/10.1109\/ICORR.2017.8009346\n                    \n                  .","DOI":"10.1109\/ICORR.2017.8009346"},{"issue":"1","key":"3300_CR22","first-page":"39","volume":"1","author":"SC Scherr","year":"2014","unstructured":"Scherr SC, Leslie C, Dort LC, Almeida FR, Bennett KM, Blumenstock NT, Demko BG, et al. Definition of an effective oral appliance for the treatment of obstructive sleep apnea and snoring: a report of the American Academy of Dental Sleep Medicine. JDSM. 2014;1(1):39\u201350.","journal-title":"JDSM"},{"key":"3300_CR23","unstructured":"Giannasi LC, de Almeida RC, Oliveira LVF. Use of an oral appliance in a marked retrognathic and severe OSA patient. Three years follow-up: clinical report. Sleep Sci. 2010;3(2):112\u2013115."},{"key":"3300_CR24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/S0022-3913(99)70248-9","volume":"81","author":"K Yoshida","year":"1999","unstructured":"Yoshida K. Elastic retracted oral appliance to treat sleep apnea in mentally impaired patients and patients with neuromuscular disabilities. J Prosthet Dent. 1999;81:196\u2013201.","journal-title":"J Prosthet Dent"},{"key":"3300_CR25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neubiorev.2016.07.004","volume":"74","author":"E Tobaldini","year":"2017","unstructured":"Tobaldini E, Costantino G, Solbiati M, Cogliati C, Kara T, Nobili L, Montano N. Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases. Neurosci Biobehav Rev. 2017;74:321\u20139.","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"3300_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.17796\/jcpd.37.1.n32m21n08417v363","volume":"37","author":"NF Furlan","year":"2012","unstructured":"Furlan NF, Gavi\u00e3o MB, Barbosa TS, Nicolau J, Castelo PM. Salivary cortisol, alpha-amylase and heart rate variation in response to dental treatment in children. J Clin Pediatr Dent. 2012;37(1):83\u20137.","journal-title":"J Clin Pediatr Dent"},{"issue":"6","key":"3300_CR27","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.rbr.2013.03.001","volume":"53","author":"DP Falc\u00e3o","year":"2013","unstructured":"Falc\u00e3o DP, Mota LM, Pires AL, Bezerra ACB. Sialometria: aspectos de interesse cl\u00ednico. Rev Bras Reumatol. 2013;53(6):525\u201331.","journal-title":"Rev Bras Reumatol"},{"issue":"1","key":"3300_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000068225","volume":"37","author":"CY Koga-Ito","year":"2003","unstructured":"Koga-Ito CY, Unterkircher CS, Watanabe H, Martins CA, Vidotto V, Jorge AO. Caries risk tests and salivary levels of immunoglobulins to Streptococcus mutants and Candida albicans in mouth breathing syndrome patients. Caries Res. 2003;37(1):38\u201343.","journal-title":"Caries Res"},{"key":"3300_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/0265407506062479","volume":"23","author":"DA Granger","year":"2006","unstructured":"Granger DA, Kivlighan KT, Blair C, et al. Integrating the measurement of salivary alpha-amylase into studies of child health, development, and social relationships. J Soc Pers Relat. 2006;23:267\u201390.","journal-title":"J Soc Pers Relat"},{"issue":"6","key":"3300_CR30","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1590\/1678-775720130603","volume":"22","author":"Fernanda Louren\u00e7\u00e3o BRIGHENTI","year":"2014","unstructured":"Brighenti FL, Medeiros AC, Matos BM, Ribeiro ZE, Koga-Ito CY. Evaluation of caries-associated virulence of biofilms from Candida albicans isolated from saliva of pediatric patients with sickle-cell anemia.J Appl Oral Sci. 2014;22(6):484\u20139.","journal-title":"Journal of Applied Oral Science"},{"issue":"7","key":"3300_CR31","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1365-2842.2010.02177.x","volume":"38","author":"F Jadid","year":"2011","unstructured":"Jadid F, Wang K, Arendt-Nielsen L, Svensson P. Effects of different stimulus locations on inhibitory responses in human jaw-closing muscles. J Oral Rehabil. 2011;38(7):487\u2013500.","journal-title":"J Oral Rehabil"},{"issue":"1","key":"3300_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1365-2842.2007.01787.x","volume":"35","author":"Y Dong","year":"2008","unstructured":"Dong Y, Wang XM, Wang MQ, Widmalm SE. Asymmetric muscle function in patients with developmental mandibular asymmetry. J Oral Rehabil. 2008;35(1):27\u201336.","journal-title":"J Oral Rehabil"},{"issue":"6","key":"3300_CR33","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.otohns.2005.07.018","volume":"133","author":"TM Weiss","year":"2005","unstructured":"Weiss TM, Atanasov S, Calhoun KH. The association of tongue scalloping with obstructive sleep apnea and related sleep pathology. Otolaryngol Head Neck Surg. 2005;133(6):966\u201371.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"12","key":"3300_CR34","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1097\/00005537-199912000-00002","volume":"109","author":"M Friedman","year":"1999","unstructured":"Friedman M, Tanyeri H, La Rosa M, Landsberg R, Vaidyanathan K, Pieri S, Caldarelli D. Clinical predictors of obstructive sleep apnea. Laryngoscope. 1999;109(12):1901\u20137.","journal-title":"Laryngoscope."},{"key":"3300_CR35","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1016\/S0031-3955(16)36806-7","volume":"36","author":"L Brodsky","year":"1989","unstructured":"Brodsky L. Modern assessment of tonsils and adenoids. Pediatr Clinic N Am. 1989;36:1551\u201369.","journal-title":"Pediatr Clinic N Am"},{"key":"3300_CR36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jelekin.2016.10.006","volume":"31","author":"F Politti","year":"2016","unstructured":"Politti F, Casellato C, Kalytczak MM, Garcia MB, Biasotto-Gonzalez DA. Characteristics of EMG frequency bands in temporomandibular disorders patients. J Electromyogr Kinesiol. 2016;31:119\u201325.","journal-title":"J Electromyogr Kinesiol"},{"key":"3300_CR37","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: rules, terminology and technical specifications. (Version 2.2)","author":"RB Berry","year":"2015","unstructured":"Berry RB, Brooks R, Gamaldo C, Harding SM, Lloyd RM, Quan SF, Troester MT, Vaughn BV. The AASM Manual for the Scoring of Sleep and Associated Events: rules, terminology and technical specifications. (Version 2.2). Darien: American Academy of Sleep Medicine; 2015."},{"key":"3300_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2409212","volume":"2018","author":"M\u00f4nica Fernandes Gomes","year":"2018","unstructured":"Gomes MF, Sichi LGB, Giannasi LC, Amorim JBO, Rocha JC, Koga-Ito CY, Salgado MAC. Phenotypic features and salivary parameters in patients with ectodermal dysplasia: report of three cases. Case Rep Dent. 2018. \n                    https:\/\/doi.org\/10.1155\/2018\/2409212\n                    \n                  .","journal-title":"Case Reports in Dentistry"},{"issue":"4","key":"3300_CR39","first-page":"12","volume":"23","author":"TFG Almeida","year":"2013","unstructured":"Almeida TFG, Falc\u00e3o DF, Amorim RFB, Montenegro G. Analysis of ph and viscosity of saliva and its correlation with periodontal disease\u2014pilot study. Braz J Periodontol. 2013;23(4):12\u20137.","journal-title":"Braz J Periodontol"},{"issue":"8","key":"3300_CR40","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1111\/odi.12867","volume":"24","author":"AML Pedersen","year":"2018","unstructured":"Pedersen AML, S\u00f8rensen CE, Procto GB, Carpenter GH. Salivary functions in mastication, taste and textural perception, swallowing and initial digestion. Oral Dis. 2018:1\u201318. \n                    https:\/\/doi.org\/10.1111\/odi.12867\n                    \n                  .","journal-title":"Oral Diseases"},{"key":"3300_CR41","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.smrv.2013.05.001","volume":"18","author":"GJ Elder","year":"2014","unstructured":"Elder GJ, Wetherell MA, Barclay NL, Ellis JG. The cortisol awakening response\u2014applications and implications for sleep medicine. Sleep Med Rev. 2014;18:215\u201324.","journal-title":"Sleep Med Rev"},{"key":"3300_CR42","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.psyneuen.2018.05.034","volume":"95","author":"Desta Fekedulegn","year":"2018","unstructured":"Fekedulegn D, Innes K, Andrew ME, Zara CT, Charles LE, Allison P, Violanti JM, Knox SS. Sleep quality and the cortisol awakening response (CAR) among law enforcement officers: the moderating role of leisure time physical activity. Psychoneuroendocrinology. 2018;95:158\u20139.","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"3300_CR43","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1590\/S0004-27302003000400008","volume":"47","author":"M Castro","year":"2003","unstructured":"Castro M, Moreira AC. An\u00e1lise cr\u00edtica do cortisol salivar na avalia\u00e7\u00e3o do eixo hipot\u00e1lamo hip\u00f3fise adrenal. Arq Bras Endocrinol Metabol. 2003;47(4):358\u201367.","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"5","key":"3300_CR44","first-page":"679","volume":"30","author":"DF Pereira","year":"2012","unstructured":"Pereira DF, Pinheiro MM, Silva PF, Teodoro GR, Brighenti FL, Koga-Ito CY. Influence of TNF-\u03b1 blockers on the oral prevalence of opportunistic microorganisms in ankylosing spondylitis patients. Clin Exp Rheumatol. 2012;30(5):679\u201385.","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"3300_CR45","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1310\/tsr1505-412","volume":"15","author":"J Chae","year":"2008","unstructured":"Chae J, Sheffler L, Knutson J. Neuromuscular electrical stimulation for motor restoration in hemiplegia. Top Stroke Rehabil. 2008;15(5):412\u201326.","journal-title":"Top Stroke Rehabil"},{"key":"3300_CR46","unstructured":"Baker LL: Electrical stimulation to increase functional activity. In: Clinical.Electrotherapy. 3rd edition. New Jersey: Prentice Hall; 1999:355\u2013410."},{"key":"3300_CR47","first-page":"49","volume":"11","author":"AP Cheida","year":"1997","unstructured":"Cheida AP. Hiperboloide: form and function. J Bras Ortodontia Orto Maxilar. 1997;11:49\u201353.","journal-title":"J Bras Ortodontia Orto Maxilar"},{"key":"3300_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2157974","volume":"2018","author":"Wei Wang","year":"2018","unstructured":"Wang W, Di C, Mona S, Wang L, Hans M. Review Article Tongue function: an underrecognized component in the treatment of obstructive sleep apnea with mandibular repositioning appliance. Can Respir J. 2018. \n                    https:\/\/doi.org\/10.1155\/2018\/2157974\n                    \n                  .","journal-title":"Canadian Respiratory Journal"},{"issue":"4","key":"3300_CR49","doi-asserted-by":"publisher","first-page":"334","DOI":"10.11607\/ijp.3284","volume":"26","author":"LC Giannasi","year":"2013","unstructured":"Giannasi LC, Almeida FR, Nacif SR, de Oliveira LV. Efficacy of an oral appliance for the treatment of obstructive sleep apnea. Int J Prosthodont. 2013;26(4):334\u20139.","journal-title":"Int J Prosthodont"},{"issue":"3","key":"3300_CR50","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/ejo\/cjq079","volume":"33","author":"A Ahrens","year":"2011","unstructured":"Ahrens A, McGrath C, H\u00e4gg U. A systematic review of the efficacy of oral appliance design in the management of obstructive sleep apnoea. Eur J Orthod. 2011;33(3):318\u201324.","journal-title":"Eur J Orthod"},{"issue":"1","key":"3300_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1136\/thoraxjnl-2012-201900","volume":"68","author":"OM Vanderveken","year":"2013","unstructured":"Vanderveken OM, Dieltjens M, Wouters K, De Backer WA, Van de Heyning PH, Braem MJ. Objective measurement of compliance during oral appliance therapy for sleep-disordered breathing. Thorax. 2013;68(1):91\u20136.","journal-title":"Thorax"},{"issue":"5","key":"3300_CR52","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1378\/chest.13-0613","volume":"144","author":"M Dieltjens","year":"2013","unstructured":"Dieltjens M, Braem MJ, Vroegop AVMT, Wouters K, Verbraecken JA, De Backer WA, Van de Heyning PH, Vanderveken OM. Objectively measured vs self-reported compliance during oral appliance therapy for sleep-disordered breathing. Chest. 2013;144(5):1495\u2013502.","journal-title":"Chest"},{"key":"3300_CR53","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1164\/rccm.201212-2223OC","volume":"187","author":"CL Phillips","year":"2013","unstructured":"Phillips CL, Grunstein RR, Darendeliler MA, Mihailidou AS, Srinivasan VK, Yee BJ, Marks GB, Cistulli PA. Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2013;187:879\u201387.","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3300-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-019-3300-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3300-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T23:39:51Z","timestamp":1586475591000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-019-3300-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3300"],"URL":"https:\/\/doi.org\/10.1186\/s13063-019-3300-0","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"1 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Human Research Ethics Committees of the Science and Technology Institute \u2013 UNESP\/SJC, S\u00e3o Jos\u00e9 dos Campos, Brazil, CEPh 2.127.141 (process number CAAE 64173616.4.0000.0077). All patient and \/or caregivers gave written, informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All images and other clinical details of the participants do not compromise their anonymity. However, the legal guardians\u2019 authorization for image and data publication were signed for each individual participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests. The sponsors will not interfere in any of the study outcomes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"215"}}