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Informed consent will be obtained from all the patients enrolled following local regulations.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MP was awarded GATRA Grifols Antithrombin Research Awards in 2016. He received payment and travel support for lectures from Shire\u00ae and Werfen\u00ae Instrumentation Laboratory. GG received payment for lectures from Pfizer, Getinge, Draeger, and Fisher & Paykel and support for travel\/congress activities from Biotest and Getinge (all unrelated to the present manuscript). The other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"349"}}