{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:27:56Z","timestamp":1770326876007,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Science and Technology Planning Project of Guangdong Province","award":["2014B070706010"],"award-info":[{"award-number":["2014B070706010"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670339"],"award-info":[{"award-number":["81670339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Guangdong General Hospital Clinical Research Fund and Guangdong Society of Interventional Cardiology Research Fund","award":["GSIC20140526"],"award-info":[{"award-number":["GSIC20140526"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13063-019-3413-5","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T15:02:22Z","timestamp":1558969342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of post-procedural oral hydration volume on risk of contrast-induced acute kidney injury following primary percutaneous coronary intervention: study protocol for a randomized controlled trial"],"prefix":"10.1186","volume":"20","author":[{"name":"the RESCIND group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feier","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"issue":"22","key":"3413_CR1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1161\/01.CIR.0000103623.63687.21","volume":"108","author":"HM Sadeghi","year":"2003","unstructured":"Sadeghi HM, Stone GW, Grines CL, et al. Impact of renal insufficiency in patients undergoing primary angioplasty for acute myocardial infarction. Circulation. 2003;108(22):2769\u201375.","journal-title":"Circulation"},{"issue":"23","key":"3413_CR2","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1093\/eurheartj\/ehu063","volume":"35","author":"A Narula","year":"2014","unstructured":"Narula A, Mehran R, Weisz G, et al. Contrast-induced acute kidney injury after primary percutaneous coronary intervention: results from the HORIZONS-AMI substudy. Eur Heart J. 2014;35(23):1533\u201340.","journal-title":"Eur Heart J"},{"issue":"6","key":"3413_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jama.289.6.747","volume":"289","author":"N Singri","year":"2003","unstructured":"Singri N, Ahya SN, Levin ML. Acute renal failure. JAMA. 2003;289(6):747\u201351.","journal-title":"JAMA"},{"issue":"5","key":"3413_CR4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/S0002-9343(97)00150-2","volume":"103","author":"PA McCullough","year":"1997","unstructured":"McCullough PA, Wolyn R, Rocher LL, Levin RN, O'Neill WW. Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. Am J Med. 1997;103(5):368\u201375.","journal-title":"Am J Med"},{"issue":"14","key":"3413_CR5","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1161\/CIRCULATIONAHA.105.595090","volume":"113","author":"M Tepel","year":"2006","unstructured":"Tepel M, Aspelin P, Lameire N. Contrast-induced nephropathy: a clinical and evidence-based approach. Circulation. 2006;113(14):1799\u2013806.","journal-title":"Circulation"},{"issue":"4","key":"3413_CR6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1161\/CIRCULATIONAHA.110.970160","volume":"123","author":"MT James","year":"2011","unstructured":"James MT, Ghali WA, Knudtson ML, et al. Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation. 2011;123(4):409\u201316.","journal-title":"Circulation"},{"issue":"7","key":"3413_CR7","first-page":"1343","volume":"44","author":"R Gupta","year":"2004","unstructured":"Gupta R, Birnbaum Y, Uretsky BF. The renal patient with coronary artery disease: current concepts and dilemmas. J Am Coll Cardiol. 2004;44(7):1343\u201353.","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"3413_CR8","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1001\/jama.1996.03530430033035","volume":"275","author":"EM Levy","year":"1996","unstructured":"Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality. A cohort analysis. JAMA. 1996;275(19):1489\u201394.","journal-title":"JAMA"},{"issue":"9","key":"3413_CR9","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/j.jacc.2004.07.043","volume":"44","author":"G Marenzi","year":"2004","unstructured":"Marenzi G, Lauri G, Assanelli E, et al. Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 2004;44(9):1780\u20135.","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"3413_CR10","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.amjcard.2012.11.018","volume":"111","author":"SA Pyxaras","year":"2013","unstructured":"Pyxaras SA, Sinagra G, Mangiacapra F, et al. Contrast-induced nephropathy in patients undergoing primary percutaneous coronary intervention without acute left ventricular ejection fraction impairment. Am J Cardiol. 2013;111(5):684\u20138.","journal-title":"Am J Cardiol"},{"key":"3413_CR11","unstructured":"Neumann Franz-Josef,Sousa-Uva Miguel,Ahlsson Anders et al. 2018 ESC\/EACTS Guidelines on myocardial revascularization. [J] Eur. Heart J. 2019;40:87-165."},{"issue":"1\u20132","key":"3413_CR12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000365090","volume":"128","author":"S Akyuz","year":"2014","unstructured":"Akyuz S, Karaca M, Kemaloglu OT, et al. Efficacy of oral hydration in the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography or intervention. Nephron Clin Pract. 2014;128(1\u20132):95\u2013100.","journal-title":"Nephron Clin Pract"},{"issue":"1","key":"3413_CR13","doi-asserted-by":"publisher","first-page":"e000317","DOI":"10.1136\/openhrt-2015-000317","volume":"2","author":"SK Agarwal","year":"2015","unstructured":"Agarwal SK, Mohareb S, Patel A, et al. Systematic oral hydration with water is similar to parenteral hydration for prevention of contrast-induced nephropathy: an updated meta-analysis of randomised clinical data. Open Heart. 2015;2(1):e000317.","journal-title":"Open Heart"},{"key":"3413_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ahj.2015.10.007","volume":"172","author":"Y Liu","year":"2016","unstructured":"Liu Y, Chen JY, Huo Y, et al. Aggressive hydration in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention to prevent contrast-induced nephropathy (ATTEMPT): study design and protocol for the randomized, controlled trial, the ATTEMPT, RESCIND 1 (first study for reduction of contrast-induced nephropathy following cardiac catheterization) trial. Am Heart J. 2016;172:88\u201395.","journal-title":"Am Heart J"},{"issue":"19","key":"3413_CR15","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1161\/CIRCULATIONAHA.109.919639","volume":"121","author":"C Briguori","year":"2010","unstructured":"Briguori C, Visconti G, Rivera NV, et al. Cystatin C and contrast-induced acute kidney injury. Circulation. 2010;121(19):2117\u201322.","journal-title":"Circulation"},{"issue":"7","key":"3413_CR16","first-page":"1393","volume":"44","author":"R Mehran","year":"2004","unstructured":"Mehran R, Aymong ED, Nikolsky E, et al. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: development and initial validation. J Am Coll Cardiol. 2004;44(7):1393\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"3413_CR17","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.ahj.2012.12.017","volume":"165","author":"N Tan","year":"2013","unstructured":"Tan N, Liu Y, Chen JY, et al. Use of the contrast volume or grams of iodine-to-creatinine clearance ratio to predict mortality after percutaneous coronary intervention. Am Heart J. 2013;165(4):600\u20138.","journal-title":"Am Heart J"},{"issue":"9","key":"3413_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.7326\/0003-4819-151-9-200911030-00008","volume":"151","author":"S Zoungas","year":"2009","unstructured":"Zoungas S, Ninomiya T, Huxley R, et al. Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy. Ann Intern Med. 2009;151(9):631\u20138.","journal-title":"Ann Intern Med"},{"issue":"5","key":"3413_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1161\/CIRCINTERVENTIONS.110.955310","volume":"3","author":"FA Sgura","year":"2010","unstructured":"Sgura FA, Bertelli L, Monopoli D, et al. Mehran contrast-induced nephropathy risk score predicts short- and long-term clinical outcomes in patients with ST-elevation-myocardial infarction. Circ Cardiovasc Interv. 2010;3(5):491\u20138.","journal-title":"Circ Cardiovasc Interv"},{"issue":"4","key":"3413_CR20","doi-asserted-by":"publisher","first-page":"3480","DOI":"10.1016\/j.ijcard.2013.04.166","volume":"168","author":"V Oduncu","year":"2013","unstructured":"Oduncu V, Erkol A, Karabay CY, et al. Relation of the severity of contrast induced nephropathy to SYNTAX score and long-term prognosis in patients treated with primary percutaneous coronary intervention. Int J Cardiol. 2013;168(4):3480\u20135.","journal-title":"Int J Cardiol"},{"issue":"6","key":"3413_CR21","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1378\/chest.114.6.1570","volume":"114","author":"AJ Taylor","year":"1998","unstructured":"Taylor AJ, Hotchkiss D, Morse RW, McCabe J. PREPARED: preparation for angiography in renal dysfunction: a randomized trial of inpatient vs outpatient hydration protocols for cardiac catheterization in mild-to-moderate renal dysfunction. Chest. 1998;114(6):1570\u20134.","journal-title":"Chest"},{"issue":"3","key":"3413_CR22","doi-asserted-by":"publisher","first-page":"170","DOI":"10.5414\/CNP61170","volume":"61","author":"C Garcia-Ruiz","year":"2004","unstructured":"Garcia-Ruiz C, Martinez-Vea A, Sempere T, et al. Low risk of contrast nephropathy in high-risk patients undergoing spiral computed tomography angiography with the contrast medium iopromide and prophylactic oral hydratation. Clin Nephrol. 2004;61(3):170\u20136.","journal-title":"Clin Nephrol"},{"issue":"1","key":"3413_CR23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ejrad.2009.07.011","volume":"77","author":"D Yoshikawa","year":"2011","unstructured":"Yoshikawa D, Isobe S, Sato K, et al. Importance of oral fluid intake after coronary computed tomography angiography: an observational study. Eur J Radiol. 2011;77(1):118\u201322.","journal-title":"Eur J Radiol"},{"issue":"9","key":"3413_CR24","first-page":"1015","volume":"68","author":"W Wrobel","year":"2010","unstructured":"Wrobel W, Sinkiewicz W, Gordon M, Wozniak-Wisniewska A. Oral versus intravenous hydration and renal function in diabetic patients undergoing percutaneous coronary interventions. Kardiol Pol. 2010;68(9):1015\u201320.","journal-title":"Kardiol Pol"},{"issue":"5","key":"3413_CR25","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1540-8183.2010.00585.x","volume":"23","author":"R Cho","year":"2010","unstructured":"Cho R, Javed N, Traub D, et al. Oral hydration and alkalinization is noninferior to intravenous therapy for prevention of contrast-induced nephropathy in patients with chronic kidney disease. J Interv Cardiol. 2010;23(5):460\u20136.","journal-title":"J Interv Cardiol"},{"issue":"5","key":"3413_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1080\/AC.67.5.2174131","volume":"67","author":"DG Kong","year":"2012","unstructured":"Kong DG, Hou YF, Ma LL, Yao DK, Wang LX. Comparison of oral and intravenous hydration strategies for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography or angioplasty: a randomized clinical trial. Acta Cardiol. 2012;67(5):565\u20139.","journal-title":"Acta Cardiol"},{"issue":"12","key":"3413_CR27","doi-asserted-by":"publisher","first-page":"618","DOI":"10.4103\/1947-2714.147977","volume":"6","author":"W Cheungpasitporn","year":"2014","unstructured":"Cheungpasitporn W, Thongprayoon C, Brabec BA, et al. Oral hydration for prevention of contrast-induced acute kidney injury in elective radiological procedures: a systematic review and meta-analysis of randomized controlled trials. N Am J Med Sci. 2014;6(12):618\u201324.","journal-title":"N Am J Med Sci"},{"issue":"3","key":"3413_CR28","doi-asserted-by":"publisher","first-page":"e60009","DOI":"10.1371\/journal.pone.0060009","volume":"8","author":"S Hiremath","year":"2013","unstructured":"Hiremath S, Akbari A, Shabana W, Fergusson DA, Knoll GA. Prevention of contrast-induced acute kidney injury: is simple oral hydration similar to intravenous? A systematic review of the evidence. PLoS One. 2013;8(3):e60009.","journal-title":"PLoS One"},{"key":"3413_CR29","doi-asserted-by":"crossref","unstructured":"Zhang W, Zhang J, Yang B, et al. Effectiveness of oral hydration in preventing contrast-induced acute kidney injury in patients undergoing coronary angiography or intervention: a pairwise and network meta-analysis. Coron Artery Dis. 2018;29(4):286\u201393.","DOI":"10.1097\/MCA.0000000000000607"},{"key":"3413_CR30","doi-asserted-by":"crossref","unstructured":"Angoulvant D, Cucherat M, Rioufol G et al. Preventing acute decrease in renal function induced by coronary angiography (PRECORD): a prospective randomized trial. Arch Cardiovasc Dis. 2009;102(11):761-767.","DOI":"10.1016\/j.acvd.2009.07.001"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3413-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-019-3413-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3413-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T23:11:39Z","timestamp":1590448299000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-019-3413-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3413"],"URL":"https:\/\/doi.org\/10.1186\/s13063-019-3413-5","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,27]]},"assertion":[{"value":"4 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided written informed consent before enrolment. All data in the study will be collected following approval by the corresponding ethics committees of the participating centers. An independent data monitoring committee will be responsible for the review of the ongoing safety of patients enrolled in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"290"}}