{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:41:05Z","timestamp":1778564465244,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["13\/87\/08"],"award-info":[{"award-number":["13\/87\/08"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["13\/87\/08"],"award-info":[{"award-number":["13\/87\/08"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13063-019-3480-7","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T13:02:27Z","timestamp":1564146147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aspirin versus placebo for the treatment of venous leg ulcers\u2014a phase II, pilot, randomised trial (AVURT)"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1312-5780","authenticated-orcid":false,"given":"Tilbrook","family":"Helen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cook","family":"Liz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clark","family":"Laura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sbizzera","family":"Illary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bland","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buckley","family":"Hannah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetter","family":"Ian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dumville","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenner","family":"Chris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forsythe","family":"Rachael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabe","family":"Rhian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harding","family":"Keith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layton","family":"Alison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Ellie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mc Daid","family":"Catriona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moffatt","family":"Christine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolfe","family":"Debbie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stansby","family":"Gerard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torgerson","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vowden","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Williams","family":"Laurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinchliffe","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"issue":"4","key":"3480_CR1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.7326\/0003-4819-138-4-200302180-00012","volume":"138","author":"T De Araujo","year":"2003","unstructured":"De Araujo T, Valencia I, Federman DG, Kirsner RS. Managing the patient with venous ulcers. Ann Intern Med. 2003;138(4):326\u201334.","journal-title":"Ann Intern Med"},{"key":"3480_CR2","first-page":"1","volume":"362","author":"CS Lim","year":"2018","unstructured":"Lim CS, Baruah M, Bahia SS. Diagnosis and management of venous leg ulcers. BMJ. 2018;362:1\u20139.","journal-title":"BMJ"},{"issue":"3","key":"3480_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1067\/mjd.2001.111633","volume":"44","author":"IC Valencia","year":"2001","unstructured":"Valencia IC, Falabella A, Kirsner RS, Eaglstein WH. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol. 2001;44(3):401\u201324.","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"3480_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/00129334-200311000-00013","volume":"16","author":"ID Graham","year":"2003","unstructured":"Graham ID, Harrison MB, Nelson EA, Lorimer K, Fisher A. Prevalence of Lower-Limb Ulceration: A Systematic Review of Prevalence Studies. Adv Skin Wound Care. 2003;16(6):305\u201316.","journal-title":"Adv Skin Wound Care"},{"key":"3480_CR5","doi-asserted-by":"crossref","unstructured":"O\u2019Meara S, Cullum N, Nelson EA, Dumville JC. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2012;11. PMID: 23152202.","DOI":"10.1002\/14651858.CD000265.pub3"},{"key":"3480_CR6","first-page":"6","volume":"7","author":"M Callam","year":"1992","unstructured":"Callam M. Prevalence of chronic leg ulceration and severe chronic venous disease in western countries. Phlebology. 1992;7:6\u201312.","journal-title":"Phlebology"},{"issue":"3","key":"3480_CR7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1177\/1742395314566824","volume":"11","author":"M Madden","year":"2015","unstructured":"Madden M. The ghost of Nora Batty: a qualitative exploration of the impact of footwear, bandaging and hosiery interventions in chronic wound care. Chronic illness. 2015;11(3):218\u201341.","journal-title":"Chronic illness"},{"issue":"8916","key":"3480_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0140-6736(94)92759-6","volume":"344","author":"A Layton","year":"1994","unstructured":"Layton A, Goodfield M, Ibbotson S, Davies J. Randomised trial of oral aspirin for chronic venous leg ulcers. Lancet. 1994;344(8916):164\u20135.","journal-title":"Lancet"},{"issue":"5","key":"3480_CR9","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.avsg.2011.02.051","volume":"26","author":"ML del R\u00edo Sol\u00e1","year":"2012","unstructured":"del R\u00edo Sol\u00e1 ML, Antonio J, Fajardo G, Puerta CV. Influence of aspirin therapy in the ulcer associated with chronic venous insufficiency. Ann Vasc Surg. 2012;26(5):620\u20139.","journal-title":"Ann Vasc Surg"},{"issue":"5","key":"3480_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","volume":"110","author":"J Vane","year":"2003","unstructured":"Vane J, Botting R. The mechanism of action of aspirin. Thromb Res. 2003;110(5):255\u20138.","journal-title":"Thromb Res"},{"issue":"18","key":"3480_CR11","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1001\/jama.297.18.2018","volume":"297","author":"CL Campbell","year":"2007","unstructured":"Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA. 2007;297(18):2018\u201324.","journal-title":"JAMA"},{"key":"3480_CR12","doi-asserted-by":"crossref","unstructured":"de Oliveira Carvalho PE, Magolbo NG, De Aquino RF, Weller CD. Oral aspirin for treating venous leg ulcers. Cochrane Database Syst Rev. 2016;(2):1\u201335. PMID: 26889740","DOI":"10.1002\/14651858.CD009432.pub2"},{"issue":"1","key":"3480_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/wrr.12502","volume":"25","author":"IA Darby","year":"2017","unstructured":"Darby IA, Weller CD. Aspirin treatment for chronic wounds: Potential beneficial and inhibitory effects. Wound Repair Regen. 2017;25(1):7\u201312.","journal-title":"Wound Repair Regen"},{"key":"3480_CR14","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3310\/hta22550","volume":"22","author":"H Tilbrook","year":"2018","unstructured":"Tilbrook H, Clark L, Cook L, Bland M, Buckley H, Chetter I, Dumville J, Fenner C, Forsythe R, Gabe R, et al. AVURT: aspirin versus placebo for the treatment of venous leg ulcers \u2013 a Phase II pilot randomised controlled trial. Health Technol Assess. 2018;22:55.","journal-title":"Health Technol Assess"},{"issue":"1","key":"3480_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13063-015-1039-9","volume":"16","author":"H Tilbrook","year":"2015","unstructured":"Tilbrook H, Forsythe RO, Rolfe D, Clark L, Bland M, Buckley H, Chetter I, Cook L, Dumville J, Gabe R. Aspirin for Venous Ulcers: Randomised Trial (AVURT): study protocol for a randomised controlled trial. Trials. 2015;16(1):1\u20139.","journal-title":"Trials"},{"key":"3480_CR16","first-page":"1","volume-title":"SIGN 120. Management of chronic venous leg ulcers. A national clinical guideline. In","author":"Scottish Intercollegiate Guidelines Network","year":"2010","unstructured":"Scottish Intercollegiate Guidelines Network. SIGN 120. Management of chronic venous leg ulcers. A national clinical guideline. In. Edinburgh: Healthcare Improvement Scotland; 2010. p. 1\u201346."},{"key":"3480_CR17","volume-title":"Guidance for industry chronic cutaneous ulcer and burn wounds \u2013 developing products for treatment","author":"FDA US Department of Health and Human Services Food and Drug Administration","year":"2006","unstructured":"FDA US Department of Health and Human Services Food and Drug Administration. Guidance for industry chronic cutaneous ulcer and burn wounds \u2013 developing products for treatment. 2006. \n                              http:\/\/www.fda.gov\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm064981.htm\n                              \n                           . Accessed 16 July 2015."},{"issue":"9920","key":"3480_CR18","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0140-6736(13)62368-5","volume":"383","author":"RL Ashby","year":"2014","unstructured":"Ashby RL, Gabe R, Ali S, Adderley U, Bland JM, Cullum NA, Dumville JC, Iglesias CP, Kang'ombe AR, Soares MO. Clinical and cost-effectiveness of compression hosiery versus compression bandages in treatment of venous leg ulcers (Venous leg Ulcer Study IV, VenUS IV): a randomised controlled trial. Lancet. 2014;383(9920):871\u20139.","journal-title":"Lancet"},{"issue":"3","key":"3480_CR19","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jan.12864","volume":"72","author":"A Jull","year":"2016","unstructured":"Jull A, Wadham A, Bullen C, Parag V, Kerse N, Waters J. Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU). J Adv Nurs. 2016;72(3):669\u201379.","journal-title":"J Adv Nurs"},{"key":"3480_CR20","doi-asserted-by":"publisher","first-page":"j5157","DOI":"10.1136\/bmj.j5157","volume":"359","author":"A Jull","year":"2017","unstructured":"Jull A, Wadham A, Bullen C, Parag V, Kerse N, Waters J. Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU). BMJ. 2017;359:j5157.","journal-title":"BMJ"},{"issue":"1","key":"3480_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13063-016-1314-4","volume":"17","author":"CD Weller","year":"2016","unstructured":"Weller CD, Barker A, Darby I, Haines T, Underwood M, Ward S, Aldons P, Dapiran E, Madan JJ, Loveland P. Aspirin in venous leg ulcer study (ASPiVLU): study protocol for a randomised controlled trial. Trials. 2016;17(1):1.","journal-title":"Trials"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3480-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13063-019-3480-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-019-3480-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T23:09:20Z","timestamp":1595632160000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-019-3480-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["3480"],"URL":"https:\/\/doi.org\/10.1186\/s13063-019-3480-7","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"19 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients willing to participate in the study gave written informed consent. The study was approved by the National Research Ethics Service (NRES) East Midlands\u2014Nottingham 2 research ethics committee (REC; reference 14\/EM\/1305) and by the Medicines and Healthcare products Regulatory Agency (MHRA).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"C. Moffatt has received grant funding from three health science-based technology companies.All others authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"459"}}