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Prostaglandins, especially intravaginal dinoprostone (Propess\u00ae), are widely used to initiate cervical ripening. If labor does not start within 24\u2009h, there is uncertainty about whether to administer a second dinoprostone pessary or to use oxytocin to induce labor in order to achieve a vaginal delivery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>RE-DINO is a prospective, open-label, multicenter, randomized superiority trial with two parallel arms running in six French hospitals. A total of 360 patients \u2265 18\u2009years of age at &gt;\u200937\u2009weeks of gestation who exhibit unfavorable cervical conditions (Bishop score\u2009&lt;\u20096) 24\u2009h after placement of the first Propess\u00ae, with fetuses in cephalic presentation, will be included. Patients with premature membrane rupture, uterine scars, or multiple pregnancies will be excluded. Our principal objective is to determine whether placement of a second Propess\u00ae (followed by oxytocin [Syntocinon\u00ae], if necessary) in women for whom the first Propess\u00ae failed to induce cervical ripening increases the vaginal delivery rate compared to direct oxytocin injection. The vaginal delivery rate is therefore the primary outcome. The secondary outcomes are the induction failure rates and maternofetal morbidity and mortality.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Discussion<\/jats:title>\n<jats:p>This study may help in determining the optimal way to induce labor after failure of a first Propess\u00ae, an unresolved problem to date. This trial explores the effectiveness and safety of placing a second Propess\u00ae and may contribute to development of an obstetric consensus.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Registered on 2 September 2016 at clinicaltrials.gov (identification number <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/NCT02888041\">NCT02888041<\/jats:ext-link>).<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13063-019-3985-0","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T13:03:04Z","timestamp":1578488584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is there an interest in repeating the vaginal administration of dinoprostone (Propess\u00ae), to promote induction of labor of pregnant women at term? 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