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However, the use of these interventions in routine care is limited. The international ImpleMentAll study is funded by the European Union\u2019s Horizon 2020 programme. It is concerned with studying and improving methods for implementing evidence-based iCBT services for common mental disorders in routine mental health care. A digitally accessible implementation toolkit (<jats:italic>ItFits-toolkit<\/jats:italic>) will be introduced to mental health care organizations with the aim to facilitate the ongoing implementation of iCBT services within local contexts. This study investigates the effectiveness of the <jats:italic>ItFits-toolkit<\/jats:italic> by comparing it to <jats:italic>implementation-as-usual<\/jats:italic> activities.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A stepped wedge cluster randomized controlled trial (SWT) design will be applied. Over a trial period of 30\u2009months, the <jats:italic>ItFits-toolkit<\/jats:italic> will be introduced sequentially in twelve routine mental health care organizations in primary and specialist care across nine countries in Europe and Australia. Repeated measures are applied to assess change over time in the outcome variables. The effectiveness of the <jats:italic>ItFits-toolkit<\/jats:italic> will be assessed in terms of the degree of normalization of the use of the iCBT services. Several exploratory outcomes including uptake of the iCBT services will be measured to feed the interpretation of the primary outcome. Data will be collected via a centralized data collection system and analysed using generalized linear mixed modelling. A qualitative process evaluation of routine implementation activities and the use of the <jats:italic>ItFits-toolkit<\/jats:italic> will be conducted within this study.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The ImpleMentAll study is a large-scale international research project designed to study the effectiveness of tailored implementation. Using a SWT design that allows to examine change over time, this study will investigate the effect of tailored implementation on the normalization of the use of iCBT services and their uptake. It will provide a better understanding of the process and methods of tailoring implementation strategies. If found effective, the <jats:italic>ItFits-toolkit<\/jats:italic> will be made accessible for mental health care service providers, to help them overcome their context-specific implementation challenges.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03652883\">NCT03652883<\/jats:ext-link>. Retrospectively registered on 29 August 2018<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-020-04686-4","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T10:03:07Z","timestamp":1603879387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Tailored implementation of internet-based cognitive behavioural therapy in the multinational context of the ImpleMentAll project: a study protocol for a stepped wedge cluster randomized trial"],"prefix":"10.1186","volume":"21","author":[{"name":"on behalf of the ImpleMentAll 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The committees concluded that this study is to be regarded as implementing evidence-based interventions and no human or animal experiments are involved. Approval letters from the committees are available on request. In Albania, there is no functional national ethical committee yet. As soon as this committee is established, the Albanian partner will submit their protocol for approval. In the meantime, they received approval from their institution to participate in the trial. Ethical approval for the process evaluation was granted by the University of Northumbria, UK (Submission Ref: 11039). Participants are required to provide and sign an informed consent indicating the purpose of the study, the nature, use and management of their data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Professor Bruno Aouizerate has received honoraria or consulting fees from Janssen-Cilag, Lundbeck, and Lilly. Dr. Samalin has received grants, honoraria, or consulting fees from Janssen-Cilag, Lundbeck, and Otsuka. All other authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"893"}}