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Delivering secondary prevention interventions against unhealthy alcohol use is challenging. Information technology has the potential to reach large parts of the general population. The present study is proposed to test a proactive secondary prevention smartphone-based intervention against unhealthy alcohol use.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a parallel-group, randomized controlled trial (1:1 allocation ratio) among 1696 university students with unhealthy alcohol use, identified by screening and followed up at 3, 6, and 12\u2009months. Participants will be randomized to receive access to a smartphone-based intervention or to a no intervention control condition.<\/jats:p>\n                <jats:p>The primary outcome will be self-reported volume of alcohol drunk over the past 30\u2009days, reported as the mean number of standard drinks per week over the past 30\u2009days, measured at 6\u2009months. Secondary outcomes will be number of heavy drinking days over the past 30\u2009days, at 6\u2009months. Additional outcomes will be maximum number of drinks on any day over the past 30\u2009days, alcohol-related consequences (measured using the Short Inventory of Problems (SIP-2R), and academic performance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The aim of this trial is to close the evidence gap on the efficacy of smartphone-based secondary prevention interventions. If proven effective, smartphone-based interventions have the potential to reach a large portion of the population, completing what is available on the Internet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ISRCTN, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1186\/ISRCTN10007691\">10007691<\/jats:ext-link>. Registered on 2 December 2019. Recruitment will start in April 2020.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-020-4145-2","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T15:07:01Z","timestamp":1581952021000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Smartphone-based secondary prevention intervention for university students with unhealthy alcohol use identified by screening: study protocol of a parallel group randomized controlled trial"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-6377","authenticated-orcid":false,"given":"Nicolas","family":"Bertholet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Schmutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique S.","family":"Grazioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Faouzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"McNeely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Gmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Bernard","family":"Daeppen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"issue":"9937","key":"4145_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0140-6736(14)60648-6","volume":"384","author":"UE Bauer","year":"2014","unstructured":"Bauer UE, Briss PA, Goodman RA, Bowman BA. 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