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The principal objective of this study is to assess the efficacy and safety of \u2018hand and foot acupuncture with twelve needles\u2019 for hemiplegia in the convalescent stage of ischaemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is the protocol for a randomised, controlled clinical trial with two groups: a \u2018hand and foot acupuncture with twelve needles\u2019 group and a routine acupuncture group. A total of 208 participants will be randomly assigned to two different groups in a 1:1 ratio and will undergo conventional rehabilitation. Limb function will be evaluated by the simplified Fugl-Meyer assessment scale, Barthel Index, modified Ashworth scale and National Institute of Health stroke scale. The participants will be evaluated at baseline (on the day of enrolment) and followed up at 2\u2009weeks, 1\u2009month, 2\u2009months and 3\u2009months after enrolment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The results of this study will provide evidence on the effectiveness of \u2018hand and foot acupuncture with twelve needles\u2019 in the treatment of limb dysfunction that can be used for future evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/chictr.org.cn\">Chictr.org.cn<\/jats:ext-link><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\">ChiCTR1900021774<\/jats:ext-link>. Registered on 8 March 2019<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13063-021-05128-5","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T22:16:06Z","timestamp":1616105766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of \u2018hand and foot acupuncture with twelve needles\u2019 on hemiplegia patients with \u2018qi deficiency and blood stasis\u2019 syndrome in the convalescent stage of Ischaemic stroke: study protocol for a randomised controlled trial"],"prefix":"10.1186","volume":"22","author":[{"given":"Wei-Hao","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3183-6690","authenticated-orcid":false,"given":"Hu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"issue":"12","key":"5128_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208398","volume":"13","author":"Y Gao","year":"2018","unstructured":"Gao Y, Jiang B, Sun H, Ru X, Sun D, Wang L, et al. 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