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It is associated with negative outcomes such as muscle wasting, decline of functional status, and increased morbidity and mortality. Oral nutritional supplements (ONS) are frequently used in nutritional therapy to increase intake. However, compliance to ONS is often limited and maybe improved by prescribing ONS in small portions timed with the medication (MEDPass). However, it is unknown whether the MEDPass administration enhances patients\u2019 total energy and protein intake.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The MEDPass Trial is a randomized, controlled, open-label superiority trial. Patients in the MEDPass group receive 50\u2009ml of ONS four times per day, distributed with the medication rounds. Patients in the control group receive ONS between meals. The primary outcome is average daily energy intake (% of calculated daily requirement). For our power analysis, we assumed that administration of ONS in the MEDPass administration mode increases energy intake by at least 10% (i.e., by 200\u2009kcal for an average energy requirement of 2200\u2009kcal\/day). Thus, with the inclusion of 200 patients, this trial has 80% power to demonstrate that intervention group patients have an average intake of 2200\u2009kcal\/day (SD 500\u2009kcal) versus 2000\u2009kcal\/day (SD 500\u2009kcal) in control group patients. Energy and protein intakes from ONS and all food consumed are monitored continuously throughout the hospital stay and are statistically compared to the patient\u2019s requirements. Secondary outcomes include average daily protein intake (% of calculated daily requirement), average intake of ONS\/day, the course of body weight, handgrip strength, appetite, and nausea. Furthermore, hospital length of stay and 30-day mortality are assessed. The primary statistical analysis will be performed as an intention-to-treat analysis adjusted for the stratification factors used in randomization.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>To our knowledge, this is the first randomized controlled trial assessing total energy and protein intake for the entire hospitalization period in patients receiving MEDPass versus conventional ONS administration. Thus, the MEDPass Trial will fill a gap and answer this relevant clinical question.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/show\/NCT03761680\">NCT03761680<\/jats:ext-link>. Registered on 3 December 2018. Kofam.ch <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.kofam.ch\/de\/studienportal\/studie\/44754\/\">SNCTP000003191<\/jats:ext-link>. Registered on 15 October 2018<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-021-05145-4","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T10:03:44Z","timestamp":1615889024000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Energy and protein intake in medical and geriatric inpatients with MEDPass versus conventional administration of oral nutritional supplements: study protocol for the randomized controlled MEDPass Trial"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-5423","authenticated-orcid":false,"given":"Silvia","family":"Kurmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Reber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F.","family":"Vasiloglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas W.","family":"Schoenenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Uhlmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Barbara","family":"Sterchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeno","family":"Stanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"issue":"11\u201312","key":"5145_CR1","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.nut.2015.06.007","volume":"31","author":"S Felder","year":"2015","unstructured":"Felder S, Lechtenboehmer C, Bally M, Fehr R, Deiss M, Faessler L, et al. 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The CEC receives annual safety and interim reports. The trial protocol version 1.2. with the request for prolongation of the trial has been accepted on December 9, 2019, by the CEC. Informed consent is obtained at inclusion from all study participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SK: SK has received honorariums from Abbott Nutrition and Fresenius Kabi.MV: MV has not received any honorariums.PS: The institution of PS has received unrestricted grant money unrelated to this project from Nestl\u00e9 Health Science and Abbott Nutrition.KU: KU has not received any honorariums.AWS: AWS has not received any honoraria.ER: ER has no conflict of interest to declare.ABS: ABS has not received honorariums or research support.ZS: The institution of ZS received speaking honorariums and research support from Nestl\u00e9 Health Science, Abbott Nutrition, and Fresenius Kabi.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"210"}}