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So far, most patients experienced improved physical function and less pain. After 2\u2009years, only 1 patient proceeded to trapeziectomy. This study assesses if we can safely lower the distraction duration from 8 to 6\u2009weeks for CMC1 joint distraction, maintaining the improvement in physical function and pain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a monocenter randomized controlled non-inferiority trial that includes patients younger than 65\u2009years of age with ongoing symptoms of CMC1 OA and an established indication for surgery. All patients will be treated with CMC1 joint distraction. The primary outcome is to assess whether 6\u2009weeks of joint distraction is not inferior to 8\u2009weeks in terms of physical function at 1\u2009year after surgery. Secondary outcomes will identify differences between groups at 1\u2009year in pain intensity, patient satisfaction, hand health status, adverse event rates, treatment failure, differences in thumb strength and range of motion, and radiographic changes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>If safe, the duration of basal thumb joint distraction can be reduced to 6\u2009weeks, reducing patient burden. Because this is a relatively new treatment, this trial will provide greater knowledge of potential adverse events. This knowledge allows for more informed decision making for patients considering CMC1 distraction treatment. Future studies can directly compare joint distraction to other treatments of CMC1 joint arthritis like splinting and trapeziectomy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Central Committee on Research Involving Human Subjects (CCMO), NL68225.100.18; registered on 9 August 2019. Medical Research Ethics Committees United (MEC-U), R19.003; registered on 9 August 2019. Netherlands Trial Register, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.trialregister.nl\/trial\/8016\">NL8016<\/jats:ext-link>; registered on 15 September 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-021-05283-9","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T11:43:03Z","timestamp":1620042183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can we decrease the duration of basal thumb joint distraction for early osteoarthritis from 8 to 6 weeks? Study protocol for a non-inferiority randomized controlled trial"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0359-0654","authenticated-orcid":false,"given":"Janna S. 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This study will be performed in accordance with the ethical standards in the 1964 Declaration of Helsinki and in accordance with the Dutch Medical Research Involving Human Subjects Act. Written informed consent to participate will be obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Figure  will be published with permission of the original authors and the Journal of Plastic Surgery and Hand Surgery. Re-used from: Spaans AJ, Minnen LP van, Braakenburg A, Mink van der Molen AB. Joint distraction for thumb carpometacarpal osteoarthritis: a feasibility study with 1-year follow-up. J Plast Surg Hand Surg. 2017;51(4):254\u20138. A. Taylor & Francis Ltd.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"JO, AB, and MvdM declare that they have no competing interests. TT has or may receive payment or benefits from AO Trauma, DePuy Synthes, and PATIENT+, outside the submitted work.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"316"}}