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This study aimed to describe the initial approaches to parent engagement in the design of the PARENT trial as well as understand parent perspectives on the acceptability and relevance of the PARENT trial and potential barriers and facilitators to participation.<\/jats:p><jats:p>Parents participating in the TARGet Kids! cohort were invited to participate in a focus group, called the PARENT panel, to co-design the PARENT trial. This focus group was conducted to capture diverse individual and collective parents\u2019 experiences. Overall methodological approaches for the PARENT panel were informed by the CIHR Strategy for Patient Oriented Research (SPOR) guiding principles (<jats:italic>mutual respect<\/jats:italic>, <jats:italic>co-building<\/jats:italic>, <jats:italic>inclusiveness<\/jats:italic>, and <jats:italic>support<\/jats:italic>) for patient engagement in research, and facilitated through the Knowledge Translation Program in the Li Ka Shing Knowledge Institute at Unity Health Toronto. Using a Nominal Group Technique, the PARENT panel provided feedback on the feasibility, relevance, and acceptability of the proposed intervention. Findings from this work will be used to further refine, adjust, and modify the next iteration of the PARENT trial, which will also serve as an opportunity to discuss the efforts made by researchers to incorporate parent suggestions and what additional steps are required for improved patient engagement.<\/jats:p>","DOI":"10.1186\/s13063-021-05305-6","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T12:03:48Z","timestamp":1621253028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Parent engagement in co-design of clinical trials: the PARENT trial"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-3717","authenticated-orcid":false,"given":"Leigh M.","family":"Vanderloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley M.","family":"Vanderhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Straus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine S.","family":"Birken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"5305_CR1","volume-title":"Strategy for patient oriented research","author":"Canadian Institutes of Health Research","year":"2019","unstructured":"Canadian Institutes of Health Research. 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Informed consent was obtained from the parents of children who participated in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The funding agencies had no role in the design and conduct of the study, the collection\/analysis, interpretation of the data, or the preparation and approval of the manuscript. PCP reports receiving a grant from the Hospital for Sick Children Foundation during the conduct of the study. PCP reports receiving the following grants unrelated to this study: a grant from Canadian Institutes of Health Research (FRN # 115059) for an ongoing investigator-initiated trial of iron deficiency in young children, for which Mead Johnson Nutrition provides non-financial support (Fer-In-Sol\u00ae liquid iron supplement) (2011\u20132017); and peer-reviewed grants for completed investigator-initiated studies from Danone Institute of Canada (2002\u20132004 and 2006\u20132009), Dairy Farmers of Ontario (2008\u20132010). JLM received an unrestricted research grant for a completed investigator-initiated study from the Dairy Farmers of Canada (2011\u20132012) and Ddrops provided non-financial support (vitamin D supplements) for an investigator-initiated study on vitamin D and respiratory tract infections (2011\u20132015). C.B. reports previously receiving a grant for a completed investigator-initiated study from the SickKids Center for Health Active Kids (CHAK) (2015\u20132016) involving the development and validation of a risk stratification tool to identify young asymptomatic children at risk for iron deficiency. These agencies had no role in the design, collection, analyses, or interpretation of the results of this study or in the preparation, review, or approval of the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"347"}}