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Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack of standard protocols. Neurologic music therapy (NMT) techniques, especially rhythmic auditory stimulation which relies on interaction between rhythm and movement, have shown to be effective in PD gait rehabilitation possibly through their reliance on neural pathways that are not affected by PD. Therapeutic instrumental music performance (TIMP) is one other NMT technique that holds promise but which mode of action and efficacy has not been investigated in PD yet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>One hundred PD participants will be randomly assigned to receive 15 sessions of either TIMP with rhythm or TIMP without rhythm, standard of care OT, or to be waitlisted (control) over 5 consecutive weeks. Brain oscillatory responses will be collected using magnetoencephalography during an auditory-motor task to understand the underlying mechanisms. The Grooved Pegboard, the UPDRS III finger tap, and the finger-thumb opposition will be assessed to investigate clinical changes related to fine motor function. This project will also serve to confirm or refute our pilot data findings suggesting NMT relies on compensatory brain networks utilized by the PD brain to bypass the dysfunctional basal ganglia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>This study aims to use standardized TIMP and OT research protocols for investigating the neuronal pathways utilized by each intervention and possibly study their efficacy with respect to fine motor rehabilitation via a randomized control trial in the PD population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03049033\">NCT03049033<\/jats:ext-link>. Registered on September 29, 2020<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-021-05560-7","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T12:02:54Z","timestamp":1630152174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Randomized controlled trial of neurologic music therapy in Parkinson\u2019s disease: research rehabilitation protocols for mechanistic and clinical investigations"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-6365","authenticated-orcid":false,"given":"Isabelle","family":"Buard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Lattanzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Sjoberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hookstadt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sillau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Thaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benzi","family":"Kluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"5560_CR1","volume-title":"Unified Parkinson\u2019s Disease Rating Scale","author":"S Fahn MotUDC","year":"1987","unstructured":"S Fahn MotUDC. 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Ethical approval was approved by the Colorado Multiple Institutional Review Board (COMIRB; #16-2308). All research procedures will be performed in a confidential setting, and all documents generated by this study, including consent, will be stored in a locked filing cabinet in the locked office of the PI. Electronic data will be de-identified with the exception of a correlational spreadsheet including demographic information and study IDs for scheduling and safety contact purposes. This, and all other research data, will be stored on a password protected network drive and backed-up on the hard-drive of the PI. Identifying information will not be shared outside of the research team or regulatory bodies (e.g., IRB). Subjects have the right to request their personal health information as well as the results of the different research measures from the investigator, although they will be notified that these do not have any clinical value.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"{27} Ethics approval and consent to participate"}},{"value":"By providing consent, subjects acknowledge the use of their information and publish study-related documents as outlined in the consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There are no disclosures related to financial or alternative competing interests within this clinical trial.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"{28} Competing interests"}}],"article-number":"577"}}