{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:26:54Z","timestamp":1772166414838,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2018-12368001"],"award-info":[{"award-number":["RF-2018-12368001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients undergoing emergency surgery for peritonitis are at increased risk of abdominal wall-related complications. In patients with peritonitis, the risk of incisional hernia (IH) is extremely elevated. The evaluation of quality of life of patients with incisional hernia showed lower mean scores on physical components of health-related quality of life and body image. Furthermore, the arise of a post-operative abdominal wall complication (i.e., wound dehiscence, evisceration and IH) greatly increases morbidity and mortality rates and prolongs the hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study aims to evaluate the efficacy of the use of a swine dermal collagen prosthesis implanted preperitoneally as a prophylactic procedure in urgency\/emergency setting against abdominal wall complications in patients operated with contaminated\/infected field in peritonitis. The sample size was defined in 90 patients divided in two arms (prosthesis positioning versus normal wall abdominal closure). The follow-up will be performed at 3, 6, and 12\u2009months after surgery. The percentage of incisional hernias, wound infections, and adverse events will be investigated by physical examination and ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The objective is to evaluate the possibility to reduce the incisional hernia rate in patients undergoing urgent\/emergent laparotomy in contaminated\/infected field with peritonitis by using swine dermal collagen prosthesis preperitoneal positioning as a prophylactic procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      NCT04681326. Registered (retrospectively after first patient recruited) on 23 December 2020.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13063-022-06103-4","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T08:41:54Z","timestamp":1646383314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PROPHYlactic Implantation of BIOlogic Mesh in peritonitis (PROPHYBIOM): a prospective multicentric randomized controlled trial"],"prefix":"10.1186","volume":"23","author":[{"given":"F.","family":"Coccolini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tarasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-9464","authenticated-orcid":false,"given":"G. L.","family":"Petracca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Disisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sartelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Carcoforo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ansaloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Catena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"6103_CR1","doi-asserted-by":"publisher","unstructured":"Moussavian MR, et al. Long term follow up for incisional hernia after severe secondary peritonitisincidence and risk factors. Am J Surg. 2010; https:\/\/doi.org\/10.1016\/j.amjsurg.2009.08.043.","DOI":"10.1016\/j.amjsurg.2009.08.043"},{"key":"6103_CR2","doi-asserted-by":"publisher","unstructured":"S\u00f8rensen LT, Hemmingsen UB, Kirkeby LT, Kallehave F, J\u00f8rgensen LN. Smoking is a risk factor for incisional hernia. Arch Surg. 2005; https:\/\/doi.org\/10.1001\/archsurg.140.2.119.","DOI":"10.1001\/archsurg.140.2.119"},{"key":"6103_CR3","doi-asserted-by":"publisher","unstructured":"Kurmann A, Beldi G, Vorburger SA, Seiler CA, Candinas D. Laparoscopic incisional hernia repair is feasible and safe after liver transplantation. Surg Endosc. 2010; https:\/\/doi.org\/10.1007\/s00464-009-0799-2.","DOI":"10.1007\/s00464-009-0799-2"},{"key":"6103_CR4","doi-asserted-by":"publisher","unstructured":"Van Ramshorst GH, et al. Abdominal wound dehiscence in adults: development and validation of a risk model. World J Surg. 2010; https:\/\/doi.org\/10.1007\/s00268-009-0277-y.","DOI":"10.1007\/s00268-009-0277-y"},{"key":"6103_CR5","doi-asserted-by":"publisher","unstructured":"van Ramshorst GH, Eker HH, van der Voet JA, Jeekel J, Lange JF. Long-term outcome study in patients with abdominal wound dehiscence: a comparative study on quality of life, body image, and incisional hernia. J Gastrointest Surg. 2013; https:\/\/doi.org\/10.1007\/s11605-013-2233-2.","DOI":"10.1007\/s11605-013-2233-2"},{"key":"6103_CR6","doi-asserted-by":"publisher","unstructured":"Strzelczyk JM, Szyma\u0144ski D, Nowicki ME, Wilczy\u0144ski W, Gaszynski T, Czupryniak L. Randomized clinical trial of postoperative hernia prophylaxis in open bariatric surgery. Br J Surg. 2006; https:\/\/doi.org\/10.1002\/bjs.5512.","DOI":"10.1002\/bjs.5512"},{"key":"6103_CR7","doi-asserted-by":"publisher","unstructured":"Bevis PM, Windhaber RAJ, Lear PA, Poskitt KR, Earnshaw JJ, Mitchell DC. Randomized clinical trial of mesh versus sutured wound closure after open abdominal aortic aneurysm surgery. Br J Surg. 2010; https:\/\/doi.org\/10.1002\/bjs.7137.","DOI":"10.1002\/bjs.7137"},{"key":"6103_CR8","doi-asserted-by":"publisher","unstructured":"Curro G, Centorrino T, Low V, Sarra G, Navarra G. Long-term outcome with the prophylactic use of polypropylene mesh in morbidly obese patients undergoing biliopancreatic diversion. Obes Surg. 2012; https:\/\/doi.org\/10.1007\/s11695-011-0486-y.","DOI":"10.1007\/s11695-011-0486-y"},{"key":"6103_CR9","doi-asserted-by":"publisher","unstructured":"Campanelli G, Catena F, Ansaloni L. Prosthetic abdominal wall hernia repair in emergency surgery: from polypropylene to biological meshes. World J Emerg Surg. 2008; https:\/\/doi.org\/10.1186\/1749-7922-3-33.","DOI":"10.1186\/1749-7922-3-33"},{"key":"6103_CR10","doi-asserted-by":"publisher","unstructured":"Gray SH, Vick CC, Graham LA, Finan KR, Neumayer LA, Hawn MT. Risk of complications from enterotomy or unplanned bowel resection during elective hernia repair. Arch Surg. 2008; https:\/\/doi.org\/10.1001\/archsurg.143.6.582.","DOI":"10.1001\/archsurg.143.6.582"},{"key":"6103_CR11","doi-asserted-by":"publisher","unstructured":"Hawn MT, Gray SH, Snyder CW, Graham LA, Finan KR, Vick CC. Predictors of mesh explantation after incisional hernia repair. Am J Surg. 2011; https:\/\/doi.org\/10.1016\/j.amjsurg.2010.10.011.","DOI":"10.1016\/j.amjsurg.2010.10.011"},{"key":"6103_CR12","doi-asserted-by":"publisher","unstructured":"Richards PC, Balch CM, Aldrete JS. Abdominal wound closure. A randomized prospective study of 571 patients comparing continuous vs. interrupted suture techniques. Ann Surg. 1983; https:\/\/doi.org\/10.1097\/00000658-198302000-00018.","DOI":"10.1097\/00000658-198302000-00018"},{"key":"6103_CR13","doi-asserted-by":"publisher","unstructured":"Mudge M, Hughes LE. Incisional hernia: a 10\u2009year prospective study of incidence and attitudes. Br J Surg. 1985; https:\/\/doi.org\/10.1002\/bjs.1800720127.","DOI":"10.1002\/bjs.1800720127"},{"issue":"4","key":"6103_CR14","first-page":"675","volume":"73","author":"DG Gallup","year":"1989","unstructured":"Gallup DG, Talledo OE, King LA. Primary mass closure of midline incisions with a continuous running monofilament suture in gynecologic patients. Obstet Gynecol. 1989;73(4):675\u20137.","journal-title":"Obstet Gynecol"},{"key":"6103_CR15","unstructured":"Gislason H, Gronbech JE, Soreide O. Burst abdomen and incisional hernia after major gastrointestinal operations - comparison of three closure techniques. Eur J Surg Acta Chir. 1995;(5):161, 349\u201354."},{"key":"6103_CR16","doi-asserted-by":"publisher","unstructured":"Coccolini F, et al. Italian Biological Prosthesis Work-Group (IBPWG): proposal for a decisional model in using biological prosthesis. World J Emerg Surg. 2012; https:\/\/doi.org\/10.1186\/1749-7922-7-34.","DOI":"10.1186\/1749-7922-7-34"},{"key":"6103_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1131-6","volume-title":"Does prophylactic biologic mesh placement protect against the development of incisional hernia in high-risk patients?","author":"OH Llaguna","year":"2011","unstructured":"Llaguna OH, Avgerinos DV, Nagda P, Elfant D, Leitman IM, Goodman E. Does prophylactic biologic mesh placement protect against the development of incisional hernia in high-risk patients? 2011. https:\/\/doi.org\/10.1007\/s00268-011-1131-6."},{"key":"6103_CR18","doi-asserted-by":"publisher","unstructured":"Darehzereshki A, et al. Biologic versus nonbiologic mesh in ventral hernia repair: a systematic review and meta-analysis. World J Surg. 2014; https:\/\/doi.org\/10.1007\/s00268-013-2232-1.","DOI":"10.1007\/s00268-013-2232-1"},{"key":"6103_CR19","doi-asserted-by":"publisher","unstructured":"Nachiappan S, Markar S, Karthikesaligam A, Ziprin P, Faiz O. Prophylactic mesh placement in high-risk patients undergoing elective laparotomy: a systematic review. World J Surg. 2013; https:\/\/doi.org\/10.1007\/s00268-013-2046-1.","DOI":"10.1007\/s00268-013-2046-1"},{"key":"6103_CR20","doi-asserted-by":"publisher","unstructured":"Kurmann A, Barnetta C, Candinas D, Beldi G. Implantation of prophylactic nonabsorbable intraperitoneal mesh in patients with peritonitis is safe and feasible. World J Surg. 2013; https:\/\/doi.org\/10.1007\/s00268-013-2019-4.","DOI":"10.1007\/s00268-013-2019-4"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-022-06103-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-022-06103-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-022-06103-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T08:48:47Z","timestamp":1646383727000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-022-06103-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6103"],"URL":"https:\/\/doi.org\/10.1186\/s13063-022-06103-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-654241\/v1","asserted-by":"object"}]},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]},"assertion":[{"value":"19 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol of the study is approved by Local Ethical Committee of Area Vasta Emilia Nord (protocol code 506\/2019\/DISP\/AOUPR). All participants will sign the informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"198"}}