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Standard infection control measures are suboptimal in LTC facilities because of residents\u2019 cognitive impairments, care needs, and susceptibility to loneliness and mental illness. Further, LTC residents living with high degrees of frailty who contract RVIs often develop the so-called atypical symptoms (e.g., delirium, worse mobility) instead of typical cough and fever, delaying infection diagnosis and treatment. Although far-UVC (222\u00a0nm) light devices have shown potent antiviral activity in vitro, clinical efficacy remains unproven.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Following a study to assay acceptability at each site, this multicenter, double-blinded, cluster-randomized, placebo-controlled trial aims to assess whether far-UVC light devices impact the incidence of RVIs in LTC facilities. Neighborhoods within LTC facilities are randomized to receive far-UVC light devices (222\u00a0nm) or identical placebo light devices that emit only visible spectrum light (400\u2013700\u00a0nm) in common areas. All residents are monitored for RVIs using both a standard screening protocol and a novel screening protocol that target atypical symptoms. The 3-year incidence of RVIs will be compared using intention-to-treat analysis. A cost-consequence analysis will follow.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>This trial aims to inform decisions about whether to implement far-UVC light in LTC facilities for RVI prevention. The trial design features align with this pragmatic intent. Appropriate additional ethical protections have been implemented to mitigate participant vulnerabilities that arise from conducting this study. Knowledge dissemination will be supported through media engagement, peer-reviewed presentations, and publications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov NCT05084898. October 20, 2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-024-07909-0","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T10:02:24Z","timestamp":1706263344000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Preventing Respiratory Viral Illness Invisibly (PRiVII): protocol for a pragmatic cluster randomized trial evaluating far-UVC light devices in long-term care facilities to reduce infections"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-5857","authenticated-orcid":false,"given":"Hayden P.","family":"Nix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R. 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An alteration of consent for the study intervention was obtained because the intervention is minimal risk, and it is a cluster-level intervention, making it infeasible for individual residents to decline exposure. Consent for data collection is obtained from participating residents if they have documented capacity to make clinical decisions, according to their medical records. If their medical records indicate\u00a0that\u00a0they lack capacity to make clinical decisions, surrogate consent is obtained from the SDM documented in their medical records. The informed consent form can be found in Additional File .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate {24}"}},{"value":"Kenneth Rockwood has asserted copyright of the Clinical Frailty Scale through Dalhousie University\u2019s Industry, Liaison, and Innovation Office, which has been licensed to Enanta Pharmaceuticals, Synairgen Research, Faraday Pharmaceuticals, KCR S. A., Icosavax, BioAge Labs, Biotest AG, AstraZeneca UK Limited, and Qu Biologics. He has also asserted copyright (with Dr. Olga Theou) for the Pictorial Fit-Frail Scale, which has been licensed to Congenica; use of both the Clinical Frailty Scale and Pictorial Fit-Frail Scale\u00a0is free for education, research, and nonprofit health care with completion of a permission agreement stipulating users will not change, charge for, or commercialize the scales. Proceeds from license fees are donated to Dalhousie University. He reports personal fees from the Burnaby Division Family Practice, United Arab Emirates University, Singapore National Research Foundation, McMaster University, Chinese Medical Association, Wake Forest University Medical School, University of Omaha, and Atria Institute. He chaired the data safety monitoring board for the ADMET-II clinical trial. He is co-founder of Ardea Outcomes, which (DGI Clinical until 2021) in the last 3\u00a0years has contracts with pharmaceutical and device manufacturers (Hollister, INmune, Novartis, Takeda) on individualized outcome measurement, but not on frailty. In 2020, on behalf of Ardea Outcomes, he attended an advisory board meeting with Nutricia on dementia. Until December 31, 2023, he was Associate Director of the Canadian Consortium on Neurodegeneration in Aging. Since January 2022, he is Special Advisor to the President of Cape Breton University on frailty and aging (both are unpaid positions.) All other co-authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests {28}"}}],"article-number":"88"}}