{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:44:30Z","timestamp":1778813070935,"version":"3.51.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF22OC0079176"],"award-info":[{"award-number":["NNF22OC0079176"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"Copenhagen University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Current management of mesenteric ischemia is primarily endovascular stent treatment. Typical CMI symptoms are postprandial abdominal pain, food fear, weight loss, and diarrhea. Revascularization is often necessary, as mesenteric ischemia may progress to bowel necrosis and death if left untreated. This study aims to compare the outcome using bare metal stent (BMS) or covered stent (CS) in the endovascular treatment of chronic and acute on chronic mesenteric ischemia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is an investigator-driven, prospective, randomized, single-blinded, and single-center, national cohort study at the Copenhagen University Hospital, Denmark. A total of 98 patients with chronic mesenteric ischemia (CMI) and acute-on-chronic mesenteric ischemia (AoCMI) will be randomized to treatment with either BeSmooth BMS (Bentley Innomed GmbH) or BeGraft CS (Bentley Innomed GmbH). Randomization occurs intraoperatively after lesion crossing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>There is currently no published data from prospective controlled trials regarding the preferred type of stent used for the treatment of chronic and acute-on-chronic mesenteric ischemia. This trial will evaluate the short- and long-term outcome of BMS versus CS when treating CMI and AoCMI, as well as the benefit of a more intense postoperative surveillance program.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov NCT05244629. Registered on February 8, 2022.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-024-08285-5","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T11:06:00Z","timestamp":1719572760000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Copenhagen Mesenteric stent study (COMESS)\u2014a randomized trial of stent versus covered stent treatment for chronic mesenteric ischemia"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8387-042X","authenticated-orcid":false,"given":"Alexandra A.","family":"Brandtz\u00e4g","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas P.","family":"Eiberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"L\u00f6nn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"Taudorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A.","family":"Resch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"issue":"4","key":"8285_CR1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ejvs.2017.01.010","volume":"53","author":"M Bjorck","year":"2017","unstructured":"Bjorck M, Koelemay M, Acosta S, Bastos Goncalves F, Kolbel T, Kolkman JJ, et al. Editor\u2019s choice - management of the diseases of mesenteric arteries and veins: clinical practice guidelines of the European Society of Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2017;53(4):460\u2013510.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"4","key":"8285_CR2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.amjmed.2011.09.013","volume":"125","author":"RP Veenstra","year":"2012","unstructured":"Veenstra RP, ter Steege RW, Geelkerken RH, Huisman AB, Kolkman JJ. The cardiovascular risk profile of atherosclerotic gastrointestinal ischemia is different from other vascular beds. Am J Med. 2012;125(4):394\u20138.","journal-title":"Am J Med"},{"issue":"2","key":"8285_CR3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1531003506291885","volume":"18","author":"EL Mitchell","year":"2006","unstructured":"Mitchell EL, Moneta GL. Mesenteric duplex scanning. Perspect Vasc Surg Endovasc Ther. 2006;18(2):175\u201383.","journal-title":"Perspect Vasc Surg Endovasc Ther"},{"issue":"3","key":"8285_CR4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jvs.2021.02.038","volume":"74","author":"A Girault","year":"2021","unstructured":"Girault A, Pellenc Q, Roussel A, Senemaud J, Cerceau P, Maggiori L, et al. Midterm results after covered stenting of the superior mesenteric artery. J Vasc Surg. 2021;74(3):902-9.e3.","journal-title":"J Vasc Surg"},{"key":"8285_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ejvs.2021.01.003","volume":"61","author":"\u00dc Altintas","year":"2021","unstructured":"Altintas \u00dc, Lawaetz M, de la Motte L, Riazi H, L\u00f6nn L, Lindh M, Sillesen H, Eiberg J. Endovascular treatment of chronic and acute on chronic mesenteric ischaemia: results from a national cohort of 245 cases. Eur J Vasc Endovasc Surg. 2021;61:603\u201311.","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"1","key":"8285_CR6","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1016\/j.jvs.2020.10.029","volume":"73","author":"TS Huber","year":"2021","unstructured":"Huber TS, Bj\u00f6rck M, Chandra A, Clouse WD, Dalsing MC, Oderich GS, et al. Chronic mesenteric ischemia: clinical practice guidelines from the Society for Vascular Surgery. J Vasc Surg. 2021;73(1):87S-115S.","journal-title":"J Vasc Surg"},{"issue":"4","key":"8285_CR7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/2050640620916681","volume":"8","author":"LG Terlouw","year":"2020","unstructured":"Terlouw LG, Moelker A, Abrahamsen J, Acosta S, Bakker OJ, Baumgartner I, et al. European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia. United European Gastroenterol J. 2020;8(4):371\u201395.","journal-title":"United European Gastroenterol J"},{"issue":"2","key":"8285_CR8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jvs.2009.03.004","volume":"50","author":"ML Schermerhorn","year":"2009","unstructured":"Schermerhorn ML, Giles KA, Hamdan AD, Wyers MC, Pomposelli FB. Mesenteric revascularization: management and outcomes in the United States, 1988\u20132006. 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