{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:19:15Z","timestamp":1771474755606,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-024-08458-2","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T10:01:56Z","timestamp":1727690516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A multi-center, randomized, double-blind, sham-stimulation controlled study of transcranial magnetic stimulation with precision navigation for the treatment of multiple system atrophy"],"prefix":"10.1186","volume":"25","author":[{"given":"Jing","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqian","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengli","family":"Di","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuedong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"issue":"6","key":"8458_CR1","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/mds.29005","volume":"37","author":"GK Wenning","year":"2022","unstructured":"Wenning GK, et al. The movement disorder society criteria for the diagnosis of multiple system atrophy. Mov Disord. 2022;37(6):1131\u201348.","journal-title":"Mov Disord"},{"issue":"2","key":"8458_CR2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/WNL.48.2.384","volume":"48","author":"Y Ben-Shlomo","year":"1997","unstructured":"Ben-Shlomo Y, et al. Survival of patients with pathologically proven multiple system atrophy: a meta-analysis. Neurology. 1997;48(2):384\u201393.","journal-title":"Neurology"},{"issue":"3","key":"8458_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/S1474-4422(12)70327-7","volume":"12","author":"GK Wenning","year":"2013","unstructured":"Wenning GK, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol. 2013;12(3):264\u201374.","journal-title":"Lancet Neurol"},{"issue":"Pt 4","key":"8458_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/brain\/121.4.589","volume":"121","author":"T Klockgether","year":"1998","unstructured":"Klockgether T, et al. The natural history of degenerative ataxia: a retrospective study in 466 patients. Brain. 1998;121(Pt 4):589\u2013600.","journal-title":"Brain"},{"issue":"5","key":"8458_CR5","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1212\/WNL.49.5.1284","volume":"49","author":"JH Bower","year":"1997","unstructured":"Bower JH, et al. Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990. Neurology. 1997;49(5):1284\u20138.","journal-title":"Neurology"},{"issue":"9","key":"8458_CR6","doi-asserted-by":"publisher","first-page":"e24369","DOI":"10.1371\/journal.pone.0024369","volume":"6","author":"P McCrone","year":"2011","unstructured":"McCrone P, et al. The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom. PLoS ONE. 2011;6(9):e24369.","journal-title":"PLoS ONE"},{"issue":"4","key":"8458_CR7","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/mds.10123","volume":"17","author":"M Merello","year":"2002","unstructured":"Merello M, et al. Accuracy of acute levodopa challenge for clinical prediction of sustained long-term levodopa response as a major criterion for idiopathic Parkinson\u2019s disease diagnosis. Mov Disord. 2002;17(4):795\u20138.","journal-title":"Mov Disord"},{"issue":"2","key":"8458_CR8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.4103\/0028-3886.314539","volume":"69","author":"M Acharya","year":"2021","unstructured":"Acharya M, et al. Predicting long-term outcome of patients of early parkinsonism with acute levodopa challenge test. Neurol India. 2021;69(2):430\u20134.","journal-title":"Neurol India"},{"issue":"4","key":"8458_CR9","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3171\/jns.2003.98.4.0882","volume":"98","author":"V Visser-Vandewalle","year":"2003","unstructured":"Visser-Vandewalle V, et al. Bilateral high-frequency stimulation of the subthalamic nucleus in patients with multiple system atrophy\u2013parkinsonism. Report of four cases. J Neurosurg. 2003;98(4):882.","journal-title":"J Neurosurg"},{"issue":"1","key":"8458_CR10","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.parkreldis.2011.09.008","volume":"18","author":"M Ullman","year":"2012","unstructured":"Ullman M, et al. Deep brain stimulation response in pathologically confirmed cases of multiple system atrophy. Parkinsonism Relat Disord. 2012;18(1):86\u20138.","journal-title":"Parkinsonism Relat Disord"},{"key":"8458_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nbd.2018.07.016","volume":"118","author":"M Lopez-Cuina","year":"2018","unstructured":"Lopez-Cuina M, et al. Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy. Neurobiol Dis. 2018;118:155\u201360.","journal-title":"Neurobiol Dis"},{"issue":"3","key":"8458_CR12","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/head.13002","volume":"57","author":"AT Barker","year":"2017","unstructured":"Barker AT, Shields K. Transcranial magnetic stimulation: basic principles and clinical applications in migraine. Headache. 2017;57(3):517\u201324.","journal-title":"Headache"},{"issue":"2","key":"8458_CR13","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","volume":"131","author":"J-P Lefaucheur","year":"2020","unstructured":"Lefaucheur J-P, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014\u20132018). Clin Neurophysiol. 2020;131(2):474\u2013528.","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"8458_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brs.2016.11.009","volume":"10","author":"G Cirillo","year":"2017","unstructured":"Cirillo G, et al. Neurobiological after-effects of non-invasive brain stimulation. Brain Stimul. 2017;10(1):1\u201318.","journal-title":"Brain Stimul"},{"issue":"2","key":"8458_CR15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brs.2009.10.005","volume":"3","author":"JM Hoogendam","year":"2010","unstructured":"Hoogendam JM, Ramakers GMJ, Di Lazzaro V. Physiology of repetitive transcranial magnetic stimulation of the human brain. Brain Stimul. 2010;3(2):95\u2013118.","journal-title":"Brain Stimul"},{"issue":"4","key":"8458_CR16","first-page":"783","volume":"38","author":"R Fu","year":"2021","unstructured":"Fu R, et al. Research progress on the effect of transcranial magnetic stimulation on learning, memory and plasticity of brain synaptic. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021;38(4):783\u20139.","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"issue":"6","key":"8458_CR17","doi-asserted-by":"publisher","first-page":"916","DOI":"10.4103\/1673-5374.158356","volume":"10","author":"ZC Zhang","year":"2015","unstructured":"Zhang ZC, et al. Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain. Neural Regen Res. 2015;10(6):916\u201324.","journal-title":"Neural Regen Res"},{"issue":"2","key":"8458_CR18","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4103\/1673-5374.346548","volume":"18","author":"FF Qian","year":"2023","unstructured":"Qian FF, et al. Repetitive transcranial magnetic stimulation promotes neurological functional recovery in rats with traumatic brain injury by upregulating synaptic plasticity-related proteins. Neural Regen Res. 2023;18(2):368\u201374.","journal-title":"Neural Regen Res"},{"issue":"5","key":"8458_CR19","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1212\/WNL.48.5.1398","volume":"48","author":"R Chen","year":"1997","unstructured":"Chen R, et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology. 1997;48(5):1398\u2013403.","journal-title":"Neurology"},{"issue":"8","key":"8458_CR20","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/S1388-2457(02)00109-8","volume":"113","author":"M Gangitano","year":"2002","unstructured":"Gangitano M, et al. Modulation of input-output curves by low and high frequency repetitive transcranial magnetic stimulation of the motor cortex. Clin Neurophysiol. 2002;113(8):1249\u201357.","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"8458_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00221-008-1294-z","volume":"187","author":"E Houdayer","year":"2008","unstructured":"Houdayer E, et al. The effects of low- and high-frequency repetitive TMS on the input\/output properties of the human corticospinal pathway. Exp Brain Res. 2008;187(2):207\u201317.","journal-title":"Exp Brain Res"},{"issue":"6","key":"8458_CR22","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.3390\/ijms21061948","volume":"21","author":"A Benussi","year":"2020","unstructured":"Benussi A, Pascual-Leone A, Borroni B. Non-invasive cerebellar stimulation in neurodegenerative ataxia: a literature review. Int J Mol Sci. 2020;21(6):1948.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"8458_CR23","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1523\/JNEUROSCI.4064-13.2014","volume":"34","author":"DJ Wang","year":"2014","unstructured":"Wang DJ, et al. Long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses requires presynaptic and postsynaptic signaling cascades. J Neurosci. 2014;34(6):2355\u201364.","journal-title":"J Neurosci"},{"issue":"6","key":"8458_CR24","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1152\/jn.00507.2021","volume":"127","author":"JH Park","year":"2022","unstructured":"Park JH. Reliability of theta burst stimulation as a neuromodulation tool. J Neurophysiol. 2022;127(6):1532\u20134.","journal-title":"J Neurophysiol"},{"issue":"7","key":"8458_CR25","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1093\/brain\/awu109","volume":"137","author":"C-T Li","year":"2014","unstructured":"Li C-T, et al. Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study. Brain. 2014;137(7):2088\u201398.","journal-title":"Brain"},{"key":"8458_CR26","doi-asserted-by":"publisher","first-page":"944437","DOI":"10.3389\/fphar.2022.944437","volume":"13","author":"KK Goh","year":"2022","unstructured":"Goh KK, et al. Efficacy and safety of intermittent theta-burst stimulation in patients with schizophrenia: a meta-analysis of randomized sham-controlled trials. Front Pharmacol. 2022;13:944437.","journal-title":"Front Pharmacol"},{"issue":"7","key":"8458_CR27","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.clinthera.2020.06.001","volume":"42","author":"AM Hurtado-Puerto","year":"2020","unstructured":"Hurtado-Puerto AM, et al. Safety considerations for cerebellar theta burst stimulation. Clin Ther. 2020;42(7):1169-1190.e1.","journal-title":"Clin Ther"},{"issue":"6","key":"8458_CR28","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/hbm.24485","volume":"40","author":"CT Li","year":"2018","unstructured":"Li CT, et al. Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta-burst stimulation. Hum Brain Mapp. 2018;40(6):2001\u20139.","journal-title":"Hum Brain Mapp"},{"issue":"6","key":"8458_CR29","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/mds.27705","volume":"34","author":"A Latorre","year":"2019","unstructured":"Latorre A, et al. The use of transcranial magnetic stimulation as a treatment for movement disorders: a critical review. Mov Disord. 2019;34(6):769\u201382.","journal-title":"Mov Disord"},{"issue":"2","key":"8458_CR30","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/mds.21242","volume":"22","author":"WN L\u00f6scher","year":"2007","unstructured":"L\u00f6scher WN, et al. Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy. Mov Disord. 2007;22(2):174\u20138.","journal-title":"Mov Disord"},{"issue":"5","key":"8458_CR31","doi-asserted-by":"publisher","first-page":"e62515","DOI":"10.1371\/journal.pone.0062515","volume":"8","author":"S Kawashima","year":"2013","unstructured":"Kawashima S, et al. Differences in dopaminergic modulation to motor cortical plasticity between Parkinson\u2019s disease and multiple system atrophy. PLoS ONE. 2013;8(5):e62515.","journal-title":"PLoS ONE"},{"key":"8458_CR32","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fnbeh.2018.00090","volume":"12","author":"Z Liu","year":"2018","unstructured":"Liu Z, et al. Effects of multi-session repetitive transcranial magnetic stimulation on motor control and spontaneous brain activity in multiple system atrophy: a pilot study. Front Behav Neurosci. 2018;12:90.","journal-title":"Front Behav Neurosci"},{"issue":"6","key":"8458_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.21037\/atm.2016.03.24","volume":"4","author":"H Wang","year":"2016","unstructured":"Wang H, et al. Increased cerebellar activation after repetitive transcranial magnetic stimulation over the primary motor cortex in patients with multiple system atrophy. Ann Transl Med. 2016;4(6):103\u2013103.","journal-title":"Ann Transl Med"},{"issue":"7","key":"8458_CR34","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1089\/brain.2014.0325","volume":"5","author":"YH Chou","year":"2015","unstructured":"Chou YH, et al. Effect of repetitive transcranial magnetic stimulation on fmri resting-state connectivity in multiple system atrophy. Brain Connect. 2015;5(7):451\u20139.","journal-title":"Brain Connect"},{"issue":"1","key":"8458_CR35","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s12311-013-0514-7","volume":"13","author":"G Grimaldi","year":"2014","unstructured":"Grimaldi G, et al. Non-invasive cerebellar stimulation\u2014a consensus paper. Cerebellum. 2014;13(1):121\u201338.","journal-title":"Cerebellum"},{"issue":"4","key":"8458_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/ner.12589","volume":"21","author":"FG Yildiz","year":"2018","unstructured":"Yildiz FG, et al. Modulation of cerebellar-cortical connections in multiple system atrophy type C by cerebellar repetitive transcranial magnetic stimulation. Neuromodulation. 2018;21(4):402\u20138.","journal-title":"Neuromodulation"},{"key":"8458_CR37","doi-asserted-by":"publisher","first-page":"827993","DOI":"10.3389\/fnagi.2022.827993","volume":"14","author":"XY Chen","year":"2022","unstructured":"Chen XY, et al. Effects of repetitive transcranial magnetic stimulation on cerebellar metabolism in patients with spinocerebellar ataxia type 3. Front Aging Neurosci. 2022;14:827993.","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"8458_CR38","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/0269215510382495","volume":"25","author":"J Marsden","year":"2011","unstructured":"Marsden J, Harris C. Cerebellar ataxia: pathophysiology and rehabilitation. Clin Rehabil. 2011;25(3):195\u2013216.","journal-title":"Clin Rehabil"},{"issue":"20","key":"8458_CR39","doi-asserted-by":"publisher","first-page":"20611","DOI":"10.18632\/aging.103946","volume":"12","author":"P Song","year":"2020","unstructured":"Song P, et al. Repetitive transcranial magnetic stimulation of the cerebellum improves ataxia and cerebello-fronto plasticity in multiple system atrophy: a randomized, double-blind, sham-controlled and TMS-EEG study. Aging (Albany NY). 2020;12(20):20611\u201322.","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"8458_CR40","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1001\/jamaneurol.2014.4380","volume":"72","author":"Y-H Chou","year":"2015","unstructured":"Chou Y-H, et al. Effects of repetitive transcranial magnetic stimulation on motor symptoms in Parkinson disease. JAMA Neurol. 2015;72(4):432.","journal-title":"JAMA Neurol"},{"key":"8458_CR41","doi-asserted-by":"publisher","first-page":"755352","DOI":"10.3389\/fneur.2021.755352","volume":"12","author":"J Pan","year":"2022","unstructured":"Pan J, et al. High-frequency repetitive transcranial magnetic stimulation over the left dorsolateral prefrontal cortex shortly alleviates fatigue in patients with multiple system atrophy: a randomized controlled trial. Front Neurol. 2022;12:755352.","journal-title":"Front Neurol"},{"issue":"1","key":"8458_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","volume":"134","author":"A Delorme","year":"2004","unstructured":"Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods. 2004;134(1):9\u201321.","journal-title":"J Neurosci Methods"},{"issue":"3","key":"8458_CR43","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.neuroimage.2005.06.067","volume":"28","author":"RK Niazy","year":"2005","unstructured":"Niazy RK, et al. Removal of FMRI environment artifacts from EEG data using optimal basis sets. Neuroimage. 2005;28(3):720\u201337.","journal-title":"Neuroimage"},{"issue":"1","key":"8458_CR44","doi-asserted-by":"publisher","first-page":"8902","DOI":"10.1038\/s41598-018-27187-6","volume":"8","author":"M Marino","year":"2018","unstructured":"Marino M, et al. Adaptive optimal basis set for BCG artifact removal in simultaneous EEG-fMRI. Sci Rep. 2018;8(1):8902.","journal-title":"Sci Rep"},{"issue":"3","key":"8458_CR45","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.mayocp.2020.10.005","volume":"96","author":"EA Coon","year":"2021","unstructured":"Coon EA, Ahlskog JE. My treatment approach to multiple system atrophy. Mayo Clin Proc. 2021;96(3):708\u201319.","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"8458_CR46","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jnnp.72.1.124","volume":"72","author":"Y Shiga","year":"2002","unstructured":"Shiga Y, et al. Transcranial magnetic stimulation alleviates truncal ataxia in spinocerebellar degeneration. J Neurol Neurosurg Psychiatry. 2002;72(1):124\u20136.","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08458-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-024-08458-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08458-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T22:55:33Z","timestamp":1727736933000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-024-08458-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8458"],"URL":"https:\/\/doi.org\/10.1186\/s13063-024-08458-2","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"22 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocols were reviewed and approved by the Ethics Committee of the First Affiliated Hospital of the Air Force Military Medical University, with the reference number KY20232118-F-1. All participants provided written informed consent prior to their involvement in the trial.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate {24}"}},{"value":"The informed consent form will be provided as Appendix 1.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication {32}"}},{"value":"The authors affirm that neither the principal investigators nor any study site has financial or competing interests related to the trial.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests {28}"}}],"article-number":"640"}}