{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:31:28Z","timestamp":1781584288124,"version":"3.54.5"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-024-08461-7","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:51:53Z","timestamp":1726761113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial"],"prefix":"10.1186","volume":"25","author":[{"given":"Katie","family":"O\u2019Hearn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kusum","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Amrein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Britz-McKibbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Cayouette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Choong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Ruth","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Fergusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Floh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fontela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Geier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Gilfoyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo Garcia","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Helmeczi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khamessan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari R.","family":"Joffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauralyn","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Ryerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Tucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayre","family":"McNally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Canadian Critical Care Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"8","key":"8461_CR1","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1097\/CCM.0000000000001081","volume":"43","author":"MM Pollack","year":"2015","unstructured":"Pollack MM, Holubkov R, Funai T, et al. Simultaneous prediction of new morbidity, mortality, and survival without new morbidity from pediatric intensive care: a new paradigm for outcomes assessment. Crit Care Med. 2015;43(8):1699.","journal-title":"Crit Care Med"},{"issue":"7","key":"8461_CR2","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00134-015-3780-7","volume":"41","author":"F Aspesberro","year":"2015","unstructured":"Aspesberro F, Mangione-Smith R, Zimmerman JJ. Health-related quality of life following pediatric critical illness. Intensive Care Med. 2015;41(7):1235\u201346.","journal-title":"Intensive Care Med"},{"issue":"1","key":"8461_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/PCC.0b013e31819371f6","volume":"10","author":"NP Conlon","year":"2009","unstructured":"Conlon NP, Breatnach C, O\u2019Hare BP, et al. Health-related quality of life after prolonged pediatric intensive care unit stay. Pediatr Crit Care Med. 2009;10(1):41\u20134.","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"8461_CR4","doi-asserted-by":"publisher","first-page":"e122","DOI":"10.1097\/PCC.0000000000001070","volume":"18","author":"NP Pinto","year":"2017","unstructured":"Pinto NP, Rhinesmith EW, Kim TY, et al. Long-term function after pediatric critical illness: results from the survivor outcomes study. Pediatr Crit Care Med. 2017;18(3):e122\u201330.","journal-title":"Pediatr Crit Care Med"},{"issue":"12","key":"8461_CR5","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1007\/s00134-009-1642-x","volume":"35","author":"P Lee","year":"2009","unstructured":"Lee P, Nair P, Eisman JA, et al. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality? Intensive Care Med. 2009;35(12):2028\u201332.","journal-title":"Intensive Care Med"},{"issue":"2","key":"8461_CR6","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/MCO.0b013e32834f0027","volume":"15","author":"K Amrein","year":"2012","unstructured":"Amrein K, Venkatesh B. Vitamin D and the critically ill patient. Curr Opin Clin Nutr Metab Care. 2012;15(2):188\u201393.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"11","key":"8461_CR7","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1097\/00003246-199011000-00005","volume":"18","author":"B Gauthier","year":"1990","unstructured":"Gauthier B, Trachtman H, Di Carmine F, et al. Hypocalcemia and hypercalcitoninemia in critically ill children. Crit Care Med. 1990;18(11):1215\u20139.","journal-title":"Crit Care Med"},{"key":"8461_CR8","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s00467-010-1452-y","volume":"25","author":"F Baeke","year":"2010","unstructured":"Baeke F, Gysemans C, Korf H, et al. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol. 2010;25:1597\u2013606.","journal-title":"Pediatr Nephrol"},{"key":"8461_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-7-28","volume":"7","author":"L Jeng","year":"2009","unstructured":"Jeng L, Yamshchikov AV, Judd SE, et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med. 2009;7:1\u20139.","journal-title":"J Transl Med"},{"issue":"12","key":"8461_CR10","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1212\/01.WNL.0000098886.90030.67","volume":"61","author":"B Banwell","year":"2003","unstructured":"Banwell B, Mildner R, Hassall A, et al. Muscle weakness in critically ill children. Neurology. 2003;61(12):1779\u201382.","journal-title":"Neurology"},{"issue":"3","key":"8461_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1017\/S0317167100007083","volume":"36","author":"YA Al-Said","year":"2009","unstructured":"Al-Said YA, Al-Rached HS, Al-Qahtani HA, et al. Severe proximal myopathy with remarkable recovery after vitamin D treatment. Can J Neurol Sci. 2009;36(3):336\u20139.","journal-title":"Can J Neurol Sci"},{"issue":"3","key":"8461_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1542\/peds.2011-3059","volume":"130","author":"JD McNally","year":"2012","unstructured":"McNally JD, Menon K, Chakraborty P, et al. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012;130(3):429\u201336.","journal-title":"Pediatrics"},{"issue":"12","key":"8461_CR13","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s00134-012-2718-6","volume":"38","author":"C Rippel","year":"2012","unstructured":"Rippel C, South M, Butt WW, et al. Vitamin D status in critically ill children. Intensive Care Med. 2012;38(12):2055\u201362.","journal-title":"Intensive Care Med"},{"issue":"5","key":"8461_CR14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027666","volume":"9","author":"M Cariolou","year":"2019","unstructured":"Cariolou M, Cupp MA, Evangelou E, et al. Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis. BMJ Open. 2019;9(5): e027666.","journal-title":"BMJ Open"},{"issue":"4","key":"8461_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13908","volume":"75","author":"M He","year":"2021","unstructured":"He M, Cao T, Wang J, et al. Vitamin D deficiency relation to sepsis, paediatric risk of mortality III score, need for ventilation support, length of hospital stay, and duration of mechanical ventilation in critically ill children: a meta-analysis. Int J Clin Pract. 2021;75(4): e13908.","journal-title":"Int J Clin Pract"},{"issue":"1","key":"8461_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-017-1875-y","volume":"21","author":"JD McNally","year":"2017","unstructured":"McNally JD, Nama N, O\u2019Hearn K, et al. Vitamin D deficiency in critically ill children: a systematic review and meta-analysis. Crit Care. 2017;21(1):1\u201313.","journal-title":"Crit Care"},{"issue":"5","key":"8461_CR17","doi-asserted-by":"publisher","first-page":"E877","DOI":"10.1210\/jc.2013-1126","volume":"98","author":"JD McNally","year":"2013","unstructured":"McNally JD, Doherty DR, Lawson ML, et al. The relationship between vitamin D status and adrenal insufficiency in critically ill children. J Clin Endocrinol Metab. 2013;98(5):E877\u201381.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"8461_CR18","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/pr.2014.167","volume":"77","author":"R Abou-Zahr","year":"2015","unstructured":"Abou-Zahr R, Kandil SB. A pediatric critical care perspective on vitamin D. Pediatr Res. 2015;77(1):164\u20137.","journal-title":"Pediatr Res"},{"issue":"7","key":"8461_CR19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/PCC.0000000000001202","volume":"18","author":"AS Suzuki","year":"2017","unstructured":"Suzuki AS, Berbel BT. Pediatric multiple organ dysfunction syndrome promising therapies: what about vitamin D supplementation? Pediatr Crit Care Med. 2017;18(7):731.","journal-title":"Pediatr Crit Care Med"},{"issue":"2","key":"8461_CR20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jped.2013.12.002","volume":"90","author":"JD McNally","year":"2014","unstructured":"McNally JD. Vitamin D as a modifiable risk factor in critical illness: questions and answers provided by observational studies. Journal de Pediatria (Rio J). 2014;90(2):99\u2013101.","journal-title":"Journal de Pediatria (Rio J)"},{"issue":"5","key":"8461_CR21","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.beem.2011.03.001","volume":"25","author":"P Lee","year":"2011","unstructured":"Lee P. Vitamin D metabolism and deficiency in critical illness. Best Pract Res Clin Endocrinol Metab. 2011;25(5):769\u201381.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"8461_CR22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1177\/0148607112444449","volume":"36","author":"DM Higgins","year":"2012","unstructured":"Higgins DM, Wischmeyer PE, Queensland KM, et al. Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. J Parenter Enter Nutr. 2012;36(6):713\u201320.","journal-title":"J Parenter Enter Nutr"},{"issue":"1","key":"8461_CR23","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13054-022-04139-1","volume":"26","author":"J Menger","year":"2022","unstructured":"Menger J, Lee Z-Y, Notz Q, et al. Administration of vitamin D and its metabolites in critically ill adult patients: an updated systematic review with meta-analysis of randomized controlled trials. Crit Care. 2022;26(1):268.","journal-title":"Crit Care"},{"key":"8461_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1083760","volume":"9","author":"A Hill","year":"2023","unstructured":"Hill A, Starchl C, Dresen E, et al. An update of the effects of vitamins D and C in critical illness. Front Med. 2023;9: 1083760.","journal-title":"Front Med"},{"issue":"4","key":"8461_CR25","first-page":"275","volume":"39","author":"P Zajic","year":"2014","unstructured":"Zajic P, Amrein K. Vitamin D deficiency in the ICU: a systematic review. Minerva Endocrinology. 2014;39(4):275\u201387.","journal-title":"Minerva Endocrinology"},{"issue":"7","key":"8461_CR26","doi-asserted-by":"publisher","first-page":"853","DOI":"10.5005\/jp-journals-10071-24260","volume":"26","author":"M Kaur","year":"2022","unstructured":"Kaur M, Soni KD, Trikha A. Does vitamin D improve all-cause mortality in critically ill adults? An updated systematic review and meta-analysis of randomized controlled trials. Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine. 2022;26(7):853.","journal-title":"Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine"},{"issue":"4","key":"8461_CR27","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.clnu.2017.05.006","volume":"37","author":"PL Langlois","year":"2018","unstructured":"Langlois PL, Szwec C, D\u2019Aragon F, et al. Vitamin D supplementation in the critically ill: a systematic review and meta-analysis. Clin Nutr. 2018;37(4):1238\u201346.","journal-title":"Clin Nutr"},{"issue":"11","key":"8461_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031083","volume":"9","author":"K Amrein","year":"2019","unstructured":"Amrein K, Parekh D, Westphal S, et al. Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study). BMJ Open. 2019;9(11): e031083.","journal-title":"BMJ Open"},{"issue":"1","key":"8461_CR29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1210\/jc.2010-2704","volume":"96","author":"AC Ross","year":"2011","unstructured":"Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96(1):53\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"8461_CR30","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1210\/jc.2013-2728","volume":"98","author":"RD Lewis","year":"2013","unstructured":"Lewis RD, Laing E, Hill Gallant K, et al. A randomized trial of vitamin D3 supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption. J Clin Endocrinol Metab. 2013;98(12):4816\u201325.","journal-title":"J Clin Endocrinol Metab"},{"issue":"15","key":"8461_CR31","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1001\/jama.2014.13204","volume":"312","author":"K Amrein","year":"2014","unstructured":"Amrein K, Schnedl C, Holl A, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA. 2014;312(15):1520\u201330.","journal-title":"JAMA"},{"issue":"1","key":"8461_CR32","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1542\/peds.2014-1703","volume":"135","author":"JD McNally","year":"2015","unstructured":"McNally JD, Iliriani K, Pojsupap S, et al. Rapid normalization of vitamin D levels: a meta-analysis. Pediatrics. 2015;135(1):e152\u201366.","journal-title":"Pediatrics"},{"issue":"3","key":"8461_CR33","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1177\/0148607115587948","volume":"41","author":"MM Gottschlich","year":"2017","unstructured":"Gottschlich MM, Mayes T, Khoury J, et al. Clinical trial of vitamin D2 vs D3 supplementation in critically ill pediatric burn patients. J Parenter Enter Nutr. 2017;41(3):412\u201321.","journal-title":"J Parenter Enter Nutr"},{"issue":"1","key":"8461_CR34","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1186\/s12887-023-04205-9","volume":"23","author":"K O\u2019Hearn","year":"2023","unstructured":"O\u2019Hearn K, Menon K, Weiler HA, et al. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). BMC Pediatr. 2023;23(1):397.","journal-title":"BMC Pediatr"},{"issue":"01","key":"8461_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0039-1696910","volume":"3","author":"MK Sahu","year":"2019","unstructured":"Sahu MK, Bipin C, Niraghatam HV, et al. Vitamin D deficiency and its response to supplementation as \u201cstoss therapy\u201d in children with cyanotic congenital heart disease undergoing open heart surgery. Journal of Cardiac Critical Care TSS. 2019;3(01):17\u201323.","journal-title":"Journal of Cardiac Critical Care TSS"},{"key":"8461_CR36","doi-asserted-by":"crossref","unstructured":"Labib JR, Ibrahem SK, Ismail MM, et al. Vitamin D supplementation and improvement of pneumonic children at a tertiary pediatric hospital in Egypt: a randomized controlled trial. Medicine. 2021;100(13):e25011.","DOI":"10.1097\/MD.0000000000025011"},{"issue":"6","key":"8461_CR37","doi-asserted-by":"publisher","first-page":"030006052092689","DOI":"10.1177\/0300060520926890","volume":"48","author":"Y Wang","year":"2020","unstructured":"Wang Y, Yang Z, Gao L, et al. Effects of a single dose of vitamin D in septic children: a randomized, double-blinded, controlled trial. J Int Med Res. 2020;48(6):0300060520926890.","journal-title":"J Int Med Res"},{"issue":"1","key":"8461_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4103\/mmj.mmj_210_19","volume":"34","author":"FM El-Gendy","year":"2021","unstructured":"El-Gendy FM, Khattab AA, Naser RG, et al. Association between vitamin D deficiency and sepsis in pediatric ICU. Menoufia Medical Journal. 2021;34(1):210.","journal-title":"Menoufia Medical Journal"},{"issue":"2","key":"8461_CR39","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1097\/PCC.0000000000001409","volume":"19","author":"C Merritt","year":"2018","unstructured":"Merritt C, Menon K, Agus MS, et al. Beyond survival: pediatric critical care interventional trial outcome measure preferences of families and healthcare professionals. Pediatr Crit Care Med. 2018;19(2):e105\u201311.","journal-title":"Pediatr Crit Care Med"},{"issue":"1","key":"8461_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13613-017-0243-z","volume":"7","author":"S Gaudry","year":"2017","unstructured":"Gaudry S, Messika J, Ricard J-D, et al. Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review. Ann Intensive Care. 2017;7(1):1\u201311.","journal-title":"Ann Intensive Care"},{"issue":"6","key":"8461_CR41","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","volume":"3","author":"JW Varni","year":"2003","unstructured":"Varni JW, Burwinkle TM, Seid M, et al. The PedsQL\u2122* 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambulatory Pediatrics. 2003;3(6):329\u201341.","journal-title":"Ambulatory Pediatrics."},{"issue":"6","key":"8461_CR42","doi-asserted-by":"publisher","first-page":"e272","DOI":"10.1097\/PCC.0000000000000727","volume":"17","author":"F Aspesberro","year":"2016","unstructured":"Aspesberro F, Fesinmeyer MD, Zhou C, et al. Construct validity and responsiveness of the pediatric quality of life inventory 4.0 generic core scales and infant scales in the PICU. Pediatr Crit Care Med. 2016;17(6):e272\u20139.","journal-title":"Pediatr Crit Care Med"},{"issue":"2","key":"8461_CR43","doi-asserted-by":"publisher","first-page":"e85","DOI":"10.1097\/PCC.0b013e3182712997","volume":"14","author":"GA Colville","year":"2013","unstructured":"Colville GA, Pierce CM. Children\u2019s self-reported quality of life after intensive care treatment. Pediatr Crit Care Med. 2013;14(2):e85\u201392.","journal-title":"Pediatr Crit Care Med"},{"issue":"1","key":"8461_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/PCC.0b013e31825b64b3","volume":"14","author":"S Ebrahim","year":"2013","unstructured":"Ebrahim S, Singh S, Hutchison JS, et al. Adaptive behavior, functional outcomes, and quality of life outcomes of children requiring urgent ICU admission. Pediatr Crit Care Med. 2013;14(1):10\u20138.","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"8461_CR45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s40273-016-0485-x","volume":"35","author":"M Dritsaki","year":"2017","unstructured":"Dritsaki M, Achana F, Mason J, et al. Methodological issues surrounding the use of baseline health-related quality of life data to inform trial-based economic evaluations of interventions within emergency and critical care settings: a systematic literature review. Pharmacoeconomics. 2017;35(5):501\u201315.","journal-title":"Pharmacoeconomics"},{"issue":"2","key":"8461_CR46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/MCO.0000000000000451","volume":"21","author":"KB Christopher","year":"2018","unstructured":"Christopher KB. Nutritional metabolomics in critical illness. Curr Opin Clin Nutr Metab Care. 2018;21(2):121.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"6","key":"8461_CR47","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/cbf.3421","volume":"37","author":"C Jenkinson","year":"2019","unstructured":"Jenkinson C. The vitamin D metabolome: an update on analysis and function. Cell Biochem Funct. 2019;37(6):408\u201323.","journal-title":"Cell Biochem Funct"},{"key":"8461_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-017-1794-y","volume":"21","author":"J Lasky-Su","year":"2017","unstructured":"Lasky-Su J, Dahlin A, Litonjua AA, et al. Metabolome alterations in severe critical illness and vitamin D status. Crit Care. 2017;21:1\u201310.","journal-title":"Crit Care"},{"issue":"9","key":"8461_CR49","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1503\/cmaj.071366","volume":"178","author":"D Cook","year":"2008","unstructured":"Cook D, Lauzier F, Rocha MG, et al. Serious adverse events in academic critical care research. CMAJ. 2008;178(9):1181\u20134.","journal-title":"CMAJ"},{"issue":"9","key":"8461_CR50","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0895-4356(99)00071-2","volume":"52","author":"KW Wyrwich","year":"1999","unstructured":"Wyrwich KW, Tierney WM, Wolinsky FD. Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life. J Clin Epidemiol. 1999;52(9):861\u201373.","journal-title":"J Clin Epidemiol"},{"key":"8461_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc2872","volume":"8","author":"R Bellomo","year":"2004","unstructured":"Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure\u2013definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:1\u20139.","journal-title":"Crit Care"},{"issue":"4","key":"8461_CR52","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1038\/s41596-020-00475-0","volume":"16","author":"M Shanmuganathan","year":"2021","unstructured":"Shanmuganathan M, Kroezen Z, Gill B, et al. The maternal serum metabolome by multisegment injection-capillary electrophoresis-mass spectrometry: a high-throughput platform and standardized data workflow for large-scale epidemiological studies. Nat Protoc. 2021;16(4):1966\u201394.","journal-title":"Nat Protoc"},{"issue":"22","key":"8461_CR53","doi-asserted-by":"publisher","first-page":"10664","DOI":"10.1021\/ac403171u","volume":"85","author":"NL Kuehnbaum","year":"2013","unstructured":"Kuehnbaum NL, Kormendi A, Britz-McKibbin P. Multisegment injection-capillary electrophoresis-mass spectrometry: a high-throughput platform for metabolomics with high data fidelity. Anal Chem. 2013;85(22):10664\u20139.","journal-title":"Anal Chem"},{"key":"8461_CR54","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.bone.2018.02.024","volume":"110","author":"H Ketha","year":"2018","unstructured":"Ketha H, Thacher TD, Oberhelman SS, et al. Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24, 25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio. Bone. 2018;110:321\u20135.","journal-title":"Bone"},{"issue":"5","key":"8461_CR55","doi-asserted-by":"publisher","first-page":"100204","DOI":"10.1016\/j.jlr.2022.100204","volume":"63","author":"E Helmeczi","year":"2022","unstructured":"Helmeczi E, Fries E, Perry L, et al. A high-throughput platform for the rapid screening of vitamin D status by direct infusion-MS\/MS. J Lipid Res. 2022;63(5):100204.","journal-title":"J Lipid Res"},{"issue":"2","key":"8461_CR56","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2021-0035","volume":"21","author":"G Griffin","year":"2021","unstructured":"Griffin G, Hewison M, Hopkin J, et al. Perspective: vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: Implications for COVID-19. Clin Med. 2021;21(2): e144.","journal-title":"Clin Med"},{"issue":"4","key":"8461_CR57","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.clnu.2020.09.028","volume":"40","author":"K Amrein","year":"2021","unstructured":"Amrein K, Lasky-Su JA, Dobnig H, et al. Metabolomic basis for response to high dose vitamin D in critical illness. Clin Nutr. 2021;40(4):2053\u201360.","journal-title":"Clin Nutr"},{"key":"8461_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-019-1543-0","volume":"15","author":"M Yamamoto","year":"2019","unstructured":"Yamamoto M, Pinto-Sanchez MI, Bercik P, et al. Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients. Metabolomics. 2019;15:1\u201318.","journal-title":"Metabolomics"},{"issue":"3","key":"8461_CR59","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1001\/jama.2021.9941","volume":"326","author":"AM Orkin","year":"2021","unstructured":"Orkin AM, Gill PJ, Ghersi D, et al. Guidelines for reporting trial protocols and completed trials modified due to the COVID-19 pandemic and other extenuating circumstances: the CONSERVE 2021 statement. JAMA. 2021;326(3):257\u201365.","journal-title":"JAMA"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-024-08461-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:56:53Z","timestamp":1726761413000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-024-08461-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8461"],"URL":"https:\/\/doi.org\/10.1186\/s13063-024-08461-7","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This trial was conducted in accordance with the Declaration of Helsinki and approved by the Children\u2019s Hospital of Eastern Ontario (coordinating center) Research Ethics Board (Clinical Trials Ontario REB number: 1761, provincial approval granted April 10, 2019; institutional approval granted April 29, 2019). REB approval was also received from all other academic centers prior to trial commencement at those sites. Written, informed consent to participate was obtained from all participants and\/or their parent or legal guardian.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"619"}}