{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:19:56Z","timestamp":1793254796965,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-024-08586-9","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T01:00:53Z","timestamp":1731114053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation randomized controlled trial"],"prefix":"10.1186","volume":"25","author":[{"given":"Lindsay J.","family":"Underhill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Cordova-Ascona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"de las Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gittelsohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Schechtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoila","family":"Vela-Clavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Tarazona-Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Beres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker K.","family":"Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishadi","family":"Rajapakse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makeda","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Tonwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaloke","family":"Mody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Cuentas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin H.","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Checkley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"D\u00e1vila-Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-1725","authenticated-orcid":false,"given":"Stella M.","family":"Hartinger-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"issue":"4","key":"8586_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223\u201337.","journal-title":"Nat Rev Nephrol"},{"key":"8586_CR2","unstructured":"World Health Organization. Fact sheets: hypertension. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hypertension. Accessed 13 Mar 2024."},{"issue":"6","key":"8586_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1161\/CIRCULATIONAHA.115.018912","volume":"134","author":"KT Mills","year":"2016","unstructured":"Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. 2016;134(6):441\u201350.","journal-title":"Circulation"},{"issue":"2","key":"8586_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/MAJ.0000000000000298","volume":"348","author":"KT Mills","year":"2014","unstructured":"Mills KT, Rubinstein A, Irazola V, Chen J, Beratarrechea A, Poggio R, et al. Comprehensive approach for hypertension control in low-income populations: rationale and study design for the hypertension control program in Argentina. Am J Med Sci. 2014;348(2):139\u201345.","journal-title":"Am J Med Sci"},{"issue":"3","key":"8586_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/00004872-199303000-00013","volume":"11","author":"Hypertension in Diabetes Study (HDS): II","year":"1993","unstructured":"Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients. J Hypertens. 1993;11(3):319\u201325.","journal-title":"J Hypertens."},{"key":"8586_CR6","unstructured":"American Heart Association. Health threats from high blood pressure. 2022. https:\/\/www.heart.org\/en\/health-topics\/high-blood-pressure\/health-threats-from-high-blood-pressure. Accessed 1 Nov 2023."},{"key":"8586_CR7","unstructured":"Medical doctors (per 10 000 population). https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator-details\/GHO\/medical-doctors-(per-10-000-population). Accessed 16 Jun 2024."},{"issue":"6","key":"8586_CR8","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.aogh.2015.12.018","volume":"81","author":"JE Villena","year":"2015","unstructured":"Villena JE. Diabetes mellitus in Peru. Ann Glob Health. 2015;81(6):765\u201375.","journal-title":"Ann Glob Health"},{"key":"8586_CR9","unstructured":"World Health Organization. HEARTS technical package for cardiovascular disease management in primary health care: risk based CVD management. 2020. https:\/\/www.who.int\/publications\/i\/item\/9789240001367. Accessed 4 Mar 2023."},{"issue":"5","key":"8586_CR10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.amepre.2007.01.011","volume":"32","author":"JN Brownstein","year":"2007","unstructured":"Brownstein JN, Chowdhury FM, Norris SL, Horsley T, Jack L, Zhang X, et al. Effectiveness of community health workers in the care of people with hypertension. Am J Prev Med. 2007;32(5):435\u201347.","journal-title":"Am J Prev Med"},{"key":"8586_CR11","doi-asserted-by":"publisher","first-page":"106864","DOI":"10.1016\/j.cct.2022.106864","volume":"120","author":"MK Shah","year":"2022","unstructured":"Shah MK, Wyatt LC, Gibbs-Tewary C, Zanowiak J, Mammen S, Mohsin FM, et al. Protocol and baseline characteristics for a community health worker-led hypertension and diabetes management program for South Asians in Atlanta: the DREAM Atlanta study. Contemp Clin Trials. 2022;120:106864.","journal-title":"Contemp Clin Trials"},{"issue":"11","key":"8586_CR12","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1001\/jama.2017.11358","volume":"318","author":"J He","year":"2017","unstructured":"He J, Irazola V, Mills KT, Poggio R, Beratarrechea A, Dolan J, et al. Effect of a community health worker-led multicomponent intervention on blood pressure control in low-income patients in Argentina: a randomized clinical trial. JAMA. 2017;318(11):1016\u201325.","journal-title":"JAMA"},{"issue":"6","key":"8586_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2458-6-13","volume":"24","author":"FP Cappuccio","year":"2006","unstructured":"Cappuccio FP, Kerry SM, Micah FB, Plange-Rhule J, Eastwood JB. A community programme to reduce salt intake and blood pressure in Ghana [ISRCTN88789643]. BMC Public Health. 2006;24(6):13.","journal-title":"BMC Public Health"},{"issue":"2","key":"8586_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10488-010-0319-7","volume":"38","author":"E Proctor","year":"2011","unstructured":"Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Ment Health. 2011;38(2):65\u201376.","journal-title":"Adm Policy Ment Health"},{"key":"8586_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fpubh.2019.00064","volume":"7","author":"RE Glasgow","year":"2019","unstructured":"Glasgow RE, Harden SM, Gaglio B, Rabin B, Smith ML, Porter GC, et al. RE-AIM planning and evaluation framework: adapting to new science and practice with a 20-year review. Front Public Health. 2019;7:64.","journal-title":"Front Public Health"},{"issue":"1","key":"8586_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13012-022-01245-0","volume":"17","author":"LJ Damschroder","year":"2022","unstructured":"Damschroder LJ, Reardon CM, Widerquist MAO, Lowery J. The updated Consolidated Framework for Implementation Research based on user feedback. Implement Sci. 2022;17(1):75.","journal-title":"Implement Sci"},{"key":"8586_CR17","unstructured":"Instituto Nacional de Estad\u00edstica e Inform\u00e1tica. Peru: Perfil Sociodemographico: Informe National. Censos Nacionales 2017: XII de Poblaci\u00f3n, VII de Vivienda y III de Comunidades Ind\u00edgenas. 2018. https:\/\/www.inei.gob.pe\/media\/MenuRecursivo\/publicaciones_digitales\/Est\/Lib1539\/. Accessed 5 Jul 2023."},{"issue":"1","key":"8586_CR18","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13012-020-01041-8","volume":"15","author":"JD Smith","year":"2020","unstructured":"Smith JD, Li DH, Rafferty MR. The Implementation Research Logic Model: a method for planning, executing, reporting, and synthesizing implementation projects. Implement Sci. 2020;15(1):84.","journal-title":"Implement Sci"},{"key":"8586_CR19","unstructured":"Tsoris A, Marlar CA. Use of the Child Pugh score in liver disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542308\/. Accessed 25 Jun 2024."},{"issue":"1","key":"8586_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2105\/AJPH.2015.302962","volume":"106","author":"L Riley","year":"2016","unstructured":"Riley L, Guthold R, Cowan M, Savin S, Bhatti L, Armstrong T, et al. The World Health Organization STEPwise approach to noncommunicable disease risk-factor surveillance: methods, challenges, and opportunities. Am J Public Health. 2016;106(1):74\u20138.","journal-title":"Am J Public Health"},{"issue":"6","key":"8586_CR21","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","volume":"88","author":"JB Saunders","year":"1993","unstructured":"Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption\u2014II. Addiction. 1993;88(6):791\u2013804.","journal-title":"Addiction"},{"key":"8586_CR22","unstructured":"Centers for Disease Control and Prevention. Global Tobacco Surveillance System Data (GTSSData). Global Adult Tobacco Survey (GATS) \u2014 overview. https:\/\/nccd.cdc.gov\/GTSSDataSurveyResources\/Ancillary\/Documentation.aspx?SUID=1&DOCT=1. Accessed 18 Oct 2024."},{"issue":"8","key":"8586_CR23","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","volume":"35","author":"CL Craig","year":"2003","unstructured":"Craig CL, Marshall AL, Sj\u00f6str\u00f6m M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381\u201395.","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"8586_CR24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1751-7117.2000.tb00211.x","volume":"15","author":"MT Kim","year":"2000","unstructured":"Kim MT, Hill MN, Bone LR, Levine DM. Development and testing of the Hill-Bone Compliance to High Blood Pressure Therapy Scale. Prog Cardiovasc Nurs. 2000;15(3):90\u20136.","journal-title":"Prog Cardiovasc Nurs"},{"key":"8586_CR25","doi-asserted-by":"crossref","unstructured":"Sripad P, McClair TL, Casseus A, Hossain S, Abuya T, Gottert A. Measuring client trust in community health workers: a multi-country validation study. J Glob Health. 2021;11:07009.","DOI":"10.7189\/jogh.11.07009"},{"issue":"10","key":"8586_CR26","doi-asserted-by":"publisher","first-page":"e002276","DOI":"10.1161\/JAHA.115.002276","volume":"4","author":"ST Hardy","year":"2015","unstructured":"Hardy ST, Loehr LR, Butler KR, Chakladar S, Chang PP, Folsom AR, et al. Reducing the blood pressure\u2013related burden of cardiovascular disease: impact of achievable improvements in blood pressure prevention and control. J Am Heart Assoc. 2015;4(10):e002276.","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"8586_CR27","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1161\/01.HYP.14.5.570","volume":"14","author":"J Stamler","year":"1989","unstructured":"Stamler J, Rose G, Stamler R, Elliott P, Dyer A, Marmot M. INTERSALT study findings. Public health and medical care implications. Hypertension. 1989;14(5):570\u20137.","journal-title":"Hypertension."},{"issue":"11","key":"8586_CR28","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1164\/rccm.202006-2319OC","volume":"203","author":"W Checkley","year":"2021","unstructured":"Checkley W, Williams KN, Kephart JL, Fandi\u00f1o-Del-Rio M, Steenland NK, Gonzales GF, et al. Effects of a household air pollution intervention with liquefied petroleum gas on cardiopulmonary outcomes in Peru. A randomized controlled trial. Am J Respir Crit Care Med. 2021;203(11):1386\u201397.","journal-title":"Am J Respir Crit Care Med."},{"issue":"8","key":"8586_CR29","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1056\/NEJMoa1911965","volume":"382","author":"TH Jafar","year":"2020","unstructured":"Jafar TH, Gandhi M, de Silva HA, Jehan I, Naheed A, Finkelstein EA, et al. A community-based intervention for managing hypertension in rural South Asia. N Engl J Med. 2020;382(8):717\u201326.","journal-title":"N Engl J Med"},{"issue":"11","key":"8586_CR30","doi-asserted-by":"publisher","first-page":"e015529","DOI":"10.1136\/bmjopen-2016-015529","volume":"7","author":"M Abdel-All","year":"2017","unstructured":"Abdel-All M, Putica B, Praveen D, Abimbola S, Joshi R. Effectiveness of community health worker training programmes for cardiovascular disease management in low-income and middle-income countries: a systematic review. BMJ Open. 2017;7(11):e015529.","journal-title":"BMJ Open"},{"issue":"1","key":"8586_CR31","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/jhh.2015.124","volume":"31","author":"A Bernabe-Ortiz","year":"2017","unstructured":"Bernabe-Ortiz A, Sanchez JF, Carrillo-Larco RM, Gilman RH, Poterico JA, Quispe R, et al. Rural-to-urban migration and risk of hypertension: longitudinal results of the PERU MIGRANT study. J Hum Hypertens. 2017;31(1):22\u20138.","journal-title":"J Hum Hypertens"},{"issue":"2","key":"8586_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/HPC.0b013e318285ef60","volume":"12","author":"AG Lerner","year":"2013","unstructured":"Lerner AG, Bernabe-Ortiz A, Gilman RH, Smeeth L, Miranda JJ. The \u2018rule of halves\u2019 does not apply in Peru: awareness, treatment, and control of hypertension and diabetes in rural, urban and rural-to-urban migrants. Crit Pathw Cardiol. 2013;12(2):53\u20138.","journal-title":"Crit Pathw Cardiol"},{"issue":"1","key":"8586_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1756-0500-1-2","volume":"1","author":"AR Davies","year":"2008","unstructured":"Davies AR, Miranda JJ, Gilman RH, Smeeth L. Hypertension among adults in a deprived urban area of Peru \u2013 undiagnosed and uncontrolled? BMC Res Notes. 2008;1(1):2.","journal-title":"BMC Res Notes"},{"issue":"46","key":"8586_CR34","first-page":"e150","volume":"2","author":"D Flood","year":"2022","unstructured":"Flood D, Edwards EW, Giovannini D, Ridley E, Rosende A, Herman WH, et al. Integrating hypertension and diabetes management in primary health care settings: HEARTS as a tool. Rev Panam Salud Publica. 2022;2(46):e150.","journal-title":"Rev Panam Salud Publica"},{"issue":"14","key":"8586_CR35","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1002\/sim.8958","volume":"40","author":"K Hemming","year":"2021","unstructured":"Hemming K, Taljaard M, Moerbeek M, Forbes A. Contamination: how much can an individually randomized trial tolerate? Stat Med. 2021;40(14):3329\u201351.","journal-title":"Stat Med"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08586-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-024-08586-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08586-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T13:02:26Z","timestamp":1731157346000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-024-08586-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,9]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8586"],"URL":"https:\/\/doi.org\/10.1186\/s13063-024-08586-9","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,9]]},"assertion":[{"value":"6 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical oversight is provided by the Universidad Peruana Cayetano Heredia in Lima, Peru Research Ethics Committee (104372). The study was also reviewed and approved by Washington University in St. Louis Human Research Protections Office (202108158) and registered at Johns Hopkins University School of Medicine institutional review board (IRB).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable. No identifying images or personal or clinical details of participants are included here or will be in the trial reports. Participant information materials and the informed consent form are available from the corresponding author upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MDH has received travel support from the American Heart Association and World Heart Federation. MDH has an appointment at The George Institute for Global Health, which has a patent, license, and has received investment funding with intent to commercialize fixed-dose combination therapy through its social enterprise business, George Medicines. MDH has pending patents for heart failure polypills.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"747"}}