{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:19:28Z","timestamp":1793701168933,"version":"4.5.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Exposure with Response Prevention (ERP) is a first-line treatment for OCD, but even when combined with first-line medications it is insufficiently effective for approximately half of patients. Compulsivity in OCD is thought to arise from an imbalance of two distinct neural circuits associated with specific subregions of striatum. Targeted modulation of these circuits via key cortical nodes (dorsolateral prefrontal cortex [dlPFC] or presupplementary motor area [pSMA]) has the potential to improve ERP efficacy by decreasing compulsions during therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The NExT (Neuromodulation\u2009+\u2009Exposure Therapy) trial is a two-phase, multisite early-stage randomized controlled trial designed to examine whether TMS augmentation of ERP alters activity in dlPFC and\/or pSMA-associated circuitry and reduces compulsions during therapy in youth with OCD age 12\u201321 years. Phase 1 (<jats:italic>N<\/jats:italic>\u2009=\u200960) will compare two different active TMS regimens with sham: A. continuous theta burst stimulation (cTBS) to pSMA vs. B. intermittent theta burst stimulation (iTBS) to dlPFC. A priori \u201cGo\/No-Go\u201d criteria will inform a decision to proceed to Phase 2 and the choice of TMS regimen. Phase 2 (<jats:italic>N<\/jats:italic>\u2009=\u200960) will compare the selected TMS regimen vs. sham in a new sample.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>This trial is the first to test TMS augmentation of ERP in youth with OCD. Results will inform the potential of TMS to enhance ERP efficacy and enhance knowledge about mechanisms of change.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov NCT05931913. Registered prospectively on July 5, 2023.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13063-024-08629-1","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:57:21Z","timestamp":1734515841000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The NExT trial: Protocol for a two-phase randomized controlled trial testing transcranial magnetic stimulation to augment exposure therapy for youth with OCD"],"prefix":"10.1186","volume":"25","author":[{"given":"Christine","family":"Conelea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Breitenfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alixandra","family":"Wilens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Herren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alik S.","family":"Widge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fiecas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-9282","authenticated-orcid":false,"given":"Kristen","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"issue":"Suppl 1","key":"8629_CR1","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1089\/104454603322126359","volume":"13","author":"J Piacentini","year":"2003","unstructured":"Piacentini J, Bergman RL, Keller M, McCracken J. Functional impairment in children and adolescents with obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2003;13(Suppl 1):S61\u20139.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"11","key":"8629_CR2","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1097\/00004583-199511000-00009","volume":"34","author":"PH Thomsen","year":"1995","unstructured":"Thomsen PH, Mikkelsen HU. Course of obsessive-compulsive disorder in children and adolescents: a prospective follow-up study of 23 Danish cases. J Am Acad Child Adolesc Psychiatry. 1995;34(11):1432\u201340.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"16","key":"8629_CR3","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1001\/jama.292.16.1969","volume":"292","author":"Pediatric OCD Treatment Study (POTS) Team","year":"2004","unstructured":"Pediatric OCD Treatment Study (POTS) Team. Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA. 2004;292(16):1969\u201376.","journal-title":"JAMA."},{"issue":"11","key":"8629_CR4","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1001\/jama.2011.1344","volume":"306","author":"ME Franklin","year":"2011","unstructured":"Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, et al. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA. 2011;306(11):1224\u201332.","journal-title":"JAMA"},{"issue":"4","key":"8629_CR5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s40501-022-00279-x","volume":"9","author":"C Lantrip","year":"2022","unstructured":"Lantrip C, Szabo YZ, Kozel FA, Holtzheimer P. Neuromodulation as an Augmenting Strategy for Behavioral Therapies for Anxiety and PTSD: a Narrative Review. Current Treatment Options in Psychiatry. 2022;9(4):406\u201318.","journal-title":"Current Treatment Options in Psychiatry"},{"issue":"3","key":"8629_CR6","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.beth.2020.07.004","volume":"52","author":"KG Benito","year":"2021","unstructured":"Benito KG, Machan J, Freeman JB, Garcia AM, Walther M, Frank H, et al. Therapist Behavior During Exposure Tasks Predicts Habituation and Clinical Outcome in Three Randomized Controlled Trials for Pediatric OCD. Behav Ther. 2021;52(3):523\u201338.","journal-title":"Behav Ther"},{"issue":"3","key":"8629_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s40501-015-0056-3","volume":"2","author":"SC Piantadosi","year":"2015","unstructured":"Piantadosi SC, Ahmari SE. Using Optogenetics to Dissect the Neural Circuits Underlying OCD and Related Disorders. Curr Treat Options Psychiatry. 2015;2(3):297\u2013311.","journal-title":"Curr Treat Options Psychiatry"},{"key":"8629_CR8","doi-asserted-by":"publisher","unstructured":"G\u00fcrsel DA, Avram M, Sorg C, Brandl F, Koch K. Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity [Internet]. Vol. 87, Neuroscience & Biobehavioral Reviews. 2018. p. 151\u201360. Available from: https:\/\/doi.org\/10.1016\/j.neubiorev.2018.01.016.","DOI":"10.1016\/j.neubiorev.2018.01.016"},{"issue":"8","key":"8629_CR9","first-page":"655","volume":"2","author":"MM Vaghi","year":"2017","unstructured":"Vaghi MM, Hampshire A, Fineberg NA, Kaser M, Br\u00fchl AB, Sahakian BJ, et al. Hypoactivation and Dysconnectivity of a Frontostriatal Circuit During Goal-Directed Planning as an Endophenotype for Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(8):655\u201363.","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"Pt 3","key":"8629_CR10","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/brain\/awu379","volume":"138","author":"P Banca","year":"2015","unstructured":"Banca P, Voon V, Vestergaard MD, Philipiak G, Almeida I, Pocinho F, et al. Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder. Brain. 2015;138(Pt 3):798\u2013811.","journal-title":"Brain"},{"issue":"7","key":"8629_CR11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.biopsych.2014.12.010","volume":"80","author":"R Gr\u00fctzmann","year":"2016","unstructured":"Gr\u00fctzmann R, Endrass T, Kaufmann C, Allen E, Eichele T, Kathmann N. Presupplementary Motor Area Contributes to Altered Error Monitoring in Obsessive-Compulsive Disorder. Biol Psychiatry. 2016;80(7):562\u201371.","journal-title":"Biol Psychiatry"},{"issue":"10","key":"8629_CR12","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1176\/appi.ajp.2012.12010073","volume":"169","author":"SJ de Wit","year":"2012","unstructured":"de Wit SJ, de Vries FE, van der Werf YD, Cath DC, Heslenfeld DJ, Veltman EM, et al. Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder. Am J Psychiatry. 2012;169(10):1100\u20138.","journal-title":"Am J Psychiatry"},{"issue":"7","key":"8629_CR13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1176\/appi.ajp.2011.10071062","volume":"168","author":"CM Gillan","year":"2011","unstructured":"Gillan CM, Papmeyer M, Morein-Zamir S, Sahakian BJ, Fineberg NA, Robbins TW, et al. Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. Am J Psychiatry. 2011;168(7):718\u201326.","journal-title":"Am J Psychiatry"},{"issue":"1","key":"8629_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brs.2016.11.009","volume":"10","author":"G Cirillo","year":"2017","unstructured":"Cirillo G, Di Pino G, Capone F, Ranieri F, Florio L, Todisco V, et al. Neurobiological after-effects of non-invasive brain stimulation. Brain Stimul. 2017;10(1):1\u201318.","journal-title":"Brain Stimul"},{"issue":"1","key":"8629_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10548-008-0067-0","volume":"21","author":"J Silvanto","year":"2008","unstructured":"Silvanto J, Pascual-Leone A. State-dependency of transcranial magnetic stimulation. Brain Topogr. 2008;21(1):1\u201310.","journal-title":"Brain Topogr"},{"issue":"89","key":"8629_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.pnpbp.2018.10.006","volume":"8","author":"AV Sathappan","year":"2019","unstructured":"Sathappan AV, Luber BM, Lisanby SH. The Dynamic Duo: Combining noninvasive brain stimulation with cognitive interventions. Prog Neuropsychopharmacol Biol Psychiatry. 2019;8(89):347\u201360.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"8629_CR17","doi-asserted-by":"publisher","unstructured":"Freyer T, Kl\u00f6ppel S, T\u00fcscher O, Kordon A, Zurowski B, Kuelz AK, et al. Frontostriatal activation in patients with obsessive\u2013compulsive disorder before and after cognitive behavioral therapy. Psychological Medicine. 2011;41:207\u201316. Available from: https:\/\/doi.org\/10.1017\/s0033291710000309.","DOI":"10.1017\/s0033291710000309"},{"issue":"12","key":"8629_CR18","first-page":"1238","volume":"49","author":"C Huyser","year":"2010","unstructured":"Huyser C, Veltman DJ, Wolters LH, de Haan E, Boer F. Functional magnetic resonance imaging during planning before and after cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2010;49(12):1238\u201348 1248.e1\u20135.","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"issue":"111147","key":"8629_CR19","first-page":"111147","volume":"136","author":"P Vicheva","year":"2024","unstructured":"Vicheva P, Osborne C, Krieg SM, Ahmadi R, Shotbolt P. Transcranial magnetic stimulation for obsessive-compulsive disorder and post-traumatic stress disorder: A comprehensive systematic review and analysis of therapeutic benefits, cortical targets, and psychopathophysiological mechanisms. Prog Neuropsychopharmacol Biol Psychiatry. 2024;136(111147):111147.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"3","key":"8629_CR20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1590\/1516-4446-2017-2279","volume":"40","author":"C Abujadi","year":"2018","unstructured":"Abujadi C, Croarkin PE, Bellini BB, Brentani H, Marcolin MA. Intermittent theta-burst transcranial magnetic stimulation for autism spectrum disorder: an open-label pilot study. Braz J Psychiatry. 2018;40(3):309\u201311.","journal-title":"Braz J Psychiatry"},{"issue":"7","key":"8629_CR21","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1017\/S0033291713002237","volume":"44","author":"M Morgi\u00e8ve","year":"2014","unstructured":"Morgi\u00e8ve M, N\u2019Diaye K, Haynes WIA, Granger B, Clair AH, Pelissolo A, et al. Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging. Psychol Med. 2014;44(7):1461\u201373.","journal-title":"Psychol Med"},{"issue":"3","key":"8629_CR22","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/ijms17030420","volume":"17","author":"ER Hawken","year":"2016","unstructured":"Hawken ER, Dilkov D, Kaludiev E, Simek S, Zhang F, Milev R. Transcranial Magnetic Stimulation of the Supplementary Motor Area in the Treatment of Obsessive-Compulsive Disorder: A Multi-Site Study. Int J Mol Sci. 2016;17(3):420.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"8629_CR23","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.brs.2014.11.015","volume":"8","author":"A Landeros-Weisenberger","year":"2015","unstructured":"Landeros-Weisenberger A, Mantovani A, Motlagh MG, de Alvarenga PG, Katsovich L, Leckman JF, et al. Randomized Sham Controlled Double-blind Trial of Repetitive Transcranial Magnetic Stimulation for Adults With Severe Tourette Syndrome. Brain Stimul. 2015;8(3):574\u201381.","journal-title":"Brain Stimul"},{"issue":"5","key":"8629_CR24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1176\/appi.ajp.2020.20060821","volume":"178","author":"RB Price","year":"2021","unstructured":"Price RB, Gillan CM, Hanlon C, Ferrarelli F, Kim T, Karim HT, et al. Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study. Am J Psychiatry. 2021;178(5):459\u201368.","journal-title":"Am J Psychiatry"},{"issue":"302","key":"8629_CR25","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jad.2022.01.048","volume":"1","author":"SMDD Fitzsimmons","year":"2022","unstructured":"Fitzsimmons SMDD, van der Werf YD, van Campen AD, Arns M, Sack AT, Hoogendoorn AW, et al. Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: A systematic review and pairwise\/network meta-analysis. J Affect Disord. 2022;1(302):302\u201312.","journal-title":"J Affect Disord"},{"issue":"1","key":"8629_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s12888-020-02769-9","volume":"20","author":"R Rostami","year":"2020","unstructured":"Rostami R, Kazemi R, Jabbari A, Madani AS, Rostami H, Taherpour MA, et al. Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): a retrospective study. BMC Psychiatry. 2020;20(1):372.","journal-title":"BMC Psychiatry"},{"issue":"3","key":"8629_CR27","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.clinph.2020.11.018","volume":"132","author":"PJ Fried","year":"2021","unstructured":"Fried PJ, Santarnecchi E, Antal A, Bartres-Faz D, Bestmann S, Carpenter LL, et al. Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee. Clin Neurophysiol. 2021;132(3):819\u201337.","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"8629_CR28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/23794925.2021.1917018","volume":"6","author":"KG Benito","year":"2021","unstructured":"Benito KG, Herren J, Freeman JB, Garcia AM, Kemp J, Chorpita BF, et al. Improving Delivery Behaviors During Exposure Therapy: A Cluster Randomized Controlled Training Trial with Community Therapists. Evidence-Based Practice in Child and Adolescent Mental Health. 2021;6(2):173\u201390.","journal-title":"Evidence-Based Practice in Child and Adolescent Mental Health"},{"key":"8629_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fnhum.2015.00029","volume":"9","author":"YH Hong","year":"2015","unstructured":"Hong YH, Wu SW, Pedapati EV, Horn PS, Huddleston DA, Laue CS, et al. Safety and tolerability of theta burst stimulation vs. single and paired pulse transcranial magnetic stimulation: a comparative study of 165 pediatric subjects. Front Hum Neurosci. 2015;9:29.","journal-title":"Front Hum Neurosci."},{"issue":"10","key":"8629_CR30","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/S0006-3223(00)01048-9","volume":"48","author":"MS George","year":"2000","unstructured":"George MS, Nahas Z, Molloy M, Speer AM, Oliver NC, Li XB, et al. A controlled trial of daily left prefrontal cortex TMS for treating depression. Biol Psychiatry. 2000;48(10):962\u201370.","journal-title":"Biol Psychiatry"},{"issue":"20","key":"8629_CR31","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1016\/j.neuron.2022.08.012","volume":"110","author":"CJ Lynch","year":"2022","unstructured":"Lynch CJ, Elbau IG, Ng TH, Wolk D, Zhu S, Ayaz A, et al. Automated optimization of TMS coil placement for personalized functional network engagement. Neuron. 2022;110(20):3263\u201377.e4.","journal-title":"Neuron"},{"issue":"4","key":"8629_CR32","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/hbm.21479","volume":"34","author":"M Windhoff","year":"2013","unstructured":"Windhoff M, Opitz A, Thielscher A. Electric field calculations in brain stimulation based on finite elements: an optimized processing pipeline for the generation and usage of accurate individual head models. Hum Brain Mapp. 2013;34(4):923\u201335.","journal-title":"Hum Brain Mapp"},{"key":"8629_CR33","unstructured":"March JS, Friesen KM. OCD in Children and Adolescents: A Cognitive-Behavioral Treatment Manual. Guilford Publications; 1998. 298 p."},{"key":"8629_CR34","unstructured":"Franklin ME, Freeman JB, March JS. Treating OCD in Children and Adolescents: A Cognitive-Behavioral Approach. Guilford Publications; 2019. 308 p."},{"issue":"4","key":"8629_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/chi.0b013e31803062e7","volume":"46","author":"EA Storch","year":"2007","unstructured":"Storch EA, Geffken GR, Merlo LJ, Mann G, Duke D, Munson M, et al. Family-based cognitive-behavioral therapy for pediatric obsessive-compulsive disorder: comparison of intensive and weekly approaches. J Am Acad Child Adolesc Psychiatry. 2007;46(4):469\u201378.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7","key":"8629_CR36","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1037\/ccp0000315","volume":"86","author":"KG Benito","year":"2018","unstructured":"Benito KG, Machan J, Freeman JB, Garcia AM, Walther M, Frank H, et al. Measuring fear change within exposures: Functionally-defined habituation predicts outcome in three randomized controlled trials for pediatric OCD. J Consult Clin Psychol. 2018;86(7):615\u201330.","journal-title":"J Consult Clin Psychol"},{"key":"8629_CR37","unstructured":"Comprehensive R Archive Network (CRAN) [Internet]. [cited 2024 Jul 2]. blockrand: Randomization for Block Random Clinical Trials. Available from: https:\/\/CRAN.R-project.org\/package=blockrand."},{"issue":"161","key":"8629_CR38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuroimage.2017.08.025","volume":"1","author":"NUF Dosenbach","year":"2017","unstructured":"Dosenbach NUF, Koller JM, Earl EA, Miranda-Dominguez O, Klein RL, Van AN, et al. Real-time motion analytics during brain MRI improve data quality and reduce costs. Neuroimage. 2017;1(161):80\u201393.","journal-title":"Neuroimage"},{"issue":"2","key":"8629_CR39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/mrm.23228","volume":"68","author":"MD Tisdall","year":"2012","unstructured":"Tisdall MD, Hess AT, Reuter M, Meintjes EM, Fischl B, van der Kouwe AJW. Volumetric navigators for prospective motion correction and selective reacquisition in neuroanatomical MRI. Magn Reson Med. 2012;68(2):389\u201399.","journal-title":"Magn Reson Med"},{"issue":"1","key":"8629_CR40","doi-asserted-by":"publisher","first-page":"5181","DOI":"10.1038\/s41467-021-25431-8","volume":"12","author":"L Vizioli","year":"2021","unstructured":"Vizioli L, Moeller S, Dowdle L, Ak\u00e7akaya M, De Martino F, Yacoub E, et al. Lowering the thermal noise barrier in functional brain mapping with magnetic resonance imaging. Nat Commun. 2021;12(1):5181.","journal-title":"Nat Commun"},{"issue":"40","key":"8629_CR41","doi-asserted-by":"publisher","first-page":"16187","DOI":"10.1073\/pnas.1301725110","volume":"110","author":"P Kundu","year":"2013","unstructured":"Kundu P, Brenowitz ND, Voon V, Worbe Y, V\u00e9rtes PE, Inati SJ, et al. Integrated strategy for improving functional connectivity mapping using multiecho fMRI. Proc Natl Acad Sci U S A. 2013;110(40):16187\u201392.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"8629_CR42","doi-asserted-by":"crossref","unstructured":"Feczko E, Conan G, Marek S, Tervo-Clemmens B, Cordova M, Doyle O, et al. Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities. bioRxiv. 2021 [cited 2024 May 21]. p. 2021.07.09.451638. Available from: https:\/\/www.biorxiv.org\/content\/10.1101\/2021.07.09.451638.","DOI":"10.1101\/2021.07.09.451638"},{"issue":"84","key":"8629_CR43","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","volume":"1","author":"JD Power","year":"2014","unstructured":"Power JD, Mitra A, Laumann TO, Snyder AZ, Schlaggar BL, Petersen SE. Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage. 2014;1(84):320\u201341.","journal-title":"Neuroimage"},{"issue":"206","key":"8629_CR44","doi-asserted-by":"publisher","first-page":"116290","DOI":"10.1016\/j.neuroimage.2019.116290","volume":"1","author":"BA Seitzman","year":"2020","unstructured":"Seitzman BA, Gratton C, Marek S, Raut RV, Dosenbach NUF, Schlaggar BL, et al. A set of functionally-defined brain regions with improved representation of the subcortex and cerebellum. Neuroimage. 2020;1(206):116290.","journal-title":"Neuroimage"},{"issue":"1","key":"8629_CR45","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.clinph.2020.10.003","volume":"132","author":"S Rossi","year":"2021","unstructured":"Rossi S, Antal A, Bestmann S, Bikson M, Brewer C, Brockm\u00f6ller J, et al. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines. Clin Neurophysiol. 2021;132(1):269\u2013306.","journal-title":"Clin Neurophysiol"},{"issue":"2","key":"8629_CR46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11910-017-0719-0","volume":"17","author":"MQ Hameed","year":"2017","unstructured":"Hameed MQ, Dhamne SC, Gersner R, Kaye HL, Oberman LM, Pascual-Leone A, et al. Transcranial Magnetic and Direct Current Stimulation in Children. Curr Neurol Neurosci Rep. 2017;17(2):11.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"5","key":"8629_CR47","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1176\/appi.ajp.2017.17050485","volume":"175","author":"PSW Boedhoe","year":"2018","unstructured":"Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, et al. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. Am J Psychiatry. 2018;175(5):453\u201362.","journal-title":"Am J Psychiatry"},{"key":"8629_CR48","doi-asserted-by":"crossref","unstructured":"Morriss J, Christakou A, van Reekum CM. Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood. Sci Rep. 2019;9(1). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/31123292\/.","DOI":"10.1038\/s41598-019-44150-1"},{"key":"8629_CR49","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neubiorev.2018.09.005","volume":"94","author":"B Larsen","year":"2018","unstructured":"Larsen B, Luna B. Adolescence as a neurobiological critical period for the development of higher-order cognition. Neurosci Biobehav Rev. 2018;94:179\u201395.","journal-title":"Neurosci Biobehav Rev"},{"key":"8629_CR50","doi-asserted-by":"publisher","unstructured":"Carmi L, Tendler A, Bystritsky A, Hollander E, Blumberger DM, Daskalakis J, et al. Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial. Am J Psychiatr. 2019;176:931\u20138. Available from: https:\/\/doi.org\/10.1176\/appi.ajp.2019.18101180.","DOI":"10.1176\/appi.ajp.2019.18101180"},{"issue":"8","key":"8629_CR51","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.clinph.2010.12.037","volume":"122","author":"S Rossi","year":"2011","unstructured":"Rossi S, Hallett M, Rossini PM, Pascual-Leone A. Screening questionnaire before TMS: an update. Clin Neurophysiol. 2011;122(8):1686.","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"8629_CR52","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1177\/10731911221143994","volume":"30","author":"DF Tolin","year":"2023","unstructured":"Tolin DF, Sain KS, Davis E, Gilliam C, Hannan SE, Springer KS, et al. The DIAMOND-KID: Psychometric Properties of a Structured Diagnostic Interview for DSM-5 Anxiety, Mood, and Obsessive-Compulsive and Related Disorders in Children and Adolescents. Assessment. 2023;30(8):2351\u201363.","journal-title":"Assessment"},{"issue":"6","key":"8629_CR53","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1097\/00004583-199706000-00023","volume":"36","author":"L Scahill","year":"1997","unstructured":"Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, et al. Children\u2019s Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry. 1997;36(6):844\u201352.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7","key":"8629_CR54","first-page":"28","volume":"4","author":"J Busner","year":"2007","unstructured":"Busner J, Targum SD. The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry. 2007;4(7):28\u201337.","journal-title":"Psychiatry"},{"issue":"12","key":"8629_CR55","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1001\/archpediatrics.2012.1276","volume":"166","author":"LM Horowitz","year":"2012","unstructured":"Horowitz LM, Bridge JA, Teach SJ, Ballard E, Klima J, Rosenstein DL, et al. Ask Suicide-Screening Questions (ASQ): a brief instrument for the pediatric emergency department. Arch Pediatr Adolesc Med. 2012;166(12):1170\u20136.","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"1","key":"8629_CR56","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.brs.2014.10.012","volume":"8","author":"C Krishnan","year":"2015","unstructured":"Krishnan C, Santos L, Peterson MD, Ehinger M. Safety of noninvasive brain stimulation in children and adolescents. Brain Stimul. 2015;8(1):76\u201387.","journal-title":"Brain Stimul"},{"issue":"3","key":"8629_CR57","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0149-7189(79)90094-6","volume":"2","author":"DL Larsen","year":"1979","unstructured":"Larsen DL, Attkisson CC, Hargreaves WA, Nguyen TD. Assessment of client\/patient satisfaction: development of a general scale. Eval Program Plann. 1979;2(3):197\u2013207.","journal-title":"Eval Program Plann"},{"issue":"5","key":"8629_CR58","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1080\/15374410903103551","volume":"38","author":"SP Whiteside","year":"2009","unstructured":"Whiteside SP. Adapting the Sheehan disability scale to assess child and parent impairment related to childhood anxiety disorders. J Clin Child Adolesc Psychol. 2009;38(5):721\u201330.","journal-title":"J Clin Child Adolesc Psychol"},{"issue":"8","key":"8629_CR59","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0005-7967(99)00130-8","volume":"38","author":"BF Chorpita","year":"2000","unstructured":"Chorpita BF, Yim L, Moffitt C, Umemoto LA, Francis SE. Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scale. Behav Res Ther. 2000;38(8):835\u201355.","journal-title":"Behav Res Ther"},{"issue":"3","key":"8629_CR60","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1076\/chin.6.3.235.3152","volume":"6","author":"IS Baron","year":"2000","unstructured":"Baron IS. Behavior rating inventory of executive function. Child Neuropsychol. 2000;6(3):235\u20138.","journal-title":"Child Neuropsychol"},{"key":"8629_CR61","unstructured":"[No title] [Internet]. [cited 2023 May 23]. Available from: https:\/\/staging.healthmeasures.net\/images\/PROMIS\/manuals\/PROMIS_Sleep_Disturbance_Scoring_Manual.pdf."},{"issue":"10","key":"8629_CR62","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","volume":"166","author":"RL Spitzer","year":"2006","unstructured":"Spitzer RL, Kroenke K, Williams JBW, L\u00f6we B. A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7. Arch Intern Med. 2006;166(10):1092\u20137.","journal-title":"Arch Intern Med"},{"issue":"9","key":"8629_CR63","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","volume":"16","author":"K Kroenke","year":"2001","unstructured":"Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606\u201313.","journal-title":"J Gen Intern Med"},{"issue":"6","key":"8629_CR64","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1080\/09638288.2019.1643416","volume":"43","author":"M Saltychev","year":"2021","unstructured":"Saltychev M, Katajapuu N, B\u00e4rlund E, Laimi K. Psychometric properties of 12-item self-administered World Health Organization disability assessment schedule 2.0 (WHODAS 2.0) among general population and people with non-acute physical causes of disability - systematic review. Disabil Rehabil. 2021;43(6):789\u201394.","journal-title":"Disabil Rehabil."}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08629-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-024-08629-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-024-08629-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T12:14:16Z","timestamp":1734524056000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-024-08629-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["8629"],"URL":"https:\/\/doi.org\/10.1186\/s13063-024-08629-1","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"13 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Advarra sIRB ABC123456 provided approval for this study. Written, informed consent to participate will be obtained from all participants (for those age 18\u2009+) and parents or legal guardians (for those age 12\u201317). Written assent will also be obtained for youth age 12\u201317.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate {24}"}},{"value":"Not applicable\u2014no identifying images or other personal or clinical details of participants are presented here or will be presented in reports of the trial results. The participant information materials and informed consent form are available from the corresponding author on request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication {32}"}},{"value":"Dr. Nelson consults for Turing Medical, which commercializes FIRMM. This interest has been reviewed and managed by the University of Minnesota in accordance with its Conflict of Interest policies. The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests {28}"}}],"article-number":"835"}}