{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:07:25Z","timestamp":1793995645928,"version":"4.8.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["199375"],"award-info":[{"award-number":["199375"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-025-08916-5","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T22:37:08Z","timestamp":1749854228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic effects of curcumin and piperine combination in critically ill patients with sepsis: a randomized double-blind controlled trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Babak","family":"Alikiaii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Khatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohaddeseh","family":"Badpeyma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmat","family":"Hasanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepide","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Kiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Hassanizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Iraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Majeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-6129","authenticated-orcid":false,"given":"Mohammad","family":"Bagherniya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"issue":"5","key":"8916_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.7748\/en.2019.e1926","volume":"27","author":"A Hunt","year":"2019","unstructured":"Hunt A. Sepsis: an overview of the signs, symptoms, diagnosis, treatment and pathophysiology. Emergency nurse\u202f: The Journal of the RCN Accident and Emergency Nursing Association. 2019;27(5):32\u201341.","journal-title":"Emergency nurse : The Journal of the RCN Accident and Emergency Nursing Association"},{"issue":"2","key":"8916_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1089\/sur.2017.278","volume":"19","author":"LM Napolitano","year":"2018","unstructured":"Napolitano LM. Sepsis 2018: definitions and guideline changes. Surg Infect. 2018;19(2):117\u201325.","journal-title":"Surg Infect"},{"key":"8916_CR3","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1007\/s12325-017-0622-8","volume":"34","author":"J Rello","year":"2017","unstructured":"Rello J, Valenzuela-S\u00e1nchez F, Ruiz-Rodriguez M, Moyano S. Sepsis: a review of advances in management. Adv Ther. 2017;34:2393\u2013411.","journal-title":"Adv Ther"},{"key":"8916_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.588863","volume":"7","author":"DO Lonsdale","year":"2020","unstructured":"Lonsdale DO, Shah RV, Lipman J. Infection, Sepsis and the Inflammatory Response: Mechanisms and Therapy. Front Med. 2020;7: 588863.","journal-title":"Front Med"},{"issue":"4","key":"8916_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1177\/0310057X0403200402","volume":"32","author":"E O'Connor","year":"2004","unstructured":"O\u2019Connor E, Venkatesh B, Mashongonyika C, Lipman J, Hall J, Thomas P. Serum procalcitonin and C-reactive protein as markers of sepsis and outcome in patients with neurotrauma and subarachnoid haemorrhage. Anaesth Intensive Care. 2004;32(4):465\u201370.","journal-title":"Anaesth Intensive Care"},{"issue":"3","key":"8916_CR6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ccc.2006.03.003","volume":"22","author":"K Reinhart","year":"2006","unstructured":"Reinhart K, Meisner M, Brunkhorst FM. Markers for sepsis diagnosis: what is useful? Crit Care Clin. 2006;22(3):503\u201319.","journal-title":"Crit Care Clin"},{"issue":"3","key":"8916_CR7","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1586\/eri.13.9","volume":"11","author":"J-L Vincent","year":"2013","unstructured":"Vincent J-L, Beumier M. Diagnostic and prognostic markers in sepsis. Expert Rev Anti Infect Ther. 2013;11(3):265\u201375.","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"4","key":"8916_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","volume":"104","author":"MD Font","year":"2020","unstructured":"Font MD, Thyagarajan B, Khanna AK. Sepsis and Septic Shock - Basics of diagnosis, pathophysiology and clinical decision making. Med Clin North Am. 2020;104(4):573\u201385.","journal-title":"Med Clin North Am"},{"issue":"1","key":"8916_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/AIA.0b013e318194ffb6","volume":"47","author":"E Trejnowska","year":"2009","unstructured":"Trejnowska E, Popovich MJ. Management of sepsis in the ICU. Int Anesthesiol Clin. 2009;47(1):55\u201366.","journal-title":"Int Anesthesiol Clin"},{"key":"8916_CR10","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jgar.2017.06.013","volume":"10","author":"S Esposito","year":"2017","unstructured":"Esposito S, De Simone G, Boccia G, De Caro F, Pagliano P. Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches. Journal of global antimicrobial resistance. 2017;10:204\u201312.","journal-title":"Journal of global antimicrobial resistance"},{"key":"8916_CR11","doi-asserted-by":"publisher","unstructured":"Kotha RR, Luthria DL. Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules (Basel, Switzerland). 2019;24(16):2930. https:\/\/doi.org\/10.3390\/molecules24162930.","DOI":"10.3390\/molecules24162930"},{"issue":"4","key":"8916_CR12","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/ptr.7778","volume":"37","author":"M Shojaei","year":"2023","unstructured":"Shojaei M, Foshati S, Abdi M, Askari G, Sukhorukov VN, Bagherniya M, et al. The effectiveness of nano-curcumin on patients with COVID-19: A systematic review of clinical trials. Phytother Res. 2023;37(4):1663\u201377.","journal-title":"Phytother Res"},{"issue":"12","key":"8916_CR13","doi-asserted-by":"publisher","first-page":"6862","DOI":"10.1002\/ptr.7273","volume":"35","author":"M Mohseni","year":"2021","unstructured":"Mohseni M, Sahebkar A, Askari G, Johnston TP, Alikiaii B, Bagherniya M. The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials. Phytother Res. 2021;35(12):6862\u201382.","journal-title":"Phytother Res"},{"key":"8916_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-030-56153-6_8","volume":"1291","author":"A Mahdavi","year":"2021","unstructured":"Mahdavi A, Moradi S, Askari G, Iraj B, Sathyapalan T, Guest PC, et al. Effect of Curcumin on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials. Adv Exp Med Biol. 2021;1291:139\u201349.","journal-title":"Adv Exp Med Biol"},{"key":"8916_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114910","volume":"164","author":"H Heidari","year":"2023","unstructured":"Heidari H, Shojaei M, Askari G, Majeed M, Bagherniya M, Barreto GE, et al. The impact of curcumin on migraine: A comprehensive review. Biomed Pharmacother. 2023;164: 114910.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"8916_CR16","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/biof.1932","volume":"49","author":"S Hassanizadeh","year":"2023","unstructured":"Hassanizadeh S, Shojaei M, Bagherniya M, Orekhov AN, Sahebkar A. Effect of nano-curcumin on various diseases: A comprehensive review of clinical trials. BioFactors. 2023;49(3):512\u201333.","journal-title":"BioFactors"},{"issue":"1","key":"8916_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12937-023-00905-1","volume":"22","author":"K Boshagh","year":"2023","unstructured":"Boshagh K, Khorvash F, Sahebkar A, Majeed M, Bahreini N, Askari G, et al. The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial. Nutr J. 2023;22(1):69.","journal-title":"Nutr J"},{"issue":"9","key":"8916_CR18","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1002\/ptr.7118","volume":"35","author":"M Bagherniya","year":"2021","unstructured":"Bagherniya M, Khedmatgozar H, Fakheran O, Xu S, Johnston TP, Sahebkar A. Medicinal plants and bioactive natural products as inhibitors of NLRP3 inflammasome. Phytother Res. 2021;35(9):4804\u201333.","journal-title":"Phytother Res"},{"key":"8916_CR19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/978-3-030-56153-6_15","volume":"1291","author":"M Bagherniya","year":"2021","unstructured":"Bagherniya M, Darand M, Askari G, Guest PC, Sathyapalan T, Sahebkar A. The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials. Adv Exp Med Biol. 2021;1291:251\u201363.","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"8916_CR20","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1186\/s13063-022-06375-w","volume":"23","author":"G Askari","year":"2022","unstructured":"Askari G, Sahebkar A, Soleimani D, Mahdavi A, Rafiee S, Majeed M, et al. The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial. Trials. 2022;23(1):472.","journal-title":"Trials"},{"key":"8916_CR21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/978-3-031-28012-2_22","volume":"1412","author":"G Askari","year":"2023","unstructured":"Askari G, Bagherniya M, Kiani Z, Alikiaii B, Mirjalili M, Shojaei M, et al. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial. Adv Exp Med Biol. 2023;1412:413\u201326.","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"8916_CR22","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1002\/ptr.6939","volume":"35","author":"B Alikiaii","year":"2021","unstructured":"Alikiaii B, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A. Evaluation of the effect of curcumin on pneumonia: A systematic review of preclinical studies. Phytother Res. 2021;35(4):1939\u201352.","journal-title":"Phytother Res"},{"issue":"1","key":"8916_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/biof.1694","volume":"47","author":"B Alikiaii","year":"2021","unstructured":"Alikiaii B, Bagherniya M, Askari G, Johnston TP, Sahebkar A. The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective. BioFactors. 2021;47(1):19\u201340.","journal-title":"BioFactors"},{"key":"8916_CR24","doi-asserted-by":"publisher","unstructured":"Jennings MR, Parks RJ. Curcumin as an Antiviral Agent. Viruses. 2020;12(11):1242. https:\/\/doi.org\/10.3390\/v12111242.","DOI":"10.3390\/v12111242"},{"key":"8916_CR25","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.2147\/DDDT.S327378","volume":"15","author":"Y Peng","year":"2021","unstructured":"Peng Y, Ao M, Dong B, Jiang Y, Yu L, Chen Z, et al. Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures. Drug Des Dev Ther. 2021;15:4503\u201325.","journal-title":"Drug Des Dev Ther"},{"issue":"5","key":"8916_CR26","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","volume":"27","author":"KR Kahkhaie","year":"2019","unstructured":"Kahkhaie KR, Mirhosseini A, Aliabadi A, Mohammadi A, Mousavi MJ, Haftcheshmeh SM, et al. Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology. 2019;27(5):885\u2013900.","journal-title":"Inflammopharmacology"},{"key":"8916_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.12.005","volume":"66","author":"A Mohammadi","year":"2019","unstructured":"Mohammadi A, Blesso CN, Barreto GE, Banach M, Majeed M, Sahebkar A. Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem. 2019;66:1\u201316.","journal-title":"J Nutr Biochem"},{"key":"8916_CR28","doi-asserted-by":"publisher","unstructured":"Shafabakhsh R, Pourhanifeh MH, Mirzaei HR, Sahebkar A, Asemi Z, Mirzaei H. Targeting regulatory T cells by curcumin: A potential for cancer immunotherapy. Pharmacological Research. 2019;147:104353. https:\/\/doi.org\/10.1016\/j.phrs.2019.104353.","DOI":"10.1016\/j.phrs.2019.104353"},{"issue":"1","key":"8916_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/biof.1066","volume":"39","author":"A Shehzad","year":"2013","unstructured":"Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. BioFactors. 2013;39(1):69\u201377.","journal-title":"BioFactors"},{"issue":"11","key":"8916_CR30","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1002\/ptr.6467","volume":"33","author":"A Karimi","year":"2019","unstructured":"Karimi A, Ghodsi R, Kooshki F, Karimi M, Asghariazar V, Tarighat-Esfanjani A. Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies. Phytother Res. 2019;33(11):2798\u2013820.","journal-title":"Phytother Res"},{"issue":"33","key":"8916_CR31","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.2174\/0929867328666210525124707","volume":"28","author":"A Ganji","year":"2021","unstructured":"Ganji A, Farahani I, Saeedifar AM, Mosayebi G, Ghazavi A, Majeed M, et al. Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity. Curr Med Chem. 2021;28(33):6915\u201330.","journal-title":"Curr Med Chem"},{"issue":"1","key":"8916_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","volume":"15","author":"SC Gupta","year":"2013","unstructured":"Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195\u2013218.","journal-title":"AAPS J"},{"issue":"6","key":"8916_CR33","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807\u201318.","journal-title":"Mol Pharm"},{"issue":"14","key":"8916_CR34","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1002\/jsfa.11372","volume":"101","author":"ME Abd El-Hack","year":"2021","unstructured":"Abd El-Hack ME, El-Saadony MT, Swelum AA, Arif M, Abo Ghanima MM, Shukry M, et al. Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J Sci Food Agric. 2021;101(14):5747\u201362.","journal-title":"J Sci Food Agric"},{"issue":"20","key":"8916_CR35","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"WM Association","year":"2013","unstructured":"Association WM. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191\u20134.","journal-title":"JAMA"},{"key":"8916_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12871-017-0369-4","volume":"17","author":"VRH Rai","year":"2017","unstructured":"Rai VRH, Phang LF, Sia SF, Amir A, Veerakumaran JS, Kassim MKA, et al. Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial. BMC Anesthesiol. 2017;17:1\u20137.","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"8916_CR37","first-page":"648","volume":"25","author":"MF Bernal-Orozco","year":"2010","unstructured":"Bernal-Orozco MF, Vizmanos B, Hunot C, Flores-Castro M, Leal-Mora D, Fern\u00e1ndez-Ballart J. Equation to estimate body weight in elderly Mexican women using anthropometric measurements. Nutr Hosp. 2010;25(4):648\u201355.","journal-title":"Nutr Hosp"},{"issue":"6","key":"8916_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1177\/0884533617716432","volume":"33","author":"MS Tarnowski","year":"2018","unstructured":"Tarnowski MS, Rabito EI, Fernandes D, Rosa M, Oliveira ML, Hirakata VN, et al. Height prediction from ulna length of critically ill patients. Nutr Clin Pract. 2018;33(6):887\u201392.","journal-title":"Nutr Clin Pract"},{"key":"8916_CR39","doi-asserted-by":"publisher","first-page":"1216708","DOI":"10.3389\/fendo.2023.1216708","volume":"14","author":"L Qiu","year":"2023","unstructured":"Qiu L, Gao C, Wang H, Ren Y, Li J, Li M, et al. Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol. 2023;14:1216708.","journal-title":"Front Endocrinol"},{"issue":"8","key":"8916_CR40","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1002\/ptr.7179","volume":"35","author":"H Zahedi","year":"2021","unstructured":"Zahedi H, Hosseinzadeh-Attar MJ, Shadnoush M, Sahebkar A, Barkhidarian B, Sadeghi O, et al. Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial. Phytother Res. 2021;35(8):4605\u201315.","journal-title":"Phytother Res"},{"issue":"5","key":"8916_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14093","volume":"46","author":"F Naeini","year":"2022","unstructured":"Naeini F, Tutunchi H, Razmi H, Mahmoodpoor A, Vajdi M, Sefidmooye Azar P, et al. Does nano-curcumin supplementation improve hematological indices in critically ill patients with sepsis? A randomized controlled clinical trial. J Food Biochem. 2022;46(5): e14093.","journal-title":"J Food Biochem"},{"key":"8916_CR42","doi-asserted-by":"publisher","unstructured":"Askari G, Bagherniya M, Kiani Z, Alikiaii B, Mirjalili M, Shojaei M, et al. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial. Application of Omic Techniques to Identify New Biomarkers and Drug Targets for COVID-19: Springer; 2023. p. 413\u201326. https:\/\/doi.org\/10.1007\/978-3-031-28012-2_22.","DOI":"10.1007\/978-3-031-28012-2_22"},{"key":"8916_CR43","doi-asserted-by":"crossref","unstructured":"da Silva TA, de Medeiros DC, da Silva Cunha de Medeiros RC, Medeiros RM, de Souza LB, de Medeiros JA, et al. Influence of curcumin on glycemic profile, inflammatory markers, and oxidative stress in HIV\u2010infected individuals: A randomized controlled trial. Phytotherapy research. 2020;34(9):2323\u201330.","DOI":"10.1002\/ptr.6683"},{"key":"8916_CR44","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fcell.2019.00108","volume":"7","author":"C Nedeva","year":"2019","unstructured":"Nedeva C, Menassa J, Puthalakath H. Sepsis: inflammation is a necessary evil. Frontiers in cell and developmental biology. 2019;7:108.","journal-title":"Frontiers in cell and developmental biology"},{"key":"8916_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155541","volume":"143","author":"AM Gorabi","year":"2021","unstructured":"Gorabi AM, Razi B, Aslani S, Abbasifard M, Imani D, Sathyapalan T, et al. Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials. Cytokine. 2021;143: 155541.","journal-title":"Cytokine"},{"issue":"11","key":"8916_CR46","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/nu10111618","volume":"10","author":"N Yahfoufi","year":"2018","unstructured":"Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):1618.","journal-title":"Nutrients"},{"issue":"9b","key":"8916_CR47","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1111\/j.1582-4934.2009.00711.x","volume":"13","author":"G Liang","year":"2009","unstructured":"Liang G, Zhou H, Wang Y, Gurley EC, Feng B, Chen L, et al. Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin. J Cell Mol Med. 2009;13(9b):3370\u20139.","journal-title":"J Cell Mol Med"},{"key":"8916_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2018.04.041","volume":"61","author":"L Chen","year":"2018","unstructured":"Chen L, Lu Y, Zhao L, Hu L, Qiu Q, Zhang Z, et al. Curcumin attenuates sepsis-induced acute organ dysfunction by preventing inflammation and enhancing the suppressive function of Tregs. Int Immunopharmacol. 2018;61:1\u20137.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"8916_CR49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13567-023-01149-x","volume":"54","author":"L Feng","year":"2023","unstructured":"Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y, et al. Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis. Vet Res. 2023;54(1):25.","journal-title":"Vet Res"},{"key":"8916_CR50","doi-asserted-by":"publisher","unstructured":"Panahi Y, Vahedian-Azimi A, Saadat A, Togeh G, Rahimibashar F, Fetrat MK, et al. The effects of curcumin on the side effects of anticancer drugs in chemotherapy: a randomized controlled trial. Natural Products and Human Diseases: Pharmacology, Molecular Targets, and Therapeutic Benefits. 2021:255\u201373. https:\/\/doi.org\/10.1007\/978-3-030-73234-9_17.","DOI":"10.1007\/978-3-030-73234-9_17"},{"issue":"1","key":"8916_CR51","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1080\/13880209.2017.1345951","volume":"55","author":"MS Hossen","year":"2017","unstructured":"Hossen MS, Tanvir E, Prince MB, Paul S, Saha M, Ali MY, et al. Protective mechanism of turmeric (Curcuma longa) on carbofuran-induced hematological and hepatic toxicities in a rat model. Pharm Biol. 2017;55(1):1937\u201345.","journal-title":"Pharm Biol"},{"issue":"8","key":"8916_CR52","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3109\/1061186X.2016.1157883","volume":"24","author":"W Liu","year":"2016","unstructured":"Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D, et al. Oral bioavailability of curcumin: problems and advancements. J Drug Target. 2016;24(8):694\u2013702.","journal-title":"J Drug Target"},{"issue":"04","key":"8916_CR53","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1055\/s-2006-957450","volume":"64","author":"G Shoba","year":"1998","unstructured":"Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(04):353\u20136.","journal-title":"Planta Med"},{"issue":"4","key":"8916_CR54","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1002\/ptr.7737","volume":"37","author":"H Heidari","year":"2023","unstructured":"Heidari H, Bagherniya M, Majeed M, Sathyapalan T, Jamialahmadi T, Sahebkar A. Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytother Res. 2023;37(4):1462\u201387.","journal-title":"Phytother Res"},{"issue":"6","key":"8916_CR55","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1258\/acb.2012.012040","volume":"49","author":"Y Panahi","year":"2012","unstructured":"Panahi Y, Sahebkar A, Parvin S, Saadat A. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem. 2012;49(6):580\u20138.","journal-title":"Ann Clin Biochem"},{"issue":"7","key":"8916_CR56","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1017\/S0007114511006544","volume":"108","author":"Y Panahi","year":"2012","unstructured":"Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL, et al. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2012;108(7):1272\u20139.","journal-title":"Br J Nutr"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-025-08916-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-025-08916-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-025-08916-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:01:09Z","timestamp":1749859269000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-025-08916-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,14]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["8916"],"URL":"https:\/\/doi.org\/10.1186\/s13063-025-08916-5","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,14]]},"assertion":[{"value":"10 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants provided informed written consent. The study procedure was performed according to CONSORT 2010 checklist. The study protocol was ethically approved by the local Ethics Committee of Isfahan University of Medical Sciences (Ethical code: IR.MUI.MED.REC.1399.759).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors approved the final version of the manuscript and agreed for all aspects of the work to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Anju Majeed is the Group Executive Chairperson of Sami-Sabinsa Group Limited. The other authors have nothing to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"205"}}