{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:21:23Z","timestamp":1793661683207,"version":"4.5.1"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009933","name":"Ethicon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009933","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-025-09006-2","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:38:31Z","timestamp":1758879511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Real-time 3D confirmation of complete ablation with margins as a local cure for colorectal liver metastases: the ACCLAIM trial"],"prefix":"10.1186","volume":"26","author":[{"given":"Constantinos T.","family":"Sofocleous","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Callstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Petre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithat","family":"Gonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Rilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeb","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Kelekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Soulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Crocetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian E.","family":"Dupuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Solbiati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"issue":"3","key":"9006_CR1","first-page":"177","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67(3):177\u201393.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"9006_CR2","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jamcollsurg.2009.12.040","volume":"210","author":"MG House","year":"2010","unstructured":"House MG, Ito H, G\u00f6nen M, Fong Y, Allen PJ, DeMatteo RP, et al. Survival after hepatic resection for metastatic colorectal cancer: trends in outcomes for 1,600 patients during two decades at a single institution. J Am Coll Surg. 2010;210(5):744\u201352, 52\u20135.","journal-title":"J Am Coll Surg"},{"issue":"3","key":"9006_CR3","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/SLA.0b013e3181b4539b","volume":"250","author":"MC de Jong","year":"2009","unstructured":"de Jong MC, Pulitano C, Ribero D, Strub J, Mentha G, Schulick RD, et al. Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg. 2009;250(3):440\u20138.","journal-title":"Ann Surg"},{"issue":"6","key":"9006_CR4","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.surg.2018.01.004","volume":"163","author":"JM Creasy","year":"2018","unstructured":"Creasy JM, Sadot E, Koerkamp BG, Chou JF, Gonen M, Kemeny NE, et al. Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure? Surgery. 2018;163(6):1238\u201344.","journal-title":"Surgery"},{"issue":"7","key":"9006_CR5","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1254::AID-CNCR5>3.0.CO;2-I","volume":"77","author":"B Nordlinger","year":"1996","unstructured":"Nordlinger B, Guiguet M, Vaillant JC, Balladur P, Boudjema K, Bachellier P, Jaeck D. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer. 1996;77(7):1254\u201362.","journal-title":"Cancer"},{"issue":"4","key":"9006_CR6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0039-6060(96)80133-4","volume":"119","author":"HJ Wanebo","year":"1996","unstructured":"Wanebo HJ, Chu QD, Avradopoulos KA, Vezeridis MP. Current perspectives on repeat hepatic resection for colorectal carcinoma: a review. Surgery. 1996;119(4):361\u201371.","journal-title":"Surgery"},{"issue":"6","key":"9006_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/00000658-200206000-00015","volume":"235","author":"H Petrowsky","year":"2002","unstructured":"Petrowsky H, Gonen M, Jarnagin W, Lorenz M, DeMatteo R, Heinrich S, et al. Second liver resections are safe and effective treatment for recurrent hepatic metastases from colorectal cancer: a bi-institutional analysis. Ann Surg. 2002;235(6):863\u201371.","journal-title":"Ann Surg"},{"issue":"6","key":"9006_CR8","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jvir.2011.01.451","volume":"22","author":"CT Sofocleous","year":"2011","unstructured":"Sofocleous CT, Petre EN, Gonen M, Brown KT, Solomon SB, Covey AM, et al. CT-guided radiofrequency ablation as a salvage treatment of colorectal cancer hepatic metastases developing after hepatectomy. J Vasc Interv Radiol. 2011;22(6):755\u201361.","journal-title":"J Vasc Interv Radiol"},{"issue":"1","key":"9006_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.gassur.2005.09.006","volume":"10","author":"Z Morise","year":"2006","unstructured":"Morise Z, Sugioka A, Fujita J, Hoshimoto S, Kato T, Hasumi A, et al. Does repeated surgery improve the prognosis of colorectal liver metastases? J Gastrointest Surg. 2006;10(1):6\u201311.","journal-title":"J Gastrointest Surg"},{"issue":"10","key":"9006_CR10","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1002\/bjs.4264","volume":"90","author":"A Oshowo","year":"2003","unstructured":"Oshowo A, Gillams A, Harrison E, Lees WR, Taylor I. Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases. Br J Surg. 2003;90(10):1240\u20133.","journal-title":"Br J Surg"},{"issue":"6","key":"9006_CR11","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.amjsurg.2008.04.013","volume":"197","author":"H Hur","year":"2009","unstructured":"Hur H, Ko YT, Min BS, Kim KS, Choi JS, Sohn SK, et al. Comparative study of resection and radiofrequency ablation in the treatment of solitary colorectal liver metastases. Am J Surg. 2009;197(6):728\u201336.","journal-title":"Am J Surg"},{"issue":"5","key":"9006_CR12","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.ejca.2013.12.008","volume":"50","author":"E Tanis","year":"2014","unstructured":"Tanis E, Nordlinger B, Mauer M, Sorbye H, van Coevorden F, Gruenberger T, et al. Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983. Eur J Cancer. 2014;50(5):912\u20139.","journal-title":"Eur J Cancer"},{"issue":"10","key":"9006_CR13","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1093\/annonc\/mds053","volume":"23","author":"T Ruers","year":"2012","unstructured":"Ruers T, Punt C, Van Coevorden F, Pierie JPEN, Borel-Rinkes I, Ledermann JA, et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol. 2012;23(10):2619\u201326.","journal-title":"Ann Oncol"},{"issue":"12","key":"9006_CR14","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","volume":"14","author":"B Nordlinger","year":"2013","unstructured":"Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208\u201315.","journal-title":"Lancet Oncol"},{"key":"9006_CR15","doi-asserted-by":"crossref","unstructured":"Jeon SH, Cho YK, Choi SA, Kim MY, HS L. Analysis of factors affecting local tumor progression of colorectal cancer liver metastasis after radiofrequency ablation. J Korean Soc Radiol. 2017;76(3):179\u201386.","DOI":"10.3348\/jksr.2017.76.3.179"},{"key":"9006_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-012-0377-1","author":"X Wang","year":"2012","unstructured":"Wang X, Sofocleous CT, Erinjeri JP, Petre EN, Gonen M, Do KG, et al. Margin size is an independent predictor of local tumor progression after ablation of colon cancer liver metastases. Cardiovasc Intervent Radiol. 2012. https:\/\/doi.org\/10.1007\/s00270-012-0377-1.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"2","key":"9006_CR17","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2214\/AJR.05.2079","volume":"188","author":"T Nakazawa","year":"2007","unstructured":"Nakazawa T, Kokubu S, Shibuya A, Ono K, Watanabe M, Hidaka H, et al. Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin. AJR Am J Roentgenol. 2007;188(2):480\u20138.","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"9006_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2478\/raon-2020-0004","volume":"54","author":"J Schaible","year":"2020","unstructured":"Schaible J, Pregler B, B\u00e4umler W, Einspieler I, Jung EM, Stroszczynski C, Beyer LP. Safety margin assessment after microwave ablation of liver tumors: inter- and intrareader variability. Radiol Oncol. 2020;54(1):57\u201361.","journal-title":"Radiol Oncol"},{"issue":"3","key":"9006_CR19","doi-asserted-by":"publisher","first-page":"758","DOI":"10.2214\/AJR.09.2954","volume":"195","author":"YS Kim","year":"2010","unstructured":"Kim YS, Lee WJ, Rhim H, Lim HK, Choi D, Lee JY. The minimal ablative margin of radiofrequency ablation of hepatocellular carcinoma (>2 and <5 cm) needed to prevent local tumor progression: 3D quantitative assessment using CT image fusion. AJR Am J Roentgenol. 2010;195(3):758\u201365.","journal-title":"AJR Am J Roentgenol"},{"issue":"1078","key":"9006_CR20","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170063","volume":"90","author":"XW Bo","year":"2017","unstructured":"Bo XW, Xu HX, Guo LH, Sun LP, Li XL, Zhao CK, et al. Ablative safety margin depicted by fusion imaging with post-treatment contrast-enhanced ultrasound and pre-treatment CECT\/CEMRI after radiofrequency ablation for liver cancers. Br J Radiol. 2017;90(1078): 20170063.","journal-title":"Br J Radiol"},{"issue":"9","key":"9006_CR21","doi-asserted-by":"publisher","first-page":"6489","DOI":"10.1007\/s00330-020-07579-x","volume":"31","author":"G Laimer","year":"2021","unstructured":"Laimer G, Jaschke N, Schullian P, Putzer D, Eberle G, Solbiati M, et al. Volumetric assessment of the periablational safety margin after thermal ablation of colorectal liver metastases. Eur Radiol. 2021;31(9):6489\u201399.","journal-title":"Eur Radiol"},{"issue":"9","key":"9006_CR22","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1111\/hepr.12049","volume":"43","author":"Y Makino","year":"2013","unstructured":"Makino Y, Imai Y, Igura T, Hori M, Fukuda K, Sawai Y, et al. Utility of computed tomography fusion imaging for the evaluation of the ablative margin of radiofrequency ablation for hepatocellular carcinoma and the correlation to local tumor progression. Hepatol Res. 2013;43(9):950\u20138.","journal-title":"Hepatol Res"},{"key":"9006_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.623098","volume":"11","author":"RM Sandu","year":"2021","unstructured":"Sandu RM, Paolucci I, Ruiter SJS, Sznitman R, de Jong KP, Freedman J, et al. Volumetric quantitative ablation margins for assessment of ablation completeness in thermal ablation of liver tumors. Front Oncol. 2021;11: 623098.","journal-title":"Front Oncol"},{"issue":"3","key":"9006_CR24","doi-asserted-by":"publisher","first-page":"707","DOI":"10.2214\/ajr.183.3.1830707","volume":"183","author":"SG Silverman","year":"2004","unstructured":"Silverman SG, Sun MR, Tuncali K, Morrison PR, vanSonnenberg E, Shankar S, et al. Three-dimensional assessment of MRI-guided percutaneous cryotherapy of liver metastases. AJR Am J Roentgenol. 2004;183(3):707\u201312.","journal-title":"AJR Am J Roentgenol"},{"issue":"12","key":"9006_CR25","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1007\/s11548-018-1765-z","volume":"13","author":"F Vandenbroucke","year":"2018","unstructured":"Vandenbroucke F, Vandemeulebroucke J, Buls N, Thoeni RF, de Mey J. Can tumor coverage evaluated 24 h post-radiofrequency ablation predict local tumor progression of liver metastases? Int J Comput Assist Radiol Surg. 2018;13(12):1981\u20139.","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"9006_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-024-10632-8","author":"YM Lin","year":"2024","unstructured":"Lin YM, Paolucci I, Albuquerque Marques Silva J, O\u2019Connor CS, Hong J, Shah KY, et al. Ablative margin quantification using deformable versus rigid image registration in colorectal liver metastasis thermal ablation: a retrospective single-center study. Eur Radiol. 2024. https:\/\/doi.org\/10.1007\/s00330-024-10632-8.","journal-title":"Eur Radiol"},{"issue":"1","key":"9006_CR27","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1080\/02656736.2022.2055795","volume":"39","author":"N Vasiniotis Kamarinos","year":"2022","unstructured":"Vasiniotis Kamarinos N, Gonen M, Sotirchos V, Kaye E, Petre EN, Solomon SB, et al. 3D margin assessment predicts local tumor progression after ablation of colorectal cancer liver metastases. Int J Hyperthermia. 2022;39(1):880\u20137.","journal-title":"Int J Hyperthermia"},{"issue":"1","key":"9006_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/02656736.2019.1569267","volume":"36","author":"M Solbiati","year":"2019","unstructured":"Solbiati M, Muglia R, Goldberg SN, Ierace T, Rotilio A, Passera KM, et al. A novel software platform for volumetric assessment of ablation completeness. Int J Hyperthermia. 2019;36(1):337\u201343.","journal-title":"Int J Hyperthermia"},{"issue":"6","key":"9006_CR29","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s11548-016-1398-z","volume":"11","author":"S Tani","year":"2016","unstructured":"Tani S, Tatli S, Hata N, Garcia-Rojas X, Olubiyi OI, Silverman SG, Tokuda J. Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map. Int J Comput Assist Radiol Surg. 2016;11(6):1133\u201342.","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"9006_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2022.110552","volume":"156","author":"RA Faber","year":"2022","unstructured":"Faber RA, Burghout KST, Bijlstra OD, Hendriks P, van Erp GCM, Broersen A, et al. Three-dimensional quantitative margin assessment in patients with colorectal liver metastases treated with percutaneous thermal ablation using semi-automatic rigid MRI\/CECT-CECT co-registration. Eur J Radiol. 2022;156: 110552.","journal-title":"Eur J Radiol"},{"key":"9006_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5809-0","author":"EA Kaye","year":"2018","unstructured":"Kaye EA, Cornelis FH, Petre EN, Tyagi N, Shady W, Shi W, et al. Volumetric 3d assessment of ablation zones after thermal ablation of colorectal liver metastases to improve prediction of local tumor progression. Eur Radiol. 2018. https:\/\/doi.org\/10.1007\/s00330-018-5809-0.","journal-title":"Eur Radiol"},{"key":"9006_CR32","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7586","volume":"346","author":"AW Chan","year":"2013","unstructured":"Chan AW, Tetzlaff JM, G\u00f8tzsche PC, Altman DG, Mann H, Berlin JA, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346: e7586.","journal-title":"BMJ"},{"issue":"1","key":"9006_CR33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1148\/radiol.14132958","volume":"273","author":"M Ahmed","year":"2014","unstructured":"Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria\u2013a 10-year update. Radiology. 2014;273(1):241\u201360.","journal-title":"Radiology"},{"key":"9006_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.963966","volume":"13","author":"SSR Vulasala","year":"2023","unstructured":"Vulasala SSR, Sutphin PD, Kethu S, Onteddu NK, Kalva SP. Interventional radiological therapies in colorectal hepatic metastases. Front Oncol. 2023;13: 963966.","journal-title":"Front Oncol"},{"issue":"10207","key":"9006_CR35","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","volume":"394","author":"E Dekker","year":"2019","unstructured":"Dekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB. Colorectal cancer. Lancet. 2019;394(10207):1467\u201380.","journal-title":"Lancet"},{"key":"9006_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/annonc\/mdp130","volume":"20 Suppl 4","author":"E Van Cutsem","year":"2009","unstructured":"Van Cutsem E, Oliveira J. Advanced colorectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2009;20 Suppl 4:61\u20133.","journal-title":"Ann Oncol"},{"issue":"2","key":"9006_CR37","first-page":"e82","volume":"20","author":"I Kurilova","year":"2021","unstructured":"Kurilova I, Bendet A, Petre EN, Boas FE, Kaye E, Gonen M, et al. Factors associated with local tumor control and complications after thermal ablation of colorectal cancer liver metastases: a 15-year retrospective cohort study. Clin Colorectal Cancer. 2021;20(2):e82\u201395.","journal-title":"Clin Colorectal Cancer"},{"issue":"1","key":"9006_CR38","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1037\/1082-989X.2.1.64","volume":"2","author":"D Hedeker","year":"1997","unstructured":"Hedeker D, Gibbons RD. Application of random-effects pattern-mixture models for missing data in longitudinal studies. Psychological Methods. 1997;2(1):64\u201378. https:\/\/doi.org\/10.1037\/1082-989X.2.1.64.","journal-title":"Psychological Methods"},{"issue":"431","key":"9006_CR39","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1080\/01621459.1995.10476615","volume":"90","author":"RJA Little","year":"1995","unstructured":"Little RJA. Modeling the drop-out mechanism in repeated-measures studies. J Am Stat Assoc. 1995;90(431):1112\u201321.","journal-title":"J Am Stat Assoc"},{"issue":"3","key":"9006_CR40","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1148\/radiol.12111851","volume":"265","author":"L Solbiati","year":"2012","unstructured":"Solbiati L, Ahmed M, Cova L, Ierace T, Brioschi M, Goldberg SN. Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. Radiology. 2012;265(3):958\u201368.","journal-title":"Radiology"},{"issue":"7","key":"9006_CR41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11547-014-0415-y","volume":"119","author":"TJ Vogl","year":"2014","unstructured":"Vogl TJ, Farshid P, Naguib NN, Darvishi A, Bazrafshan B, Mbalisike E, et al. Thermal ablation of liver metastases from colorectal cancer: radiofrequency, microwave and laser ablation therapies. Radiol Med. 2014;119(7):451\u201361.","journal-title":"Radiol Med"},{"issue":"6","key":"9006_CR42","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s11547-013-0968-1","volume":"118","author":"AM Ierardi","year":"2013","unstructured":"Ierardi AM, Floridi C, Fontana F, Chini C, Giorlando F, Piacentino F, et al. Microwave ablation of liver metastases to overcome the limitations of radiofrequency ablation. Radiol Med. 2013;118(6):949\u201361.","journal-title":"Radiol Med"},{"issue":"1","key":"9006_CR43","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1080\/00015458.2014.11680975","volume":"114","author":"XG Zhang","year":"2014","unstructured":"Zhang XG, Zhang ZL, Hu SY, Wang YL. Ultrasound-guided ablative therapy for hepatic malignancies: a comparison of the therapeutic effects of microwave and radiofrequency ablation. Acta Chir Belg. 2014;114(1):40\u20135.","journal-title":"Acta Chir Belg"},{"issue":"2","key":"9006_CR44","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jvir.2017.08.021","volume":"29","author":"W Shady","year":"2018","unstructured":"Shady W, Petre EN, Do KG, Gonen M, Yarmohammadi H, Brown KT, et al. Percutaneous microwave versus radiofrequency ablation of colorectal liver metastases: ablation with clear margins (A0) provides the best local tumor control. J Vasc Interv Radiol. 2018;29(2):268-75.e1.","journal-title":"J Vasc Interv Radiol"},{"issue":"6","key":"9006_CR45","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/02656736.2017.1368095","volume":"34","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zheng J, Chen H, Hu C, Sun B, Wang H, et al. A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation. Int J Hyperthermia. 2018;34(6):853\u201362.","journal-title":"Int J Hyperthermia"},{"issue":"6","key":"9006_CR46","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1046\/j.1365-2168.2002.02081.x","volume":"89","author":"D Elias","year":"2002","unstructured":"Elias D, De Baere T, Smayra T, Ouellet JF, Roche A, Lasser P. Percutaneous radiofrequency thermoablation as an alternative to surgery for treatment of liver tumour recurrence after hepatectomy. Br J Surg. 2002;89(6):752\u20136.","journal-title":"Br J Surg"},{"issue":"2","key":"9006_CR47","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1148\/radiol.2015142489","volume":"278","author":"W Shady","year":"2016","unstructured":"Shady W, Petre EN, Gonen M, Erinjeri JP, Brown KT, Covey AM, et al. Percutaneous radiofrequency ablation of colorectal cancer liver metastases: factors affecting outcomes\u2013a 10-year experience at a single center. Radiology. 2016;278(2):601\u201311.","journal-title":"Radiology"},{"issue":"3","key":"9006_CR48","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1148\/radiol.2016151005","volume":"280","author":"VS Sotirchos","year":"2016","unstructured":"Sotirchos VS, Petrovic LM, Gonen M, Klimstra DS, Do RK, Petre EN, et al. Colorectal cancer liver metastases: biopsy of the ablation zone and margins can be used to predict oncologic outcome. Radiology. 2016;280(3):949\u201359.","journal-title":"Radiology"},{"key":"9006_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2024.01.001","author":"M Zirakchian Zadeh","year":"2024","unstructured":"Zirakchian Zadeh M, Sotirchos VS, Kirov A, Lafontaine D, G\u00f6nen M, Yeh R, et al. Three-dimensional margin as a predictor of local tumor progression after microwave ablation: intraprocedural versus 4-8-week postablation assessment. J Vasc Interv Radiol. 2024. https:\/\/doi.org\/10.1016\/j.jvir.2024.01.001.","journal-title":"J Vasc Interv Radiol"},{"issue":"4","key":"9006_CR50","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/RLI.0000000000001023","volume":"59","author":"YM Lin","year":"2024","unstructured":"Lin YM, Paolucci I, Albuquerque Marques Silva J, O\u2019Connor CS, Fellman BM, Jones AK, et al. Intraprocedural versus initial follow-up minimal ablative margin assessment after colorectal liver metastasis thermal ablation: which one better predicts local outcomes? Invest Radiol. 2024;59(4):314\u20139.","journal-title":"Invest Radiol"},{"issue":"10","key":"9006_CR51","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1093\/annonc\/mds053","volume":"23","author":"T Ruers","year":"2012","unstructured":"Ruers T, Punt C, Van Coevorden F, Pierie JP, Borel-Rinkes I, Ledermann JA, et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol. 2012;23(10):2619\u201326.","journal-title":"Ann Oncol"},{"issue":"8","key":"9006_CR52","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s00270-018-1959-3","volume":"41","author":"MR Meijerink","year":"2018","unstructured":"Meijerink MR, Puijk RS, van Tilborg A, Henningsen KH, Fernandez LG, Neyt M, et al. Radiofrequency and microwave ablation compared to systemic chemotherapy and to partial hepatectomy in the treatment of colorectal liver metastases: a systematic review and meta-analysis. Cardiovasc Intervent Radiol. 2018;41(8):1189\u2013204.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"9","key":"9006_CR53","doi-asserted-by":"publisher","first-page":"djx015","DOI":"10.1093\/jnci\/djx015","volume":"109","author":"T Ruers","year":"2017","unstructured":"Ruers T, Van Coevorden F, Punt CJ, Pierie JE, Borel-Rinkes I, Ledermann JA, et al. Local treatment of unresectable colorectal liver metastases: results of a randomized phase ii trial. J Natl Cancer Inst. 2017;109(9):djx015.","journal-title":"J Natl Cancer Inst"},{"key":"9006_CR54","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejca.2023.03.038","volume":"187","author":"P Tinguely","year":"2023","unstructured":"Tinguely P, Ruiter SJS, Engstrand J, de Haas RJ, Nilsson H, Candinas D, et al. A prospective multicentre trial on survival after microwave ablation versus resection for resectable colorectal liver metastases (MAVERRIC). Eur J Cancer. 2023;187:65\u201376.","journal-title":"Eur J Cancer"},{"key":"9006_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030693","author":"N Vasiniotis Kamarinos","year":"2022","unstructured":"Vasiniotis Kamarinos N, Vakiani E, Gonen M, Kemeny NE, Sigel C, Saltz LB, et al. Biopsy and margins optimize outcomes after thermal ablation of colorectal liver metastases. Cancers (Basel). 2022. https:\/\/doi.org\/10.3390\/cancers14030693.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"9006_CR56","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jvir.2021.11.008","volume":"33","author":"N Vasiniotis Kamarinos","year":"2022","unstructured":"Vasiniotis Kamarinos N, Vakiani E, Fujisawa S, Gonen M, Fan N, Romin Y, et al. Immunofluorescence assay of ablated colorectal liver metastases: the frozen section of image-guided tumor ablation? J Vasc Interv Radiol. 2022;33(3):308-15.e1.","journal-title":"J Vasc Interv Radiol"},{"issue":"17_suppl","key":"9006_CR57","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA3501","volume":"42","author":"MR Meijerink","year":"2024","unstructured":"Meijerink MR, van der Lei S, Dijkstra M, Versteeg KS, Buffart TE, Lissenberg-Witte BI, et al. Surgery versus thermal ablation for small-size colorectal liver metastases (COLLISION): an international, multicenter, phase III randomized controlled trial. J Clin Oncol. 2024;42(17_suppl): LBA3501-LBA.","journal-title":"J Clin Oncol"},{"issue":"2","key":"9006_CR58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1470-2045(24)00660-0","volume":"26","author":"S van der Lei","year":"2025","unstructured":"van der Lei S, Puijk RS, Dijkstra M, Schulz HH, Vos DJW, De Vries JJJ, et al. Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): an international, randomised, controlled, phase 3 non-inferiority trial. Lancet Oncol. 2025;26(2):187\u201399.","journal-title":"Lancet Oncol"},{"issue":"1","key":"9006_CR59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00270-023-03573-0","volume":"47","author":"PL Pereira","year":"2024","unstructured":"Pereira PL, Bale R, Fretland \u00c5A, Goldberg SN, Helmberger T, Meijerink MR, et al. Local tumour control following microwave ablation: protocol for the prospective observational CIEMAR study. Cardiovasc Intervent Radiol. 2024;47(1):121\u20139.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"3","key":"9006_CR60","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.radonc.2018.06.035","volume":"129","author":"F Petrelli","year":"2018","unstructured":"Petrelli F, Comito T, Barni S, Pancera G, Scorsetti M, Ghidini A. Stereotactic body radiotherapy for colorectal cancer liver metastases: a systematic review. Radiother Oncol. 2018;129(3):427\u201334.","journal-title":"Radiother Oncol"},{"issue":"10185","key":"9006_CR61","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/S0140-6736(18)32487-5","volume":"393","author":"DA Palma","year":"2019","unstructured":"Palma DA, Olson R, Harrow S, Gaede S, Louie AV, Haasbeek C, et al. Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial. Lancet. 2019;393(10185):2051\u20138.","journal-title":"Lancet"},{"issue":"25","key":"9006_CR62","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1200\/JCO.20.00818","volume":"38","author":"DA Palma","year":"2020","unstructured":"Palma DA, Olson R, Harrow S, Gaede S, Louie AV, Haasbeek C, et al. Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: long-term results of the SABR-COMET phase II randomized trial. J Clin Oncol. 2020;38(25):2830\u20138.","journal-title":"J Clin Oncol"},{"issue":"4","key":"9006_CR63","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.ijrobp.2022.05.004","volume":"114","author":"S Harrow","year":"2022","unstructured":"Harrow S, Palma DA, Olson R, Gaede S, Louie AV, Haasbeek C, et al. Stereotactic radiation for the comprehensive treatment of oligometastases (SABR-COMET): extended long-term outcomes. Int J Radiat Oncol Biol Phys. 2022;114(4):611\u20136.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10256","key":"9006_CR64","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(20)32023-7","volume":"396","author":"NV Kamarinos","year":"2020","unstructured":"Kamarinos NV, Dawson LA, Saltz LB, Crane CH, Overman MJ, Vauthey JN, et al. Trials of locoregional therapies inspired by SABR-COMET. Lancet. 2020;396(10256):956\u20137.","journal-title":"Lancet"},{"issue":"9","key":"9006_CR65","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1007\/s00432-018-2692-7","volume":"144","author":"C Franzese","year":"2018","unstructured":"Franzese C, Comito T, Clerici E, Di Brina L, Tomatis S, Navarria P, et al. Liver metastases from colorectal cancer: propensity score-based comparison of stereotactic body radiation therapy vs. microwave ablation. J Cancer Res Clin Oncol. 2018;144(9):1777\u201383.","journal-title":"J Cancer Res Clin Oncol"},{"key":"9006_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174303","author":"S Nieuwenhuizen","year":"2021","unstructured":"Nieuwenhuizen S, Dijkstra M, Puijk RS, Timmer FEF, Nota IM, Opperman J, et al. Thermal ablation versus stereotactic ablative body radiotherapy to treat unresectable colorectal liver metastases: a comparative analysis from the prospective Amsterdam CORE registry. Cancers (Basel). 2021. https:\/\/doi.org\/10.3390\/cancers13174303.","journal-title":"Cancers (Basel)"},{"issue":"8","key":"9006_CR67","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1007\/s00270-023-03498-8","volume":"46","author":"S van der Lei","year":"2023","unstructured":"van der Lei S, Dijkstra M, Nieuwenhuizen S, Schulz HH, Vos DJW, Versteeg KS, et al. Unresectable intermediate-size (3\u20135 cm) colorectal liver metastases: stereotactic ablative body radiotherapy versus microwave ablation (COLLISION-XL): protocol of a phase II\/III multicentre randomized controlled trial. Cardiovasc Intervent Radiol. 2023;46(8):1076\u201385.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"4","key":"9006_CR68","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1067\/msy.2002.127545","volume":"132","author":"BW Kuvshinoff","year":"2002","unstructured":"Kuvshinoff BW, Ota DM. Radiofrequency ablation of liver tumors: influence of technique and tumor size. Surgery. 2002;132(4):605\u201311; discussion 11-2.","journal-title":"Surgery"},{"issue":"1","key":"9006_CR69","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1148\/radiol.2020200109","volume":"298","author":"K Han","year":"2021","unstructured":"Han K, Kim JH, Yang SG, Park SH, Choi HK, Chun SY, et al. A single-center retrospective analysis of periprocedural variables affecting local tumor progression after radiofrequency ablation of colorectal cancer liver metastases. Radiology. 2021;298(1):212\u20138.","journal-title":"Radiology"},{"issue":"6","key":"9006_CR70","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.2214\/AJR.07.2798","volume":"190","author":"SK Kei","year":"2008","unstructured":"Kei SK, Rhim H, Choi D, Lee WJ, Lim HK, Kim YS. Local tumor progression after radiofrequency ablation of liver tumors: analysis of morphologic pattern and site of recurrence. AJR Am J Roentgenol. 2008;190(6):1544\u201351.","journal-title":"AJR Am J Roentgenol"},{"issue":"6","key":"9006_CR71","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.2214\/AJR.07.2798","volume":"190","author":"SK Kei","year":"2008","unstructured":"Kei SK, Rhim H, Choi D, Lee WJ, Lim HK, Kim YS. Local tumor progression after radiofrequency ablation of liver tumors: analysis of morphologic pattern and site of recurrence. AJR Am J Roentgenol. 2008;190(6):1544\u201351.","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"9006_CR72","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221373","volume":"307","author":"YM Lin","year":"2023","unstructured":"Lin YM, Paolucci I, O\u2019Connor CS, Anderson BM, Rigaud B, Fellman BM, et al. Ablative margins of colorectal liver metastases using deformable CT image registration and autosegmentation. Radiology. 2023;307(2): e221373.","journal-title":"Radiology"},{"issue":"8","key":"9006_CR73","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.acra.2006.05.011","volume":"13","author":"C Fujioka","year":"2006","unstructured":"Fujioka C, Horiguchi J, Ishifuro M, Kakizawa H, Kiguchi M, Matsuura N, et al. A feasibility study: evaluation of radiofrequency ablation therapy to hepatocellular carcinoma using image registration of preoperative and postoperative CT. Acad Radiol. 2006;13(8):986\u201394.","journal-title":"Acad Radiol"},{"key":"9006_CR74","doi-asserted-by":"crossref","unstructured":"Kaye EA, Cornelis FH, Petre EN, Tyagi N, Shady W, Shi W, et al. Volumetric 3D assessment of ablation zones after thermal ablation of colorectal liver metastases to improve prediction of local tumor progression. Eur Radiol. 2018;In Press.","DOI":"10.1007\/s00330-018-5809-0"},{"key":"9006_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15245806","author":"DD Chlorogiannis","year":"2023","unstructured":"Chlorogiannis DD, Sotirchos VS, Georgiades C, Filippiadis D, Arellano RS, Gonen M, et al. The importance of optimal thermal ablation margins in colorectal liver metastases: a systematic review and meta-analysis of 21 studies. Cancers (Basel). 2023. https:\/\/doi.org\/10.3390\/cancers15245806.","journal-title":"Cancers (Basel)"},{"key":"9006_CR76","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae165","author":"I Paolucci","year":"2024","unstructured":"Paolucci I, Albuquerque Marques Silva J, Lin YM, Laimer G, Cignini V, Menchini F, et al. Identification of a0 minimum ablative margins for colorectal liver metastases: multicentre, retrospective study using deformable CT registration and artificial intelligence-based autosegmentation. Br J Surg. 2024. https:\/\/doi.org\/10.1093\/bjs\/znae165.","journal-title":"Br J Surg"},{"issue":"5","key":"9006_CR77","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S2468-1253(25)00024-X","volume":"10","author":"BC Odisio","year":"2025","unstructured":"Odisio BC, Albuquerque J, Lin YM, Anderson BM, O\u2019Connor CS, Rigaud B, et al. Software-based versus visual assessment of the minimal ablative margin in patients with liver tumours undergoing percutaneous thermal ablation (COVER-ALL): a randomised phase 2 trial. Lancet Gastroenterol Hepatol. 2025;10(5):442\u201351.","journal-title":"Lancet Gastroenterol Hepatol"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-025-09006-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-025-09006-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-025-09006-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:05:16Z","timestamp":1758881116000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/s13063-025-09006-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9006"],"URL":"https:\/\/doi.org\/10.1186\/s13063-025-09006-2","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"360"}}