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Written, informed consent to participate will be obtained from all participants. This trial does not involve collecting biological specimens for storage. In the informed consent form, all provisions related to posttrial care, potential risks, and compensation have been explicitly addressed and thoroughly communicated to participants. Specifically, participants are informed that no harm is anticipated from their involvement, that routine clinical care will continue uninterrupted during and after the trial, and that any adverse events related to the study will be managed by the research team, including coverage of treatment costs and compensation if necessary.Any protocol amendments will be promptly documented and submitted to the relevant ethics committee for approval prior to implementation. Significant changes will be communicated to participants and study personnel as appropriate. 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