{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:06:14Z","timestamp":1771297574310,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/s13063-026-09463-3","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:53:17Z","timestamp":1769053997000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect and safety of mivacurium chloride and succinylcholine for bronchoscopy: study protocol for a single-center, randomized, non-inferiority, and positive-controlled clinical trial"],"prefix":"10.1186","volume":"27","author":[{"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-1694","authenticated-orcid":false,"given":"Peng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"9463_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.596925","volume":"7","author":"J Jiang","year":"2020","unstructured":"Jiang J, Chang SH, Kent AJ, Geraci TC, Cerfolio RJ. Current novel advances in bronchoscopy. Front Surg. 2020;7:596925. https:\/\/doi.org\/10.3389\/fsurg.2020.596925.","journal-title":"Front Surg"},{"issue":"8","key":"9463_CR2","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1080\/02770903.2016.1276587","volume":"54","author":"C Bellinger","year":"2017","unstructured":"Bellinger C, Bleecker ER, Peters S, Pascual R, Krings J, Smith R, et al. Effects of bronchoscopy on lung function in asthmatics. J Asthma. 2017;54(8):866\u201371. https:\/\/doi.org\/10.1080\/02770903.2016.1276587.","journal-title":"J Asthma"},{"key":"9463_CR3","doi-asserted-by":"publisher","unstructured":"The application value of laryngeal mask airway general anesthesia in pa inless bronchoscopy and its influence on the sense of comfort and satisfaction. SV. https:\/\/doi.org\/10.22514\/sv.2023.103","DOI":"10.22514\/sv.2023.103"},{"key":"9463_CR4","doi-asserted-by":"publisher","unstructured":"Schreiber J-U, Lysakowski C, Fuchs-Buder T, Tram\u00e8r Martin\u00a0R. Prevention of Succinylcholine-induced Fasciculation and Myalgia. Anesthesiology. 103(4):877\u2013884. https:\/\/doi.org\/10.1097\/00000542-200510000-00027","DOI":"10.1097\/00000542-200510000-00027"},{"issue":"1","key":"9463_CR5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/00000542-200601000-00022","volume":"104","author":"JAJ Martyn","year":"2006","unstructured":"Martyn JAJ, Richtsfeld M. Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology. 2006;104(1):158\u201369. https:\/\/doi.org\/10.1097\/00000542-200601000-00022.","journal-title":"Anesthesiology"},{"issue":"4","key":"9463_CR6","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/bja\/aev306","volume":"115","author":"TK Kim","year":"2015","unstructured":"Kim TK, Niklewski PJ, Martin JF, Obara S, Egan TD. Enhancing a sedation score to include truly noxious stimulation: the extended observer\u2019s assessment of alertness and sedation (EOAA\/S). Br J Anaesth. 2015;115(4):569\u201377. https:\/\/doi.org\/10.1093\/bja\/aev306.","journal-title":"Br J Anaesth"},{"issue":"1","key":"9463_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/lbr.0000000000000784","volume":"29","author":"NJ Pastis","year":"2022","unstructured":"Pastis NJ, Hill NT, Yarmus LB, Schippers F, Imre M, Sohngen W, et al. Correlation of vital signs and depth of sedation by modified observer\u2019 s assessment of alertness and sedation (MOAA\/S) scale in bronchoscopy. J Bronchol Interv Pulmonol. 2022;29(1):54\u201361. https:\/\/doi.org\/10.1097\/lbr.0000000000000784.","journal-title":"J Bronchol Interv Pulmonol"},{"issue":"2","key":"9463_CR8","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0952-8180(92)90034-x","volume":"4","author":"SJ Basta","year":"1992","unstructured":"Basta SJ. Clinical pharmacology of mivacurium chloride: a review. J Clin Anesth. 1992;4(2):153\u201363. https:\/\/doi.org\/10.1016\/0952-8180(92)90034-x.","journal-title":"J Clin Anesth"},{"issue":"17","key":"9463_CR9","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000003441","volume":"95","author":"R-C Huang","year":"2016","unstructured":"Huang R-C, Hung N-K, Lu C-H, Wu Z-F. Removal of laryngeal mask airway in adults under target-controlled, propofol-fentanyl infusion anesthesia. Medicine (Baltimore). 2016;95(17):e3441. https:\/\/doi.org\/10.1097\/md.0000000000003441.","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"9463_CR10","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1093\/bja\/aer503","volume":"108","author":"MK S\u00f8rensen","year":"2012","unstructured":"S\u00f8rensen MK, Bretlau C, G\u00e4tke MR, S\u00f8rensen AM, Rasmussen LS. Rapid sequence induction and intubation with rocuronium\u2013sugammadex com pared with succinylcholine: a randomized trial. Br J Anaesth. 2012;108(4):682\u20139. https:\/\/doi.org\/10.1093\/bja\/aer503.","journal-title":"Br J Anaesth"},{"key":"9463_CR11","doi-asserted-by":"publisher","unstructured":"Lee C, Jahr Jonathan S, Candiotti Keith A, Warriner B, Zornow Mark H, Naguib M. Reversal of Profound Neuromuscular Block by Sugammadex Administered Three Minutes after Rocuronium. Anesthesiology. 110(5):1020\u20131025. https:\/\/doi.org\/10.1097\/aln.0b013e31819dabb0","DOI":"10.1097\/aln.0b013e31819dabb0"},{"issue":"3","key":"9463_CR12","doi-asserted-by":"publisher","first-page":"414","DOI":"10.12025\/j.issn.1008-6358.2023.20230181","volume":"30","author":"Y-x Li","year":"2023","unstructured":"Li Y-x, Ma Y-m, Du F, Shi Y-c, Cang J, Miao C-h, et al. Rapid sequence induction and intubation with a divided dose of mivacurium compared with rocuronium: a non-inferiority clinical trial. Chin J Clin Med. 2023;30(3):414\u201320. https:\/\/doi.org\/10.12025\/j.issn.1008-6358.2023.20230181.","journal-title":"Chin J Clin Med."},{"issue":"9","key":"9463_CR13","doi-asserted-by":"publisher","DOI":"10.2196\/28018","volume":"23","author":"L Vogt","year":"2021","unstructured":"Vogt L, Klasen M, Rossaint R, Goeretz U, Ebus P, Sopka S. Virtual reality tour to reduce perioperative anxiety in an operating S etting before anesthesia: randomized clinical trial. J Med Internet Res. 2021;23(9):e28018. https:\/\/doi.org\/10.2196\/28018.","journal-title":"J Med Internet Res"},{"key":"9463_CR14","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000126935.87196.4c","author":"R Miller","year":"2004","unstructured":"Miller R. Will succinylcholine ever disappear? Anesth Analg. 2004. https:\/\/doi.org\/10.1213\/01.ane.0000126935.87196.4c.","journal-title":"Anesth Analg"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13063-026-09463-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-026-09463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13063-026-09463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:03:55Z","timestamp":1771293835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s13063-026-09463-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["9463"],"URL":"https:\/\/doi.org\/10.1186\/s13063-026-09463-3","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"23 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent will be obtained from all participants, or their legal representatives, in writing prior to inclusion in the trial. The study protocol has been approved by the Medical Ethics Committee of the West China Hospital, Sichuan University, on September 20, 2024 (Approval No. 1625). This study is registered with the Chinese Clinical Trial Registry (ChiCTR2400091276, registered on 23 October 2024) and with ClinicalTrials.gov (NCT06709066).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate {24}"}},{"value":"Not applicable. No identifying images or personal details of participants are included in this protocol or will be included in the trial results. A model consent form is available from the corresponding author upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication {32}"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests {28}"}}],"article-number":"137"}}