{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:45:12Z","timestamp":1740145512464,"version":"3.37.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD092381","HD092381","HD092381","HD092381"],"award-info":[{"award-number":["HD092381","HD092381","HD092381","HD092381"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neural Dev"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neural progenitors produce diverse cells in a stereotyped birth order, but can specify each cell type for only a limited duration. In the <jats:italic>Drosophila<\/jats:italic> embryo, neuroblasts (neural progenitors) specify multiple, distinct neurons by sequentially expressing a series of temporal identity transcription factors with each division. Hunchback (Hb), the first of the series, specifies early-born neuronal identity. Neuroblast competence to generate early-born neurons is terminated when the <jats:italic>hb<\/jats:italic> gene relocates to the neuroblast nuclear lamina, rendering it refractory to activation in descendent neurons. Mechanisms and trans-acting factors underlying this process are poorly understood. Here we identify Corto, an enhancer of Trithorax\/Polycomb (ETP) protein, as a new regulator of neuroblast competence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We used the GAL4\/UAS system to drive persistent misexpression of Hb in neuroblast 7\u20131 (NB7-1), a model lineage for which the early competence window has been well characterized, to examine the role of Corto in neuroblast competence. We used immuno-DNA Fluorescence <jats:italic>in situ<\/jats:italic> hybridization (DNA FISH) in whole embryos to track the position of the <jats:italic>hb<\/jats:italic> gene locus specifically in neuroblasts across developmental time, comparing <jats:italic>corto<\/jats:italic> mutants\u00a0to control embryos. Finally, we used immunostaining in whole embryos to examine Corto\u2019s role in repression of Hb and a known target gene, Abdominal B (Abd-B).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found that in <jats:italic>corto<\/jats:italic> mutants, the <jats:italic>hb<\/jats:italic>\u00a0gene relocation to the neuroblast nuclear lamina is delayed and the early competence window is extended. The delay in gene relocation occurs after <jats:italic>hb<\/jats:italic> transcription is already terminated in the neuroblast and is not due to prolonged transcriptional activity. Further, we find that Corto genetically interacts with Posterior Sex Combs (Psc), a core subunit of polycomb group complex 1 (PRC1), to terminate early competence. Loss of Corto does not result in derepression of Hb or its Hox target, Abd-B, specifically in neuroblasts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These results show that in neuroblasts, Corto genetically interacts with PRC1 to regulate timing of nuclear architecture reorganization and support the model that distinct mechanisms of silencing are implemented in a step-wise fashion during development to regulate cell fate gene expression in neuronal progeny.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13064-022-00159-3","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T20:06:39Z","timestamp":1645128399000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancer of trithorax\/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts"],"prefix":"10.1186","volume":"17","author":[{"given":"Terry L.","family":"Hafer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofiya","family":"Patra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Tagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoree","family":"Kohwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"issue":"16","key":"159_CR1","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1242\/dev.129.16.3763","volume":"129","author":"T Brody","year":"2002","unstructured":"Brody T, Odenwald WF. 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