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DC (Rutaceae) is well known for inhibiting the proliferation of human gastric, liver, kidney and lung cancer cells, though research on its potential use in treating leukaemia is relatively rare. Twenty-six compounds were isolated from the chloroform and petroleum ether extracts of the roots and leaves of\n                    <jats:italic>Z. nitidium<\/jats:italic>\n                    (\n                    <jats:italic>Zanthoxylum nitidium<\/jats:italic>\n                    ). They were (\u2009+)-9\u2032-\n                    <jats:italic>O<\/jats:italic>\n                    -transferuloyl-5, 5\u2032-dimethoxylaricriresinol (1), 8-(3\u2032-oxobut-1\u2032-en-1\u2032-yl)-5, 7-dimethoxy-coumarin (2), 5, 7, 8-trimethoxy-coumarin (3), 5-(3\u2032, 3\u2032-dimethyl-2\u2032-butenyloxy)-7, 8-dimethoxy-coumarin (4), 2-(5-methoxy-2-methyl-1\n                    <jats:italic>H<\/jats:italic>\n                    -indol-3-yl) methyl acetate (5), 2\u2032-(5, 6-dihydrochleletrythrine-6-yl) ethyl acetate (6), 6-acetonyldi-hydrochelerythrine (7), 6\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -hydroxymethyldihydronitidine (8), bocconoline (9), zanthoxyline (10),\n                    <jats:italic>O<\/jats:italic>\n                    -methylzanthoxyline (11), rhoifoline B (12),\n                    <jats:italic>N<\/jats:italic>\n                    -nornitidine (13), nitidine (14), chelerythrine (15), 4-hydroxyl-7,8-dimethoxy-furoquinoline (16), dictamnine (17),\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -fagarine (18), skimmianine (19), robustine (20), R-(\u2009+)-platydesmine (21), 4-methoxyl-1-methyl-2-quinoline (22), 4-methoxy-2-quinolone (23), liriodenine (24), aurantiamide acetate (25), 10\n                    <jats:italic>-O<\/jats:italic>\n                    -demethyl-12-\n                    <jats:italic>O<\/jats:italic>\n                    -methylarnottianamide (26). Four among them, compounds\n                    <jats:bold>4\u00a0\u2013\u00a06<\/jats:bold>\n                    and\n                    <jats:bold>16<\/jats:bold>\n                    , were first confirmed in this study by UV, IR, 1D, 2D NMR and HR-ESI\u2013MS spectra. Compounds\n                    <jats:bold>1\u00a0\u2013\u00a02<\/jats:bold>\n                    and\n                    <jats:bold>11<\/jats:bold>\n                    were isolated from\n                    <jats:italic>Z. nitidium<\/jats:italic>\n                    for the first time. Of the assayed compounds,\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>9<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    ,\n                    <jats:bold>14<\/jats:bold>\n                    ,\n                    <jats:bold>15<\/jats:bold>\n                    and\n                    <jats:bold>24,<\/jats:bold>\n                    exhibited good inhibitory activities in the leukaemia cell line HEL, whereas compound\n                    <jats:bold>14<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 3.59\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M) and compound\n                    <jats:bold>24<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 15.95\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M) exhibited potent inhibitory activities. So, to further investigate the possible mechanisms, cell cycle and apoptosis assays were performed, which indicated that compound\n                    <jats:bold>14<\/jats:bold>\n                    causes obvious S-phase arrest in HEL cells and induced apoptosis, whereas compound\n                    <jats:bold>24<\/jats:bold>\n                    only induced apoptosis. The present results suggested both compounds\n                    <jats:bold>14<\/jats:bold>\n                    and\n                    <jats:bold>24<\/jats:bold>\n                    are promising potential anti-leukaemia drug candidates.\n                  <\/jats:p>","DOI":"10.1186\/s13065-021-00771-0","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T15:03:11Z","timestamp":1627052591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Active constituents of Zanthoxylum nitidium from Yunnan Province against leukaemia cells in vitro"],"prefix":"10.1186","volume":"15","author":[{"given":"Ying","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"issue":"2","key":"771_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1046\/j.1365-2141.2001.02411.x","volume":"112","author":"G Piller","year":"2001","unstructured":"Piller G. 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