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However, conversion of N-1 substituted 4-Quinolone 3-Carboxylate to its corresponding carbamates is highly restrictive. This motivated us to adopt a much simpler, scalable and efficient methodology for the synthesis of highly pure N-1 substituted 4- Quinolone-3-Carboxamides with excellent yields. Our adopted methodology not only provides a robust pathway for the convenient synthesis of N-1 substituted 4- Quinolone-3-Carboxamides which can then be explored for their therapeutic potential, this may also be adaptable for the derivatization of other such less reactive carboxylate species.<\/jats:p>","DOI":"10.1186\/s13065-022-00902-1","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T22:23:44Z","timestamp":1670538224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A green and efficient synthetic methodology towards the synthesis of 1-allyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives"],"prefix":"10.1186","volume":"16","author":[{"given":"Muhammad Shoaib Ali","family":"Gill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nursyuhada","family":"Azzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharifah Syed","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Adnan Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafees","family":"Ahemad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"issue":"4","key":"902_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.bjbas.2017.07.005","volume":"6","author":"MC Mandewale","year":"2017","unstructured":"Mandewale MC, Patil UC, Shedge SV, Dappadwad UR, Yamgar RS. 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