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However, the drug-loaded nanoparticles significantly decreased the colony-forming units (CFUs) within the cell lines compared to free drugs. In conclusion, the synthesis of nanoparticles adhered to environmentally friendly practices and demonstrated safety. The sustained drug release over 100\u00a0h facilitated drug accumulation at the bacterial site, resulting in a heightened therapeutic effect on <jats:italic>B. melitensis<\/jats:italic> and improved outcomes in brucellosis treatment. 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