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Analytical separation was performed using a Promosil C\n                    <jats:sub>18<\/jats:sub>\n                    column and ultraviolet detection at 210\u00a0nm. The separation was achieved within only 8\u00a0min. For both mixtures, an aqueous solution, composed of (Acetonitrile: Methanol: 0. 2\u00a0M phosphoric acid) within ratio of (30: 30: 40) adjusted to final pH 3.0, was the mobile phase. This method was validated as per the International Conference on Harmonization guidelines. The linearity ranges of these proposed method of the (Mixture (I)) were 25.0\u2013400.0\u00a0\u00b5g\/mL Amoxicillin, 0.5\u20138.0\u00a0\u00b5g\/mL Vonoprazan, and 12.5\u2013200.0\u00a0\u00b5g\/mL Clarithromycin. And the linearity ranges of the (Mixture (II)) were 10.0\u2013300.0\u00a0\u00b5g\/mL Amoxicillin, 0.3\u20139.0 \u00b5g\/mL Lansoprazole and 5.0\u2013150.0\u00a0\u00b5g\/mL Clarithromycin. This method was firstly applied for effective separation of Amoxicillin, Vonoprazan and Clarithromycin [Mixture (I)]. It fulfilled good repeatability, sensitivity, and accuracy (R.S.D.\u2009&lt;\u20092.0%). The mean recoveries of the analytes in their Tri-Pak formulations were acceptable. The greenness of the developed chromatographic methods was assessed using an Eco-scale method and it was applied for content uniformity testing as per the United States Pharmacopoeia (USP) and the acceptance value of Amoxicillin, in Mixture (I) was 2.88, the acceptance values for Amoxicillin, Lansoprazole in Mixture (II) were 2.592, 2.424, respectively.\n                  <\/jats:p>","DOI":"10.1186\/s13065-024-01215-1","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T23:36:31Z","timestamp":1718148991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validated chromatographic approach for determination of two ternary mixtures in newly approved formulations for helicobacter pylori eradication: assessment of greenness profile and content uniformity"],"prefix":"10.1186","volume":"18","author":[{"given":"Yomna A.","family":"Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah A.","family":"Elsabour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"El-Masry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"issue":"2","key":"1215_CR1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.20524\/aog.2023.0783","volume":"36","author":"A Boustany","year":"2023","unstructured":"Boustany A, et al. 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