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The weak nuclease activity of compounds\n                    <jats:bold>(3a<\/jats:bold>\n                    \u2013\n                    <jats:bold>f)<\/jats:bold>\n                    against pBR322 plasmid DNA was greatly enhanced by irradiation at 365\u00a0nm. Compounds\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    , incorporating thienyl and pyridyl moieties, respectively, exhibited the utmost nuclease activity in degrading pBR322 plasmid DNA through singlet oxygen and superoxide free radicals\u2019 species. Furthermore, compounds\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    affinities towards calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were investigated using UV\u2013Vis and fluorescence spectroscopic analysis. They revealed good binding characteristics towards CT-DNA with K\n                    <jats:sub>b<\/jats:sub>\n                    values of 6.68\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    \u00a0M\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 1.19\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    \u00a0M\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    , respectively. In addition, compounds\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    ability to release free radicals on radiation were targeted to be used as cytotoxic compounds in vitro for colon (HCT116) and breast cancer (MDA-MB-231) cells. A significant reduction in the cell viability on illumination at 365\u00a0nm was observed, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 23 and 25\u00a0\u00b5M against HCT116 cells, and 30 and 9\u00a0\u00b5M against MDA-MB-231 cells for compounds\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    , respectively. In conclusion, compounds\n                    <jats:bold>3b<\/jats:bold>\n                    and\n                    <jats:bold>3c<\/jats:bold>\n                    exhibited remarkable DNA cleavage and cytotoxic activity on illumination at 365\u00a0nm which might be associated with free radicals\u2019 production in addition to having a good affinity for interacting with CT-DNA and BSA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1186\/s13065-024-01284-2","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:01:55Z","timestamp":1726815715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Novel thiazole-based cyanoacrylamide derivatives: DNA cleavage, DNA\/BSA binding properties and their anticancer behaviour against colon and breast cancer cells"],"prefix":"10.1186","volume":"18","author":[{"given":"Karim","family":"Barakat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Ragheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa H.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M.","family":"Abdelmoniem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail A.","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"1284_CR1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.bioorg.2019.01.019","volume":"85","author":"P Dong","year":"2019","unstructured":"Dong P, Rakesh KP, Manukumar HM, Mohammed YHE, Karthik CS, Sumathi S, et al. 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