{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:36:31Z","timestamp":1793835391440,"version":"4.6.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["70011"],"award-info":[{"award-number":["70011"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Chemistry"],"DOI":"10.1186\/s13065-024-01299-9","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T18:02:19Z","timestamp":1726682539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantification of morphine in exhaled breath condensate using a double network polymeric hybrid hydrogel functionalized with AuNPs"],"prefix":"10.1186","volume":"18","author":[{"given":"Zahra","family":"Karimzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghasem","family":"Jouyban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khoubnasabjafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Jouyban-Gharamaleki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Rahimpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"issue":"7","key":"1299_CR1","doi-asserted-by":"publisher","first-page":"e5555","DOI":"10.1002\/bmc.5555","volume":"37","author":"C Ververi","year":"2023","unstructured":"Ververi C, Vincenti M, Salomone A. Recent advances in the detection of drugs of abuse by dried blood spots. Biomed Chromatogr. 2023;37(7):e5555.","journal-title":"Biomed Chromatogr"},{"issue":"10","key":"1299_CR2","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1021\/acschemneuro.8b00150","volume":"9","author":"AL Devereaux","year":"2018","unstructured":"Devereaux AL, Mercer SL, Cunningham CW. DARK classics in chemical neuroscience: Morphine. ACS Chem Neurosci. 2018;9(10):2395\u2013407.","journal-title":"ACS Chem Neurosci"},{"key":"1299_CR3","first-page":"2276","volume":"2766","author":"AD Al-Onizi","year":"2023","unstructured":"Al-Onizi AD, Abu-hasabu BA, Al-Hwaiti DN, Al-Ali RaM, Al-Madani NM. El Rabey, General review on opioids. J ISSN. 2023;2766:2276.","journal-title":"J ISSN"},{"key":"1299_CR4","doi-asserted-by":"publisher","first-page":"113367","DOI":"10.1016\/j.jelechem.2019.113367","volume":"850","author":"VA Kumary","year":"2019","unstructured":"Kumary VA, Abraham P, Renjini S, Swamy BK, Nancy TM, Sreevalsan A. A novel heterogeneous catalyst based on reduced graphene oxide supported copper coordinated amino acid\u2013A platform for morphine sensing. J Electroanal Chem. 2019;850:113367.","journal-title":"J Electroanal Chem"},{"issue":"7","key":"1299_CR5","first-page":"447","volume":"58","author":"M Schulz","year":"2003","unstructured":"Schulz M, Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Die Pharmazie-An Int J Pharm Sci. 2003;58(7):447\u201374.","journal-title":"Die Pharmazie-An Int J Pharm Sci"},{"key":"1299_CR6","doi-asserted-by":"publisher","first-page":"122977","DOI":"10.1016\/j.saa.2023.122977","volume":"302","author":"L Zhao","year":"2023","unstructured":"Zhao L, Wei Y, Fu H, Yang R, Zhao Q, Zhang H, Cai W. Solid chip-based detection of trace morphine in solutions via portable surface-enhanced Raman spectroscopy. Spectrochim Acta Part A Mol Biomol Spectrosc. 2023;302:122977.","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"1299_CR7","doi-asserted-by":"crossref","unstructured":"Karimzadeh Z, Rahimpour E, Jouyban A. A follow-up study on a sensitive determination of morphine in plasma using AuNPs@ UiO-66\/PVA hydrogel as an advanced optical scaffold. Heliyon 9(4) (2023).","DOI":"10.1016\/j.heliyon.2023.e15267"},{"issue":"1","key":"1299_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/separations10010058","volume":"10","author":"M Malak","year":"2023","unstructured":"Malak M, Ebrahim H, Sonbol H, Ali A, Aboulella Y, Hadad G, Emara S. Highly sensitive in-capillary derivatization and field amplified sample stacking to analyze narcotic drugs in human serum by capillary zone electrophoresis. Separations. 2023;10(1):58.","journal-title":"Separations"},{"issue":"5","key":"1299_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/chromsci\/bmaa108","volume":"59","author":"A Ghorani-Azam","year":"2021","unstructured":"Ghorani-Azam A, Balali-Mood M, Khatami S-M, Asoodeh A, Es\u2019 haghi Z. Riahi-Zanjani, Plant extract and herbal products as potential source of sorbent for analytical purpose: an experimental study of morphine and codeine determination using HPLC and LC\u2013MSMS. J Chromatogr Sci. 2021;59(5):482\u20139.","journal-title":"J Chromatogr Sci"},{"issue":"7\u20138","key":"1299_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/ansa.202000121","volume":"2","author":"R Jain","year":"2021","unstructured":"Jain R, Singh M, Kumari A, Tripathi RM. A rapid and cost-effective method based on dispersive liquid\u2010liquid microextraction coupled to injection port silylation\u2010gas chromatography\u2010mass spectrometry for determination of morphine in illicit opium. Anal Sci Adv. 2021;2(7\u20138):387\u201396.","journal-title":"Anal Sci Adv"},{"key":"1299_CR11","doi-asserted-by":"publisher","first-page":"110183","DOI":"10.1016\/j.msec.2019.110183","volume":"106","author":"G Bahrami","year":"2020","unstructured":"Bahrami G, Ehzari H, Mirzabeigy S, Mohammadi B, Arkan E. Fabrication of a sensitive electrochemical sensor based on electrospun magnetic nanofibers for morphine analysis in biological samples. Mater Sci Engineering: C. 2020;106:110183.","journal-title":"Mater Sci Engineering: C"},{"issue":"17","key":"1299_CR12","doi-asserted-by":"publisher","first-page":"11563","DOI":"10.1021\/acsomega.1c00773","volume":"6","author":"E Verrinder","year":"2021","unstructured":"Verrinder E, Wester N, Leppanen E, Lilius T, Kalso E, Mikladal Br, Varjos I, Koskinen J, Laurila T. Electrochemical Detection of Morphine in Untreated Human Capillary whole blood. ACS Omega. 2021;6(17):11563\u20139.","journal-title":"ACS Omega"},{"issue":"19","key":"1299_CR13","doi-asserted-by":"publisher","first-page":"13244","DOI":"10.1039\/D3CP00524K","volume":"25","author":"M Chen","year":"2023","unstructured":"Chen M, Burn P, Shaw P. Luminescence-based detection and identification of illicit drugs. Phys Chem Chem Phys. 2023;25(19):13244\u201359.","journal-title":"Phys Chem Chem Phys"},{"key":"1299_CR14","doi-asserted-by":"crossref","unstructured":"Karimzadeh Z, Jouyban A, Rahimpour E. Development of a Nanocluster-Based Platform for Determination of Sofosbuvir, Pharmaceutical Sciences (2021).","DOI":"10.34172\/PS.2021.57"},{"key":"1299_CR15","doi-asserted-by":"publisher","first-page":"129238","DOI":"10.1016\/j.foodchem.2021.129238","volume":"351","author":"B Brasiunas","year":"2021","unstructured":"Brasiunas B, Popov A, Ramanavicius A, Ramanaviciene A. Gold nanoparticle based colorimetric sensing strategy for the determination of reducing sugars. Food Chem. 2021;351:129238.","journal-title":"Food Chem"},{"key":"1299_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bios.2018.12.023","volume":"127","author":"M Mahmoudpour","year":"2019","unstructured":"Mahmoudpour M, Ezzati Nazhad Dolatabadi J, Torbati M, Homayouni-Rad A. Nanomaterials based surface plasmon resonance signal enhancement for detection of environmental pollutions. Biosens Bioelectron. 2019;127:72\u201384.","journal-title":"Biosens Bioelectron"},{"key":"1299_CR17","doi-asserted-by":"crossref","unstructured":"Kumar PPP, Kaushal S, Lim D-K. Recent advances in nano\/microfabricated substrate platforms and artificial intelligence for practical surface-enhanced Raman scattering-based bioanalysis. TRAC Trends Anal Chem (2023) 117341.","DOI":"10.1016\/j.trac.2023.117341"},{"issue":"46","key":"1299_CR18","doi-asserted-by":"publisher","first-page":"29602","DOI":"10.1039\/D2RA02761E","volume":"12","author":"M Mahmoudpour","year":"2022","unstructured":"Mahmoudpour M, Dolatabadi JEN, Hasanzadeh M, Rad AH, Torbati M, Seidi F. Aptasensing of ciprofloxacin residue using graphene oxide modified with gold nanoparticles and branched polyethyleneimine. RSC Adv. 2022;12(46):29602\u201312.","journal-title":"RSC Adv"},{"key":"1299_CR19","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.snb.2018.02.119","volume":"264","author":"M Zhou","year":"2018","unstructured":"Zhou M, Guo J, Yang C. Ratiometric fluorescence sensor for Fe3\u2009+\u2009ions detection based on quantum dot-doped hydrogel optical fiber. Sens Actuators B. 2018;264:52\u20138.","journal-title":"Sens Actuators B"},{"key":"1299_CR20","doi-asserted-by":"publisher","first-page":"102705","DOI":"10.1016\/j.cis.2022.102705","volume":"305","author":"Z Karimzadeh","year":"2022","unstructured":"Karimzadeh Z, Mahmoudpour M, Rahimpour E, Jouyban A. Nanomaterial based PVA nanocomposite hydrogels for biomedical sensing: advances toward designing the ideal flexible\/wearable nanoprobes. Adv Colloid Interface Sci. 2022;305:102705.","journal-title":"Adv Colloid Interface Sci"},{"issue":"2","key":"1299_CR21","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/polym11020275","volume":"11","author":"C Dannert","year":"2019","unstructured":"Dannert C, Stokke BT, Dias RS. Nanoparticle-hydrogel composites: from molecular interactions to macroscopic behavior. Polymers. 2019;11(2):275.","journal-title":"Polymers"},{"key":"1299_CR22","doi-asserted-by":"crossref","unstructured":"Shah M, Hameed A, Kashif M, Majeed N, Muhammad J, Shah N, Rehan T, Khan A, Uddin J, Khan A. Advances in agar-based composites: a comprehensive review. Carbohydr Polym (2024) 122619.","DOI":"10.1016\/j.carbpol.2024.122619"},{"key":"1299_CR23","doi-asserted-by":"publisher","first-page":"391","DOI":"10.18433\/jpps33121","volume":"25","author":"N Hashemzadeh","year":"2022","unstructured":"Hashemzadeh N, Rahimpour E, Jouyban A. Applications of exhaled breath condensate analysis for drug monitoring and bioequivalence study of inhaled drugs. J Pharm Pharm Sci. 2022;25:391\u2013401.","journal-title":"J Pharm Pharm Sci"},{"issue":"2","key":"1299_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4155\/bio-2017-0205","volume":"10","author":"M Khoubnasabjafari","year":"2018","unstructured":"Khoubnasabjafari M, Rahimpour E, Jouyban A. Exhaled breath condensate as an alternative sample for drug monitoring. Bioanalysis. 2018;10(2):61\u20134.","journal-title":"Bioanalysis"},{"issue":"15","key":"1299_CR25","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1039\/C4AN00583J","volume":"139","author":"MJ Nunes de Paiva","year":"2014","unstructured":"Nunes de Paiva MJ, de Menezes HC. Lourdes Cardeal, Sampling and analysis of metabolomes in biological fluids. Analyst. 2014;139(15):3683\u201394.","journal-title":"Analyst"},{"issue":"12","key":"1299_CR26","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.3390\/jcm10122697","volume":"10","author":"J Po\u0142omska","year":"2021","unstructured":"Po\u0142omska J, Bar K, Soza\u0144ska B. Exhaled breath condensate\u2014a non-invasive approach for diagnostic methods in asthma. J Clin Med. 2021;10(12):2697.","journal-title":"J Clin Med"},{"key":"1299_CR27","unstructured":"Jouyban A, Khoubnasabjafari M, Ansarin K, Jouyban-Gharamaleki V. Breath Sampl Setup Iran Patent 81363 (2013)."},{"issue":"5","key":"1299_CR28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/nano8050320","volume":"8","author":"EC Alegria","year":"2018","unstructured":"Alegria EC, Ribeiro AP, Mendes M, Ferraria AM, Do Rego AMB, Pombeiro AJ. Effect of phenolic compounds on the synthesis of gold nanoparticles and its catalytic activity in the reduction of nitro compounds. Nanomaterials. 2018;8(5):320.","journal-title":"Nanomaterials"},{"key":"1299_CR29","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.molliq.2019.03.135","volume":"284","author":"M Rajaei","year":"2019","unstructured":"Rajaei M, Foroughi MM, Jahani S, Shahidi Zandi M, Hassani H, Nadiki. Sensitive detection of morphine in the presence of dopamine with La3\u2009+\u2009doped fern-like CuO nanoleaves\/MWCNTs modified carbon paste electrode. J Mol Liq. 2019;284:462\u201372.","journal-title":"J Mol Liq"},{"issue":"17","key":"1299_CR30","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/elan.200302966","volume":"16","author":"J Garrido","year":"2004","unstructured":"Garrido J, Delerue-Matos C, Borges F, Macedo TR, Oliveira\u2010Brett A. Voltammetric oxidation of drugs of abuse I. Morphine and metabolites, Electroanalysis: An International Journal devoted to fundamental and practical. Aspects Electroanalysis. 2004;16(17):1419\u201326.","journal-title":"Aspects Electroanalysis"},{"issue":"3","key":"1299_CR31","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1039\/C7RA12810J","volume":"8","author":"S Gandhi","year":"2018","unstructured":"Gandhi S, Banga I, Maurya PK, Eremin SA. A gold nanoparticle-single-chain fragment variable antibody as an immunoprobe for rapid detection of morphine by dipstick. RSC Adv. 2018;8(3):1511\u20138.","journal-title":"RSC Adv"},{"issue":"24","key":"1299_CR32","doi-asserted-by":"publisher","first-page":"5955","DOI":"10.1007\/s00216-014-8001-7","volume":"406","author":"T Teerinen","year":"2014","unstructured":"Teerinen T, Lappalainen T, Erho T. A paper-based lateral flow assay for morphine. Anal Bioanal Chem. 2014;406(24):5955\u201365.","journal-title":"Anal Bioanal Chem"},{"key":"1299_CR33","doi-asserted-by":"crossref","unstructured":"Zhang X, Chen M, Cao G, Hu G. Determination of morphine and codeine in human urine by gas chromatography-mass spectrometry, Journal of Analytical Methods in Chemistry 2013 (2013).","DOI":"10.1155\/2013\/151934"},{"issue":"6","key":"1299_CR34","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jpha.2017.03.001","volume":"7","author":"M Bahram","year":"2017","unstructured":"Bahram M, Madrakian T, Alizadeh S. Simultaneous colorimetric determination of morphine and ibuprofen based on the aggregation of gold nanoparticles using partial least square. J Pharm Anal. 2017;7(6):411\u20136.","journal-title":"J Pharm Anal"},{"key":"1299_CR35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.talanta.2018.04.094","volume":"186","author":"B Yu","year":"2018","unstructured":"Yu B, Cao C, Li P, Mao M, Xie Q, Yang L. Sensitive and simple determination of zwitterionic morphine in human urine based on liquid-liquid micro-extraction coupled with surface-enhanced Raman spectroscopy. Talanta. 2018;186:427\u201332.","journal-title":"Talanta"},{"key":"1299_CR36","doi-asserted-by":"publisher","first-page":"340252","DOI":"10.1016\/j.aca.2022.340252","volume":"1227","author":"Z Karimzadeh","year":"2022","unstructured":"Karimzadeh Z, Jouyban A, Ostadi A, Gharakhani A, Rahimpour E. A sensitive determination of morphine in plasma using AuNPs@UiO-66\/PVA hydrogel as an advanced optical scaffold. Anal Chim Acta. 2022;1227:340252.","journal-title":"Anal Chim Acta"},{"issue":"6","key":"1299_CR37","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1021\/acs.jafc.6b05305","volume":"65","author":"C Zhang","year":"2017","unstructured":"Zhang C, Han Y, Lin L, Deng N, Chen B, Liu Y. Development of Quantum dots-labeled antibody fluorescence immunoassays for the detection of Morphine. J Agric Food Chem. 2017;65(6):1290\u20135.","journal-title":"J Agric Food Chem"}],"container-title":["BMC Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13065-024-01299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13065-024-01299-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13065-024-01299-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T18:03:37Z","timestamp":1726682617000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcchem.biomedcentral.com\/articles\/10.1186\/s13065-024-01299-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,18]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1299"],"URL":"https:\/\/doi.org\/10.1186\/s13065-024-01299-9","relation":{},"ISSN":["2661-801X"],"issn-type":[{"value":"2661-801X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,18]]},"assertion":[{"value":"13 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee at Tabriz University of Medical Sciences. Patients receiving morphine signed a consent form authorized by code of IR.TBZMED.VCR.REC.1401.140. The \u201cinformed\u201d consent to participate was obtained from all of the participants in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"175"}}