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This study explores the application of Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) for this purpose. In MEKC method, the separation was done using fused silica capillary (41.5\u00a0cm\u2009\u00d7\u200950\u00a0\u00b5m id) and a back ground electrolyte consisting of 50\u00a0mM borate buffer (pH 9) containing 50\u00a0mM sodium lauryl sulphate (SLS) and 10% organic modifier (Acetonitrile). In HPLC method, separation was performed on a ZORBAX Extend-C18 (4.6\u2009\u00d7\u2009250\u00a0mm, 5\u00a0\u00b5m) column, using a gradient mobile phase consisting of 50\u00a0mM phosphate buffer pH 3 and methanol. Both methods attained good linearity (r\u2009\u2265\u20090.9996) with low values of LOD and LOQ. Both methods were successfully applied in the determination of co-administered single, binary and ternary dosage form of the studied drugs. Moreover, application of various combinations of co-administered dosage forms was achieved in rat plasma, confirming the applicability of these methods in different matrices. The use of micellar solutions in MEKC enhances separation efficiency while reducing the need for organic solvents, aligning with green chemistry principles. HPLC methods were optimized using environmentally benign solvents, ensuring reduced toxicity and waste production. The methodologies were evaluated through green, white, and blue metrics to ensure comprehensive sustainability, considering ecological impact, safety, and practical efficiency. These methods were not only cost-effective and time-saving but achieved high efficiency, sensitivity, and reproducibility making them ideal for routine use in pharmaceutical analysis.<\/jats:p>","DOI":"10.1186\/s13065-024-01303-2","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:01:54Z","timestamp":1728565314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simple simultaneous analysis of various cardiovascular drug mixtures with vincamine: comparative eco-friendly assessment"],"prefix":"10.1186","volume":"18","author":[{"given":"Sara S.","family":"Mourad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda A.","family":"Barary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira F.","family":"El-Yazbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"1303_CR1","unstructured":"World Health Organization (WHO), Cardiovascular diseases, 2024. https:\/\/www.who.int\/health-topics\/cardiovascular-diseases."},{"key":"1303_CR2","volume-title":"Cardiovascular disease","author":"E Olvera Lopez","year":"2024","unstructured":"Olvera Lopez E, Ballard BD, Jan A. 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