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Domperidone (DOM) is a prokinetic agent that enhances gastrointestinal motility, helping to alleviate nausea, vomiting, and bloating caused by motility disorders. Their combination (Pantosec-D) provides rapid and comprehensive relief from both acid-related and motility-related symptoms, significantly improving patient comfort and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to develop and validate three eco-friendly spectrophotometric techniques\u2014ratio difference (RD), first derivative (1DD), and mean centering (MC) of ratio spectra\u2014for the simultaneous determination of PAN and DOM in pharmaceutical formulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      The proposed methods resolve spectral overlap through ratio spectra manipulation. In the RD method, DOM is quantified by measuring the amplitude difference at 209\u00a0nm and 233\u00a0nm, while PAN is determined at 254\u00a0nm and 223\u00a0nm. The\n                      <jats:sup>1<\/jats:sup>\n                      DD method detects DOM at 215\u00a0nm and PAN at 249\u00a0nm, whereas the MC method quantifies PAN at 254\u00a0nm and DOM at 209\u00a0nm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The suggested methods were validated according to ICH regulations. Pharmaceutical formulations comprising PAN and DOM were effectively analyzed using the linear correlations obtained for both drugs over concentration ranges of 0.5\u201352\u00a0\u00b5g\/mL and 1\u201318\u00a0\u00b5g\/mL, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with reported spectrophotometric techniques, ratio methods are especially beneficial for routine pharmaceutical analysis due to their ease of use, capacity for\u00a0handling overlapping spectra, and robustness to experimental variations. Compared with reported chromatographic methods, these techniques provide easy-to-use, reasonably priced, less solvent, and dependable substitutes for the standard quality control of these medications in pharmaceutical dosage forms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13065-025-01414-4","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T22:19:47Z","timestamp":1740953987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A green three-ratio manipulating spectrophotometric approaches for the determination of a binary mixture of pantoprazole and domperidone"],"prefix":"10.1186","volume":"19","author":[{"given":"Hamed H. 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