{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:34:20Z","timestamp":1780338860265,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"the Key Laboratory Project for Quality Control of Traditional Chinese Medicines and Decoction Pieces, National Medical Products Administration","award":["No. 2024GSMPA-KL01"],"award-info":[{"award-number":["No. 2024GSMPA-KL01"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"2023 National Drug Standard Revision Research Project","award":["No. BZ20230279"],"award-info":[{"award-number":["No. BZ20230279"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"name":"Key Research and Development Program of Xinjiang Uygur Autonomous Region","award":["No. 2023B03001-2"],"award-info":[{"award-number":["No. 2023B03001-2"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574563"],"award-info":[{"award-number":["82574563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Chemistry"],"DOI":"10.1186\/s13065-025-01672-2","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:51:19Z","timestamp":1763135479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["On-line identification of chemical constituents in Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata based on UHPLC-Q-Orbitrap-Linear Ion Trap-MS"],"prefix":"10.1186","volume":"19","author":[{"given":"Rui","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Han","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Zhong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Guang","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"1672_CR1","first-page":"183","volume-title":"Pharmacopoeia of the people\u2019s Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2020","unstructured":"Chinese Pharmacopoeia Commission. Pharmacopoeia of the people\u2019s Republic of China. Beijing: China Medical Science and Technology; 2020. pp. 183\u20134."},{"key":"1672_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.biopha.2018.01.033","volume":"99","author":"JB Yang","year":"2018","unstructured":"Yang JB, Li WF, Liu Y, Wang Q, Cheng XL, Wei F, et al. Acute toxicity screening of different extractions, components and constituents of polygonum multiflorum Thunb. On zebrafish (Danio rerio) embryos in vivo. Biomed Pharmacother. 2018;99:205\u201313. 10.1016 \/j.biopha. 2018.01.033.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"1672_CR3","doi-asserted-by":"publisher","first-page":"610","DOI":"10.19803\/j.1672-8629.2022.06.06","volume":"19","author":"JB Yang","year":"2022","unstructured":"Yang JB, Gao BW, Sun H, Jin HT, Gao HY, Niu H, et al. Research progress on material basis of liver toxicity of polygonum multiflorum thunb. Chin J Pharmacovigil. 2022;19(6):610\u20134. https:\/\/doi.org\/10.19803\/j.1672-8629.2022.06.06.","journal-title":"Chin J Pharmacovigil"},{"issue":"7\u20138","key":"1672_CR4","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1089\/omi.2011.0138","volume":"16","author":"XJ Wang","year":"2012","unstructured":"Wang XJ, Zhang AH, Sun H. Future perspectives of Chinese medical formulae: chinmedomics as an effector. OMICS. 2012;16(7\u20138):414\u201321. https:\/\/doi.org\/10.1089\/omi.2011.0138.","journal-title":"OMICS"},{"issue":"2","key":"1672_CR5","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1039\/c1mb05350g","volume":"8","author":"B Zhou","year":"2012","unstructured":"Zhou B, Xiao JF, Tuli L, Ressom HW. LC-MS-based metabolomics. Mol Biosyst. 2012;8(2):470\u201381. https:\/\/doi.org\/10.1039\/c1mb05350g.","journal-title":"Mol Biosyst"},{"issue":"9","key":"1672_CR6","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1007\/s00204-016-1764-1","volume":"90","author":"HH Maurer","year":"2016","unstructured":"Maurer HH, Meyer MR. High-resolution mass spectrometry in toxicology: current status and future perspectives. Arch Toxicol. 2016;90(9):2161\u201372. https:\/\/doi.org\/10.1007\/s00204-016-1764-1.","journal-title":"Arch Toxicol"},{"key":"1672_CR7","doi-asserted-by":"crossref","unstructured":"Wong MY, So PK, Yao ZP. Direct analysis of traditional Chinese medicines by mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1026:2\u201314. 10.1016\/j.jchromb. 2015. 11.032.","DOI":"10.1016\/j.jchromb.2015.11.032"},{"key":"1672_CR8","doi-asserted-by":"publisher","first-page":"1158717","DOI":"10.3389\/fchem.2023.1158717","volume":"11","author":"XT Wang","year":"2023","unstructured":"Wang XT, Yang JB, Cheng XL, Wang Y, Gao HY, Song YF, et al. On-line identification of the chemical constituents of polygoni multiflori radix by UHPLC-Q-ToF MS\/MS. Front Chem. 2023;11:1158717. https:\/\/doi.org\/10.3389\/fchem.2023.1158717.","journal-title":"Front Chem"},{"key":"1672_CR9","volume-title":"Study on quality control standards for polygonum multiflorum based on Anthraquinone-Induced hepatotoxicity","author":"HY Gao","year":"2022","unstructured":"Gao HY. Study on quality control standards for polygonum multiflorum based on Anthraquinone-Induced hepatotoxicity. Beijing: National Institutes for Food and Drug Control; 2022."},{"issue":"4","key":"1672_CR10","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","volume":"48","author":"EL Schymanski","year":"2014","unstructured":"Schymanski EL, Jeon J, Gulde R, et al. Identifying small molecules via high resolution mass spectrometry: communicating confidence. Environ Sci Technol. 2014;48(4):2097\u20138. https:\/\/doi.org\/10.1021\/es5002105.","journal-title":"Environ Sci Technol"},{"key":"1672_CR11","doi-asserted-by":"publisher","first-page":"757490","DOI":"10.3389\/fphar.2022.757490","volume":"13","author":"JQ Bai","year":"2022","unstructured":"Bai JQ, Chen WT, Huang J, Su H, Zhang DC, Xu W, et al. Transformation of Stilbene glucosides from reynoutria multiflora during processing. Front Pharmacol. 2022;13:757490. https:\/\/doi.org\/10.3389\/fphar.2022.757490.","journal-title":"Front Pharmacol"},{"key":"1672_CR12","doi-asserted-by":"publisher","first-page":"114070","DOI":"10.1016\/j.jpba.2021.114070","volume":"200","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Chu S, Gui S, Qin Y, Xu R, Shan T, et al. Tissue-specific metabolite profiling of fallopia multiflora (Heshouwu) and fallopia multiflora var. Angulata by mass spectrometry imaging and laser microdissection combined with UPLC-Q\/TOF-MS. J Pharm Biomed Anal. 2021;200:114070. https:\/\/doi.org\/10.1016\/j.jpba.2021.114070.","journal-title":"J Pharm Biomed Anal"},{"key":"1672_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.chroma.2012.11.051","volume":"1292","author":"XH Qiu","year":"2013","unstructured":"Qiu XH, Zhang J, Huang ZH, Zhu DY, Xu W. Profiling of phenolic constituents in polygonum multiflorum Thun b. by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap mass spectrometry. J Chromatogr A. 2013;1292:121\u201331. https:\/\/doi.org\/10.1016\/j.chroma.2012.11.051.","journal-title":"J Chromatogr A"},{"issue":"2","key":"1672_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1021\/acs.jnatprod.7b00540","volume":"81","author":"SG Li","year":"2018","unstructured":"Li SG, Huang XJ, Li MM, Liu Q, Liu H, Wang Y, et al. Multiflorumisides A-G, dimeric Stilbene glucosides with rare coupling patterns from the roots of polygonum multiflorum. J Nat Prod. 2018;81(2):254\u201363. https:\/\/doi.org\/10.1021\/acs.jnatprod.7b00540.","journal-title":"J Nat Prod"},{"issue":"13","key":"1672_CR15","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.3390\/molecules26133977","volume":"26","author":"SY Wang","year":"2021","unstructured":"Wang SY, Sun XZ, An S, Sang F, Zhao YL, Yu ZG. High-Throughput identification of organic compounds from polygoni multiflori radix praeparata (Zhiheshouwu) by UHPLC-Q-Exactive Orbitrap-MS. Molecules. 2021;26(13):3977. https:\/\/doi.org\/10.3390\/molecules26133977.","journal-title":"Molecules"},{"key":"1672_CR16","volume-title":"Investigation on the material basis and changes in absorption and metabolism processes of polygonum multiflorum before and after processing","author":"J Huang","year":"2020","unstructured":"Huang J. Investigation on the material basis and changes in absorption and metabolism processes of polygonum multiflorum before and after processing. Guangzhou: Guangzhou University of Chinese Medicine; 2020."},{"key":"1672_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jpba.2017.03.016","volume":"140","author":"L Wang","year":"2017","unstructured":"Wang L, Sang M, Liu E, Banahene PO, Zhang Y, Wang T, et al. Rapid profiling and Pharmacokinetic studies of major compounds in crude extract from polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC-MS\/MS. J Pharm Biomed Anal. 2017;140:45\u201361. https:\/\/doi.org\/10.1016\/j.jpba.2017.03.016.","journal-title":"J Pharm Biomed Anal"},{"key":"1672_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jpba.2019.03.049","volume":"172","author":"JB Yang","year":"2019","unstructured":"Yang JB, Liu Y, Wang Q, Ma SC, Wang AG, Cheng XL, et al. Characterization and identification of the chemical constituents of polygonum multiflorum Thunb. By high-performance liquid chromatography coupled with ultraviolet detection and linear ion trap FT-ICR hybrid mass spectrometry. J Pharm Biomed Anal. 2019;172:149\u201366. https:\/\/doi.org\/10.1016\/j.jpba.2019.03.049.","journal-title":"J Pharm Biomed Anal"},{"issue":"5","key":"1672_CR19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1875-5364(18)30070-0","volume":"16","author":"J Huang","year":"2018","unstructured":"Huang J, Zhang JP, Bai JQ, Wen MJ, Zhang J, Huang ZH, et al. Chemical profiles and metabolite study of Raw and processed polygoni multiflori radix in rats by UPLC-LTQ-Orbitrap MSn spectrometry. Chin J Nat Med (Amsterdam Neth. 2018;16(5):375\u2013400. https:\/\/doi.org\/10.1016\/S1875-5364(18)30070-0.","journal-title":"Chin J Nat Med (Amsterdam Neth"},{"issue":"2","key":"1672_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/chromsci\/bmz086","volume":"58","author":"W Rui","year":"2020","unstructured":"Rui W, Xia WX, Zhao W, Li BL, Li J, Feng YF, et al. Differential constituents in Roots, stems and leaves of polygonum multiflorum Thunb. Screened by UPLC\/ESI-Q-TOF-MS and multivariate statistical analysis. J Chromatogr Sci. 2020;58(2):136\u201343. 10.1093 \/chromsci \/bmz086.","journal-title":"J Chromatogr Sci"},{"issue":"2","key":"1672_CR21","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.3390\/molecules18022255","volume":"18","author":"HY Wang","year":"2013","unstructured":"Wang HY, Song LX, Feng SB, Liu YC, Zuo G, Lai FL, et al. Characterization of proanthocyanidins in stems of polygonum multiflorum thunb as strong starch hydrolase inhibitors. Molecules. 2013;18(2):2255\u201365. https:\/\/doi.org\/10.3390\/molecules18022255.","journal-title":"Molecules"},{"key":"1672_CR22","doi-asserted-by":"publisher","unstructured":"Feng GF, Gao M, Wang LW et al. Dual-resolving of positional and geometric isomers of C\u2009=\u2009C bonds via bifunctional photocycloaddition-photoisomerization reaction system. Nat Commun. 2022;13(1):2652. Published 2022 May 12. https:\/\/doi.org\/10.1038\/s41467-022-30249-z","DOI":"10.1038\/s41467-022-30249-z"},{"issue":"03","key":"1672_CR23","doi-asserted-by":"publisher","first-page":"614","DOI":"10.19540\/j.cnki.cjcmm.20201111.302","volume":"46","author":"YD Xu","year":"2021","unstructured":"Xu YD, Zhou P, Liu Y, Xiao YQ. Analysis of common changes in material basis during four processing methods of polygonum multiflorum. China J Chin Materia Med. 2021;46(03):614\u20139. https:\/\/doi.org\/10.19540\/j.cnki.cjcmm.20201111.302.","journal-title":"China J Chin Materia Med"},{"issue":"4","key":"1672_CR24","doi-asserted-by":"publisher","first-page":"493","DOI":"10.5009\/gnl.2011.5.4.493","volume":"5","author":"KA Jung","year":"2011","unstructured":"Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, et al. Drug-Induced liver injury: Twenty five cases of acute hepatitis following ingestion of polygonum multiflorum thunb. Gut Liver. 2011;5(4):493\u20139. https:\/\/doi.org\/10.5009\/gnl.2011.5.4.493.","journal-title":"Gut Liver"},{"issue":"6","key":"1672_CR25","first-page":"601","volume":"37","author":"P de Witte","year":"1990","unstructured":"de Witte P, Lemli L. The metabolism of anthranoid laxatives. Hepatogastroenterology. 1990;37(6):601\u20135. 2289777.","journal-title":"Hepatogastroenterology"},{"key":"1672_CR26","doi-asserted-by":"publisher","first-page":"110524","DOI":"10.1016\/j.biopha.2020.110524","volume":"131","author":"HY Li","year":"2020","unstructured":"Li HY, Yang JB, Li WF, Qiu CX, Hu G, Wang ST, et al. In vivo hepatotoxicity screening of different extracts, components, and constituents of polygoni multiflori Thunb. In zebrafish (Danio rerio) larvae. Biomed Pharmacother. 2020;131:110524. https:\/\/doi.org\/10.1016\/j.biopha.2020.110524.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1672_CR27","doi-asserted-by":"publisher","first-page":"17952","DOI":"10.1038\/s41598-017-18231-y","volume":"7","author":"Q Wang","year":"2017","unstructured":"Wang Q, Wang Y, Li Y, Wen BY, Dai Z, Ma SC, et al. Identification and characterization of the structure-activity relationships involved in UGT1A1 Inhibition by anthraquinone and dianthrone constituents of polygonum multiflorum. Sci Rep. 2017;7(1):17952. https:\/\/doi.org\/10.1038\/s41598-017-18231-y.","journal-title":"Sci Rep"},{"issue":"6","key":"1672_CR28","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3736\/jcim20100608","volume":"8","author":"RC Zhang","year":"2010","unstructured":"Zhang RC, Liu B, Sun ZX, Xu DY. [Effects of extract of polygonum multiflorum on cell cycle arrest and apoptosis of human liver cell line L02]. Zhong Xi Yi Jie He Xue Bao. 2010;8(6):554\u201361. https:\/\/doi.org\/10.3736\/jcim20100608.","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"issue":"12","key":"1672_CR29","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.19803\/j.1672-8629.20220458","volume":"19","author":"YY Li","year":"2022","unstructured":"Li YY, Wang Y, Zhang NP, Yang JB, Liu Y, Wang Q, et al. Effects of duration of steaming on 26 chemical compositions of polygoni multiflori radix based on UPLC-MS\/MS detection technology. Chin J Pharmacovigil. 2022;19(12):1295\u2013302. https:\/\/doi.org\/10.19803\/j.1672-8629.20220458.","journal-title":"Chin J Pharmacovigil"},{"issue":"2","key":"1672_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1021\/acs.jnatprod.9b00777","volume":"83","author":"TA Nguyen","year":"2020","unstructured":"Nguyen TA, Ha MT, Park SE, Choi JS, Min BS, Kim JA. Stilbenes with potent protein tyrosine Phosphatase-1B inhibitory activity from the roots of polygonum multiflorum. J Nat Prod. 2020;83(2):323\u201332. https:\/\/doi.org\/10.1021\/acs.jnatprod.9b00777.","journal-title":"J Nat Prod"},{"issue":"3","key":"1672_CR31","first-page":"451","volume":"30","author":"TT Yuan","year":"2023","unstructured":"Yuan TT, Jiang X, Li X, Wang HY. Intervention effects of TSG on SUR2B subtype KATP channel in renal tissue of diabetic nephropathy rats. Chin J Traditional Med Sci Technol. 2023;30(3):451\u20134.","journal-title":"Chin J Traditional Med Sci Technol"},{"key":"1672_CR32","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jpba.2018.11.034","volume":"164","author":"YC Xing","year":"2019","unstructured":"Xing YC, Wang LL, Wang CX, Zhang YC, Zhang Y, Hu LM, et al. Pharmacokinetic studies unveiled the drug-drug interaction between trans-2,3,5,4\u2019-tetrahydroxystilbene-2-O-\u03b2-D-glucopyranoside and Emodin that May contribute to the idiosyncratic hepatotoxicity of polygoni multiflori radix. J Pharm Biomed Anal. 2019;164:672\u201380. https:\/\/doi.org\/10.1016\/j.jpba.2018.11.034.","journal-title":"J Pharm Biomed Anal"},{"issue":"07","key":"1672_CR33","doi-asserted-by":"publisher","first-page":"694","DOI":"10.16025\/j.1674-1307.2016.07.023","volume":"35","author":"J Song","year":"2016","unstructured":"Song J, Ma ZJ, Wang JB, Xiao XH, Zhao KJ. Study on the hepatotoxic effects of polygonum multiflorum and its main components on normal human L02 hepatocytes. Beijing J Traditional Chin Med. 2016;35(07):694\u20137. https:\/\/doi.org\/10.16025\/j.1674-1307.2016.07.023.","journal-title":"Beijing J Traditional Chin Med"},{"key":"1672_CR34","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.fct.2017.10.033","volume":"119","author":"RB Feng","year":"2018","unstructured":"Feng RB, Wang Y, He C, Yang Y, Wan JB. Gallic acid, a natural polyphenol, protects against tert- Butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. Food Chem Toxicol. 2018;119:479\u201388. https:\/\/doi.org\/10.1016\/j.fct.2017.10.033.","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"1672_CR35","doi-asserted-by":"publisher","first-page":"42","DOI":"10.13995\/j.cnki.11-1802\/ts.034635","volume":"50","author":"S Wang","year":"2024","unstructured":"Wang S, Liang T, Luo L, Liu YQ, Fang Y, Li S, et al. Study on the antioxidant activity and neuroprotective effect of Quinic acid. Food Ferment Industries. 2024;50(5):42\u20137. https:\/\/doi.org\/10.13995\/j.cnki.11-1802\/ts.034635.","journal-title":"Food Ferment Industries"},{"issue":"8","key":"1672_CR36","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1002\/jps.2600610821","volume":"61","author":"S Ghosal","year":"1972","unstructured":"Ghosal S, Dutta SK, Bhattacharya SK. Erythrina\u2013chemical and Pharmacological evaluation II: alkaloids of erythrina variegata L. J Pharm Sci. 1972;61(8):1274\u20137. https:\/\/doi.org\/10.1002\/jps.2600610821.","journal-title":"J Pharm Sci"},{"issue":"15","key":"1672_CR37","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.7501\/j.issn.0253-2670.2022.15.008","volume":"53","author":"T Zhang","year":"2022","unstructured":"Zhang T, Zhang Q, Yi HY, et al. Analysis on multi-index components of polygoni multiflori radix and its processed products based on fingerprints and chemometrics. Chin Traditional Herb Drugs. 2022;53(15):4653\u201362. https:\/\/doi.org\/10.7501\/j.issn.0253-2670.2022.15.008.","journal-title":"Chin Traditional Herb Drugs"},{"issue":"15","key":"1672_CR38","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.7501\/j.issn.0253-2670.2024.15.004","volume":"55","author":"ZX Kang","year":"2024","unstructured":"Kang ZX, Sun E, Guo SC, et al. Analysis of rheum palmatum\u2019s components changes before and after steaming with wine based on UPLC-Q\/TOF-MS. Chin Traditional Herb Drugs. 2024;55(15):5033\u201349. https:\/\/doi.org\/10.7501\/j.issn.0253-2670.2024.15.004.","journal-title":"Chin Traditional Herb Drugs"}],"container-title":["BMC Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13065-025-01672-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13065-025-01672-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13065-025-01672-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T15:51:29Z","timestamp":1763135489000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcchem.biomedcentral.com\/articles\/10.1186\/s13065-025-01672-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1672"],"URL":"https:\/\/doi.org\/10.1186\/s13065-025-01672-2","relation":{},"ISSN":["2661-801X"],"issn-type":[{"value":"2661-801X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"6 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"302"}}