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For the plasma studies, drug-free human plasma was acquired as a commercially available, completely anonymized biological substance from the Egyptian Holding Company for Biological Products and Vaccines (VACSERA, Giza, Egypt). Because the plasma was obtained anonymously for analytical method development and was not collected specifically for the present investigation, the study falls outside the institutional ethical approval and informed consent requirements applicable to research involving identifiable human participants, as stipulated by Article 3 of the Egyptian Clinical Research Law No. 214 of 2020 and the relevant VACSERA policy governing secondary use of biological materials. The experimental work was nevertheless performed in accordance with internationally accepted ethical principles, including those set out in the Declaration of Helsinki and its subsequent amendments.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"193"}}