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Shifting production to bioactive compounds, such as antimicrobial peptides, could provide an opportunity to increase the economic viability of biorefineries.<\/jats:p>\n <\/jats:sec>\n \n \n Results<\/jats:bold>\n <\/jats:title>\n \n Recombinant production of the antimicrobial peptide pediocin\u00a0PA-1 in\n Corynebacterium glutamicum<\/jats:italic>\n was transferred from yeast extract-based media to minimal media based on lignocellulosic spent sulfite liquor. Induced batch, fed batch, and extended batch process modes were compared for highest pediocin\u00a0PA-1 production.\n <\/jats:p>\n <\/jats:sec>\n \n \n Conclusion<\/jats:bold>\n <\/jats:title>\n \n For pediocin\u00a0PA-1 production on lignocellulosic residues, extended batch cultivation was identified as the optimal process mode, producing up to\n \n \n $$\\simeq$$<\/jats:tex-math>\n \n \u2243<\/mml:mo>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n \u00a0104\u00a0mg\/L active pediocin\u00a0PA-1. Moreover, the production of pediocin\u00a0PA-1 on this sustainable second generation resource exceeded its state-of-the-art production on yeast extract-based media\n \n \n $$\\simeq$$<\/jats:tex-math>\n \n \u2243<\/mml:mo>\n <\/mml:math>\n <\/jats:alternatives>\n <\/jats:inline-formula>\n \u00a01.5-fold.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s13068-024-02587-1","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:39:05Z","timestamp":1734532745000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u00a0Antimicrobial peptide production with Corynebacterium glutamicum on lignocellulosic side streams"],"prefix":"10.1186","volume":"17","author":[{"given":"Daniel","family":"Waldschitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark-Richard","family":"Neudert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Kitzm\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hwi","family":"Bong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Bus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Karner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Spadiut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"2587_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2021.111258","volume":"148","author":"Z Usmani","year":"2021","unstructured":"Usmani Z, Sharma M, Awasthi AK, Lukk T, Tuohy MG, Gong L, et al. 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