{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:33:55Z","timestamp":1792499635516,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s13071-014-0525-3","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T17:02:11Z","timestamp":1416589331000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The speed of kill of fluralaner (Bravecto\u2122) against Ixodes ricinus ticks on dogs"],"prefix":"10.1186","volume":"7","author":[{"given":"Christina","family":"Wengenmayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Zschiesche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Langenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer KA","family":"Roepke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja R","family":"Heckeroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"525_CR1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.vetpar.2011.03.040","volume":"179","author":"B Chomel","year":"2011","unstructured":"Chomel B: Tick-borne infections in dogs-an emerging infectious threat. Vet Parasitol. 2011, 179: 294-301. 10.1016\/j.vetpar.2011.03.040.","journal-title":"Vet Parasitol"},{"key":"525_CR2","first-page":"30","volume-title":"2nd Canine Vector-Borne Disease (CVBD) Symposium","author":"SE Little","year":"2007","unstructured":"Little SE: Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. 2nd Canine Vector-Borne Disease (CVBD) Symposium. 2007, Mazara del Vallo, Sicily, Italy, 30-34."},{"key":"525_CR3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.pt.2012.07.003","volume":"28","author":"F Dantas-Torres","year":"2012","unstructured":"Dantas-Torres F, Chomel BB, Otranto D: Ticks and tick-borne diseases: a One health perspective. Trends Parasitol. 2012, 28: 437-446. 10.1016\/j.pt.2012.07.003.","journal-title":"Trends Parasitol"},{"key":"525_CR4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.ento.53.103106.093429","volume":"53","author":"J Piesman","year":"2008","unstructured":"Piesman J, Eisen L: Prevention of tick-borne diseases. Annu Rev Entomol. 2008, 53: 323-343. 10.1146\/annurev.ento.53.103106.093429.","journal-title":"Annu Rev Entomol"},{"key":"525_CR5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pt.2013.12.001","volume":"30","author":"PJ Irwin","year":"2014","unstructured":"Irwin PJ: It shouldn't happen to a dog - or a veterinarian: clinical paradigms for canine vector-borne diseases. Trends Parasitol. 2014, 30: 104-112. 10.1016\/j.pt.2013.12.001.","journal-title":"Trends Parasitol"},{"key":"525_CR6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pt.2009.02.005","volume":"25","author":"D Otranto","year":"2009","unstructured":"Otranto D, Dantas-Torres F, Breitschwerdt EB: Managing canine vector-borne diseases of zoonotic concern: part two. Trends Parasitol. 2009, 25: 228-235. 10.1016\/j.pt.2009.02.005.","journal-title":"Trends Parasitol"},{"key":"525_CR7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.vetpar.2011.03.047","volume":"179","author":"F Jongejan","year":"2011","unstructured":"Jongejan F, Fourie JJ, Chester ST, Manavella C, Mallouk Y, Pollmeier MG, Baggott D: The prevention of transmission of Babesia canis canis by Dermacentor reticulatus ticks to dogs using a novel combination of fipronil, amitraz and (S)-methoprene. Vet Parasitol. 2011, 179: 343-350. 10.1016\/j.vetpar.2011.03.047.","journal-title":"Vet Parasitol"},{"key":"525_CR8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1051\/parasite\/2013037","volume":"20","author":"JJ Fourie","year":"2013","unstructured":"Fourie JJ, Luus HG, Stanneck D, Jongejan F: The efficacy of Advantix to prevent transmission of Ehrlichia canis to dogs by Rhipicephalus sanguineus ticks. Parasite. 2013, 20: 36-10.1051\/parasite\/2013037.","journal-title":"Parasite"},{"key":"525_CR9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.vetpar.2013.07.026","volume":"197","author":"JJ Fourie","year":"2013","unstructured":"Fourie JJ, Stanneck D, Luus HG, Beugnet F, Wijnveld M, Jongejan F: Transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks feeding on dogs and on artificial membranes. Vet Parasitol. 2013, 197: 595-603. 10.1016\/j.vetpar.2013.07.026.","journal-title":"Vet Parasitol"},{"key":"525_CR10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","volume":"45","author":"M Gassel","year":"2014","unstructured":"Gassel M, Wolf C, Noack S, Williams H, Ilg T: The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod gamma-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal\/acaricidal activity. Insect Biochem Mol Biol. 2014, 45: 111-124. 10.1016\/j.ibmb.2013.11.009.","journal-title":"Insect Biochem Mol Biol"},{"key":"525_CR11","unstructured":"Bravecto EPAR summary for the public.European Medicines Agency ., [ http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Summary_for_the_public\/veterinary\/002526\/WC500163861.pdf ]"},{"key":"525_CR12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.bbrc.2009.11.131","volume":"391","author":"Y Ozoe","year":"2010","unstructured":"Ozoe Y, Asahi M, Ozoe F, Nakahira K, Mita T: The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem Biophys Res Commun. 2010, 391: 744-749. 10.1016\/j.bbrc.2009.11.131.","journal-title":"Biochem Biophys Res Commun"},{"key":"525_CR13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1756-3305-7-87","volume":"7","author":"FM Walther","year":"2014","unstructured":"Walther FM, Allan MJ, Roepke RK, Nuernberger MC: Safety of fluralaner chewable tablets (Bravecto), a novel systemic antiparasitic drug, in dogs after oral administration. Parasit Vectors. 2014, 7: 87-10.1186\/1756-3305-7-87.","journal-title":"Parasit Vectors"},{"key":"525_CR14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1756-3305-7-86","volume":"7","author":"FM Walther","year":"2014","unstructured":"Walther FM, Paul AJ, Allan MJ, Roepke RK, Nuernberger MC: Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-\/-) Collies after oral administration. Parasit Vectors. 2014, 7: 86-10.1186\/1756-3305-7-86.","journal-title":"Parasit Vectors"},{"key":"525_CR15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1756-3305-7-85","volume":"7","author":"S Kilp","year":"2014","unstructured":"Kilp S, Ramirez D, Allan MJ, Roepke RK, Nuernberger MC: Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration. Parasit Vectors. 2014, 7: 85-10.1186\/1756-3305-7-85.","journal-title":"Parasit Vectors"},{"key":"525_CR16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1756-3305-7-83","volume":"7","author":"N Rohdich","year":"2014","unstructured":"Rohdich N, Roepke RK, Zschiesche E: A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto (fluralaner) against Frontline (fipronil) in flea- and tick-infested dogs. Parasit Vectors. 2014, 7: 83-10.1186\/1756-3305-7-83.","journal-title":"Parasit Vectors"},{"key":"525_CR17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","volume":"379","author":"G Stanek","year":"2012","unstructured":"Stanek G, Wormser GP, Gray J, Strle F: Lyme borreliosis. Lancet. 2012, 379: 461-473. 10.1016\/S0140-6736(11)60103-7.","journal-title":"Lancet"},{"key":"525_CR18","first-page":"742","volume":"10","author":"L Kidd","year":"2003","unstructured":"Kidd L, Breitschwerdt EB: Tranmission times and prevention of tick-borne diseases in dogs. Compend Contin Educ Pract Vet. 2003, 10: 742-751.","journal-title":"Compend Contin Educ Pract Vet"},{"key":"525_CR19","first-page":"584","volume":"88","author":"CH Heile","year":"2007","unstructured":"Heile CH, Hoffmann-K\u00f6hler P, Weimann A, Schein E: Uebertragungszeiten von durch Zecken \u00fcbertragenen Erregern beim Hund: Borrelien, Anaplasmen\/Ehrlichien und Babesien. Praktischer Tierarzt. 2007, 88: 584-590.","journal-title":"Praktischer Tierarzt"},{"key":"525_CR20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1086\/318818","volume":"183","author":"F des Vignes","year":"2001","unstructured":"des Vignes F, Piesman J, Heffernan R, Schulze TL, Stafford KC, Fish D: Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs. J Infect Dis. 2001, 183: 773-778. 10.1086\/318818.","journal-title":"J Infect Dis"},{"key":"525_CR21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/153036602760260724","volume":"2","author":"M Crippa","year":"2002","unstructured":"Crippa M, Rais O, Gern L: Investigations on the mode and dynamics of transmission and infectivity of Borrelia burgdorferi sensu stricto and Borrelia afzelii in Ixodes ricinus ticks. Vector Borne Zoonotic Dis. 2002, 2: 3-9. 10.1089\/153036602760260724.","journal-title":"Vector Borne Zoonotic Dis"},{"key":"525_CR22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.vetpar.2011.03.043","volume":"179","author":"JB Prullage","year":"2011","unstructured":"Prullage JB, Hair JA, Everett WR, Yoon SS, Cramer LG, Franke S, Cornelison K, Hunter JS: The prevention of attachment and the detachment effects of a novel combination of fipronil, amitraz and (S)-methoprene for Rhipicephalus sanguineus and Dermacentor variabilis on dogs. Vet Parasitol. 2011, 179: 311-317. 10.1016\/j.vetpar.2011.03.043.","journal-title":"Vet Parasitol"},{"key":"525_CR23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-4017(02)00410-7","volume":"112","author":"B Davoust","year":"2003","unstructured":"Davoust B, Marie JL, Mercier S, Boni M, Vandeweghe A, Parzy D, Beugnet F: Assay of fipronil efficacy to prevent canine monocytic ehrlichiosis in endemic areas. Vet Parasitol. 2003, 112: 91-100. 10.1016\/S0304-4017(02)00410-7.","journal-title":"Vet Parasitol"},{"key":"525_CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vetpar.2012.12.009","volume":"193","author":"JJ Fourie","year":"2013","unstructured":"Fourie JJ, Ollagnier C, Beugnet F, Luus HG, Jongejan F: Prevention of transmission of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs treated with a combination of fipronil, amitraz and (S)-methoprene (CERTIFECT(R)). Vet Parasitol. 2013, 193: 223-228. 10.1016\/j.vetpar.2012.12.009.","journal-title":"Vet Parasitol"},{"key":"525_CR25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.vetpar.2008.02.008","volume":"153","author":"D Otranto","year":"2008","unstructured":"Otranto D, Paradies P, Testini G, Latrofa MS, Weigl S, Cantacessi C, Mencke N, de Caprariis D, Parisi A, Capelli G, Stanneck D: Application of 10% imidacloprid\/50% permethrin to prevent Ehrlichia canis exposure in dogs under natural conditions. Vet Parasitol. 2008, 153: 320-328. 10.1016\/j.vetpar.2008.02.008.","journal-title":"Vet Parasitol"},{"key":"525_CR26","first-page":"69","volume":"3","author":"BL Blagburn","year":"2005","unstructured":"Blagburn BL, Spencer JA, Butler JM, Land TM, Billeter SA, Dykstra CC, Stafford KC, Pough MB, Levy SA, Endrizzi M, Hostetler J: Prevention of transmission of Borrelia burgdorferi and Anaplasma phagoyctophilum from ticks to dogs using K9 Advantix and Frontline Plus applied 25 days before exposure to infected ticks. Intern J Appl Res Vet Med. 2005, 3: 69-75.","journal-title":"Intern J Appl Res Vet Med"},{"key":"525_CR27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.vetpar.2011.03.046","volume":"179","author":"JW McCall","year":"2011","unstructured":"McCall JW, Baker CF, Mather TN, Chester ST, McCall SD, Irwin JP, Young SL, Cramer LG, Pollmeier MG: The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis. Vet Parasitol. 2011, 179: 335-342. 10.1016\/j.vetpar.2011.03.046.","journal-title":"Vet Parasitol"},{"key":"525_CR28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1051\/parasite\/2011184319","volume":"18","author":"JJ Fourie","year":"2011","unstructured":"Fourie JJ, Beugnet F, Ollagnier C, Pollmeier MG: Study of the sustained speed of kill of the combination of fipronil\/amitraz\/(S)-methoprene and the combination of imidacloprid\/permethrin against Dermacentor reticulatus, the European dog tick. Parasite. 2011, 18: 319-323. 10.1051\/parasite\/2011184319.","journal-title":"Parasite"},{"key":"525_CR29","first-page":"42","volume":"10","author":"BN Kunkle","year":"2012","unstructured":"Kunkle BN, Everett WR, Yoon SS, Beugnet F, Pollmeier M: Study of the sustained speed of kill of the combination fipronil\/amitraz\/(S)-methoprene and the combination imidacloprid\/permethrin against newly acquired Dermacentor variabilis (American Dog Tick). Intern J Appl Res Vet Med. 2012, 10: 42-47.","journal-title":"Intern J Appl Res Vet Med"},{"key":"525_CR30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.vetpar.2011.03.042","volume":"179","author":"JS Hunter 3rd","year":"2011","unstructured":"Hunter JS, Baggott D, Everett WR, Fourie JJ, Cramer LG, Yoon SS, Collidor N, Mallouk Y, Lee L, Blair J, Prullage JB: Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations of brown dog ticks (Rhipicephalus sanguineus) on dogs. Vet Parasitol. 2011, 179: 318-323. 10.1016\/j.vetpar.2011.03.042.","journal-title":"Vet Parasitol"},{"key":"525_CR31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.vetpar.2011.03.044","volume":"179","author":"CF Baker","year":"2011","unstructured":"Baker CF, Hunter JS, McCall JW, Young DR, Hair JA, Everett WR, Yoon SS, Irwin JP, Young SL, Cramer LG, Pollmeier MG, Prullage JB: Efficacy of a novel topical combination of fipronil, amitraz and (S)-methoprene for treatment and control of induced infestations with four North American tick species (Dermacentor variabilis, Ixodes scapularis, Amblyomma americanum and Amblyomma maculatum) on dogs. Vet Parasitol. 2011, 179: 324-329. 10.1016\/j.vetpar.2011.03.044.","journal-title":"Vet Parasitol"},{"key":"525_CR32","first-page":"69","volume":"126","author":"S Beck","year":"2013","unstructured":"Beck S, Schein E, Baldermann C, von Samson-Himmelstjerna G, Kohn B: [Tick infestation and tick prophylaxis in dogs in the area of Berlin\/Brandenburg-results of a questionnaire study]. Berl Munch Tierarztl Wochenschr. 2013, 126: 69-76.","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"525_CR33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vetpar.2013.04.007","volume":"195","author":"N Mencke","year":"2013","unstructured":"Mencke N: Future challenges for parasitology: vector control and 'One health' in Europe: the veterinary medicinal view on CVBDs such as tick borreliosis, rickettsiosis and canine leishmaniosis. Vet Parasitol. 2013, 195: 256-271. 10.1016\/j.vetpar.2013.04.007.","journal-title":"Vet Parasitol"},{"key":"525_CR34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1756-3305-6-62","volume":"6","author":"M Leschnik","year":"2013","unstructured":"Leschnik M, Feiler A, Duscher GG, Joachim A: Effect of owner-controlled acaricidal treatment on tick infestation and immune response to tick-borne pathogens in naturally infested dogs from Eastern Austria. Parasit Vectors. 2013, 6: 62-10.1186\/1756-3305-6-62.","journal-title":"Parasit Vectors"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-014-0525-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-014-0525-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-014-0525-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T22:52:03Z","timestamp":1553640723000},"score":1,"resource":{"primary":{"URL":"http:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-014-0525-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["525"],"URL":"https:\/\/doi.org\/10.1186\/s13071-014-0525-3","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]},"article-number":"525"}}