{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:47:13Z","timestamp":1793371633569,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-014-0610-7","type":"journal-article","created":{"date-parts":[[2015,1,7]],"date-time":"2015-01-07T18:09:04Z","timestamp":1420654144000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Alteration of immunoproteome profile of Echinococcus granulosus hydatid fluid with progression of cystic echinococcosis"],"prefix":"10.1186","volume":"8","author":[{"given":"Chun-Seob","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-An","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Taek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Jong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insug","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"610_CR1","first-page":"107","volume":"27","author":"J Eckert","year":"2009","unstructured":"Eckert J, Deplazes P: Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern.\n                  Clin Microbiol Rev 2009, 27:107\u2013135.","journal-title":"Clin Microbiol Rev"},{"key":"610_CR2","doi-asserted-by":"crossref","unstructured":"Zhang W, Zhang Z, Wu W, Shi B, Li J, Zhou X, Wen H, McManus DP: Epidemiology and control of echinococcosis in central Asia, with particular reference to the People\u2019s Republic of China.\n                  Acta Trop 2014. http:\/\/dx.doi.org\/10.1016\/j.actatropica.2014.03.014.","DOI":"10.1016\/j.actatropica.2014.03.014"},{"key":"610_CR3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/1756-3305-5-146","volume":"5","author":"YR Yang","year":"2012","unstructured":"Yang YR, Clements AC, Gray DJ, Atkinson JA, Williams GM, Barnes TS, McManus DP: Impact of anthropogenic and natural environmental changes on\n                  Echinococcus\n                  transmission in Ningxia Hui Autonomous Region, the People\u2019s Republic of China.\n                  Parasit Vectors 2012, 5:146.","journal-title":"Parasit Vectors"},{"key":"610_CR4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S1473-3099(07)70134-2","volume":"7","author":"PS Craig","year":"2007","unstructured":"Craig PS, McManus DP, Lightowlers MW, Chabalgoity JA, Garcia HH, Gavidia CM, Gilman RH, Gonzalez AE, Lorca M, Naquira C, Nieto A, Schantz PM: Prevention and control of cystic echinococcosis.\n                  Lancet Infect Dis 2007, 7:385\u2013394.","journal-title":"Lancet Infect Dis"},{"key":"610_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","volume":"114","author":"E Brunetti","year":"2010","unstructured":"Brunetti E, Kern P, Vuitton DA: Writing panel for the WHO-IWGE. expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans.\n                  Acta Trop 2010, 114:1\u201316.","journal-title":"Acta Trop"},{"key":"610_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/BF00157397","volume":"9","author":"M Caremani","year":"1993","unstructured":"Caremani M, Maestrini R, Occhini U, Sassoli S, Accorsi A, Giorgio A, Filice C: Echographic epidemiology of cystic hydatid disease in Italy.\n                  Eur J Epidemiol 1993, 9:401\u2013404.","journal-title":"Eur J Epidemiol"},{"key":"610_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0001-706X(96)00641-9","volume":"64","author":"R Perdomo","year":"1997","unstructured":"Perdomo R, Alvarez C, Monti J, Ferreira C, Chiesa A, Carb\u00f3 A, Alvez R, Grauert R, Stern D, Carmona C, Yarzabal L: Principles of the surgical approach in human liver cystic echinococcosis.\n                  Acta Trop 1997, 64:109\u2013122.","journal-title":"Acta Trop"},{"key":"610_CR8","volume-title":"WHO\/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern","author":"J Eckert","year":"2001","unstructured":"Eckert J, Gemmell MA, Meslin FX, Pawlowski ZS: WHO\/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern. Paris: WHO\/OIE; 2001."},{"key":"610_CR9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10140-013-1137-5","volume":"20","author":"MS Taheri","year":"2013","unstructured":"Taheri MS, Pourghorban R, Faghihi Langroudi T, Shabestari AA, Haghighatkhah H, Bagheri SM: Not-to-tap cystic lesions: spectrum of hydatid disease.\n                  Emerg Radiol 2013, 20:553\u2013561.","journal-title":"Emerg Radiol"},{"key":"610_CR10","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.ijpara.2008.06.003","volume":"38","author":"A Siracusano","year":"2008","unstructured":"Siracusano A, Margutti P, Delunardo F, Profumo E, Rigan\u00f2 R, Buttari B, Teggi A, Ortona E: Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of\n                  Echinococcus antigen\n                  B in cystic echinococcosis.\n                  Int J Parasitol 2008, 38:1371\u20131376.","journal-title":"Int J Parasitol"},{"key":"610_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1046\/j.1365-3024.2000.00336.x","volume":"22","author":"E Ortona","year":"2000","unstructured":"Ortona E, Rigan\u00f2 R, Margutti P, Notargiacomo S, Ioppolo S, Vaccari S, Barca S, Buttari B, Profumo E, Teggi A, Siracusano A: Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis.\n                  Parasite Immunol 2000, 22:553\u2013559.","journal-title":"Parasite Immunol"},{"key":"610_CR12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1017\/S0031182005008309","volume":"131","author":"C Lorenzo","year":"2005","unstructured":"Lorenzo C, Last JA, Gonz\u00e1lez-Sapienza GG: The immunogenicity of\n                  Echinococcus granulosus\n                  antigen 5 is determined by its post-translational modifications.\n                  Parasitology 2005, 131:669\u2013677.","journal-title":"Parasitology"},{"key":"610_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.gene.2004.02.027","volume":"333","author":"KL Haag","year":"2004","unstructured":"Haag KL, Alves-Junior L, Zaha A, Ayala FJ: Contingent, non-neutral evolution in a multicellular parasite: natural selection and gene conversion in the\n                  Echinococcus granulosus\n                  antigen B gene family.\n                  Gene 2004, 333:157\u2013167.","journal-title":"Gene"},{"key":"610_CR14","doi-asserted-by":"publisher","first-page":"e784","DOI":"10.1371\/journal.pntd.0000784","volume":"4","author":"W Zhang","year":"2010","unstructured":"Zhang W, Li J, Jones MK, Zhang Z, Zhao L, Blair D, McManus DP: The\n                  Echinococcus granulosus\n                  antigen B gene family comprises at least 10 unique genes in five subclasses which are differentially expressed.\n                  PLoS Negl Trop Dis 2010, 4:e784.","journal-title":"PLoS Negl Trop Dis"},{"key":"610_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0166-6851(91)90223-S","volume":"44","author":"JC Shepherd","year":"1991","unstructured":"Shepherd JC, Aitken A, McManus DP: A protein secreted in vivo by\n                  Echinococcus granulosus\n                  inhibits elastase activity and neutrophil chemotaxis.\n                  Mol Biochem Parasitol 1991, 44:81\u201390.","journal-title":"Mol Biochem Parasitol"},{"key":"610_CR16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/00034983.2000.11813546","volume":"94","author":"AO Daeki","year":"2000","unstructured":"Daeki AO, Craig PS, Shambesh MK: IgG-subclass antibody responses and the natural history of hepatic cystic echinococcosis in asymptomatic patients.\n                  Ann Trop Med Parasitol 2000, 94:319\u2013328.","journal-title":"Ann Trop Med Parasitol"},{"key":"610_CR17","doi-asserted-by":"publisher","first-page":"e1642","DOI":"10.1371\/journal.pntd.0001642","volume":"6","author":"G Obal","year":"2012","unstructured":"Obal G, Ramos AL, Silva V, Lima A, Batthyany C, Bessio MI, Ferreira F, Salinas G, Ferreira AM: Characterisation of the native lipid moiety of\n                  Echinococcus granulosus\n                  antigen B.\n                  PLoS Negl Trop Dis 2012, 6:e1642.","journal-title":"PLoS Negl Trop Dis"},{"key":"610_CR18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.2008.79.301","volume":"79","author":"T Junghanss","year":"2008","unstructured":"Junghanss T, da Silva AM, Horton J, Chiodini PL, Brunetti E: Clinical management of cystic echinococcosis: state of the art, problems, and perspectives.\n                  Am J Trop Med Hyg 2008, 79:301\u2013311.","journal-title":"Am J Trop Med Hyg"},{"key":"610_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4269\/ajtmh.13-0341","volume":"90","author":"M Mariconti","year":"2014","unstructured":"Mariconti M, Bazzocchi C, Tamarozzi F, Meroni V, Genco F, Maserati R, Brunetti E: Immunoblotting with human native antigen shows stage-related sensitivity in the serodiagnosis of hepatic cystic echinococcosis.\n                  Am J Trop Med Hyg 2014, 90:75\u201379.","journal-title":"Am J Trop Med Hyg"},{"key":"610_CR20","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1002\/prca.200800084","volume":"2","author":"YA Bae","year":"2008","unstructured":"Bae YA, Jeong YT, Chung JY, Kim SH, Mahanta J, Feng Z, Chong CK, Kim TS, Kong Y: A recombinant chimeric antigen toward a standardized serodiagnosis of\n                  Taenia solium\n                  neurocysticercosis.\n                  Proteomics Clin Appl 2008, 2:1596\u20131610.","journal-title":"Proteomics Clin Appl"},{"key":"610_CR21","doi-asserted-by":"publisher","first-page":"e1551","DOI":"10.1371\/journal.pntd.0001551","volume":"6","author":"KM Monteiro","year":"2012","unstructured":"Monteiro KM, Cardoso MB, Follmer C, da Silveira NP, Vargas DM, Kitajima EW, Zaha A, Ferreira HB: Echinococcus granulosus\n                  antigen B structure: subunit composition and oligomeric states.\n                  PLoS Negl Trop Dis 2012, 6:e1551.","journal-title":"PLoS Negl Trop Dis"},{"key":"610_CR22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0166-6851(89)90149-7","volume":"37","author":"MW Lightowlers","year":"1989","unstructured":"Lightowlers MW, Liu DY, Haralambous A, Rickard MD: Subunit composition and specificity of the major cyst fluid antigens of\n                  Echinococcus granulosus\n                  .\n                  Mol Biochem Parasitol 1989, 37:171\u2013182.","journal-title":"Mol Biochem Parasitol"},{"key":"610_CR23","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-3024.2006.00837.x","volume":"28","author":"AR Khabiri","year":"2006","unstructured":"Khabiri AR, Bagheri F, Assmar M, Siavashi MR: Analysis of specific IgE and IgG subclass antibodies for diagnosis of\n                  Echinococcus granulosus\n                  .\n                  Parasite Immunol 2006, 28:357\u2013362.","journal-title":"Parasite Immunol"},{"key":"610_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1017\/S0031182002002044","volume":"125","author":"MM Ibrahem","year":"2002","unstructured":"Ibrahem MM, Rafiei A, Dar FK, Azwai SM, Carter SD, Craig PS: Serodiagnosis of cystic echinococcosis in naturally infected camels.\n                  Parasitology 2002, 125:245\u2013251.","journal-title":"Parasitology"},{"key":"610_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/pim.12072","volume":"36","author":"DP McManus","year":"2004","unstructured":"McManus DP: Immunodiagnosis of sheep infections with\n                  Echinococcus granulosus\n                  : in 35\u00a0years where have we come?\n                  Parasite Immunol 2004, 36:125\u2013130.","journal-title":"Parasite Immunol"},{"key":"610_CR26","doi-asserted-by":"publisher","first-page":"4016","DOI":"10.1002\/pmic.200700332","volume":"7","author":"EG Lee","year":"2007","unstructured":"Lee EG, Kim SH, Bae YA, Chung JY, Suh M, Na BK, Kim TS, Kang I, Ma L, Kong Y: A hydrophobic ligand binding protein of the\n                  Taenia solium\n                  metacestode mediates uptake of the host lipid: implication for the maintenance of parasitic cellular homeostasis.\n                  Proteomics 2007, 7:4016\u20134030.","journal-title":"Proteomics"},{"key":"610_CR27","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.ijpara.2011.07.004","volume":"41","author":"SH Kim","year":"2011","unstructured":"Kim SH, Bae YA, Yang Y, Hong ST, Kong Y: Paralogous proteins comprising the 150\u00a0kDa hydrophobic-ligand-binding-protein complex of the\n                  Taenia solium\n                  metacestode have evolved non-overlapped binding affinities toward fatty acid analogs.\n                  Int J Parasitol 2011, 41:1207\u20131215.","journal-title":"Int J Parasitol"},{"key":"610_CR28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1046\/j.1365-2249.2003.02123.x","volume":"132","author":"VG Virginio","year":"2003","unstructured":"Virginio VG, Hern\u00e1ndez A, Rott MB, Monteiro KM, Zandonai AF, Nieto A, Zaha A, Ferreira HB: A set of recombinant antigens from\n                  Echinococcus granulosus\n                  with potential for use in the immunodiagnosis of human cystic hydatid disease.\n                  Clin Exp Immunol 2003, 132:309\u2013315.","journal-title":"Clin Exp Immunol"},{"key":"610_CR29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.molbiopara.2012.01.001","volume":"183","author":"VG Virginio","year":"2012","unstructured":"Virginio VG, Monteiro KM, Drumond F, de Carvalho MO, Vargas DM, Zaha A, Ferreira HB: Excretory\/secretory products from in vitro-cultured\n                  Echinococcus granulosus\n                  protoscoleces.\n                  Mol Biochem Parasitol 2012, 183:15\u201322.","journal-title":"Mol Biochem Parasitol"},{"key":"610_CR30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jprot.2013.04.013","volume":"84","author":"SJ Cui","year":"2013","unstructured":"Cui SJ, Xu LL, Zhang T, Xu M, Yao J, Fang CY, Feng Z, Yang PY, Hu W, Liu F: Proteomic characterization of larval and adult developmental stages in\n                  Echinococcus granulosus\n                  reveals novel insight into host-parasite interactions.\n                  J Proteomics 2013, 84:158\u2013175.","journal-title":"J Proteomics"},{"key":"610_CR31","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1128\/MMBR.00036-07","volume":"72","author":"C Gancedo","year":"2008","unstructured":"Gancedo C, Flores C: Moonlighting proteins in yeasts.\n                  Microbiol Mol Biol Rev 2008, 72:197\u2013210.","journal-title":"Microbiol Mol Biol Rev"},{"key":"610_CR32","doi-asserted-by":"publisher","first-page":"e1000188","DOI":"10.1371\/journal.ppat.1000188","volume":"4","author":"S Pomel","year":"2008","unstructured":"Pomel S, Luk FC, Beckers CJ: Host cell egress and invasion induce marked relocations of glycolytic enzymes in\n                  Toxoplasma gondii\n                  tachyzoites.\n                  PLoS Pathog 2008, 4:e1000188.","journal-title":"PLoS Pathog"},{"key":"610_CR33","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.gene.2012.06.046","volume":"506","author":"KR Lorenzatto","year":"2012","unstructured":"Lorenzatto KR, Monteiro KM, Paredes R, Paludo GP, da Fons\u00eaca MM, Galanti N, Zaha A, Ferreira HB: Fructose-bisphosphate aldolase and enolase from\n                  Echinococcus granulosus\n                  : genes, expression patterns and protein interactions of two potential moonlighting proteins.\n                  Gene 2012, 506:76\u201384.","journal-title":"Gene"},{"key":"610_CR34","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0076-6879(98)90029-5","volume":"290","author":"J Buchner","year":"1998","unstructured":"Buchner J, Grallert H, Jakob U: Analysis of chaperone function using citrate synthase as nonnative substrate protein.\n                  Methods Enzymol 1998, 290:323\u2013338.","journal-title":"Methods Enzymol"},{"key":"610_CR35","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1128\/IAI.68.6.3385-3393.2000","volume":"68","author":"H Asahi","year":"2000","unstructured":"Asahi H, Osman A, Cook RM, LoVerde PT, Stadecker MJ: Schistosoma mansoni\n                  phosphoenolpyruvate carboxykinase, a novel egg antigen: immunological properties of the recombinant protein and identification of a T-cell epitope.\n                  Infect Immun 2000, 68:3385\u20133393.","journal-title":"Infect Immun"},{"key":"610_CR36","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/pmic.200900506","volume":"10","author":"KM Monteiro","year":"2010","unstructured":"Monteiro KM, de Carvalho MO, Zaha A, Ferreira HB: Proteomic analysis of the\n                  Echinococcus granulosus\n                  metacestode during infection of its intermediate host.\n                  Proteomics 2010, 10:1985\u20131999.","journal-title":"Proteomics"},{"key":"610_CR37","first-page":"325","volume":"25","author":"J Ambrosio","year":"1994","unstructured":"Ambrosio J, Landa A, Merchant MT, Laclette JP: Protein uptake by cysticerci of\n                  Taenia crassiceps\n                  .\n                  Arch Med Res 1994, 25:325\u2013330.","journal-title":"Arch Med Res"}],"container-title":["Parasites & Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-014-0610-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-014-0610-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-014-0610-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-014-0610-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:08:07Z","timestamp":1630566487000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-014-0610-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["610"],"URL":"https:\/\/doi.org\/10.1186\/s13071-014-0610-7","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]},"assertion":[{"value":"30 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"10"}}