{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:14:29Z","timestamp":1790154869204,"version":"4.0.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Parasites Vectors"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13071-015-0636-5","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T12:47:53Z","timestamp":1421066873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Protective immunity induced by peptides of AMA1, RON2 and RON4 containing T-and B-cell epitopes via an intranasal route against toxoplasmosis in mice"],"prefix":"10.1186","volume":"8","author":[{"given":"Tie-E","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Rong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"636_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/CMR.11.2.267","volume":"11","author":"JP Dubey","year":"1998","unstructured":"Dubey JP, Lindsay DS, Speer CA. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin Microbiol Rev. 1998;11:267\u201399.","journal-title":"Clin Microbiol Rev"},{"key":"636_CR2","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/j.1469-0691.2008.02091.x","volume":"14","author":"F Derouin","year":"2008","unstructured":"Derouin F, Pelloux H. Prevention of toxoplasmosis in transplant patients. Clin Microbiol Infect. 2008;14:1089\u2013101.","journal-title":"Clin Microbiol Infect"},{"key":"636_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1863-2378.2009.01276.x","volume":"57","author":"EA Innes","year":"2010","unstructured":"Innes EA. A brief history and overview of Toxoplasma gondii. Zoonoses Public Health. 2010;57:1\u20137.","journal-title":"Zoonoses Public Health"},{"key":"636_CR4","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","volume":"30","author":"AM Tenter","year":"2000","unstructured":"Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000;30:1217\u201358.","journal-title":"Int J Parasitol"},{"key":"636_CR5","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1186\/s13071-014-0564-9","volume":"7","author":"H Andiappan","year":"2014","unstructured":"Andiappan H, Nissapatorn V, Sawangjaroen N, Nyunt M, Lau Y, Khaing S, et al. Comparative study on Toxoplasma infection between Malaysian and Myanmar pregnant women. Parasites Vectors. 2014;7:564\u201377.","journal-title":"Parasites Vectors"},{"key":"636_CR6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/rmv.307","volume":"11","author":"H Iijima","year":"2001","unstructured":"Iijima H, Takahashi I, Kiyono H. Mucosal immune network in the gut for the control of infectious diseases. Rev Med Virol. 2001;11:117\u201333.","journal-title":"Rev Med Virol"},{"key":"636_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1590\/S0074-02762009000200019","volume":"104","author":"E Jongert","year":"2009","unstructured":"Jongert E, Roberts CW, Gargano N, F\u00f6rster-Waldl E, Petersen E. Vaccines against Toxoplasma gondii: challenges and opportunities. Mem Inst Oswaldo Cruz. 2009;104:252\u201366.","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"636_CR8","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1091\/mbc.E05-04-0281","volume":"16","author":"J Mital","year":"2005","unstructured":"Mital J, Meissner M, Soldati D, Ward GE. Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion. Mol Biol Cell. 2005;16:4341\u20139.","journal-title":"Mol Biol Cell"},{"key":"636_CR9","doi-asserted-by":"publisher","first-page":"15644","DOI":"10.1074\/jbc.M109.092619","volume":"285","author":"J Crawford","year":"2010","unstructured":"Crawford J, Tonkin ML, Grujic O, Boulanger MJ. Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii. J Biol Chem. 2010;285:15644\u201352.","journal-title":"J Biol Chem"},{"key":"636_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.1199284","volume":"331","author":"JM Santos","year":"2010","unstructured":"Santos JM, Ferguson DJ, Blackman MJ, Soldati-Favre D. Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode. Science. 2010;331:473\u20137.","journal-title":"Science"},{"key":"636_CR11","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.pt.2011.04.002","volume":"27","author":"JS Tyler","year":"2011","unstructured":"Tyler JS, Treeck M, Boothroyd JC. Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication. Trends Parasitol. 2011;27:410\u201320.","journal-title":"Trends Parasitol"},{"key":"636_CR12","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1371\/journal.ppat.0010017","volume":"1","author":"DL Alexander","year":"2005","unstructured":"Alexander DL, Mital J, Ward GE, Bradley P, Boothroyd JC. Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles. PLoS Pathog. 2005;1:e17.","journal-title":"PLoS Pathog"},{"key":"636_CR13","doi-asserted-by":"publisher","first-page":"e1000309","DOI":"10.1371\/journal.ppat.1000309","volume":"5","author":"S Besteiro","year":"2009","unstructured":"Besteiro S, Michelin A, Poncet J, Dubremetz J-F, Lebrun M. Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS Pathog. 2009;5:e1000309.","journal-title":"PLoS Pathog"},{"key":"636_CR14","doi-asserted-by":"publisher","first-page":"e1001276","DOI":"10.1371\/journal.ppat.1001276","volume":"7","author":"M Lamarque","year":"2011","unstructured":"Lamarque M, Besteiro S, Papoin J, Roques M, Vulliez-Le Normand B, Morlon-Guyot J, et al. The RON2-AMA1 interaction is a critical step in moving junction dependent invasion by apicomplexan parasites. PLoS Pathog. 2011;7:e1001276.","journal-title":"PLoS Pathog"},{"key":"636_CR15","doi-asserted-by":"publisher","first-page":"e1001282","DOI":"10.1371\/journal.ppat.1001282","volume":"7","author":"JS Tyler","year":"2011","unstructured":"Tyler JS, Boothroyd JC. The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex. PLoS Pathog. 2011;7:e1001282.","journal-title":"PLoS Pathog"},{"key":"636_CR16","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1111\/j.1462-5822.2005.00646.x","volume":"7","author":"M Lebrun","year":"2005","unstructured":"Lebrun M, Michelin A, El Hajj H, Poncet J, Bradley PJ, Vial H, et al. The rhoptry neck protein RON4 relocalizes at the moving junction during Toxoplasma gondii invasion. Cell Microbiol. 2005;7:1823\u201333.","journal-title":"Cell Microbiol"},{"key":"636_CR17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.exppara.2007.01.017","volume":"116","author":"G Dautu","year":"2007","unstructured":"Dautu G, Munyaka B, Carmen G, Zhang G, Omata Y, Xuenan X, et al. Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential. Exp Parasitol. 2007;116:273\u201382.","journal-title":"Exp Parasitol"},{"key":"636_CR18","doi-asserted-by":"publisher","first-page":"13275","DOI":"10.1073\/pnas.1110303108","volume":"108","author":"P Srinivasan","year":"2011","unstructured":"Srinivasan P, Beatty WL, Diouf A, Herrera R, Ambroggio X, Moch JK, et al. Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion. Proc Natl Acad Sci U S A. 2011;108:13275\u201380.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"636_CR19","doi-asserted-by":"publisher","first-page":"8838","DOI":"10.1016\/j.vaccine.2011.09.099","volume":"29","author":"I Rashid","year":"2011","unstructured":"Rashid I, Hedhli D, Moir\u00e9 N, Pierre J, Debierre-Grockiego F, Dimier-Poisson I, et al. Immunological responses induced by a DNA vaccine expressing RON4 and by immunogenic recombinant protein RON4 failed to protect mice against chronic toxoplasmosis. Vaccine. 2011;29:8838\u201346.","journal-title":"Vaccine"},{"key":"636_CR20","doi-asserted-by":"publisher","first-page":"8619","DOI":"10.1016\/j.vaccine.2011.09.016","volume":"29","author":"Y Wang","year":"2011","unstructured":"Wang Y, Wang M, Wang G, Pang A, Fu B, Yin H, et al. Increased survival time in mice vaccinated with a branched lysine multiple antigenic peptide containing B- and T-cell epitopes from T. gondii antigens. Vaccine. 2011;29:8619\u201323.","journal-title":"Vaccine"},{"key":"636_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/1471-2334-13-207","volume":"13","author":"G Zhao","year":"2013","unstructured":"Zhao G, Zhou A, Lv G, Meng M, Sun M, Bai Y, et al. Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis. BMC Infect Dis. 2013;13:207.","journal-title":"BMC Infect Dis"},{"key":"636_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/BF02786362","volume":"16","author":"HY Wu","year":"1997","unstructured":"Wu HY, Russell MW. Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system. Immunol Res. 1997;16:187\u2013201.","journal-title":"Immunol Res"},{"key":"636_CR23","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.actatropica.2014.05.001","volume":"137","author":"HL Wang","year":"2014","unstructured":"Wang HL, Pang M, Yin LT, Zhang JH, Meng XL, Yu BF, et al. Intranasal immunisation of the recombinant Toxoplasma gondii receptor for activated C kinase 1 partly protects mice against T. gondiiin fection. Acta Trop. 2014;137:58\u201366.","journal-title":"Acta Trop"},{"key":"636_CR24","doi-asserted-by":"publisher","first-page":"e70884","DOI":"10.1371\/journal.pone.0070884","volume":"8","author":"HL Wang","year":"2013","unstructured":"Wang HL, Li YQ, Yin LT, Meng XL, Guo M, Zhang JH, et al. Toxoplasma gondii protein disulfide isomerase (TgPDI) is a novel vaccine candidate against toxoplasmosis. PLoS One. 2013;8:e70884.","journal-title":"PLoS One"},{"key":"636_CR25","doi-asserted-by":"publisher","first-page":"e82765","DOI":"10.1371\/journal.pone.0082765","volume":"8","author":"LT Yin","year":"2013","unstructured":"Yin LT, Hao HX, Wang HL, Zhang JH, Meng XL, Yin GR. Intranasal immunisation with recombinant Toxoplasma gondii actin partly protects mice against toxoplasmosis. PLoS One. 2013;8:e82765.","journal-title":"PLoS One"},{"key":"636_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1590\/S1984-29612010000400004","volume":"19","author":"M Igarashi","year":"2010","unstructured":"Igarashi M, Zulpo DL, Cunha IA, Barros LD, Pereira VF, Taroda A, et al. Toxoplasma gondii: humoral and cellular immune response of BALB\/c mice immunized via intranasal route with rTgROP2. Rev Bras Parasitol Vet. 2010;19:210\u20136.","journal-title":"Rev Bras Parasitol Vet"},{"key":"636_CR27","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00262-008-0651-x","volume":"58","author":"JM Yang","year":"2009","unstructured":"Yang JM, Wang HJ, Du L, Han XM, Ye ZY, Fang Y, et al. Screening and identification of novel B cell epitopes in human heparanase and their anti-invasion property for hepatocellular carcinoma. Cancer Immunol Immunother. 2009;58:1387\u201396.","journal-title":"Cancer Immunol Immunother"},{"key":"636_CR28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.vetmic.2009.07.011","volume":"140","author":"ZW Zhang","year":"2010","unstructured":"Zhang ZW, Zhang YG, Wang YL, Pan L, Fang YZ, Jiang ST, et al. Screening and identification of B cell epitopes of structural proteins of foot-and-mouth disease virus serotype Asia1. Vet Microbiol. 2010;140:25\u201333.","journal-title":"Vet Microbiol"},{"key":"636_CR29","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.exppara.2012.09.015","volume":"132","author":"Y Bai","year":"2012","unstructured":"Bai Y, He S, Zhao G, Chen L, Shi N, Zhou H, et al. Toxoplasma gondii: Bioinformatics analysis, cloning and expression of a novel protein TgIMP1. Exp Parasitol. 2012;132:458\u201364.","journal-title":"Exp Parasitol"},{"key":"636_CR30","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.vetpar.2013.06.013","volume":"197","author":"H Yu","year":"2013","unstructured":"Yu H, Huang B, Zhuo X, Chen X, Du A. Evaluation of a real-time PCR assay based on the single-copy SAG1 gene for the detection of Toxoplasma gondii. Vet Parasitol. 2013;197:670\u20133.","journal-title":"Vet Parasitol"},{"key":"636_CR31","first-page":"3960","volume":"1","author":"ED Cisney","year":"2012","unstructured":"Cisney ED, Fernandez S, Hall SI, Krietz GA, Ulrich RG. Examining the role of nasopharyngeal-associated lymphoreticular tissue (NALT) in mouse responses to vaccines. J Vis Exp. 2012;1:3960.","journal-title":"J Vis Exp"},{"key":"636_CR32","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.imbio.2010.08.007","volume":"216","author":"AL Goldoni","year":"2011","unstructured":"Goldoni AL, Maciel Jr M, Rigato PO, Piubelli O, de Brito CA, Melo A, et al. Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP\/gag DNA vaccine in mice. Immunobiology. 2011;216:505\u201312.","journal-title":"Immunobiology"},{"key":"636_CR33","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1016\/j.vaccine.2008.04.046","volume":"26","author":"H Cong","year":"2008","unstructured":"Cong H, Gu QM, Yin HE, Wang JW, Zhao QL, Zhou HY, et al. Multi-epitope DNA vaccine linked to the A2\/B subunit of cholera toxin protect mice against Toxoplasma gondii. Vaccine. 2008;26:3913\u201321.","journal-title":"Vaccine"},{"key":"636_CR34","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ijpara.2003.11.023","volume":"34","author":"L Kasper","year":"2004","unstructured":"Kasper L, Courret N, Darche S, Luangsay S, Mennechet F, Minns L, et al. Toxoplasma gondii and mucosal immunity. Int J Parasitol. 2004;34:401\u20139.","journal-title":"Int J Parasitol"},{"key":"636_CR35","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1586\/erv.11.196","volume":"11","author":"Y Fujkuyama","year":"2012","unstructured":"Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, et al. Novel vaccine development strategies for inducing mucosal immunity. Expert Rev Vaccines. 2012;11:367\u201379.","journal-title":"Expert Rev Vaccines"},{"key":"636_CR36","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1016\/j.vaccine.2006.12.001","volume":"25","author":"P Brandtzaeg","year":"2007","unstructured":"Brandtzaeg P. Induction of secretory immunity and memory at mucosal surfaces. Vaccine. 2007;25:5467\u201384.","journal-title":"Vaccine"},{"key":"636_CR37","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1128\/IAI.68.2.969-972.2000","volume":"68","author":"F Velge-Roussel","year":"2000","unstructured":"Velge-Roussel F, Marcelo P, Lepage AC, Buzoni-Gatel D, Bout DT. Intranasal immunization with Toxoplasma gondii SAG1 induces protective cells into both NALT and GALT compartments. Infect Immun. 2000;68:969\u201372.","journal-title":"Infect Immun"},{"key":"636_CR38","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1586\/erv.12.81","volume":"11","author":"A Gebril","year":"2012","unstructured":"Gebril A, Alsaadi M, Acevedo R, Mullen AB, Ferro VA. Optimizing efficacy of mucosal vaccines. Expert Rev Vaccines. 2012;11:1139\u201355.","journal-title":"Expert Rev Vaccines"},{"key":"636_CR39","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1051\/medsci\/2007234371","volume":"23","author":"F Anju\u00e8re","year":"2007","unstructured":"Anju\u00e8re F, Czerkinsky C. Mucosal immunity and vaccine development. Med Sci (Paris). 2007;23:371\u20138.","journal-title":"Med Sci (Paris)"},{"issue":"2 Suppl","key":"636_CR40","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/j.jpeds.2009.11.014","volume":"156","author":"P Brandtzaeg","year":"2010","unstructured":"Brandtzaeg P. The Mucosal immune system and its integration with the mammary glands. J Pediatr. 2010;156(2 Suppl):S8\u201315.","journal-title":"J Pediatr"},{"key":"636_CR41","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1172\/JCI116153","volume":"90","author":"DG Mack","year":"1992","unstructured":"Mack DG, McLeod R. Human Toxoplasma gondii-specific secretory immunoglobulin A reduces T. gondii infection of enterocytes in vitro. J Clin Invest. 1992;90:2585\u201392.","journal-title":"J Clin Invest"},{"key":"636_CR42","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.imlet.2011.04.007","volume":"138","author":"NE Zorgi","year":"2011","unstructured":"Zorgi NE, Costa A, Galisteo Jr AJ, do Nascimento N, de Andrade Jr HF. Humoral responses and immune protection in mice immunized with irradiated T.gondii tachyzoites and challenged with three genetically distinct strains of T.gondii. Immunol Lett. 2011;138:187\u201396.","journal-title":"Immunol Lett"},{"key":"636_CR43","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1016\/j.vaccine.2004.04.022","volume":"22","author":"AC Stanley","year":"2004","unstructured":"Stanley AC, Buxton D, Innes EA, Huntley JF. Intranasal immunisation with Toxoplasma gondii tachyzoite antigen encapsulated into PLG microspheres induces humoral and cell-mediated immunity in sheep. Vaccine. 2004;22:3929\u201341.","journal-title":"Vaccine"},{"key":"636_CR44","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.4049\/jimmunol.164.5.2629","volume":"164","author":"H Kang","year":"2000","unstructured":"Kang H, Remington JS, Suzuki Y. Decreased resistance of B cell deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma: TNF-alpha, and inducible nitric oxide synthase. J Immunol. 2000;164:2629\u201334.","journal-title":"J Immunol"},{"key":"636_CR45","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1128\/IAI.68.3.1026-1033.2000","volume":"68","author":"PC Sayles","year":"2000","unstructured":"Sayles PC, Gibson GW, Johnson LL. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun. 2000;68:1026\u201333.","journal-title":"Infect Immun"},{"key":"636_CR46","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1586\/erv.09.27","volume":"8","author":"J Kur","year":"2009","unstructured":"Kur J, Holec-Gasior L, Hiszczynska-Sawicka E. Current status of toxoplasmosis vaccine development. Expert Rev Vaccines. 2009;8:791\u2013808.","journal-title":"Expert Rev Vaccines"},{"key":"636_CR47","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1385\/IR:29:1-3:187","volume":"29","author":"B Pulendran","year":"2004","unstructured":"Pulendran B. Modulating TH1\/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors. Immunol Res. 2004;29:187\u201396.","journal-title":"Immunol Res"},{"key":"636_CR48","first-page":"148","volume":"204","author":"TR Mosmann","year":"1997","unstructured":"Mosmann TR, Li L, Hen gartner H, Kagi D, Fu W, Sad S. Differentiation and functions of T cell subsets. Ciba Found Symp. 1997;204:148\u201354. discussion 154-158.","journal-title":"Ciba Found Symp"},{"key":"636_CR49","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1016\/j.vaccine.2010.01.031","volume":"28","author":"E Jongert","year":"2010","unstructured":"Jongert E, Lemiere A, Van Ginderachter J, De Craeye S, Huygen K, D'Souza S. Functional characterization of in vivo effector CD4(+) and CD8(+) T cell responses in acute toxoplasmosis: an interplay of IFN-gamma and cytolytic T cells. Vaccine. 2010;28:2556\u201364.","journal-title":"Vaccine"},{"key":"636_CR50","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1017\/S1462399411002018","volume":"13","author":"Y Suzuki","year":"2011","unstructured":"Suzuki Y, Sa Q, Gehman M, Ochiai E. Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain. Expert Rev Mol Med. 2011;13:e31.","journal-title":"Expert Rev Mol Med"},{"key":"636_CR51","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.4049\/jimmunol.157.6.2564","volume":"157","author":"Y Suzuki","year":"1996","unstructured":"Suzuki Y, Yang Q, Yang S, Nguyen N, Lim S, Liesenfeld O, et al. IL-4 is protective against development of Toxoplasmic encephalitis. J Immunol. 1996;157:2564\u20139.","journal-title":"J Immunol"},{"key":"636_CR52","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vetpar.2011.12.007","volume":"187","author":"R Fang","year":"2012","unstructured":"Fang R, Feng H, Hu M, Khan MK, Wang L, Zhao J. Evaluation of immune responses induced by SAG1 and MIC3 vaccine cocktails against Toxoplasma gondii. Vet Parasitol. 2012;187:140\u20136.","journal-title":"Vet Parasitol"}],"container-title":["Parasites &amp; Vectors"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-0636-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13071-015-0636-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-0636-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13071-015-0636-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T20:27:18Z","timestamp":1690835238000},"score":1,"resource":{"primary":{"URL":"https:\/\/parasitesandvectors.biomedcentral.com\/articles\/10.1186\/s13071-015-0636-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,13]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["636"],"URL":"https:\/\/doi.org\/10.1186\/s13071-015-0636-5","relation":{},"ISSN":["1756-3305"],"issn-type":[{"value":"1756-3305","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,13]]},"assertion":[{"value":"17 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"15"}}